{"id":20345,"date":"2022-03-30T14:42:42","date_gmt":"2022-03-30T14:42:42","guid":{"rendered":"https:\/\/zeepedia.com\/?p=20345"},"modified":"2022-04-01T10:43:43","modified_gmt":"2022-04-01T10:43:43","slug":"pantoprazole-accord","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/pantoprazole-accord\/","title":{"rendered":"Pantoprazole Accord &#8211; Pantoprazole uses, dose and side effects"},"content":{"rendered":"\n<p>40 mg&nbsp;powder for&nbsp;solution for&nbsp;injection<br>pantoprazole<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Pantoprazole Accord is and what it is used for<\/h2>\n\n\n\n<p>Pantoprazole is a\u00a0selective\u00a0proton pump inhibitor, a drug that reduces the amount of stomach acid produced.\u00a0It is used to treat diseases associated with acid in the stomach and intestines.<\/p>\n\n\n\n<p>The medicine is injected into a vein and you will only get it if your doctor thinks it is better for you at the moment than pantoprazole tablets.&nbsp;As soon as your doctor considers it appropriate, you may switch to tablets.<\/p>\n\n\n\n<p><strong>Pantoprazole Accord is used to treat:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Reflux esophagitis: an&nbsp;inflammation&nbsp;of the esophagus with acid regurgitation.<\/li><li>Ulcers in the stomach and&nbsp;duodenum&nbsp;one.<\/li><li>Zollinger-Ellison syndrome&nbsp;and other conditions in which the stomach produces too much acid.<\/li><\/ul>\n\n\n\n<p>Pantoprazole contained in Pantoprazole Accord may also be approved for the treatment of other conditions not mentioned in this product information.\u00a0Ask your doctor, pharmacist, or other healthcare professionals if you have any further questions, and always follow their instructions.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using Pantoprazole Accord<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Pantoprazole Accord<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to pantoprazole or any of the other ingredients of this medicine (listed in section 6)<\/li><li>if you are allergic to medicines containing other\u00a0proton pump inhibitors.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse before using Pantoprazole Accord:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have severe liver problems.\u00a0Tell your doctor if you have had liver problems before.\u00a0He\/she will then check your liver enzyme values \u200b\u200bmore often.\u00a0If liver enzyme levels rise, treatment should be discontinued.<\/li><li>if you are taking HIV\u00a0protease inhibitors\u00a0at the same time as pantoprazole,\u00a0e.g.\u00a0Atazanavir (for the treatment of\u00a0HIV\u00a0infection\u00a0) you should talk to\u00a0your doctor for special advice.<\/li><li>Use of\u00a0proton pump inhibitors\u00a0such as pantoprazole and especially if you use pantoprazole for more than a year may increase the risk of having a hip, wrist, or vertebral fracture (bone fracture).<\/li><li>Tell your doctor if you have osteoporosis\u00a0or\u00a0if you are taking medicines called corticosteroids as they may increase the risk of osteoporosis.<\/li><li>If you use Pantoprazole Accord for more than three months, your blood magnesium levels may drop.\u00a0Low levels of\u00a0magnesium\u00a0can manifest as fatigue, involuntary muscle movements, confusion, cramps, dizziness, rapid heartbeat.\u00a0If you get any of these symptoms, contact your doctor immediately.\u00a0Low levels of\u00a0magnesium\u00a0can also lead to decreased levels of\u00a0potassium\u00a0or\u00a0calcium\u00a0in the blood.\u00a0Your doctor may measure the level of magnesium in your blood using regular blood tests.\u00a0<\/li><li>if you have ever had a skin reaction after treatment with a medicine similar to Pantoprazole Accord which reduces the amount of stomach acid.<\/li><li>if you are going to have a specific blood test (chromogranin A)<\/li><\/ul>\n\n\n\n<p>If you get a rash, especially in areas exposed to the sun, tell your doctor as soon as possible as you may need to stop taking Pantoprazole Accord.\u00a0Also remember to mention any other\u00a0side effects, such as joint pain.<\/p>\n\n\n\n<p>If you get any of the following symptoms, tell your\u00a0<strong>doctor immediately, before or after taking this medicine<\/strong>.