{"id":20276,"date":"2022-03-29T11:48:40","date_gmt":"2022-03-29T11:48:40","guid":{"rendered":"https:\/\/zeepedia.com\/?p=20276"},"modified":"2022-03-30T14:16:51","modified_gmt":"2022-03-30T14:16:51","slug":"palonosetron-accord","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/palonosetron-accord\/","title":{"rendered":"Palonosetron Accord &#8211; Palonosetron uses, dose and side effects"},"content":{"rendered":"\n<p>250 micrograms&nbsp;solution&nbsp;for injection<br>palonosetron<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Palonosetron Accord is and what it is used for<\/h2>\n\n\n\n<p>Palonosetron Accord belongs to a group of medicines called\u00a0serotonin\u00a0(\u00a05HT\u00a0<sub>3<\/sub>\u00a0)\u00a0antagonists.<\/p>\n\n\n\n<p>They can block the action of the chemical serotonin which can cause nausea and vomiting.<\/p>\n\n\n\n<p>Palonosetron Accord is used for the prevention of nausea and vomiting in adults, adolescents, and children over one month of age in connection with\u00a0chemotherapy\u00a0for cancer.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using Palonosetron Accord<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Palonosetron Accord<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to palonosetron or any of the other ingredients of this medicine (listed in section 6).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse before you are given Palonosetron Accord<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have\u00a0an acute\u00a0intestinal obstruction or have previously had constipation repeatedly,<\/li><li>if you are taking Palonosetron Accord with other medicines that may trigger abnormal heart rhythms such as\u00a0amiodarone, nicardipine,\u00a0quinidine, moxifloxacin, erythromycin,\u00a0haloperidol, chlorpromazine, quetiapine, thioridazine, domperidone,<\/li><li>if you or someone in your family has or has had changes in your heart rhythm (extended\u00a0QT interval\u00a0),<\/li><li>if you have other heart problems,<\/li><li>if you have an imbalance in certain minerals in the blood, e.g.\u00a0potassium\u00a0and\u00a0magnesium, which have not been treated.<\/li><\/ul>\n\n\n\n<p>The use of Palonosetron Accord in the next few days after&nbsp;chemotherapy&nbsp;is only recommended if a new chemotherapy cycle is to be started.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Palonosetron Accord<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines, including:<\/p>\n\n\n\n<p>Selective serotonin reuptake inhibitors (\u00a0SSRIs\u00a0) including\u00a0fluoxetine,\u00a0paroxetine\u00a0,\u00a0sertraline, fluvoxamine,\u00a0citalopram,\u00a0and escitalopram used to treat depression and\/or anxiety.<\/p>\n\n\n\n<p>SNRIs\u00a0(\u00a0serotonin\u00a0and norepinephrine reuptake inhibitors) including\u00a0venlafaxine\u00a0and duloxetine are used to treat depression and\/or anxiety.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p><strong>Pregnancy<\/strong><\/p>\n\n\n\n<p>If you are pregnant or think you may be, your doctor will prescribe treatment with Palonosetron Accord only when necessary.<\/p>\n\n\n\n<p>It is not known if Palonosetron Accord can cause harmful effects when used during pregnancy.<\/p>\n\n\n\n<p>Ask your doctor or pharmacist for advice before taking any medicine if you are pregnant or think you may be.<\/p>\n\n\n\n<p><strong>Breast-feeding<\/strong><\/p>\n\n\n\n<p>It is not known if Palonosetron Accord passes into breast milk.<\/p>\n\n\n\n<p>If you are breastfeeding, talk to your doctor or pharmacist before using Palonosetron Accord.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Palonosetron Accord may cause dizziness or tiredness.&nbsp;If this happens, do not drive or use any tools or machines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Palonosetron Accord contains sodium<\/h2>\n\n\n\n<p>This medicine contains less than 1 mmol\u00a0sodium\u00a0(23 mg) per\u00a0vial, ie essentially &#8216;sodium-free&#8217;.\u00a0is next to &#8220;sodium-free&#8221;.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Palonosetron Accord<\/h2>\n\n\n\n<p>As a rule, it is a doctor or nurse who gives an&nbsp;injection&nbsp;with Palonosetron Accord about 30 minutes before the start of chemotherapy.<\/p>\n\n\n\n<p><strong>Adults<\/strong><\/p>\n\n\n\n<p>The recommended&nbsp;dose&nbsp;of Palonosetron Accord is 250 micrograms, given as a rapid&nbsp;injection&nbsp;into a vein.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Use in children and adolescents (aged 1 month to 17 years)<\/h2>\n\n\n\n<p>Your doctor will decide on a&nbsp;dose&nbsp;depending on your body weight, but the highest&nbsp;dose&nbsp;is 1,500 micrograms.<\/p>\n\n\n\n<p>Palonosetron Accord will be given as a slow&nbsp;infusion&nbsp;into a vein.