Women<\/em><\/p>\n\n\n\nPregnancy should be ruled out before starting treatment.<\/p>\n\n\n\n
During the first month of your treatment, menstrual-like bleeding may occur. After that, your periods usually end. Talk to your doctor if you experience bleeding after the first month of your treatment.<\/p>\n\n\n\n
Your period should start about 2 months after your last\u00a0injection.\u00a0You should use a non-hormonal contraceptive throughout the treatment and for one month after the last\u00a0injection, as\u00a0birth control pills\u00a0or other hormone-based contraceptives are not sufficient to prevent pregnancy.<\/p>\n\n\n\n
Children and young people<\/h2>\n\n\n\n
Tell your doctor if your child has a progressive brain tumor.<\/p>\n\n\n\n
This can affect how the doctor decides to treat.<\/p>\n\n\n\n
Girls with early puberty may experience menstrual-like bleeding during the first month of treatment.<\/p>\n\n\n\n
At the end of treatment, your child develops pubertal features.<\/p>\n\n\n\n
Information regarding future fertility is still limited. In most girls, regular menstruation begins about a year after the end of treatment.<\/p>\n\n\n\n
A disorder in the upper growing part of the femur (femur) at the hip, so-called slippage of the femoral epiphysis, can occur after the end of treatment.\u00a0This can cause lameness, pain in the knees or hips, stiffness in the hips, outstretched legs, and limited mobility in the hips.<\/p>\n\n\n\n
Talk to your doctor if you have any of the above.<\/p>\n\n\n\n
Other medicines and Pamorelin<\/h2>\n\n\n\n
Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n
Pamorelin may affect certain other medicines used to treat heart rhythm disorders (eg\u00a0quinidine,\u00a0procainamide,\u00a0amiodarone,\u00a0and sotalol) or may increase the risk of heart rhythm disorders when used with other medicines (eg\u00a0methadone\u00a0(used for pain and in treatment of drug addiction), moxifloxacin (an\u00a0antibiotic\u00a0), antipsychotics (used for severe mental illness).<\/p>\n\n\n\n
Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n
If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n
Pamorelin should not be used during pregnancy or breastfeeding.<\/p>\n\n\n\n
If you are a woman of\u00a0childbearing potential, you will be carefully examined by a doctor to rule out pregnancy before starting treatment.\u00a0You should use non-hormonal contraceptives during treatment until menstruation returns.\u00a0Talk to your doctor for further advice.<\/p>\n\n\n\n
Driving and using machines<\/h2>\n\n\n\n
Even if Pamorelin is used as\u00a0prescribed,\u00a0side effects\u00a0can occur to such an extent that the ability to drive or use machines is impaired.\u00a0You may feel dizzy, tired, or have vision problems e.g.\u00a0dimsyn.\u00a0It may be a\u00a0side effect\u00a0of the treatment or the underlying disease.\u00a0If you experience any of these\u00a0side effects, do not drive or use machines.<\/p>\n\n\n\n
You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened vigilance.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0Descriptions of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n
Pamorelin contains sodium<\/h2>\n\n\n\n
This medicine contains less than 1 mmol (23 mg)\u00a0sodium\u00a0per\u00a0vial, ie essentially ‘sodium-free’.\u00a0is next to “sodium-free”.<\/p>\n\n\n\n
How to use Pamorelin<\/h2>\n\n\n\n
Always use this medicine exactly as your doctor has told you. Consult a doctor if you are unsure.<\/p>\n\n\n\n
The injections of Pamorelin are given by healthcare professionals.<\/p>\n\n\n\n
Men<\/strong><\/p>\n\n\n\nIf you have prostate cancer, the usual dose is 3.75 mg triptorelin (1 vial ), injected into a muscle once a month (every 4 weeks). The injections are given alternately in the right and left gluteal muscles.<\/p>\n\n\n\n
