{"id":20491,"date":"2022-04-05T08:08:59","date_gmt":"2022-04-05T08:08:59","guid":{"rendered":"https:\/\/zeepedia.com\/?p=20491"},"modified":"2022-04-06T10:25:20","modified_gmt":"2022-04-06T10:25:20","slug":"paricalcitol-alternova","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/paricalcitol-alternova\/","title":{"rendered":"Paricalcitol Alternova &#8211; Paricalcitol uses, dose and side effects"},"content":{"rendered":"\n<p>1 and 2 micrograms&nbsp;soft capsule<br>paricalcitol<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Paricalcitol Alternova is and what it is used for<\/h2>\n\n\n\n<p>Paricalcitol Alternova contains the active substance paricalcitol, which is a&nbsp;synthetic&nbsp;form of active&nbsp;vitamin&nbsp;D.<\/p>\n\n\n\n<p>Active\u00a0vitamin\u00a0D is needed for many of the body&#8217;s\u00a0tissues, including the\u00a0parathyroid gland\u00a0and skeleton, to function normally.\u00a0In people who have normal kidney function, this active form of\u00a0vitamin\u00a0D is produced naturally in the kidney, but in\u00a0renal failure, the production of active\u00a0vitamin\u00a0D is markedly reduced.\u00a0Paricalcitol Alternova therefore actively supplies\u00a0vitamin\u00a0D, when the body cannot produce enough.\u00a0Paricalcitol Alternova helps prevent the effects of low\u00a0vitamin D levels, namely high levels of parathyroid hormone, which can cause skeletal problems.\u00a0Paricalcitol Alternova is used by adult patients with stage 3, 4, and 5 kidney disease and by children from 10 to 16 years of age with stage 3 and 4 kidney disease.<\/p>\n\n\n\n<p>Paricalcitol contained in Paricalcitol Alternova may also be approved for the treatment of other conditions not mentioned in this product information.\u00a0Ask your doctor, pharmacist, or other healthcare professionals if you have any further questions, and always follow their instructions.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you use Paricalcitol Alternova<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Paricalcitol Alternova:<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to paricalcitol or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you have very high&nbsp;calcium&nbsp;or&nbsp;vitamin&nbsp;D levels in your blood.<\/li><\/ul>\n\n\n\n<p>Your doctor can tell you if this applies to you.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse before using Paricalcitol Alternova.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Before starting treatment, it is important to reduce the amount of\u00a0phosphate\u00a0in your diet.<\/li><li>Phosphate-binding drugs may be needed to control phosphate levels.\u00a0If you are taking calcium-based phosphate binders, your doctor may need to adjust\u00a0the dosage.<\/li><li>Your doctor will need to take blood samples to check your treatment.<\/li><li>In some patients with stage 3 and 4\u00a0chronic\u00a0kidney disease, an increase in\u00a0creatinine\u00a0has been seen in the blood.\u00a0However, this increase does not mean that kidney function has deteriorated.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Paricalcitol Alternova<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>Some medicines may affect the way this medicine works or increase the risk of\u00a0side effects.\u00a0It is especially important to tell your doctor if you are taking any of the following medicines:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>medicines for fungal infections such as candida or cod (eg\u00a0ketoconazole\u00a0),<\/li><li>heart or\u00a0blood pressure\u00a0medicines (eg\u00a0digoxin\u00a0and\u00a0diuretics\u00a0or\u00a0diuretics\u00a0),<\/li><li>drugs that contain a source of phosphate (eg drugs to lower the level of calcium in the blood),<\/li><li>medicines containing\u00a0calcium\u00a0or\u00a0vitamin D, including supplements and multivitamins that can be bought without a prescription,<\/li><li>medicines containing\u00a0magnesium\u00a0or aluminum (eg certain types of medicines for acid stomachs called antacids) and phosphate binders,<\/li><li>drugs to treat elevated cholesterol levels (eg cholestyramine).