{"id":20489,"date":"2022-04-05T08:07:55","date_gmt":"2022-04-05T08:07:55","guid":{"rendered":"https:\/\/zeepedia.com\/?p=20489"},"modified":"2022-04-06T10:25:26","modified_gmt":"2022-04-06T10:25:26","slug":"paricalcitol-accord","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/paricalcitol-accord\/","title":{"rendered":"Paricalcitol Accord &#8211; Paricalcitol uses, dose and side effects"},"content":{"rendered":"\n<p>5 micrograms\/ml\u00a0solution for\u00a0injection<br>paricalcitol<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Paricalcitol Accord is and what it is used for<\/h2>\n\n\n\n<p>Paricalcitol Accord contains the active substance paricalcitol which is a&nbsp;synthetic&nbsp;form of active&nbsp;vitamin&nbsp;D.<\/p>\n\n\n\n<p>Active\u00a0vitamin\u00a0D is needed for many of the body&#8217;s\u00a0tissues, including the\u00a0parathyroid gland\u00a0and skeleton, to function normally.\u00a0In people who have normal kidney function, this active form of\u00a0vitamin\u00a0D is produced naturally in the kidneys, but in\u00a0kidney failure, the production of active\u00a0vitamin\u00a0D is markedly reduced.\u00a0Paricalcitol Accord therefore actively supplies\u00a0vitamin\u00a0D, when the body cannot produce enough.\u00a0Paricalcitol Accord helps prevent the effects of low\u00a0vitamin\u00a0D levels in patients with\u00a0chronic kidney disease, namely high levels of parathyroid hormone, which can cause skeletal problems.\u00a0Paricalcitol Accord is used in adult patients with stage 5 kidney disease.<\/p>\n\n\n\n<p>Paricalcitol contained in the Paricalcitol Accord may also be approved for the treatment of other diseases not mentioned in this product information.\u00a0Ask your doctor, pharmacist, or another healthcare professional if you have any further questions, and always follow their instructions.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using Paricalcitol Accord<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Paricalcitol Accord<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to paricalcitol or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you have elevated levels of&nbsp;calcium&nbsp;or&nbsp;vitamin D&nbsp;in your blood.<\/li><\/ul>\n\n\n\n<p>Your doctor can tell you if this applies to you.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or nurse before using Paricalcitol Accord<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Before starting treatment, it is important to limit the amount of\u00a0phosphate\u00a0in your diet.\u00a0Examples of foods high in\u00a0phosphate\u00a0are tea, soft drinks, beer, cheese, milk, cream, fish, chicken or beef liver, beans, peas, breakfast cereals, nuts, and cereals.<\/li><li>Phosphate-binding drugs that prevent\u00a0phosphate\u00a0from being absorbed from food may be needed to control phosphate levels.<\/li><li>If you are taking calcium-based phosphate binders, your doctor may need to adjust\u00a0the dosage.<\/li><li>Your doctor will need to take blood samples to check your treatment.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Paricalcitol Accord<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>Some medicines may or may not affect the effect of this medicine or increase the risk of\u00a0side effects.\u00a0It is especially important to tell your doctor if you are taking any of the following:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>medicines for fungal infections such as candida or cod (eg\u00a0ketoconazole\u00a0)<\/li><li>medicines for heart problems or high\u00a0blood pressure\u00a0(eg\u00a0digoxin,\u00a0diuretics,\u00a0or\u00a0diuretics\u00a0)<\/li><li>medicines containing a phosphate source (eg medicines to lower the level of calcium in the blood)<\/li><li>medicines containing\u00a0calcium\u00a0or\u00a0vitamin D, including supplements and multivitamins that can be bought without a prescription<\/li><li>medicines containing\u00a0magnesium\u00a0or aluminum (eg certain types of medicines for acid stomachs, so-called antacids) and phosphate binders<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Paricalcitol Accord with food and drink<\/h2>\n\n\n\n<p>Paricalcitol Accord can be given with or without food.