Treatment of prostate cancer with Pamorelin requires long-term treatment.<\/p>\n\n\n\n
For the treatment of localized high-risk and locally advanced hormone-dependent prostate cancer in combination with radiation therapy, the recommended treatment period is 2-3 years.<\/p>\n\n\n\n
Women<\/strong><\/p>\n\n\n\nBreast cancer<\/em><\/p>\n\n\n\nThe recommended dose of Pamorelin is an injection into a muscle once a month (every 4 weeks). The treatment can last for up to 5 years.<\/p>\n\n\n\n
Pamorelin is used with a medicine that contains tamoxifen or an aromatase inhibitor. If you need to take an aromatase inhibitor, you will need to be treated with Pamorelin for at least six to eight weeks before you start taking the aromatase inhibitor. You will receive at least two injections of Pamorelin (at an interval of 4 weeks between injections ) before you start taking the aromatase inhibitor.<\/p>\n\n\n\n
Endometriosis<\/em><\/p>\n\n\n\nIf you have\u00a0endometriosis, the usual\u00a0dose\u00a0is 3.75 mg triptorelin (1\u00a0vial\u00a0), injected into a muscle once a month (every 4 weeks).\u00a0The injections\u00a0are given alternately in the right and left gluteal muscles.<\/p>\n\n\n\n
In women, the treatment of endometriosis should not last longer than 6 months.<\/p>\n\n\n\n
Children<\/strong><\/p>\n\n\n\nIn children with premature puberty (before the age of 8 for girls and before the age of 10 for boys) the recommended dose is:<\/p>\n\n\n\n
Children over 30 kg:<\/em> 2 ml suspension (1 vial ), injected into a muscle every 4 weeks (28 days)<\/p>\n\n\n\nChildren weighing between 20 and 30 kg:<\/em>\u00a01.3 ml of\u00a0suspension\u00a0one (two-thirds of the volume of the vial), injected into a muscle every 4 weeks (28 days).<\/p>\n\n\n\nChildren weighing less than 20 kg:<\/em> 1 ml of suspension one (half the volume of the vial), injected into a muscle every 4 weeks (28 days).<\/p>\n\n\n\nIf you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n
If you stop using Pamorelin<\/h2>\n\n\n\n
Do not stop treatment with Pamorelin without talking to your doctor first. This is especially important if you are being treated for your breast cancer and you are taking Pamorelin in combination with an aromatase inhibitor. This is because discontinuation of treatment can cause an increase in estrogen levels. Your doctor will monitor your estrogen levels during treatment with Pamorelin.<\/p>\n\n\n\n
If you stop taking Pamorelin, you must stop taking the aromatase inhibitor within one month of receiving your last dose of Pamorelin.<\/p>\n\n\n\n
Possible side effects<\/h2>\n\n\n\n
Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n
Contact a doctor immediately if you experience symptoms that indicate an allergic or\u00a0anaphylactic reaction, which may include dizziness, swelling of the face, tongue, or throat;\u00a0difficulty swallowing;\u00a0hives,\u00a0and difficulty breathing (\u00a0angioedema\u00a0).<\/p>\n\n\n\n
For other triptorelin drugs, pressure-sensitive accumulations of substance in tissue have been reported at the injection site following injection under the skin. This is less common.<\/p>\n\n\n\n
Men<\/strong><\/p>\n\n\n\nVery common side effects (affects more than 1 user in 10):<\/em><\/p>\n\n\n\n- Hot flashes<\/li>
- Impotence<\/li>
- Increased sweating<\/li>
- Back pain<\/li>
- An ant crawls, tingling or numbness in the legs<\/li>
- Decreased sexual desire<\/li>
- Impotence<\/li><\/ul>\n\n\n\n
Common side effects (affects more than 1 user in 100):<\/em><\/p>\n\n\n\n- Nausea, dry mouth<\/li>
- Pain, bruising, redness and swelling at the injection site, edema (fluid accumulation in body tissues )<\/li>
- Muscle and skeletal pain, pain in arms and legs, pain in the lower abdomen<\/li>
- High blood pressure<\/li>
- Allergic reaction<\/li>
