{"id":20268,"date":"2022-03-29T11:39:34","date_gmt":"2022-03-29T11:39:34","guid":{"rendered":"https:\/\/zeepedia.com\/?p=20268"},"modified":"2022-03-30T14:17:09","modified_gmt":"2022-03-30T14:17:09","slug":"padviram","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/padviram\/","title":{"rendered":"Padviram &#8211; Efavirenz \/ emtricitabine \/ tenofovir disoproxil uses, dose and side effects"},"content":{"rendered":"\n<p>600 mg \/ 200 mg \/ 245 mg&nbsp;film-coated tablets<br>efavirenz \/ emtricitabine \/ tenofovir disoproxil<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Padviram is and what it is used for<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>efavirenz is a nucleoside-type non-reverse transcriptase inhibitor (NNRTI)<\/li><li>emtricitabine is a reverse nucleotide-type transcriptase inhibitor (NRTI)<\/li><li>tenofovir is a nucleotide-type reverse transcriptase inhibitor (NtRTI)<\/li><\/ul>\n\n\n\n<p><strong>Padviram contains three active substances<\/strong>&nbsp;that are used to treat human immunodeficiency virus (&nbsp;HIV&nbsp;) infection:<\/p>\n\n\n\n<p>These three active substances are antiretroviral drugs that act by affecting the normal function of an&nbsp;enzyme&nbsp;(reverse transcriptase) that the&nbsp;virus&nbsp;needs for its reproduction.<\/p>\n\n\n\n<p><strong>Padviram is a treatment for human immunodeficiency virus (&nbsp;HIV&nbsp;)&nbsp;<\/strong>&nbsp;infection in adults aged 18 years and older who have previously been treated with other antiretroviral drugs and who have had their&nbsp;HIV&nbsp;-1&nbsp;infection&nbsp;under control for at least three months.&nbsp;Patients must not have shown treatment failure with previous&nbsp;HIV&nbsp;treatment.<\/p>\n\n\n\n<p>Efavirenz, emtricitabine, and tenofovir disoproxil contained in Padviram may also be approved for the treatment of other conditions not mentioned in this product information.\u00a0Ask your doctor, pharmacist, or other healthcare professionals if you have any further questions, and always follow their instructions.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you take Padviram<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Padviram<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>If you are allergic<\/strong>\u00a0to efavirenz, emtricitabine, tenofovir, tenofovir disoproxil, or any of the other ingredients of this medicine (listed in section 6).<\/li><li>If you have severe liver disease.<\/li><li>If you have heart problems, such as an arrhythmia called\u00a0QT\u00a0prolongation.\u00a0This can lead to a high risk of developing severe heart rhythm problems (\u00a0torsade de pointes\u00a0).<\/li><li>If someone in your family (parents, grandparents, brothers, or sisters) has died suddenly due to heart problems or was born with heart problems.<\/li><li>If your doctor has told you that you have high or low levels of\u00a0electrolytes, such as\u00a0potassium\u00a0or\u00a0magnesium, in your blood.<\/li><li>If you are taking\u00a0any of the following medicines at the same time (see also &#8220;Other medicines and Padviram&#8221;):<ul><li>astemizole or terfenadine\u00a0(used to treat hay fever or other\u00a0allergies\u00a0)<\/li><li>bepridil\u00a0(used to treat heart disease)<\/li><li>cisapride\u00a0(used to treat heartburn)<\/li><li>elbasvir\/grazoprevir\u00a0(used to treat\u00a0hepatitis\u00a0C)<\/li><li>ergot alkaloids\u00a0(eg\u00a0ergotamine, dihydroergotamine, ergonovine, and methylergonovine) (used to treat\u00a0migraines\u00a0and cluster headaches)<\/li><li>midazolam or triazolam\u00a0(sleeping pills)<\/li><li>pimozide, imipramine, amitriptyline, or clomipramine\u00a0(used to treat certain mental illnesses)<\/li><li>St. John&#8217;s wort\u00a0(\u00a0Hypericum perforatum\u00a0) (an herbal medicine used for mild depression and mild anxiety)<\/li><li>voriconazole\u00a0(used to treat fungal infections)<\/li><li>flecainide,\u00a0metoprolol\u00a0(for the treatment of irregular heartbeat)<\/li><li>certain\u00a0antibiotics\u00a0(\u00a0macrolides\u00a0,\u00a0fluoroquinolones\u00a0, imidazole)<\/li><li>certain\u00a0antifungal drugs (triazoles)<\/li><li>certain anti-malarial<strong>\u00a0drugs<\/strong><\/li><li><strong>methadone<\/strong>\u00a0(for the treatment of opioid dependence).