{"id":20278,"date":"2022-03-29T11:49:46","date_gmt":"2022-03-29T11:49:46","guid":{"rendered":"https:\/\/zeepedia.com\/?p=20278"},"modified":"2022-03-30T14:16:47","modified_gmt":"2022-03-30T14:16:47","slug":"palonosetron-fresenius-kabi","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/palonosetron-fresenius-kabi\/","title":{"rendered":"Palonosetron Fresenius Kabi &#8211; Palonosetron uses, dose and side effects"},"content":{"rendered":"\n<p>250 micrograms&nbsp;solution&nbsp;for injection<br>palonosetron<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Palonosetron is and what it is used for<\/h2>\n\n\n\n<p>Palonosetron contains the active substance palonosetron.&nbsp;It belongs to a group of medicines called&nbsp;serotonin&nbsp;&#8211; (&nbsp;5HT&nbsp;<sub>3<\/sub>&nbsp;)&nbsp;antagonist&nbsp;er.<\/p>\n\n\n\n<p>Palonosetron is used in adults, adolescents, and children over one month of age to prevent nausea and vomiting during so-called chemotherapy (\u00a0chemotherapy\u00a0) against cancer.<\/p>\n\n\n\n<p>It works by blocking the activity of the chemical substance\u00a0serotonin, which can make you feel sick or vomit.<\/p>\n\n\n\n<p>Palonosetron contained in Palonosetron Fresenius Kabi may also be approved for the treatment of other conditions not mentioned in this product information.\u00a0Ask your doctor, pharmacist, or another healthcare professional if you have any further questions, and always follow their instructions.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you use Palonosetron<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Palonosetron<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>you are allergic to palonosetron or any of the other ingredients of this medicine (listed in section 6).<\/li><\/ul>\n\n\n\n<p>You will not receive Palonosetron if any of the above apply to you.&nbsp;If you are not sure, talk to your doctor or nurse before taking this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or nurse before using Palonosetron if:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>you have an obstruction in the intestine or have had constipation repeatedly in the past.<\/li><li>you have had heart problems or if there are heart problems in the family, such as a change in heart rate (&#8220;extended\u00a0QT\u00a0interval&#8221;).<\/li><li>You have an imbalance of certain minerals in the blood that has not been treated, such as\u00a0potassium\u00a0and\u00a0magnesium.<\/li><\/ul>\n\n\n\n<p>If any of the above apply to you (or you are not sure), talk to your doctor or nurse before taking Palonosetron.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Palonosetron<\/h2>\n\n\n\n<p>Tell your doctor if you are taking, have recently taken, or might take any other medicines.\u00a0You must tell us if you are taking the following medicines:<\/p>\n\n\n\n<p><strong>Medicines for depression or anxiety<\/strong><\/p>\n\n\n\n<p>Tell your doctor or nurse if you are taking any medicines for depression or anxiety, for example:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>so-called\u00a0SSRIs\u00a0(selective serotonin reuptake inhibitors) such as\u00a0fluoxetine,\u00a0paroxetine\u00a0,\u00a0sertraline, fluvoxamine,\u00a0citalopram, escitalopram<\/li><li>so-called\u00a0SNRIs\u00a0(serotonin noradrenaline reuptake inhibitors) such as\u00a0venlafaxine, duloxetine (may lead to the development of serotonin syndrome and should be used with caution).<\/li><\/ul>\n\n\n\n<p><strong>Drugs that can affect the heartbeat<\/strong><\/p>\n\n\n\n<p>Tell your doctor or nurse if you are taking any other medicines that may affect your heart rate &#8211; you may have heart problems if you take them with Palonosetron.&nbsp;These are:<\/p>\n\n\n\n<p>If any of the above apply to you (or you are not sure), talk to your doctor or nurse before taking Palonosetron &#8211; you may have heart problems if you take these medicines with Palonosetron.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this medicine.<\/p>\n\n\n\n<p>The reason is that it is not known whether Palonosetron can harm the baby.<\/p>\n\n\n\n<p>It is not known if Palonosetron passes into breast milk.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>You may feel dizzy or tired after taking this medicine.&nbsp;If this happens, do not drive or use any tools or machines.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0Descriptions of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Palonosetron contains sodium<\/h2>\n\n\n\n<p>This medicine contains 4.55 mg\u00a0sodium\u00a0(the main ingredient in table salt\/table salt) per\u00a0vial.\u00a0This corresponds to 0.23% of the highest recommended daily intake of\u00a0sodium\u00a0for adults.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Palonosetron<\/h2>\n\n\n\n<p>Palonosetron is usually given by a doctor or nurse.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>You will receive the medicine about 30 minutes before the start of chemotherapy.<\/li><\/ul>\n\n\n\n<p><strong>Adults<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The recommended\u00a0dose\u00a0of Palonosetron is 250 micrograms.<\/li><li>It is given as an\u00a0injection\u00a0to a friend.<\/li><\/ul>\n\n\n\n<p><strong>Children and adolescents (from 1 month to 17 years of age)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The doctor calculates the correct&nbsp;dose&nbsp;based on body weight.