- Weight gain<\/li>
- Dizziness, headache<\/li>
- Lost sexual desire<\/li>
- Depression, mood swings<\/li><\/ul>\n\n\n\n
Uncommon side effects (affects more than 1 user in 1,000):<\/em><\/p>\n\n\n\n- Increased\u00a0platelet count<\/li>
- Palpitation<\/li>
- Earring (\u00a0tinnitus\u00a0), feeling that the surroundings are moving, visual impairment<\/li>
- Stomach pain, constipation, diarrhea, vomiting<\/li>
- Drowsiness chills associated with sweating and fever, drowsiness, pain<\/li>
- Effects on blood count (including elevated liver function values), high\u00a0blood pressure<\/li>
- Weight loss<\/li>
- Loss of appetite, increased appetite,\u00a0gout\u00a0(severe pain and swelling in joints, usually in the big toe),\u00a0diabetes, high blood fats<\/li>
- Joint pain, muscle cramps, muscle weakness, muscle pain, swelling and tenderness, skeletal pain<\/li>
- Ants crawling, tingling, or numbness<\/li>
- Insomnia, irritability<\/li>
- Breast augmentation in men, pain in the breasts, decreased size of the testicles, pain in the testicles<\/li>
- Breathing difficulties<\/li>
- Acne, hair loss,\u00a0itching, rash, redness, hives<\/li>
- Waking up at night to empty the bladder, difficulty emptying the bladder<\/li>
- Nasal blood<\/li><\/ul>\n\n\n\n
Rare side effects (affects more than 1 user in 10,000):<\/em><\/p>\n\n\n\n- Red-purple discolorations on the skin<\/li>
- Abnormal sensation in the eye, visual disturbances<\/li>
- Stretched abdomen, gas problems, taste changes<\/li>
- Chest pain<\/li>
- Difficulty standing<\/li>
- Flu-like symptoms, fever<\/li>
- Anaphylactic reaction\u00a0(a severe\u00a0allergic reaction\u00a0that may cause dizziness or difficulty breathing)<\/li>
- Inflammation\u00a0of the nose and throat<\/li>
- Stiff joints, joint swelling, stiffness in muscles and bones, bone and joint inflammation<\/li>
- Impaired memory<\/li>
- Confusion, decreased activity, elation<\/li>
- Shortness of breath in supine position\/rest<\/li>
- Blisters<\/li>
- Low\u00a0blood pressure<\/li>
- Elevated liver function values<\/li><\/ul>\n\n\n\n
Adverse reactions that have been reported (occurring in an unknown number of users):<\/em><\/p>\n\n\n\nAnaphylactic\u00a0shock\u00a0(\u00a0hypersensitivity reaction\u00a0with fever, rash, swelling, and sometimes drop in blood pressure), changes (\u00a0QT\u00a0prolongation) in\u00a0ECG\u00a0(\u00a0electrocardiogram\u00a0), malaise, anxiety, swelling of the face, tongue, or throat;\u00a0difficulty swallowing;\u00a0hives\u00a0and difficulty breathing (\u00a0angioedema\u00a0), urine leakage.<\/p>\n\n\n\n
With an existing pituitary tumor, there is an increased risk of bleeding in the area.<\/p>\n\n\n\n
Patients receiving long-term treatment with\u00a0GnRH\u00a0analog\u00a0in\u00a0combination with radiation may have more\u00a0side effects, especially gastrointestinal side effects, related to radiation therapy.<\/p>\n\n\n\n
Women<\/strong><\/p>\n\n\n\nBreast cancer<\/em><\/p>\n\n\n\nThe following side effects have been observed when Pamorelin is used for breast cancer in combination with either tamoxifen or an aromatase inhibitor:<\/p>\n\n\n\n
Very common side effects (affects more than 1 user in 10):<\/em><\/p>\n\n\n\n- nausea<\/li>
- strong fatigue<\/li>
- joint and muscle pain<\/li>
- osteoporosis<\/li>
- hot flashes<\/li>
- increased sweating<\/li>
- difficulty sleeping<\/li>
- Depression<\/li>
- decreased sexual desire, vaginal dryness, pain during or after intercourse<\/li>
- urinary incontinence<\/li>
- increased blood pressure<\/li><\/ul>\n\n\n\n
Common side effects (affects more than 1 user in 100):<\/em><\/p>\n\n\n\n- diabetes<\/li>
- high blood sugar (\u00a0hyperglycemia\u00a0)<\/li>
- pain, bruising,\u00a0redness,\u00a0and swelling at the injection site<\/li>
- allergic reaction<\/li>
- bone fractures<\/li>