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before using this medicine.<\/p>\n\n\n\n<p>It is not known if it is safe for pregnant women to use this medicine.&nbsp;Therefore, use during pregnancy or if you are planning to become pregnant is not recommended.<\/p>\n\n\n\n<p>It is not known if paricalcitol passes into breast milk.\u00a0Talk to your doctor before breastfeeding if you are taking Paricalcitol Accord.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Paricalcitol Accord may make you feel dizzy, which may affect your ability to drive or use machines.<\/p>\n\n\n\n<p>Do not drive or use machines if you feel dizzy.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or side effects.\u00a0Descriptions of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<p><strong>Paricalcitol Accord contains anhydrous&nbsp;ethanol<\/strong><\/p>\n\n\n\n<p>This medicine contains up to 2.21 g of\u00a0ethanol\u00a0(alcohol) per\u00a0dose\u00a0equivalent to approximately 32 mg\/kg.\u00a0The amount in each\u00a0dose\u00a0of this medicine corresponds to 55 ml of beer or 22 ml of wine.<\/p>\n\n\n\n<p>The amount of alcohol in this medicine is unlikely to have any effects on adults and adolescents and its effect on children is probably not noticeable.\u00a0It can have some effects on younger children, e.g.\u00a0fatigue.<\/p>\n\n\n\n<p>The alcohol in this medicine may affect the effectiveness of other medicines.\u00a0Tell your doctor or pharmacist if you are taking other medicines.<\/p>\n\n\n\n<p>If you are pregnant or breastfeeding, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n<p>If you are or have been addicted to alcohol, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Paricalcitol Accord<\/h2>\n\n\n\n<p>Your doctor will use the results of your laboratory tests to determine what is the right starting dose for you.<\/p>\n\n\n\n<p>At the beginning of treatment with Paricalcitol Accord, the&nbsp;dose&nbsp;may need to be adjusted depending on the results of routine laboratory tests.&nbsp;With the help of your results, your doctor will help determine what is the right&nbsp;dose&nbsp;for you.<\/p>\n\n\n\n<p>Paricalcitol Accord will be given by a doctor or nurse while you are being treated with\u00a0dialysis.\u00a0The medicine will be given through the tubing used to connect you to the dialysis machine.\u00a0You will not need to receive an\u00a0injection\u00a0as Paricalcitol Accord can be administered directly into the tubing used for your treatment.<\/p>\n\n\n\n<p>You will not receive Paricalcitol Accord more often than every other day and no more than three times a week.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you use more Paricalcitol Accord than you should<\/h2>\n\n\n\n<p>Too much Paricalcitol Accord can lead to abnormally high levels of&nbsp;calcium&nbsp;in the blood, which can be harmful.&nbsp;Symptoms that may occur shortly after taking too much Paricalcitol Accord may be:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>a feeling of weakness and\/or drowsiness<\/li><li>headache<\/li><li>nausea or vomiting<\/li><li>dry mouth, constipation<\/li><li>muscle or skeletal pain<\/li><li>metallic taste in the mouth<\/li><\/ul>\n\n\n\n<p>If you get high levels of&nbsp;calcium&nbsp;in your blood after receiving the Paricalcitol Accord, your doctor will make sure you are given the appropriate treatment to get your&nbsp;calcium&nbsp;levels back to normal.&nbsp;When your calcium levels return to normal, you may receive a lower&nbsp;dose&nbsp;of Paricalcitol Accord.<\/p>\n\n\n\n<p>However, your doctor will check your blood levels.\u00a0If you experience any of the above symptoms or if you have ingested too much medicine or if e.g.\u00a0If a child has ingested the medicine by mistake, you should immediately contact a doctor or hospital for risk assessment and advice.