<\/li><li>The maximum&nbsp;dose&nbsp;is 1500 micrograms.<\/li><li>Palonosetron is given as a drip (a slow&nbsp;infusion&nbsp;into a vein).<\/li><\/ul>\n\n\n\n<p>You should not receive Palonosetron in the next few days after a chemotherapy treatment unless you are to receive another round of\u00a0chemotherapy.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p>The following&nbsp;side effects&nbsp;may be caused by this medicine:<\/p>\n\n\n\n<p><strong>Serious&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>Tell your doctor immediately if you get any of the following serious side effects:<\/p>\n\n\n\n<p>Tell your doctor immediately if you get any of the&nbsp;side effects&nbsp;listed above.<\/p>\n\n\n\n<p><strong>Other&nbsp;side effects&nbsp;ar<\/strong><\/p>\n\n\n\n<p>Tell your doctor if you get any of the following side effects:<\/p>\n\n\n\n<p><strong>Common:<\/strong>&nbsp;may affect up to 1 in 10 users<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>headache, dizziness<\/li><li>constipation, diarrhea<\/li><\/ul>\n\n\n\n<p><strong>Uncommon:<\/strong>&nbsp;may affect up to 1 in 100 people<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>high or low&nbsp;blood pressure<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li>abnormal heart rate or insufficient blood supply to the heart<\/li><li>abnormally high or low levels of&nbsp;potassium&nbsp;in the blood<\/li><li>high levels of sugar in the blood or sugar in the urine<\/li><li>low levels of&nbsp;calcium&nbsp;in the blood<\/li><li>high levels of the pigment&nbsp;bilirubin&nbsp;in the blood<\/li><li>high levels of certain liver enzymes<\/li><li>abnormal&nbsp;ECG&nbsp;(&nbsp;electrocardiogram&nbsp;) (&nbsp;QT&nbsp;prolongation).<\/li><\/ul>\n\n\n\n<p><strong>Very rare:<\/strong>&nbsp;may affect up to 1 in 10,000 people<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>burning, pain, or\u00a0redness\u00a0at the injection site.<\/li><\/ul>\n\n\n\n<p><strong>Additional&nbsp;side effects&nbsp;are in children and adolescents<\/strong><\/p>\n\n\n\n<p><strong>Common:<\/strong>&nbsp;may affect up to 1 in 10 users<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>headache<\/li><\/ul>\n\n\n\n<p><strong>Uncommon:<\/strong>&nbsp;may affect up to 1 in 100 people<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>dizziness<\/li><li>jerky body movements<\/li><li>abnormal heart rate<\/li><li>cough or shortness of breath<\/li><li>nosebleeds<\/li><li>itchy skin rash or&nbsp;hives<\/li><li>fever<\/li><li>pain at the infusion site<\/li><\/ul>\n\n\n\n<p>Tell your doctor if you get any of the&nbsp;side effects&nbsp;listed above.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Palonosetron<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the\u00a0vial\u00a0and carton after EXP.\u00a0day.\u00a0or EXP.\u00a0The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Do not use this medicine if the solution is not clear or if it has visible particles.<\/p>\n\n\n\n<p>This medicine does not require any special storage instructions.<\/p>\n\n\n\n<p>For single use only, any remaining solution is discarded.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is palonosetron (as hydrochloride)<\/li><li>Each ml of solution contains 50 micrograms of palonosetron.\u00a0Each\u00a0vial\u00a0of 5 ml solution contains 250 micrograms of palonosetron.<\/li><li>The other ingredients are mannitol (E421), disodium edetate, sodium citrate (E331), citric acid (E330) and water for injections, sodium hydroxide (for\u00a0pH\u00a0adjustment),\u00a0hydrochloric acid\u00a0(for\u00a0pH\u00a0adjustment).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Palonosetron&nbsp;solution for injection&nbsp;is a clear, colorless solution and is supplied in disposable glass vials with halobutyl rubber stoppers and closed with a removable aluminum plastic cap.<\/p>\n\n\n\n<p>Pack sizes:<\/p>\n\n\n\n<p>1 or 10 vials<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Fresenius Kabi Austria GmbH<\/p>\n\n\n\n<p>Hafnerstrasse 36<\/p>\n\n\n\n<p>A-8055 Graz<\/p>\n\n\n\n<p>Austria<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Palonosetron contains the active substance palonosetron. It belongs to a group of medicines called serotonin &#8211; ( 5HT 3 ) antagonist er.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200],"tags":[20686,20701,10844,20697,20700,20685,10845,20698,20699,10846],"class_list":["post-20278","post","type-post","status-publish","format-standard","hentry","category-medicines","tag-benefits-of-palonosetron","tag-benefits-of-palonosetron-fresenius-kabi","tag-palonosetron","tag-palonosetron-fresenius-kabi","tag-palonosetron-fresenius-kabi-side-effects","tag-palonosetron-side-effects","tag-what-is-palonosetron","tag-what-is-palonosetron-fresenius-kabi","tag-what-palonosetron-fresenius-kabi-is-used-for","tag-what-palonosetron-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20278","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=20278"}],"version-history":[{"count":3,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20278\/revisions"}],"predecessor-version":[{"id":20320,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20278\/revisions\/20320"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=20278"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=20278"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=20278"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}