<\/li><\/ul><\/li><\/ul>\n\n\n\n<p>\u2192&nbsp;<strong>If you are taking any of these medicines, tell your doctor immediately.&nbsp;<\/strong>Taking these medicines together with Padviram may cause serious or life-threatening&nbsp;side effects&nbsp;or counteract the effects of these medicines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before taking this medicine.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>You can still transmit\u00a0HIV\u00a0infection while <\/strong>taking this medicine, even though the risk of effective\u00a0antiviral\u00a0therapy is reduced.\u00a0Discuss with your doctor the necessary steps to avoid infecting others.\u00a0This medicine does not\u00a0cure\u00a0HIV\u00a0infection.\u00a0While you are taking this medicine, you may still develop\u00a0infections\u00a0or other diseases associated\u00a0with\u00a0HIV\u00a0infection.<\/li><li>You must continue to be under medical supervision while taking this medicine.<\/li><li>Inform your doctor:<ul><li>if you are taking other medicines\u00a0\u00a0containing efavirenz, emtricitabine, tenofovir disoproxil, tenofoviralafenamide, <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/triumeq\/\">lamivudine<\/a> or adefovir dipivoxi.\u00a0This medicine should not be taken with any of these medicines.<\/li><li>if you have or have had kidney disease\u00a0or if tests have shown that you have kidney problems.\u00a0This medicine is not recommended if you have moderate to severe kidney disease.<br>This medicine may affect your kidneys.\u00a0Before starting treatment, your doctor may prescribe a blood test to check your kidney function.\u00a0Your doctor may also prescribe blood tests during treatment to check your kidneys.<br>This medicine is not usually taken with other medicines that can damage the kidneys (see\u00a0\u00a0Other medicines and Padviram).\u00a0If this is unavoidable, your doctor will check your kidney function once a week.<\/li><li>if you have a heart condition, such as an abnormal electrical signal called an extended\u00a0QT interval.<\/li><li>if you have had a mental illness including depression or drug or alcohol abuse. Tell your doctor immediately if you feel depressed, have suicidal thoughts, or have strange thoughts (see section 4,\u00a0Possible side effects).<\/li><li>if you have had seizures\u00a0or if you are being treated with anticonvulsants such as carbamazepine, phenobarbital, and\u00a0phenytoin.\u00a0If you are taking any of these medicines, your doctor may need to check how much of the medicine is in your bloodstream to ensure that it is not affected when you take this medicine.\u00a0Your doctor may give you another medicine for seizures.<\/li><li>if you have had liver disease, including chronic active\u00a0hepatitis.\u00a0Patients with liver disease, including\u00a0chronic\u00a0hepatitis\u00a0B or C, who are being treated with combination antivirals are at increased risk for serious and potentially life-threatening liver problems.\u00a0Your doctor may take blood samples to check your liver function or allow you to switch to another medicine.\u00a0If you have severe liver disease, do not take Padviram\u00a0(see section 2,\u00a0Do not take Padviram).<br>If you have a hepatitis B\u00a0infection, your doctor will carefully choose the best treatment for you.\u00a0Tenofovir disoproxil and emtricitabine, two of the active substances in this medicine, have some activity against the hepatitis B\u00a0virus\u00a0even though emtricitabine is not approved for the treatment of hepatitis B\u00a0infection.\u00a0The symptoms of your hepatitis may worsen after you stop taking this medicine.\u00a0Your doctor may then take blood samples regularly to check your liver function (see section 3,\u00a0\u00a0If you stop taking Padviram).