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Adults<\/strong><\/p>\n\n\n\n<p>Common (may affect up to 1 in 10 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>headache<\/li><li>dizziness<\/li><li>constipation and diarrhea.<\/li><\/ul>\n\n\n\n<p>Uncommon (may affect up to 1 in 100 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>high or low\u00a0blood pressure<\/li><li>abnormal heart rate or insufficient blood supply to the heart<\/li><li>color changes and\/or magnification<\/li><li>abnormally high or low amount of\u00a0potassium\u00a0in the blood<\/li><li>high blood sugar or sugar in the urine<\/li><li>low calcium in the blood<\/li><li>high levels of the pigment\u00a0bilirubin\u00a0in the blood<\/li><li>high levels of certain liver enzymes<\/li><li>elation or anxiety<\/li><li>drowsiness or insomnia<\/li><li>loss of appetite or loss of appetite<\/li><li>weakness, fatigue, fever, or\u00a0flu-like symptoms<\/li><li>numbness, burning, tingling, or ant crawling on the skin<\/li><li>skin rash with\u00a0itching<\/li><li>impaired vision or eye irritation<\/li><li>motion sickness<\/li><li>tinnitus<\/li><li>hiccups, gas,\u00a0dry mouth,\u00a0or indigestion<\/li><li>abdominal pain<\/li><li>urination difficulties<\/li><li>joint pain<\/li><li>ECG\u00a0abnormalities (prolonged\u00a0QT interval\u00a0).<\/li><\/ul>\n\n\n\n<p>Very rare (may affect up to 1 in 10,000 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>allergic reactions to Palonosetron Accord:<br>swelling of the lips, face, tongue, or throat, difficulty breathing, collapse, rash (\u00a0hives\u00a0) with bumps and\u00a0itching, burning, or pain at the injection site.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Common (may affect up to 1 in 10 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>headache.<\/li><\/ul>\n\n\n\n<p>Uncommon (may affect up to 1 in 100 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>dizziness<\/li><li>jerky body movements<\/li><li>abnormal heart rate<\/li><li>cough and shortness of breath<\/li><li>nosebleeds<\/li><li>itchy rash or hives<\/li><li>fever<\/li><li>pain at the infusion site.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Palonosetron Accord<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton and vial after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>No special storage instructions.<\/p>\n\n\n\n<p>For single use only, discard any remaining solution.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is palonosetron (as hydrochloride). Each ml of solution contains 50 micrograms of palonosetron. Each\u00a0vial\u00a0of 5 ml of solution contains 250 micrograms of palonosetron.<\/li><li>The other ingredients are mannitol, disodium edetate, sodium citrate, citric acid monohydrate, sodium hydroxide (for\u00a0pH\u00a0adjustment),\u00a0hydrochloric acid, concentrated (for\u00a0pH\u00a0adjustment), and water for injections (see section 2 Palonosetron Accord contains\u00a0sodium\u00a0).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Palonosetron Accord\u00a0solution for injection\u00a0is a clear, colorless solution delivered in a 6 ml\u00a0vial, closed with a chlorobutyl rubber stopper, and sealed with a flip-off aluminum seal.\u00a0One\u00a0vial\u00a0contains one\u00a0dose.<\/p>\n\n\n\n<p>Pack size: one\u00a0vial.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>Accord Healthcare SLU<\/p>\n\n\n\n<p>World Trade Center, Moll de Barcelona, \u200b\u200bs \/ n,<\/p>\n\n\n\n<p>Edifici Est 6\u00aa planta,<\/p>\n\n\n\n<p>08039 Barcelona,<\/p>\n\n\n\n<p>Spain<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Accord Healthcare BV,<\/p>\n\n\n\n<p>Winthontlaan 200,<\/p>\n\n\n\n<p>3526 kV Utrecht,<\/p>\n\n\n\n<p>Netherlands<\/p>\n\n\n\n<p>Accord Healthcare Polska Sp.z oo,<\/p>\n\n\n\n<p>ul.&nbsp;Lutomierska 50,95-200 Pabianice, Polan<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Palonosetron Accord belongs to a group of medicines called serotonin ( 5HT 3 ) antagonists .<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18527],"tags":[20686,20706,10844,20702,20685,10845,20703,10846],"class_list":["post-20276","post","type-post","status-publish","format-standard","hentry","category-medicines","category-p","tag-benefits-of-palonosetron","tag-benefits-of-palonosetron-accord","tag-palonosetron","tag-palonosetron-accord","tag-palonosetron-side-effects","tag-what-is-palonosetron","tag-what-is-palonosetron-accord","tag-what-palonosetron-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20276","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=20276"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20276\/revisions"}],"predecessor-version":[{"id":20321,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20276\/revisions\/20321"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=20276"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=20276"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=20276"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}