<\/p>\n\n\n\n<p>Symptoms that may occur if you take too much Paricalcitol Accord over a long period may be:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>loss of appetite<\/li><li>drowsiness<\/li><li>weight loss<\/li><li>pain in the eyes<\/li><li>Runny nose<\/li><li>skin itching<\/li><li>feeling of fever<\/li><li>decreased sex drive<\/li><li>severe abdominal pain (due to inflamed\u00a0pancreas\u00a0)<\/li><li>kidney stone<\/li><li>your\u00a0blood pressure\u00a0may be affected and irregular heartbeat (palpitations) may occur.\u00a0Results of blood and urine tests may show high levels of\u00a0cholesterol,\u00a0urea, nitrogen, and liver enzymes.\u00a0Paricalcitol Accord can in rare cases cause mental changes including confusion, drowsiness, insomnia, and nervousness.<\/li><\/ul>\n\n\n\n<p>Paricalcitol Accord contains 30% (v \/ v) propylene glycol as ingredient.\u00a0Isolated cases of poisoning associated with high\u00a0doses\u00a0of propylene glycol have been reported but are not expected when given to patients via dialysis apparatus as propylene glycol disappears from the blood during\u00a0dialysis.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p>Various allergic reactions may occur with Paricalcitol Accord.&nbsp;Important:&nbsp;<strong>Contact your doctor or nurse immediately if you get any of the following side effects:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>shortness of breath<\/li><li>difficulty breathing or swallowing<\/li><li>rosslingar<\/li><li>rash, itchy skin, or hives<\/li><li>swelling of the face, lips, mouth, tongue, or throat<\/li><\/ul>\n\n\n\n<p><strong>Tell your doctor or nurse if you get any of the following side effects:<\/strong><\/p>\n\n\n\n<p><strong><em><strong>Common (may affect up to 1 in 10 people):<\/strong><\/em><\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>headache<\/li><li>unusual taste in the mouth<\/li><li>skin itching<\/li><li>low levels of parathyroid hormone<\/li><li>high levels of&nbsp;calcium&nbsp;(nausea or vomiting, constipation or confusion),&nbsp;phosphate&nbsp;in the blood (probably causes no symptoms but may increase the risk of bone fractures)<\/li><\/ul>\n\n\n\n<p><strong><em>Uncommon (may affect up to 1 in 100 people):<\/em><\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>sepsis,\u00a0pneumonia, sore throat,\u00a0vaginal\u00a0infection,\u00a0flu<\/li><li>breast cancer<\/li><li>decreased number of\u00a0red blood cells\u00a0(\u00a0anemia\u00a0&#8211; weakness, shortness of breath, pallor), decreased number of\u00a0white blood cells\u00a0(increased risk of\u00a0infection\u00a0), swollen\u00a0glands\u00a0in the neck, armpits, and\/or groin<\/li><li>high levels of\u00a0parathyroid hormone<\/li><li>high levels of\u00a0potassium\u00a0in the blood, low levels of\u00a0calcium\u00a0in the blood, decreased appetite<\/li><li>confusion (sometimes severe,\u00a0delirium\u00a0), personality change, anxiety (restlessness, anxiety), sleep problems, nervousness<\/li><li>coma\u00a0(deep unconsciousness when the person in question does not react to the environment),\u00a0stroke, fainting, muscle twitching in arms and legs, even during sleep, decreased feeling, tingling or numbness, dizziness<\/li><li>increased pressure in the eye, red eyes (itchy\/irritated eyelids)<\/li><li>earache<\/li><li>heart attack, irregular\/fast heartbeat<\/li><li>low\u00a0blood pressure, high\u00a0blood pressure<\/li><li>fluid in the lungs,\u00a0asthma, wheezing, shortness of breath, nosebleeds, cough<\/li><li>anal bleeding,\u00a0inflammation\u00a0of the colon, diarrhea, abdominal pain, difficulty swallowing, constipation, nausea, vomiting,\u00a0dry mouth<\/li><li>skin rash with itchy blisters, hair loss, increased hair growth, excessive and unpredictable sweating<\/li><li>joint pain, joint stiffness, back pain, muscle twitching, muscle pain<\/li><li>chest pain, erection difficulties<\/li><li>abnormal gait, general swelling or local swelling of the ankles, feet, and legs (\u00a0edema\u00a0), injection site pain, fever, chest pain, unusual tiredness or feeling of weakness, general feeling of discomfort, thirst<\/li><li>prolonged bleeding time (blood coagulates more slowly), increase in liver enzyme, change in laboratory samples, weight loss<\/li><\/ul>\n\n\n\n<p><strong><em>Has been reported (occurs in the unknown number of users):<\/em><\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>swelling of the face, lips, mouth, tongue, or throat which may cause difficulty in swallowing or breathing, skin itching (\u00a0hives\u00a0), and stomach bleeding.