<\/li><li>Whether or not you have had liver disease, your doctor will consider taking regular blood tests to check your liver function.<\/li><li>if you are over 65 years old.\u00a0The insufficient number of patients over 65 years has been studied.\u00a0If you are over 65 years of age and have been prescribed this medicine, your doctor will monitor you closely.<\/li><\/ul><\/li><li>When you start taking Padviram you should be observant of:<ul><li>symptoms such as dizziness, difficulty sleeping, drowsiness, difficulty concentrating, or abnormal dreams.\u00a0These side effects may occur in the first 1 to 2 days after treatment and usually disappear after 2 to 4 weeks.<\/li><li>symptoms of rash.\u00a0This medicine may cause a rash.\u00a0If you get a severe rash with blistering or fever, stop taking Padviram and tell your doctor straight away.\u00a0If you get a rash while taking another NNRTI, you may be at greater risk of getting a rash with this medicine.<\/li><li>symptoms of inflammation or infection.\u00a0In some patients with advanced\u00a0HIV\u00a0infection (\u00a0AIDS\u00a0) and who have previously had opportunistic\u00a0infections, signs and symptoms of\u00a0inflammation\u00a0from previous\u00a0infections\u00a0may appear shortly after starting treatment for HIV.\u00a0These symptoms are probably due to an improvement in the body&#8217;s\u00a0immune response, which enables the body to fight\u00a0infections\u00a0that may have been present but without any obvious symptoms.\u00a0Tell your doctor immediately if you notice any symptoms of\u00a0infection.<br>In addition to opportunistic\u00a0infections, autoimmune disorders (conditions in which the immune system attacks healthy body tissues) can also occur after you start taking medicines to treat\u00a0your\u00a0HIV\u00a0infection.\u00a0Autoimmune disorders can occur several months after starting treatment.\u00a0If you get any symptoms of\u00a0infection\u00a0or other symptoms such as muscle weakness, weakness that starts in the hands or feet and moves to the torso, palpitations, tremors, or hyperactivity, inform your doctor immediately for the necessary treatment.<\/li><li>skeletal problems.\u00a0Some patients receiving combination\u00a0antiretroviral\u00a0therapy may develop a skeletal disease called\u00a0osteonecrosis\u00a0(skeletal tissue dies due to lost blood supply to the skeleton).\u00a0Some of the many risk factors for developing the disease are long-term\u00a0antiretroviral\u00a0combination therapy, use of\u00a0corticosteroids, alcohol consumption, a severe weakening of the immune system, and a higher body mass index.\u00a0Signs of\u00a0osteonecrosis\u00a0are stiffness in the joints and pain (especially hip, knee, and shoulder) and difficulty moving.\u00a0Tell your doctor if you experience any of these symptoms.<br>Skeletal problems (which manifest as persistent or aggravated skeletal pain and sometimes lead to\u00a0fractures\u00a0) may also occur due to damage to renal tubules (see section 4,\u00a0Possible\u00a0side effects\u00a0).\u00a0Tell your doctor if you have skeletal pain or\u00a0a fracture.<br>Tenofovir disoproxil may also cause bone loss.\u00a0The most pronounced loss of bone mass was seen in\u00a0clinical trials\u00a0when patients were treated with tenofovir disoproxil in combination with an enhanced\u00a0protease inhibitor.<br>Overall, the effects of tenofovir disoproxil on long-term skeletal health and future fracture risk in adults and children are uncertain.<br>Tell your doctor if you know you have osteoporosis.\u00a0Patients with bone beauty are at higher risk for\u00a0fractures.<\/li><\/ul><\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p><strong>Padviram should not be given to children and adolescents <\/strong>under 18 years of age.\u00a0This medicine has not yet been studied in children and adolescents.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Padviram<\/h2>\n\n\n\n<p><strong>You must not take certain medicines with Padviram.