- blood clot in a blood vessel<\/li><\/ul>\n\n\n\n
Uncommon side effects (affects more than 1 user in 1,000):<\/em><\/p>\n\n\n\n- bleeding in the brain<\/li>
- lack of blood supply to the brain or heart.<\/li><\/ul>\n\n\n\n
Rare side effects (affects more than 1 user in 10,000):<\/em><\/p>\n\n\n\n- change in ECG ( QT prolongation)<\/li><\/ul>\n\n\n\n
Endometriosis<\/em><\/p>\n\n\n\nVery common side effects (affects more than 1 user in 10):<\/em><\/p>\n\n\n\n- sleep disorders, mood swings<\/li>
- headache<\/li>
- hot flashes<\/li>
- increased sweating,\u00a0acne, oily skin<\/li>
- changes in the breasts, pain during intercourse, genital bleeding, decreased sexual desire, overproduction in the ovaries, enlargement of the ovaries, pelvic pain,\u00a0vaginal\u00a0dryness<\/li><\/ul>\n\n\n\n
Common side effects (affects more than 1 user in 100):<\/em><\/p>\n\n\n\n- nausea, abdominal pain, stomach upset<\/li>
- joint pain, muscle twitching, pain in arms and legs<\/li>
- chest pain<\/li>
- pain, bruising,\u00a0redness,\u00a0and swelling at the injection site<\/li>
- swelling and tenderness<\/li>
- fatigue<\/li>
- allergic reaction<\/li>
- weight gain<\/li>
- depression, nervousness<\/li>
- dizziness<\/li><\/ul>\n\n\n\n
Uncommon side effects (affects more than 1 user in 1,000):<\/em><\/p>\n\n\n\n- palpitation<\/li>
- feeling that the environment is moving<\/li>
- dry eyes, visual impairment<\/li>
- distended abdomen, vomiting, gas problems,\u00a0dry mouth, cold sores<\/li>
- weight loss<\/li>
- decreased appetite, accumulation of fluid in the body<\/li>
- back pain, muscle pain<\/li>
- altered taste perception, decreased sensation, fainting, impaired memory, difficulty concentrating, an ant crawling, tingling or numbness, involuntary tremors<\/li>
- mood swings, anxiety, confusion<\/li>
- bleeding after intercourse, bulging anterior vaginal wall, irregular menstruation, menstrual cramps and heavy menstruation, small cysts (fluid-filled blisters) on the ovaries that can cause pain, discharge<\/li>
- difficulty breathing, nosebleeds<\/li>
- hair loss, increased body hair<\/li>
- dry skin, brittle nails,\u00a0itching, rash<\/li><\/ul>\n\n\n\n
Adverse reactions that have been reported (occurring in an unknown number of users):<\/em><\/p>\n\n\n\nAnaphylactic\u00a0shock\u00a0(\u00a0hypersensitivity reaction\u00a0with fever, rash, swelling, and sometimes drop in blood pressure), confusion, visual disturbances, diarrhea, swelling of the face, tongue, or throat, difficulty swallowing,\u00a0hives,\u00a0and difficulty breathing (\u00a0angioedema\u00a0),\u00a0hives, muscle weakness, weakness, menstrual weakness, altered blood levels (including elevated liver function values), high\u00a0blood pressure.\u00a0With an existing pituitary tumor, there is an increased risk of bleeding in the area.<\/p>\n\n\n\n
With endometriosis treatment, the symptoms for which the treatment has been justified (pelvic pain, menstrual pain) may worsen at the beginning of the treatment but should disappear within one to two weeks.\u00a0This can occur even if the treatment has a beneficial effect.\u00a0However, you should tell your doctor immediately about this phenomenon.<\/p>\n\n\n\n
Children<\/strong><\/p>\n\n\n\nVery common side effects (affects more than 1 user in 10):<\/em><\/p>\n\n\n\n- Vaginal bleeding may occur in girls during the first month of treatment<\/li><\/ul>\n\n\n\n
Common side effects (affects more than 1 user in 100):<\/em><\/p>\n\n\n\n- Allergic reaction<\/li>
- Headache<\/li>
- Hot flashes<\/li>
- Stomach pain<\/li>
- Pain, bruising,\u00a0redness,\u00a0and swelling at the injection site<\/li>
- Weight gain<\/li>
- Acne<\/li><\/ul>\n\n\n\n
Uncommon side effects (affects more than 1 user in 1,000):<\/em><\/p>\n\n\n\n- Dimsyn<\/li>
- Vomiting, constipation, nausea<\/li>