\u00a0These could be signs of another, more serious, medical condition.\u00a0<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>unintentional weight loss<\/li><li>repeated vomiting<\/li><li>difficulty swallowing or pain when swallowing<\/li><li>bloody vomit, which may look like dark coffee grounds in the vomit<\/li><li>pallor and feeling of weakness (\u00a0anemia\u00a0)<\/li><li>bloody stools, which may be black or tar-colored<\/li><li>chest pain<\/li><li>abdominal pain<\/li><li>severe and\/or persistent diarrhea, as a link has been found between Pantoprazole Accord and a small increase in infectious diarrhea.<\/li><\/ul>\n\n\n\n<p>Your doctor may want to do some tests to rule out that you are suffering from a tumor disease.\u00a0Pantoprazole can relieve cancer symptoms and therefore make it take longer before a correct diagnosis is made.\u00a0If symptoms persist despite treatment, further examinations may be necessary.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Pantoprazole Accord is not recommended for use in children as it is not effective in children under 18 years of age.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Pantoprazole Accord<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines, including medicines obtained without a prescription.\u00a0This is because pantoprazole may affect the way other medicines work.\u00a0Other medicines may also affect the way pantoprazole works.<\/p>\n\n\n\n<p>Tell your doctor if you are taking any of the following medicines:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Drugs such as\u00a0ketoconazole, itraconazole, and posaconazole (used to treat fungal infections) or erlotinib (used to treat certain types of cancer), as pantoprazole may prevent them from working properly<\/li><li>Warfarin\u00a0or phenprocoumon (blood-thinning drug).\u00a0Additional checks may be necessary.\u00a0Medicines for the treatment of\u00a0HIV\u00a0infection\u00a0such as atazanavir.<\/li><li>Methotrexate (used to treat\u00a0rheumatoid arthritis,\u00a0psoriasis,\u00a0and cancer).\u00a0If you are taking methotrexate, your doctor may temporarily stop taking Pantoprazole Accord, as pantoprazole may increase the levels of methotrexate in your blood.<\/li><li>Fluvoxamine (for the treatment of depression and other psychiatric disorders).\u00a0If you are taking fluvoxamine, your doctor may reduce the\u00a0dose\u00a0one.<\/li><li>Rifampicin (for the treatment of\u00a0infections\u00a0).<\/li><li>St. John&#8217;s wort\u00a0(Hypericum perforatum) (for the treatment of mild depression).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>There are insufficient data on the use of pantoprazole in pregnant women.\u00a0Excretion in human breast milk has been reported.\u00a0If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n<p>You should only use this medicine if your doctor thinks that the benefits to you outweigh the risks to the fetus or baby.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Pantoprazole Accord has no or negligible effect on the ability to drive and use machines.<\/p>\n\n\n\n<p>If you experience&nbsp;side effects&nbsp;such as dizziness or visual disturbances, do not drive or use machines.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0Descriptions of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pantoprazole Accord contains sodium<\/h2>\n\n\n\n<p>This medicine contains less than 1 mmol\u00a0sodium\u00a0(23 mg) per\u00a0vial, ie essentially &#8216;sodium-free&#8217;.\u00a0it is next to &#8220;sodium-free&#8221;.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Pantoprazole Accord<\/h2>\n\n\n\n<p>A doctor or nurse will give you the daily&nbsp;dose&nbsp;as an&nbsp;injection&nbsp;into a blood vessel for 2-15 minutes.<\/p>\n\n\n\n<p>The recommended&nbsp;dose&nbsp;is:<\/p>\n\n\n\n<p><strong>Adults<\/strong><\/p>\n\n\n\n<p><strong>For the treatment of\u00a0gastric ulcers<\/strong>, duodenal ulcers,<strong> and\u00a0reflux oesophagitis<\/strong><\/p>\n\n\n\n<p>One&nbsp;vial&nbsp;(40 mg pantoprazole) per day.<\/p>\n\n\n\n<p><strong>For long-term treatment of&nbsp;Zollinger-Ellison syndrome&nbsp;and other conditions with excessive production of stomach acid<\/strong><\/p>\n\n\n\n<p>Two vials (80 mg pantoprazole) per day.