\u00a0<\/strong>These are listed under\u00a0\u00a0<em>Do not take Padviram<\/em>, at the beginning of section 2 and include some common medicines and some herbal medicines (including St. John&#8217;s wort) which may cause serious\u00a0interactions.<\/p>\n\n\n\n<p><strong>Tell your doctor <\/strong>or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>In addition, this medicine should not be taken with other medicines containing efavirenz (unless your doctor recommends it), emtricitabine, tenofovir disoproxil, tenofoviralafenamide, lamivudine or adefovir dipivoxil.<\/p>\n\n\n\n<p><strong>Tell your doctor<\/strong>&nbsp;if you are taking other medicines that may damage your kidneys.&nbsp;Examples of such drugs are:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>aminoglycosides, vancomycin (medicine for bacterial infection)<\/li><li>foskarnet, ganciclovir, cidofovir (medicines for viral infections)<\/li><li>amphotericin B, pentamidine (medicine for fungal infections)<\/li><li>interleukin\u00a0-2 (for the treatment of cancer)<\/li><li>non-steroidal anti-inflammatory drugs (\u00a0NSAIDs, to relieve skeletal or muscle pain).<\/li><\/ul>\n\n\n\n<p>Padviram may interact with other medicines, including herbal medicines such as\u00a0\u00a0<em>Ginkgo biloba<\/em>\u00a0extract.\u00a0As a result, the amount of Padviram or other medicines in the blood may be affected.\u00a0This can lead to the medicines not working properly or the side effects getting worse.\u00a0In some cases, your doctor may need to adjust your\u00a0dose\u00a0or check your blood levels.\u00a0You must tell<strong> your doctor or pharmacist if you are taking any of the following:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Drugs containing didanosine (for HIV\u00a0infection\u00a0):\u00a0<\/strong>\u00a0If you take this medicine together with other antiviral medicines containing didanosine, your blood levels of didanosine may increase and your CD4 cell count may decrease.\u00a0Rare cases of pancreatitis and lactic acidosis (excess lactic acid in the blood), in some cases fatal, have been reported during concomitant treatment with drugs containing tenofovir disoproxil and didanosine.\u00a0Your doctor will carefully consider whether you can be treated with medicines containing tenofovir and didanosine.<\/li><li><strong>Other medicines used to treat HIV infection:\u00a0<\/strong>\u00a0The following protease inhibitors: darunavir, indinavir, lopinavir\/ritonavir, ritonavir, or ritonavir with an increased\u00a0dose\u00a0of atazanavir or saquinavir.\u00a0Your doctor may consider giving you alternative medicines or changing the\u00a0dose\u00a0of one of your protease inhibitors.\u00a0Also, tell your doctor if you are taking maraviroc.<\/li><li>Medicines used to treat\u00a0hepatitis\u00a0C\u00a0virus infection:\u00a0elbasvir\u00a0\/ grazoprevir, glekaprevir \/ pibrentasvir, sofosbuvir \/ velpatasvir, sofosbuvir \/ velpatasvir \/ voxilaprevir.<\/li><li>Drugs used to lower blood fats (also called statins):\u00a0\u00a0Atorvastatin, pravastatin,\u00a0simvastatin.\u00a0This medicine may reduce the number of statins in your blood.\u00a0Your doctor will check your cholesterol level and, if necessary, consider changing your statin dose.<\/li><li>Drugs used in the treatment of seizures (\u00a0antiepileptic drugs\u00a0):\u00a0Carbamazepine,\u00a0phenytoin, phenobarbital.\u00a0Padviram may reduce the number of\u00a0antiepileptic drugs\u00a0in the blood.\u00a0Carbamazepine may reduce the amount of efavirenz, one of the ingredients in this medicine, in the blood.\u00a0Your doctor may consider giving you another\u00a0antiepileptic drug.<\/li><li>Drugs for the treatment of bacterial infections,\u00a0including tuberculosis and AIDS-related\u00a0Mycobacterium avium\u00a0complex: Clarithromycin, rifabutin, rifampicin.\u00a0Your doctor may consider changing your dose or giving you another antibiotic.\u00a0Your doctor may also consider adding a dose of efavirenz to treat\u00a0your\u00a0HIV\u00a0infection.<\/li><li>Medicines used to treat fungal infections:\u00a0\u00a0Itraconazole or posaconazole.