- Feeling sick<\/li>
- Overweight<\/li>
- Neck pain<\/li>
- Mood swings<\/li>
- Chest pain<\/li>
- Nasal blood<\/li>
- Itching, rash, or\u00a0hives<\/li><\/ul>\n\n\n\n
Adverse reactions\u00a0that have been reported (occurring in an unknown number of users):<\/em>\u00a0Anaphylactic\u00a0shock\u00a0(\u00a0hypersensitivity reaction\u00a0with fever, rash, swelling, and sometimes drop in blood pressure), mood swings, depression, nervousness, visual disturbances, swelling of the face, tongue or throat, difficulty swallowing,\u00a0hives\u00a0and difficulty breathing (\u00a0angioedema\u00a0), muscle pain, altered blood levels including hormone levels, high\u00a0blood pressure.<\/p>\n\n\n\nHow to store Pamorelin<\/h2>\n\n\n\n
Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n
Do not store above 25 \u00b0 C.<\/p>\n\n\n\n
Do not use this medicine after the expiry date which is stated on the carton and the EXP label.\u00a0The expiration date is the last day of the specified month.<\/p>\n\n\n\n
Ready-mixed suspension should be used immediately.<\/p>\n\n\n\n
Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.<\/p>\n\n\n\n
Contents of the pack and other information<\/h2>\n\n\n\nContent declaration<\/h2>\n\n\n\n
The active substance is triptorelin.<\/p>\n\n\n\n
One\u00a0vial\u00a0contains triptorelin embonate equivalent to 3.75 mg of triptorelin.<\/p>\n\n\n\n
After reconstitution with 2 ml of\u00a0diluent, 1 ml of reconstituted\u00a0suspension\u00a0contains 1,875 mg of triptorelin.<\/p>\n\n\n\n
Other ingredients are:<\/p>\n\n\n\n
Powder: poly (d, l-lactide-coglycolide), mannitol, carmellose sodium, polysorbate 80.<\/p>\n\n\n\n
Diluent: water for injections.<\/p>\n\n\n\n
What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n
The powder is a white to off-white powder and the diluent is a clear solution.<\/p>\n\n\n\n
Pamorelin 3.75 mg is available in pack sizes:<\/p>\n\n\n\n
1\u00a0vial, 1\u00a0ampoule,\u00a0and 1 blister containing 1\u00a0syringe\u00a0and 2 syringes.<\/p>\n\n\n\n
3 vials, 3\u00a0ampoules,\u00a0and 3 blisters containing 1\u00a0syringe\u00a0and 2 syringes.<\/p>\n\n\n\n
Not all pack sizes may be marketed.<\/p>\n\n\n\n
Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n
Marketing Authorisation Holder<\/em><\/p>\n\n\n\nInstitut Synthesis Institute (IPSEN) AB<\/p>\n\n\n\n
Kista Science Tower<\/p>\n\n\n\n
F\u00e4r\u00f6gatan 33<\/p>\n\n\n\n
164 51 Kista<\/p>\n\n\n\n
Manufacturer<\/em><\/p>\n\n\n\nIpsen Pharma Biotech<\/p>\n\n\n\n
Plateau de Signes Activity Park<\/p>\n\n\n\n
Departmental Road No. 402<\/p>\n\n\n\n
83870 Signes<\/p>\n\n\n\n
France<\/p>\n","protected":false},"excerpt":{"rendered":"
Pamorelin works by lowering the levels of male sex hormone ( testosterone ) and female sex hormone ( estrogen ) in the body.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18527],"tags":[20815,14104,20811,20814,14100,14105,20812,14101,20813,14102],"class_list":["post-20331","post","type-post","status-publish","format-standard","hentry","category-medicines","category-p","tag-benefits-of-pamorelin","tag-benefits-of-triptorelin","tag-pamorelin","tag-pamorelin-side-effects","tag-triptorelin","tag-triptorelin-side-effects","tag-what-is-pamorelin","tag-what-is-triptorelin","tag-what-pamorelin-is-used-for","tag-what-triptorelin-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20331","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=20331"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20331\/revisions"}],"predecessor-version":[{"id":20388,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20331\/revisions\/20388"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=20331"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=20331"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=20331"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}