{"id":20286,"date":"2022-03-29T11:55:29","date_gmt":"2022-03-29T11:55:29","guid":{"rendered":"https:\/\/zeepedia.com\/?p=20286"},"modified":"2022-03-30T14:16:29","modified_gmt":"2022-03-30T14:16:29","slug":"pamidronate-disodium-pfizer","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/pamidronate-disodium-pfizer\/","title":{"rendered":"Pamidronate disodium Pfizer &#8211; Disodium uses, dose and side effects"},"content":{"rendered":"\n<p>3 mg \/ ml, 6 mg \/ ml and 9 mg \/ ml&nbsp;concentrate for solution for&nbsp;infusion&nbsp;pamidronate<br>disodium<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Pamidronate disodium Pfizer is and what it is used for<\/h2>\n\n\n\n<p>Pamidronate disodium Pfizer belongs to a group of medicines called bisphosphonates.&nbsp;The medicinal effect is that they bind to bone and counteract the breakdown of bone.<\/p>\n\n\n\n<p>The drug is used against elevated calcium levels in the blood that are caused by\u00a0tumors\u00a0and to prevent the bone-degrading effect of certain types of\u00a0tumors, including in patients with breast cancer or multiple\u00a0myeloma.\u00a0Talk to your doctor if you are wondering why you have been given this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you use Pfizer Pamidronate Disodium<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Pamidizer disodium disodium<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to pamidronate disodium or any of the other ingredients of this medicine (listed in section 6) or other bisphosphonates (the group of medicines to which Pamidronate disodium Pfizer belongs)<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or nurse before using Pfizer Pamidronate Disodium<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have or have ever had thyroid problems<\/li><li>if you suffer from any kidney disease<\/li><li>if you suffer from any heart problems<\/li><li>if you have blood disorders (\u00a0anemia\u00a0(\u00a0anemia\u00a0),\u00a0leukopenia\u00a0(low levels of\u00a0white blood cells\u00a0), or\u00a0thrombocytopenia\u00a0(low levels of\u00a0platelets\u00a0))<\/li><li>Pamidronate disodium Pfizer may cause eye irritation<\/li><li>Pfizer pamidronate disodium is not recommended for use in children<\/li><li>if you have or have had pain, swelling, or numbness in the jaw, a feeling of heaviness, or that any tooth has come loose.\u00a0Your doctor may recommend that you have a dental examination before starting treatment with Pamidronate disodium Pfizer.<\/li><li>If you are undergoing dental treatment or undergoing dental surgery, inform your dentist that you are being treated with Pamidronate disodium Pfizer and inform your doctor about your dental treatment.<\/li><\/ul>\n\n\n\n<p>While you are being treated with Pfidronate disodium Pfizer, you should maintain good oral hygiene (including regular toothbrushing) and have regular dental check-ups.<\/p>\n\n\n\n<p>Contact your doctor and dentist immediately if you experience any problems with your mouth or teeth, such as loose teeth, pain or swelling, wounds that do not heal, or fluids, as this may be a sign of a condition called\u00a0osteonecrosis\u00a0of the jaw (bone damage in the jaw ).<\/p>\n\n\n\n<p>Patients undergoing\u00a0chemotherapy\u00a0and\/or radiation therapy, taking\u00a0steroids, undergoing dental surgery, not receiving regular dental care, having gum problems, smoking, or being previously treated with a bisphosphonate (used to treat or prevent bone diseases) may be at higher risk of developing\u00a0osteonecrosis\u00a0of the jaw.<\/p>\n\n\n\n<p>When you are being treated with Pamidronate disodium Pfizer, your doctor will&nbsp;prescribe&nbsp;regular tests to check your treatment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>There is no clinical experience in children and adolescents (&lt;18 years old).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Pfizer&#8217;s Pamidronate disodium<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Pamidronate disodium Pfizer should not be used at the same time as other bisphosphonates (the group to which Pfizer belongs to Pamidron disodium) or other drugs that lower calcium levels.<\/li><li>Other medicines that affect the kidneys (your doctor or nurse knows which ones they are).<\/li><li>Thalidomide (used to treat multiple\u00a0myeloma\u00a0).<\/li><\/ul>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n<p>There are no clinical data on the use of Pfidronate disodium Pfizer during pregnancy.\u00a0Animal studies have shown harmful effects on the fetus (skeletal changes).\u00a0The potential risk to humans is unknown.\u00a0Pamidronate treatment is not recommended during pregnancy unless necessary.<\/p>\n\n\n\n<p>Breast-feeding is not recommended when you are being treated with Pamidronate disodium Pfizer.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>If you feel drowsy or dizzy after being treated with pamidronate disodium, do not drive or use machines that require sharpened attention until these effects have stopped.