\u00a0This medicine may reduce the amount of ketoconazole or posaconazole in the blood.\u00a0Your doctor may consider giving you another medicine for a fungal infection.<\/li><li>Medicines used to treat malaria:\u00a0Atovaquone\/proguanil or artemether \/ lumefantrine: this medicine may reduce the amount of atovaquone \/ proguanil or artemeter \/ lumefantrine in the blood.<\/li><li>Hormonal contraceptives, such as\u00a0birth control pills,an injected contraceptive (eg Depo-Provera) o,r a contraceptive implant (eg Implanon):\u00a0You must always use a reliable barrier contraceptive method (see Pregnancy and breast-feeding).\u00a0Padviram may have a worse effect on hormonal contraceptives.\u00a0Pregnancy has occurred in women taking efavirenz, one of the ingredients of this medicine, while using a contraceptive implant, although it has not been established that efavirenz treatment was the reason for the lack of contraceptive effect.<\/li><li>Sertraline, is a medicine used to treat depression, your doctor may change your dose of sertraline.<\/li><li>Bupropion,a medicine used to treat depression or to help quit smoking, your doctor may change your dose of bupropion.<\/li><li>Diltiazem or similar medicines (so-called calcium channel blockers):\u00a0\u00a0When you start taking this medicine, your doctor may need to adjust your\u00a0dose\u00a0of the calcium channel blockers.<\/li><li>Drugs used to prevent the rejection of transplanted organs (and also called immunosuppressive drugs)\u00a0such as ciclosporin, sirolimus o,r tacrolimus.\u00a0When you start or stop taking this medicine, your doctor will make frequent checks on your plasma levels of the immunosuppressive medicine and may need to adjust its\u00a0dose.Warfarin or acenocoumarol\u00a0\u00a0(medicines used to inhibit blood\u00a0clotting\u00a0): Your doctor may need to adjust your\u00a0dose\u00a0of\u00a0warfarin\u00a0or acenocoumarol.<\/li><li>Ginkgo\u00a0biloba extract\u00a0\u00a0(an herbal medicine).<\/li><li>Metamizole,a medicine used to treat pain and fever.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or brbreastfeedingthink you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n<p><strong>Women should not become pregnant during treatment with Padviram or for 12 weeks thereafter<\/strong>.Your doctor may ask you to take a pregnancy test to make sure you are not pregnant before starting your treatment with this medicine.<\/p>\n\n\n\n<p><strong>If you could become pregnant during treatment with Padviram<\/strong>, you must use a reliable barrier contraceptive method (eg condoms) together with other contraceptive methods such as tablets (\u00a0birth control pills\u00a0) or other hormonal contraceptive methods (eg\u00a0implants,\u00a0injection\u00a0).\u00a0Efavirenz, one of the ingredients of this medicine, may remain in the blood for some time after stopping treatment.\u00a0You should therefore continue to use contraception, as described above, for 12 weeks after stopping taking this medicine.<\/p>\n\n\n\n<p><strong>Tell your doctor immediately if you are pregnant or planning to become pregnant.&nbsp;<\/strong>If you are pregnant, you should only take Padviram if you and your doctor decide that there is a clear need.<\/p>\n\n\n\n<p>Serious malformations have been observed in fetal animals and neonates in women treated with efavirenz during pregnancy.<\/p>\n\n\n\n<p>Ask your doctor or pharmacist for advice before taking any medicine.<\/p>\n\n\n\n<p>If you have taken Padviram during your pregnancy, your doctor may ask you to have regular blood tests and other tests to check your baby&#8217;s development.\u00a0For children whose momothersook NRTIs during pregnancy, the benefit of HIV protection outweighs the risk of side effects.<\/p>\n\n\n\n<p><strong>Do not breastfeed during treatment with Padviram.\u00a0<\/strong>Both HIV and the ingredients in this medicine can be transferred to breast milk and can seriously harm your baby.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p><strong>Padviram may cause dizziness, impaired concentration,nd drowsiness.