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Paricalcitol Alternova with food and drink<\/h2>\n\n\n\n<p>Paricalcitol Alternova can be taken with or without food.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n<p><em>Pregnancy<\/em><\/p>\n\n\n\n<p>There are no adequate data on the use of paricalcitol in pregnant women.\u00a0The risk to humans is unknown and therefore paricalcitol should be used during pregnancy only when needed.<\/p>\n\n\n\n<p><em>Breast-feeding<\/em><\/p>\n\n\n\n<p>It is not known if paricalcitol passes into breast milk.\u00a0Talk to your doctor before breastfeeding if you are taking Paricalcitol Alternova.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Paricalcitol Alternova should not affect your ability to drive or use machines.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0Descriptions of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Paricalcitol Alternova contains excipients<\/h2>\n\n\n\n<p>This medicine contains small amounts of\u00a0ethanol\u00a0(alcohol), less than 100 mg per capsule, which may reduce or increase the effect of other medicines.\u00a0This can be harmful to people who have liver disease, alcoholism,\u00a0epilepsy, brain damage or disease, and pregnant or breastfeeding women and children.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Paricalcitol Alternova<\/h2>\n\n\n\n<p>Always use this medicine exactly as your doctor or pharmacist has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p><strong>Chronic&nbsp;kidney disease stage 3 and 4<\/strong><\/p>\n\n\n\n<p>The usual starting dose for adult patients is one capsule a day, either daily or every other day, up to three times a week.<\/p>\n\n\n\n<p>Your doctor will use the results of your laboratory tests to determine what is the right&nbsp;dose&nbsp;for you.&nbsp;At the beginning of treatment with Paricalcitol Alternova, a&nbsp;dose&nbsp;may need to be adjusted according to how you respond to the treatment.&nbsp;Your doctor will decide on the right&nbsp;dose&nbsp;of Paricalcitol Alternova for you.<\/p>\n\n\n\n<p><strong>Chronic&nbsp;kidney disease stage 5<\/strong><\/p>\n\n\n\n<p>The usual starting dose for adult patients is one capsule every other day, up to three times a week.&nbsp;Your doctor will use the results of your laboratory tests to determine what is the right&nbsp;dose&nbsp;for you.&nbsp;At the beginning of treatment with Paricalcitol Alternova, a&nbsp;dose&nbsp;may need to be adjusted according to how you respond to the treatment.&nbsp;Your doctor will decide on the right&nbsp;dose&nbsp;of Paricalcitol Alternova for you.<\/p>\n\n\n\n<p><strong>Liver disease<\/strong><\/p>\n\n\n\n<p>If you have mild or moderate liver disease, your&nbsp;dose&nbsp;will not need to be changed.&nbsp;However, there is no experience in patients with severe liver disease.<\/p>\n\n\n\n<p><strong>Kidney transplant patients<\/strong><\/p>\n\n\n\n<p>The usual\u00a0dose\u00a0is one capsule a day, either every day or every other day three times a week.\u00a0Your doctor will use the results of your laboratory tests to determine the correct\u00a0dose\u00a0for you.\u00a0Once treatment with Paricalcitol Alternova has started, dose one will likely need to be changed, depending on how you respond to treatment.\u00a0Your doctor will decide which\u00a0dose\u00a0of Paricalcitol Alternova is right for you.<\/p>\n\n\n\n<p><strong><br>Use for children and adolescents<\/strong><\/p>\n\n\n\n<p>For children aged 10 to 16 years with&nbsp;chronic&nbsp;kidney disease Stage 3 or 4, the normal starting dose is one capsule every other day up to three times a week.&nbsp;Your doctor will use the results of your laboratory tests to determine the right&nbsp;dose&nbsp;for you.