<\/li><\/ul>\n\n\n\n<p>Some of these&nbsp;side effects&nbsp;you may not even notice you have unless your doctor tells you to.<\/p>\n\n\n\n<p>If any of the\u00a0side effects\u00a0gets serious, or if you notice any\u00a0side effects\u00a0not listed in this leaflet, please tell your doctor, nurse, or pharmacist immediately.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Paricalcitol Accord<\/h2>\n\n\n\n<p>Keep this medicine out of the sight&nbsp;<strong>and<\/strong>&nbsp;reach of children.<\/p>\n\n\n\n<p>No special temperature instructions.&nbsp;Keep the&nbsp;ampoule&nbsp;or vial in the outer carton.&nbsp;Sensitive to light.<\/p>\n\n\n\n<p>Paricalcitol Accord should be used immediately after opening.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Do not use this medicine if you notice particles or discoloration.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is paricalcitol.\u00a0One ml of solution contains 5 micrograms of paricalcitol.<\/li><li>The other ingredients are anhydrous\u00a0ethanol\u00a0(alcohol), propylene glycol, and water for injections.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Paricalcitol Accord\u00a0solution for injection\u00a0is a clear and colorless\u00a0aqueous solution, free from visible particles.<\/p>\n\n\n\n<p>The medicine is supplied in cartons of 1 or 5 1 ml or 2 ml glass vials<\/p>\n\n\n\n<p>or 5&nbsp;glass ampoules&nbsp;are 1 ml or 2 ml.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>Accord Healthcare BV<\/p>\n\n\n\n<p>Winthontlaan 200<\/p>\n\n\n\n<p>3526 kV Utrecht<\/p>\n\n\n\n<p>Netherlands<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Accord Healthcare Limited&nbsp;<\/p>\n\n\n\n<p>Sage House, 319 Pinner Road,<\/p>\n\n\n\n<p>North Harrow, Middlesex, HA1 4HF&nbsp;<\/p>\n\n\n\n<p>UK&nbsp;<\/p>\n\n\n\n<p>Wessling Hungary Kft<\/p>\n\n\n\n<p>Footnote 56., Budapest, 1047, Hungary<\/p>\n\n\n\n<p>Accord Healthcare Polska Sp.z oo,<\/p>\n\n\n\n<p>ul.&nbsp;Lutomierska 50,95-200 Pabianice, Poland<\/p>\n","protected":false},"excerpt":{"rendered":"<p>5 micrograms\/ml\u00a0solution for\u00a0injectionparicalcitol What Paricalcitol Accord is and what it is used for Paricalcitol Accord contains the active substance paricalcitol which is a&nbsp;synthetic&nbsp;form of active&nbsp;vitamin&nbsp;D. Active\u00a0vitamin\u00a0D is needed for many of the body&#8217;s\u00a0tissues, including the\u00a0parathyroid gland\u00a0and skeleton, to function normally.\u00a0In people who have normal kidney function, this active form of\u00a0vitamin\u00a0D is produced naturally in the [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18527],"tags":[20914,20925,20910,20921,20924,20920,20913,20922,20923,20912],"class_list":["post-20489","post","type-post","status-publish","format-standard","hentry","category-medicines","category-p","tag-benefits-of-paricalcitol","tag-benefits-of-paricalcitol-accord","tag-paricalcitol","tag-paricalcitol-accord","tag-paricalcitol-accord-side-effects","tag-paricalcitol-injection","tag-paricalcitol-side-effects","tag-what-is-paricalcitol-accord","tag-what-paricalcitol-accord-is-used-for","tag-what-paricalcitol-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20489","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=20489"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20489\/revisions"}],"predecessor-version":[{"id":20527,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20489\/revisions\/20527"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=20489"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=20489"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=20489"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}