\u00a0<\/strong>If you get these symptoms, do not drive, use any tools or machines.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects anand\/or side effects\u00a0.\u00a0Descriptions of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Padviram contains sodium<\/h2>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg)&nbsp;sodium&nbsp;per tablet, ie essentially &#8216;sodium-free&#8217;.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Padviram<\/h2>\n\n\n\n<p>Always take this medicine exactly as your doctor or pharmacist has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p><strong>The recommended dose is:<\/strong><\/p>\n\n\n\n<p>One tablet once a day by mouth.&nbsp;Padviram is recommended to be taken on an empty stomach (usually defined as 1 hour before or 2 hours after a meal), preferably at bedtime.&nbsp;This may help reduce certain side effects (eg dizziness, drowsiness).&nbsp;Swallow the tablet whole with water.<\/p>\n\n\n\n<p>Padviram must be taken every day.<\/p>\n\n\n\n<p>If your doctor decides to remove one of the ingredients of this medicine, you may receive efavirenz, emtricitabine, anand\/tenofovir disoproxil separately or with other medicines to treat your HIV\u00a0infection.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you take more Virviram than you should<\/h2>\n\n\n\n<p>If you accidentally take too many tablets of Padviram, you may be at greater risk of side effects from this medicine (see section 4,\u00a0<em>Possible\u00a0side\u00a0effects\u00a0)<\/em>.<\/p>\n\n\n\n<p>If you have ingested too much medicine or if e.g.\u00a0If a child has ingested the medicine by mistake, contact a doctor or hospital for risk assessment and advice.\u00a0Save the outer carton or jar so that you can easily describe what you have taken.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Padviram<\/h2>\n\n\n\n<p>you mustn&#8217;t a dose of Padviram.<\/p>\n\n\n\n<p><strong>If you miss a\u00a0dose\u00a0of Padviram within 12 hours of the time it is usually taken<\/strong>, take it as soon as possible, and then take the next\u00a0dose\u00a0at its usual time.<\/p>\n\n\n\n<p><strong>If it is almost time (less than 12 hours) for the next\u00a0dose,\u00a0<\/strong>\u00a0do not take the missed dose.\u00a0Wait and take the next\u00a0dose\u00a0at its usual time.\u00a0Do not take a double dose to make up for a forgotten tablet.<\/p>\n\n\n\n<p><strong>If you vomit the tablet (within 1 hour of taking Padviram)<\/strong>, take a new tablet.\u00a0Do not wait until it is time for your next tablet.\u00a0You do not need to take a new tablet if you vomit for more than<\/p>\n\n\n\n<p>1 hour after taking Padviram.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking Padviram<\/h2>\n\n\n\n<p><strong>Do not stop taking Padviram without talking to your doctor.\u00a0<\/strong>Discontinuation of treatment with this drug can seriously affect how you respond to treatment in the future.\u00a0If you have stopped taking this medicine, talk to your doctor before taking tablets again.\u00a0If you have problems or need to adjust the\u00a0dose, your doctor may consider giving you the ingredients of this medicine separately.<\/p>\n\n\n\n<p><strong>When your Padviram tablets start to run out<\/strong>,be sure to get more from your doctor or pharmacist.\u00a0This is very important because the amount of virus can start to increase as soon as you stop taking the medicine, even if it is only for a short time.\u00a0The virus\u00a0can then be more difficult to treat.<\/p>\n\n\n\n<p><strong>If you have both\u00a0HIV\u00a0infection\u00a0and\u00a0hepatitis\u00a0B<\/strong>,\u00a0you mustn&#8217;t stop treatment without talking to your doctor first.\u00a0Some patients&#8217; blood tests or symptoms have shown that their\u00a0hepatitis\u00a0worsens when treatment is stopped with emtricitabine or tenofovir disoproxil (two of the three ingredients in this medicine).\u00a0If you stop taking this medicine, your doctor may recommend that you resume\u00a0hepatitis\u00a0B treatment.