&nbsp;Once treatment with Paricalcitol Alternova has started, the&nbsp;dose&nbsp;may need to be adjusted according to how you respond to treatment.&nbsp;Your doctor will help determine what is the right&nbsp;dose&nbsp;for you.<\/p>\n\n\n\n<p>The effect of Paricalcitol Alternova in children with&nbsp;chronic&nbsp;stage 5 kidney disease has not been established.<\/p>\n\n\n\n<p>There is no information on the use of Paricalcitol Alternova in children under 10 years of age.<\/p>\n\n\n\n<p><strong>Use for the elderly<\/strong><\/p>\n\n\n\n<p>There is limited experience with the use of paricalcitol in patients 65 years of age and older.&nbsp;In general, there was no difference in safety and efficacy in the treatment of elderly patients (65 years and older) and younger patients.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you take more Paricalcitol Alternova than you should<\/h2>\n\n\n\n<p>If you have ingested too much medicine or if e.g.\u00a0If a child has accidentally ingested the medicine, contact a doctor or hospital immediately for an assessment of the risk and advice.<\/p>\n\n\n\n<p>Too much Paricalcitol Alternova can cause abnormally high levels of\u00a0calcium\u00a0in the blood, which can be harmful.\u00a0Symptoms that may occur after taking too much Paricalcitol Alternova may be feeling weak and\/or drowsy, headache, nausea or vomiting,\u00a0dry mouth, constipation, muscle or skeletal pain, and a metallic taste in the mouth.<\/p>\n\n\n\n<p>Symptoms that may occur if you take too much Paricalcitol Alternova for a long period may include loss of appetite, drowsiness, weight loss, eye pain, runny nose, itchy skin, fever,\u00a0impotence,\u00a0and severe stomach pain (due to the inflamed\u00a0pancreas\u00a0) and\u00a0kidney stones.\u00a0Your\u00a0blood pressure\u00a0may be affected and irregular heartbeat (palpitations) may occur.\u00a0Results of blood and urine tests may show high levels of\u00a0cholesterol,\u00a0urea, nitrogen, and liver enzymes.\u00a0Paricalcitol Alternova can in rare cases cause mental changes including confusion, drowsiness, insomnia, and nervousness.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Paricalcitol Alternova<\/h2>\n\n\n\n<p>If you forget to take a\u00a0dose, take it as soon as you remember.\u00a0If it is almost time for the next capsule, do not take the capsule you forgot, but continue treatment according to your doctor&#8217;s\u00a0prescription\u00a0(\u00a0dose\u00a0and time).<\/p>\n\n\n\n<p>Do not take a double\u00a0dose\u00a0to make up for a forgotten\u00a0dose.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking Paricalcitol Alternova<\/h2>\n\n\n\n<p>Unless your doctor tells you to stop treatment, you must continue to take Paricalcitol Alternova as your doctor\u00a0prescribes it.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Important: Contact your doctor immediately if you get any of the following side effects:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>allergic reactions (eg shortness of breath, wheezing, rash,\u00a0itching,\u00a0or swelling of the face and lips)<\/li><\/ul>\n\n\n\n<p>Tell your doctor or nurse if you experience any of the following side effects:<br><strong>Common<\/strong>&nbsp;(may affect up to 1 in 10 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>elevated levels of\u00a0calcium\u00a0in the blood, as well as the amount of\u00a0calcium\u00a0with another substance in the blood called\u00a0phosphate\u00a0(in patients with severe\u00a0chronic\u00a0kidney disease)<\/li><li>levels of\u00a0phosphate\u00a0in the blood can also increase<\/li><\/ul>\n\n\n\n<p><br><strong>Uncommon<\/strong>&nbsp;(may affect up to 1 in 100 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Pneumonia<\/li><li>decreased levels of parathyroid hormone<\/li><li>loss of appetite<\/li><li>decreased levels of&nbsp;calcium<\/li><li>dizziness<\/li><li>taste