<\/p>\n\n\n\n<p>The doctor can later adjust the\u00a0dose\u00a0depending on how much stomach acid is produced.\u00a0If you are prescribed more than two vials (80 mg) per day, the\u00a0injections\u00a0will be divided into two equal\u00a0doses.\u00a0Your doctor may\u00a0prescribe\u00a0a temporary\u00a0dose\u00a0higher than four vials (160 mg) per day.\u00a0If stomach acid levels need to be adjusted quickly, a starting dose of 160 mg (four vials) should be sufficient to reduce the amount of stomach acid to the desired levels.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Patients with hepatic impairment:<\/strong>&nbsp;If you have severe liver problems, the daily&nbsp;dose&nbsp;should only be 20 mg (half a&nbsp;vial&nbsp;).<\/li><li><strong>Use in children and adolescents:<\/strong>&nbsp;These&nbsp;injections&nbsp;are not recommended for children and adolescents under 18 years of age<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">If you use more Pantoprazole Accord than you should<\/h2>\n\n\n\n<p>The doses&nbsp;are carefully monitored by a nurse or doctor, so it is very unlikely that you will receive an overdose.&nbsp;There are no known symptoms of overdose.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>If you get any of the following\u00a0side effects, contact your doctor immediately or visit an emergency department at the nearest hospital:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Severe allergic reactions (rare; may affect up to 1 in 1,000 people):<\/strong>\u00a0swelling of the tongue and\/or throat, difficulty swallowing,\u00a0hives, difficulty breathing, allergic facial swelling (Quincke&#8217;s edema\/angioedema), severe dizziness with very rapid heartbeat and heavy sweating.<\/li><li>Severe skin conditions (not known frequency; can not be calculated from the available data):\u00a0blisters on the skin and rapid deterioration of your general condition, skin and mucous membrane changes (including bleeding) in the eyes, nose, mouth\/lips, or genitals (\u00a0Stevens-Johnson syndrome,\u00a0Lyell&#8217;s syndrome\u00a0and erythema multiforme) and photosensitivity.<\/li><li>Other serious conditions (no known frequency; can not be calculated from the available data):\u00a0skin and whites of the eyes get a yellowish tone (severe liver damage and jaundice) or fever, rash, and enlarged kidneys, sometimes with painful urination and pain in the lower back (severe\u00a0inflammation\u00a0of the kidneys) which can lead to\u00a0kidney failure.<\/li><\/ul>\n\n\n\n<p><strong>Other side effects:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Common<\/strong>&nbsp;(may affect up to 1 in 10 people)<br>Inflammation&nbsp;of the walls of the blood vessel (vein) and blood clotting (&nbsp;thrombophlebitis&nbsp;) at the site of injection, benign&nbsp;polyps&nbsp;in the stomach.<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Uncommon<\/strong>\u00a0(may affect up to 1 in 100 people)<br>Headache;\u00a0dizziness;\u00a0diarrhea;\u00a0nausea;\u00a0vomiting;\u00a0run-up and gas formation;\u00a0constipation;\u00a0dry mouth;\u00a0pain and discomfort in the abdomen;\u00a0rash;\u00a0redness of the skin: blisters;\u00a0itching;\u00a0feeling of weakness, exhaustion, or general malaise;\u00a0sleep disorders, hip, wrist or vertebral fracture (bone fracture).<\/li><li>Rare\u00a0(may affect up to 1 in 1,000 people)<br>Distortion or total lack of taste;\u00a0visual disturbances, including blurred vision;\u00a0hives;\u00a0joint pain;\u00a0muscle aches;\u00a0weight changes;\u00a0(high fever;\u00a0swollen legs or arms (peripheral\u00a0edema\u00a0);\u00a0allergic reactions;\u00a0Depression;\u00a0breast augmentation in men.<\/li><li>Very rare\u00a0(may affect up to 1 in 10,000 people) Confusion.<\/li><li>No known frequency\u00a0(can not be calculated from the available data)<br>Hallucinations, confusion (especially in patients who have previously had these symptoms);\u00a0decreased sodium content in the blood, decreased magnesium content in the blood (see section 2), feeling of tingling, tingling, and crawling, burning sensation or numbness;\u00a0skin rash, possibly with joint pain;\u00a0inflammation\u00a0of the colon, which gives rise to persistent watery diarrhea.