\u00a0You may need to submit blood samples for 4 months after stopping treatment to check your liver function.\u00a0In some patients with advanced liver or cirrhosis of the liver, discontinuation of treatment is not recommended as this may lead to hepatitis\u00a0one worsening, which can be life-threatening.<\/p>\n\n\n\n<p>\u2192 Tell your doctor immediately about new or unusual symptoms that occur after stopping treatment, especially symptoms associated with\u00a0hepatitis\u00a0B\u00a0infection.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects,although not everybody gets them.<\/p>\n\n\n\n<p><strong>Important\u00a0side effects\u00a0or symptoms to be aware of and measures to take if you are affected:<\/strong><br>This medicine may cause allergic reactions.\u00a0Symptoms may include wheezing, difficulty breathing, swelling of the eyelids, face or lips, rash or\u00a0itching,especially those that cover your entire body.<br>Another serious\u00a0side effect\u00a0is a condition where you breathe slower or weaker than expected.\u00a0This mainly affects elderly and weak patients.<br>If you are experiencing these important\u00a0side effects, consult a doctor immediately.<\/p>\n\n\n\n<p><strong>Other\u00a0side effects\u00a0that may occur:<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Very common:<\/strong>&nbsp;(may affect more than 1 in 10 people)<\/td><td>nausea, vomiting, dizziness, drowsiness, headache.<\/td><\/tr><tr><td><strong>Common:<\/strong>&nbsp;(may affect up to 1 in 10 people)<\/td><td>decreased appetiteconcernconfusionhallucinationssleeping problems abnormalreamsshakingredness\u00a0isconstipationdiarrheaindigestiondry mouthitchingincreased sweatingrashmuscle cramp feeling of weaknessfatiguefeeling of changed body temperature<\/td><\/tr><tr><td><strong>Uncommon:<\/strong>(may affect up to 1 in 100 people)<\/td><td>Depressionorientation difficultiesagitation\u00a0_\u00a0_nervousnessrestlessnesselated mood disturbed attention memory impairmentfainting sensationdrowsiness (\u00a0sedation\u00a0)difficulties in controlling movements difficulty speakingnumbnessabnormal sensations in the skin (eg tickling tingling)muscle twitchingabnormal sin increased\u00a0heart ratepalpitationdecreased\u00a0blood pressure dangerously slow or shallow breathing (\u00a0respiratory depression\u00a0)decreased oxygen in the blood respiratory distress feeling of discomfort in the abdomenhivesfeeling of heavinessdelay in emptying the bladder, frequent urinationwithdrawal symptoms (\u00a0abstinence\u00a0) of drugs (see &#8220;If you stop taking Palexia&#8221;)accumulation of water in the\u00a0tissues\u00a0(\u00a0edema\u00a0)feel abnormal feeling of intoxication, irritability feeling of relaxation<\/td><\/tr><tr><td><strong>Rare:<\/strong>(affects 1-10 of10,000 users)<\/td><td>allergic reactions of the drug including swelling under the skin,\u00a0hives,\u00a0and in severe cases difficulty breathing, drop in blood pressure, collapse or\u00a0shock\u00a0)abnormal thought epileptic seizuresimpaired consciousnessabnormal coordination decreased\u00a0heart rate impaired emptying of the stomach<\/td><\/tr><tr><td><strong>Not known:<\/strong><\/td><td>delirium<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>In general, patients with chronic\u00a0pain\u00a0are more likely to have suicidal thoughts and behaviors.\u00a0In addition, some medications used for depression (which affect neurotransmitters in the brain) may increase this risk, especially at the beginning of treatment.\u00a0Although tapentadol also affects neurotransmitters, data from the use of tapentadol in humans do not provide any evidence of increased risk.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Palexia<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton after \u201cEXP\u201d.&nbsp;and on the blister after &#8220;EXP&#8221;.<br>The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>No special storage instructions.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<p>The&nbsp;<strong>active<\/strong>&nbsp;substance is tapentadol.