changes<\/li><li>headache<\/li><li>irregular heartbeat<\/li><li>stomach upset or stomach pain<\/li><li>constipation<\/li><li>diarrhea<\/li><li>dry mouth<\/li><li>heartburn (reflux or indigestion)<\/li><li>nausea<\/li><li>vomiting<\/li><li>acne<\/li><li>itching<\/li><li>rash<\/li><li>hives<\/li><li>muscle cramps<\/li><li>muscle pain<\/li><li>sore breasts<\/li><li>feeling weak<\/li><li>fatigue, feeling of discomfort<\/li><li>swelling of the legs<\/li><li>pain<\/li><li>increased levels of&nbsp;creatinine<\/li><li>changes in liver function results<\/li><\/ul>\n\n\n\n<p><br>Contact your doctor immediately if you have an\u00a0allergic reaction.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Paricalcitol Alternova<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>No special storage instructions.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton and label after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is paricalcitol.\u00a0Each soft capsule contains 1 microgram or 2 micrograms.<\/li><li>The other ingredients are Medium-chain triglycerides,\u00a0ethanol\u00a0(alcohol) anhydrous, and butylhydroxytoluene.<\/li><li>The shell of the capsule contains Gelatin;\u00a0glycerol, anhydrous;\u00a0titanium dioxide (E171).<\/li><\/ul>\n\n\n\n<p>1 microgram capsule: iron oxide, black (E172)<\/p>\n\n\n\n<p>2 micrograms capsule: iron oxide, yellow (E172);&nbsp;iron oxide, red (E172)<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p><em>Appearance<\/em><\/p>\n\n\n\n<p>Paricalcitol Alternova 1 microgram soft capsule is a gray, oval, soft gelatin capsule.<\/p>\n\n\n\n<p>Paricalcitol Alternova 2 micrograms soft capsules are light brown, oval, soft gelatin capsule.<\/p>\n\n\n\n<p><em>Pack sizes<\/em><\/p>\n\n\n\n<p>Blister: 7, 28, or 30 capsules.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p><em>Marketing Authorisation Holder<\/em><\/p>\n\n\n\n<p>Alternova A \/ S, Lodshusvej 11, 4230 Sk\u00e6lsk\u00f8r, Denmark<\/p>\n\n\n\n<p><em>Manufacturer<\/em><\/p>\n\n\n\n<p>GAPSA Agisilaou Str. 46, 17341 A Agios Dimitirum, Athens, Greece.<\/p>\n\n\n\n<p><em>and<\/em><\/p>\n\n\n\n<p>Reform SA, These Poussi Hantzi, 19002 Paiania, Athens, Greece.<\/p>\n\n\n\n<p><em>and<\/em><\/p>\n\n\n\n<p>Viminco A \/ S, Lodshusvej 11, 4230 Sk\u00e6lsk\u00f8r, Denmark.<\/p>\n\n\n\n<p><strong>This medicinal product is authorized under the European Economic Area under the names:<\/strong><\/p>\n\n\n\n<p>Portugal: Paricalcitol Rafarm UK&nbsp;<\/p>\n\n\n\n<p>Cyprus: Rexton<\/p>\n\n\n\n<p>Spain: Paricalcitol Aurovitas Spain 1 microgram EFG mixed capsules<\/p>\n\n\n\n<p>Czech Republic: Rikalpa<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Paricalcitol Alternova contains the active substance paricalcitol, which is a synthetic form of active vitamin D.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18527],"tags":[20914,20919,20910,20915,20918,20913,20911,20916,20917,20912],"class_list":["post-20491","post","type-post","status-publish","format-standard","hentry","category-medicines","category-p","tag-benefits-of-paricalcitol","tag-benefits-of-paricalcitol-alternova","tag-paricalcitol","tag-paricalcitol-alternova","tag-paricalcitol-alternova-side-effects","tag-paricalcitol-side-effects","tag-what-is-paricalcitol","tag-what-is-paricalcitol-alternova","tag-what-paricalcitol-alternova-is-used-for","tag-what-paricalcitol-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20491","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=20491"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20491\/revisions"}],"predecessor-version":[{"id":20526,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20491\/revisions\/20526"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=20491"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=20491"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=20491"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}