<\/li><\/ul>\n\n\n\n<p><strong>Side effects&nbsp;detected with the help of blood tests:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Uncommon<\/strong>\u00a0(may affect up to 1 in 100 people)Elevated liver enzymes.<\/li><li><strong>Rare<\/strong>\u00a0(may affect up to 1 in 1,000 people)Elevated bilirubin;\u00a0elevated blood fats;\u00a0sharp decrease in circulating granular\u00a0white blood cells\u00a0associated with a high fever.<\/li><li>Very rare\u00a0(may affect up to 1 in 10,000 people)Decreased\u00a0platelet count, which may lead to more bleeding or bruising than normal;\u00a0decreased\u00a0white blood cell count, which can lead to more infections;\u00a0concomitant abnormal decrease in the number of red and\u00a0white blood cells\u00a0and\u00a0platelets.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Pantoprazole Accord<\/h2>\n\n\n\n<p>Keep this medicine out of the sight&nbsp;<strong>and<\/strong>&nbsp;reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton after EXP.&nbsp;or the vial after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Do not store above 25 \u00b0 C.&nbsp;Keep the vial in the outer carton.&nbsp;Sensitive to light.<\/p>\n\n\n\n<p>After\u00a0reconstitution, or\u00a0reconstitution\u00a0and dilution, chemical and physical in-use stability has been demonstrated for 12 hours at 25 \u00b0 C.\u00a0From a microbiological perspective, the product should be used immediately, unless the method of opening and dilution excludes the risk of\u00a0microbial\u00a0contamination.<\/p>\n\n\n\n<p>Do not use this medicine if visible changes (eg cloudiness or precipitation) are noticed.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<p>The active substance is pantoprazole (as sodium sesquihydrate).<\/p>\n\n\n\n<p>Each&nbsp;vial&nbsp;of powder for solution for&nbsp;injection&nbsp;contains 42.29 mg of pantoprazole sodium equivalent to 40 mg of pantoprazole.<\/p>\n\n\n\n<p>The other ingredient is sodium hydroxide.&nbsp;(See section 2 for sodium content).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Pantoprazole Accord is a white to off-white lyophilized powder.\u00a0The powder is prepared into a solution before it is given to you.<\/p>\n\n\n\n<p>Pack sizes:<\/p>\n\n\n\n<p>1&nbsp;vial<\/p>\n\n\n\n<p>10 vials<\/p>\n\n\n\n<p>20 vials<\/p>\n\n\n\n<p>50 vials<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>Accord Healthcare BV<\/p>\n\n\n\n<p>Winthontlaan 200<\/p>\n\n\n\n<p>3526 VK Utrecht<\/p>\n\n\n\n<p>Netherlands<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Accord Healthcare Limited<\/p>\n\n\n\n<p>Sage House<\/p>\n\n\n\n<p>319 Pinner Road<\/p>\n\n\n\n<p>North Harrow<\/p>\n\n\n\n<p>Middlesex, HA1 4HF<\/p>\n\n\n\n<p>UK<\/p>\n\n\n\n<p>Wessling Hungary Kft<\/p>\n\n\n\n<p>Footnote 56, Budapest, 1047,<\/p>\n\n\n\n<p>Hungary<\/p>\n\n\n\n<p>Accord Healthcare Polska Sp.z oo,<\/p>\n\n\n\n<p>ul.&nbsp;Lutomierska 50,95-200 Pabianice, Poland<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Pantoprazole is a selective proton pump inhibitor , a drug that reduces the amount of stomach acid produced. It is used to treat diseases associated with acid in the stomach and intestines.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18527],"tags":[20754,20778,20749,20773,20776,20777,20753,20752,20750,20774,20775,20751],"class_list":["post-20345","post","type-post","status-publish","format-standard","hentry","category-medicines","category-p","tag-benefits-of-pantoprazole","tag-benefits-of-pantoprazole-accord","tag-pantoprazole","tag-pantoprazole-accord","tag-pantoprazole-accord-injection","tag-pantoprazole-accord-side-effects","tag-pantoprazole-side-effects","tag-pantoprazole-tablet","tag-what-is-pantoprazole","tag-what-is-pantoprazole-accord","tag-what-pantoprazole-accord-is-used-for","tag-what-pantoprazole-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20345","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=20345"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20345\/revisions"}],"predecessor-version":[{"id":20381,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20345\/revisions\/20381"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=20345"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=20345"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=20345"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}