<br>Each tablet contains 50 mg tapentadol (as 58.24 mg tapentadol hydrochloride).<br>Each tablet contains 75 mg of tapentadol (as 87.36 mg of tapentadol hydrochloride).<br>Each tablet contains 100 mg of tapentadol (as 116.48 mg of tapentadol hydrochloride).<\/p>\n\n\n\n<p><strong>Other<\/strong>&nbsp;ingredients are:<\/p>\n\n\n\n<p>Palexia 50 mg film-coated tablets:<br>Tablet core: microcrystalline cellulose,\u00a0lactose monohydrate, croscarmellose sodium, povidone K30, magnesium stearate.\u00a0Tablet cover: polyvinyl alcohol, titanium dioxide (E 171), macrogol 3350, talc.<\/p>\n\n\n\n<p>Palexia 75 mg film-coated tablets:<br>Tablet core: microcrystalline cellulose,\u00a0lactose monohydrate, croscarmellose sodium, povidone K30, magnesium stearate.\u00a0Tablet cover: polyvinyl alcohol, titanium dioxide (E 171), macrogol 3350, talc, iron oxide, yellow (E172), iron oxide, red (E172).<\/p>\n\n\n\n<p>Palexia 100 mg film-coated tablets:<br>Tablet core: microcrystalline cellulose,\u00a0lactose monohydrate, croscarmellose sodium, povidone K30, magnesium stearate.\u00a0Tablet cover: polyvinyl alcohol, titanium dioxide (E 171), macrogol 3350, talc, iron oxide, yellow (E172), iron oxide, red (E172), iron oxide, black (E172).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Palexia 50 mg film-coated tablets:<br>white round film-coated tablets 7 mm in diameter marked with the Gr\u00fcnenthal logo on one side and \u201cH6\u201d on the other side.<\/p>\n\n\n\n<p>Palexia 75 mg film-coated tablets:<br>pale yellow round 8-mm film-coated tablets marked with the Gr\u00fcnenthal logo on one side and \u201cH7\u201d on the other side.<\/p>\n\n\n\n<p>Palexia 100 mg film-coated tablets<br>light pink round film-coated tablets 9 mm marked with the Gr\u00fcnenthal logo on one side and &#8220;H8&#8221; on the other side.<\/p>\n\n\n\n<p>Palexia film-coated tablets are packaged in blisters and are supplied in cartons of 5, 10, 10&#215;1, 14, 14&#215;1, 20, 20&#215;1, 24, 28, 28&#215;1, 30, 30&#215;1, 40, 50, 50&#215;1, 54, 56, 56&#215;1, 60, 60&#215;1, 90, 90&#215;1, 100 and 100&#215;1 tablets.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p>Gr\u00fcnenthal GmbH<br>Zieglerstrasse 6<br>52078 Aachen<br>Germany<\/p>\n\n\n\n<p><strong>This medicinal product is authorized under the European Economic Area under the names:<\/strong><\/p>\n\n\n\n<p>Germany: Palexia Akutschmerz<\/p>\n\n\n\n<p>Belgium, Cyprus, Denmark, Finland, France, Greece, Ireland, Italy, Croatia, Luxembourg, Netherlands, Norway, Poland, Portugal, Slovakia, Slovenia, Spain, United Kingdom, Sweden, Czech Republic, Austria: PALEXIA<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Padviram contains three active substances that are used to treat human immunodeficiency virus ( HIV ) infection:<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18527],"tags":[4358,4361,3398,3401,20737,20740,3389,4331,9712,8832,4359,4318,20738,4330,20739,13322],"class_list":["post-20268","post","type-post","status-publish","format-standard","hentry","category-medicines","category-p","tag-efavirenz","tag-efavirenz-side-effects","tag-emtricitabine","tag-emtricitabine-side-effects","tag-padviram","tag-padviram-side-effects","tag-tenofovir-disoproxil","tag-tenofovir-disoproxil-side-effects","tag-what-efavirenz-is-used-for","tag-what-emtricitabine-is-used-for","tag-what-is-efavirenz","tag-what-is-emtricitabine","tag-what-is-padviram","tag-what-is-tenofovir-disoproxil","tag-what-padviram-is-used-for","tag-what-tenofovir-disoproxil-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20268","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=20268"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20268\/revisions"}],"predecessor-version":[{"id":20325,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20268\/revisions\/20325"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=20268"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=20268"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=20268"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}