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened vigilance.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0Descriptions of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pamidronate disodium Pfizer contains sodium<\/h2>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg)\u00a0sodium\u00a0per maximum\u00a0dose\u00a0(90 mg), ie essentially &#8216;sodium-free&#8217;.\u00a0However, if a saline solution (9 mg\/ml sodium chloride solution) is used to dilute Pfizer Pamidronate disodium before\u00a0administration, the sodium dose will be higher.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Pfizer Pamidronate disodium<\/h2>\n\n\n\n<p>Pamidronate disodium Pfizer is given very slowly into a vein (\u00a0intravenous\u00a0infusion\u00a0), never as a rapid\u00a0injection.\u00a0Your doctor will decide what is the right\u00a0dose\u00a0for you.\u00a0The infusion time can be up to several hours depending on\u00a0dose\u00a0one.\u00a0Your doctor will decide how many\u00a0infusions\u00a0you need and how often to give them.<\/p>\n\n\n\n<p>The recommended&nbsp;dose&nbsp;per course of treatment is between 15 mg and 90 mg.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p>The most common\u00a0side effects\u00a0are decreased calcium levels in the blood,\u00a0flu-like symptoms,\u00a0and fever (body temperature rises by 1-2 \u00b0 C) which occur when treatment is started and can last for 48 hours.<\/p>\n\n\n\n<p>Some patients notice increased leg pain shortly after starting treatment.&nbsp;This usually improves after a few days.&nbsp;If not, tell your doctor.<\/p>\n\n\n\n<p>Healthcare professionals can stop\u00a0administering\u00a0Pamidronate disodium Pfizer immediately if you experience symptoms of\u00a0angioedema, such as the swollen face, tongue, or throat, difficulty swallowing,\u00a0hives,\u00a0and difficulty breathing (uncommon side effects: may affect up to 1 in 100 people).<\/p>\n\n\n\n<p>Tell your doctor immediately if you notice any of the following&nbsp;side effects&nbsp;from anaphylactic&nbsp;shock&nbsp;(severe&nbsp;allergic reaction&nbsp;):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>a feeling of pressure over the chest, difficulty breathing, extensive rash,\u00a0hives, swelling of the skin and mucous membranes, sudden drop in\u00a0blood pressure.\u00a0(Very rare\u00a0side effects\u00a0that may affect up to 1 in 10,000 people).<\/li><\/ul>\n\n\n\n<p>Other&nbsp;side effects&nbsp;that may occur:<\/p>\n\n\n\n<p><em>Very common (may affect more than 1 user in 10):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Fever and\u00a0flu-like symptoms, sometimes accompanied by malaise, stiffness, fatigue, and sudden feeling of heat.<\/li><li>Decreased levels of\u00a0calcium\u00a0and\u00a0phosphate\u00a0in the blood.<\/li><\/ul>\n\n\n\n<p><em>Common (may affect up to 1 in 10 people):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Decreased\u00a0white blood cell count\u00a0(lymphocytopenia),<\/li><li>anemia\u00a0decreased\u00a0platelet\u00a0count\u00a0(\u00a0thrombocytopenia\u00a0),<\/li><li>decreased levels of\u00a0potassium\u00a0and\u00a0magnesium\u00a0in the blood,<\/li><li>headache,<\/li><li>insomnia,<\/li><li>drowsiness,<\/li><li>nausea,<\/li><li>vomiting,<\/li><li>diarrhea, constipation, abdominal pain, loss of appetite,<\/li><li>transient leg pain, joint pain, muscle aches, muscle cramps, general aches, pains,<\/li><li>redness\u00a0or swelling at the infusion site,<\/li><li>tenderness or pain in the veins, possibly concomitantly with a local blood clot,<\/li><li>high\u00a0blood pressure,<\/li><li>tingling in the hands and feet,<\/li><li>numbness,<\/li><li>inflammation\u00a0of the\u00a0conjunctiva\u00a0of the eye (\u00a0conjunctivitis\u00a0), skin rash,<\/li><li>increased\u00a0serum\u00a0creatinine\u00a0(\u00a0a blood test that measures kidney function).<\/li><\/ul>\n\n\n\n<p><em>Uncommon (may affect up to 1 in 100 people):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Allergic reaction,<\/li><li>respiratory cramps,<\/li><li>seizures,<\/li><li>indignation,<\/li><li>dizziness,<\/li><li>mental lethargy (\u00a0lethargy\u00a0),<\/li><li>inflammation\u00a0of the eye which causes pain and\u00a0redness,<\/li><li>low\u00a0blood pressure,<\/li><li>upset stomach, indigestion,<\/li><li>itching,<\/li><li>muscle cramps,<\/li><li>bone tissue death (\u00a0osteonecrosis\u00a0),<\/li><li>abnormal liver function tests,<\/li><li>increased level of\u00a0urea\u00a0in blood\/serum,<\/li><li>acute\u00a0renal failure.<\/li><\/ul>\n\n\n\n<p><em>Rare (may affect up to 1 in 1,000 people):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Kidney problems<\/li><li>Unusual femoral fractures, especially in patients receiving long-term treatment for osteoporosis, may occur in rare cases.<\/li><\/ul>\n\n\n\n<p><strong>Contact your doctor<\/strong>\u00a0if you experience pain, weakness, or discomfort in the thigh, hip, or groin as this may be an early sign of a possible femoral fracture.<\/p>\n\n\n\n<p><em>Very rare (may affect up to 1 in 10,000 people):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Flushing cold sores\/blisters or\u00a0shingles\u00a0(reactivation of the\u00a0herpes\u00a0virus\u00a0),<\/li><li>decreased\u00a0white blood cell count\u00a0(\u00a0leukopenia\u00a0),<\/li><li>increased levels of\u00a0potassium\u00a0and\u00a0sodium\u00a0in the blood,<\/li><li>confusion,<\/li><li>heart failure,<\/li><li>breathing difficulties,<\/li><li>lung disease,\u00a0<\/li><li>kidney problems (usually in patients with a history of kidney problems),\u00a0<\/li><li>blood in the urine,<\/li><li>visual hallucinations (seeing things that do not exist),<\/li><li>visual disturbances\/eye pain,<\/li><li>pneumonia\u00a0that can cause coughing, difficulty breathing, and rumbling sounds in the chest,<\/li><li>anaphylactic\u00a0shock\u00a0(severe\u00a0allergic reaction\u00a0).<\/li><li>Talk to a doctor\u00a0if you have ear pain, discharge from the ear, and \/ or an ear infection.\u00a0This may be a sign of a bone injury in the ear.<\/li><\/ul>\n\n\n\n<p><em>Has been reported (occurs in an unknown number of users)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Irregular heart rhythm (\u00a0atrial fibrillation\u00a0) has been seen in patients receiving pamidronate.\u00a0It is currently unclear whether pamidronate causes irregular heartbeat.\u00a0You should\u00a0<strong>tell your doctor<\/strong>\u00a0if you experience irregular heartbeat during treatment with pamidronate.<\/li><li>Redness\u00a0in the area around the eyes.<\/li><li>Idiopathic\u00a0(benign)\u00a0intracranial\u00a0hypertension\u00a0(\u00a0pseudotumor cerebri\u00a0), is a disorder associated with the nervous system.<\/li><li>Pain in the mouth, teeth, and\/or jaw, swelling or sores that do not heal on the inside of the mouth or jaw, warts, numbness, or a feeling of heaviness in the jaw or\u00a0tooth loss.\u00a0This may be a sign of bone damage in the jaw (\u00a0osteonecrosis\u00a0).\u00a0Tell your doctor and dentist immediately if you experience such symptoms while you are being treated with Pamidronate disodium Pfizer or after stopping treatment.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Pamidronate disodium Pfizer<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton and bottle label after EXP: The expiration date is the last day of that month.<\/p>\n\n\n\n<p>Do not store above 25 \u00b0 C.<\/p>\n\n\n\n<p>After dilution, the drug should be used immediately.&nbsp;If the diluted medicine can not be used immediately, it can be stored for a maximum of 24 hours at 2 \u00b0 C-8 \u00b0 C.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is pamidronate disodium.\u00a0Each milliliter (ml) solution contains 3 mg, 6 mg, or 9 mg of pamidronate disodium.<\/li><li>The other ingredients are mannitol,\u00a0phosphoric acid, sodium hydroxide, and water for injections.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Pamidronate disodium Pfizer concentrates for solution for\u00a0infusion\u00a0(sterile concentrate) is a clear, colorless solution.<\/p>\n\n\n\n<p><em>Pamidizer Pamidronate disodium 3 mg \/ ml:<\/em><\/p>\n\n\n\n<p>5 ml clear glass vials in packs of 5 vials or 4 x (5 x 5 ml) vials.&nbsp;10 ml clear glass vials in packs of 1&nbsp;vial&nbsp;or 4 x (1 x 10 ml) vials.<\/p>\n\n\n\n<p><em>Pamidizer disodium Pfizer 6 mg \/ ml and 9 mg \/ ml:<\/em><\/p>\n\n\n\n<p>10 ml clear glass vials in packs of 1&nbsp;vial&nbsp;or 4 x (1 x 10 ml) vials.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>Pfizer AB<\/p>\n\n\n\n<p>191 90 Sollentuna<\/p>\n\n\n\n<p>Phone: 08-550 520 00<\/p>\n\n\n\n<p>Email: eumedinfo@pfizer.com<\/p>\n\n\n\n<p><strong>Manufacturer:<\/strong><\/p>\n\n\n\n<p>Pfizer Service Company BVBA, Hoge Wei 10, 1930 Zaventem, Belgium<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Pamidronate disodium Pfizer belongs to a group of medicines called bisphosphonates. The medicinal effect is that they bind to bone and counteract the breakdown of bone.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18527],"tags":[20669,20674,20665,20668,20670,20673,20667,20666,20671,20672],"class_list":["post-20286","post","type-post","status-publish","format-standard","hentry","category-medicines","category-p","tag-benefits-of-disodium","tag-benefits-of-pamidronate-disodium-pfizer","tag-disodium","tag-disodium-side-effects","tag-pamidronate-disodium-pfizer","tag-pamidronate-disodium-pfizer-side-effects","tag-what-disodium-is-used-for","tag-what-is-disodium","tag-what-is-pamidronate-disodium-pfizer","tag-what-pamidronate-disodium-pfizer-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20286","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=20286"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20286\/revisions"}],"predecessor-version":[{"id":20316,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20286\/revisions\/20316"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=20286"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=20286"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=20286"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}