{"id":20266,"date":"2022-03-29T11:38:33","date_gmt":"2022-03-29T11:38:33","guid":{"rendered":"https:\/\/zeepedia.com\/?p=20266"},"modified":"2022-03-30T14:17:20","modified_gmt":"2022-03-30T14:17:20","slug":"paclitaxel-pfizer","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/paclitaxel-pfizer\/","title":{"rendered":"Paclitaxel Pfizer uses, dose and side effects"},"content":{"rendered":"\n<p>6 mg \/ ml,&nbsp;concentrate for&nbsp;solution for&nbsp;infusion<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Paclitaxel Pfizer is and what it is used for<\/h2>\n\n\n\n<p>Paclitaxel Pfizer prevents the growth of certain cancer cells, especially in special cancers of the breast, ovaries, and lungs, as well as a special\u00a0AIDS-related cancer that originates in the connective tissue (\u00a0Kaposi&#8217;s sarcoma\u00a0).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using Paclitaxel Pfizer<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Paclitaxel Pfizer<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to paclitaxel or any of the other ingredients of this medicine (listed in section 6), in particular, macrogol glycerol castin oil (polyoxyethylated castor oil)<\/li><li>if you are breast-feeding<\/li><li>if you have too few\u00a0white blood cells\u00a0(\u00a0neutrophils\u00a0).\u00a0This is measured by healthcare<\/li><li>if you have\u00a0Kaposi&#8217;s sarcoma\u00a0and at the same time have a serious\u00a0infection<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or nurse before using Paclitaxel Pfizer:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have heart problems or severe liver disease<\/li><li>because the medicine contains alcohol (see under the heading \u201cPaclitaxel Pfizer contains alcohol\u201d)<\/li><li>if you have previously had neurological problems in your hands and feet (ie&nbsp;peripheral&nbsp;neuropathy&nbsp;)<\/li><li>when you have changes in the composition of your blood<\/li><li>if you intend to have children.&nbsp;Women should avoid pregnancy during treatment with Paclitaxel Pfizer.&nbsp;The treating physician should be informed immediately if pregnancy should occur<\/li><li>when Paclitaxel Pfizer is given in combination with radiation therapy to the lungs<\/li><\/ul>\n\n\n\n<p>Talk to your doctor or nurse if you experience visual impairment during treatment with Paclitaxel Pfizer. In case of visual impairment, especially blurred vision, have your eyes and eyesight examined immediately.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Paclitaxel Pfizer<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>Talk to your doctor while taking paclitaxel while taking any of the following:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>medicines to treat your\u00a0infection\u00a0(ie\u00a0antibiotics\u00a0such as erythromycin, rifampicin, trimethoprim, etc., ask your doctor, nurse, or pharmacist if you are unsure whether the medicine you are taking is\u00a0an antibiotic\u00a0), and medicines to treat fungal infections (eg\u00a0ketoconazole\u00a0)\u00a0_<\/li><li>drugs used to help stabilize your mood, also called antidepressants (eg\u00a0fluoxetine\u00a0)<\/li><li>medicines for seizures (\u00a0epilepsy\u00a0) (eg carbamazepine,\u00a0phenytoin\u00a0)<\/li><li>drugs used to help lower blood lipid levels (eg gemfibrozil)<\/li><li>medicines used to treat heartburn or\u00a0stomach ulcers\u00a0(eg cimetidine)<\/li><li>medicines for\u00a0HIV\u00a0and\u00a0AIDS\u00a0(eg ritonavir, saquvinavir, indinavir, nelfinavir, efavirenz, nevirapine)<\/li><li>a drug called clopidogrel, which is used to prevent blood clots<\/li><li>a drug called deferasirox, which is used to treat persistently high levels of iron in the body<\/li><li>a (traditional) herbal medicine containing\u00a0St. John&#8217;s wort, which is used for mild depression or mild anxiety.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>Ask your doctor or pharmacist for advice before taking any medicine.\u00a0Paclitaxel Pfizer should only be used during pregnancy when necessary.\u00a0Reliable contraceptives should be used while Paclitaxel Pfizer is being used for at least 6 months after stopping treatment. Male patients should seek advice on freezing semen before treatment with paclitaxel due to the risk of\u00a0infertility.\u00a0There is no data on whether paclitaxel passes into breast milk.\u00a0Paclitaxel Pfizer should not be used during breastfeeding.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Do not drive because Paclitaxel Pfizer contains alcohol.&nbsp;The amount of alcohol in this medicine may impair your ability to drive or use machines.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened vigilance.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0Descriptions of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Paclitaxel Pfizer contains alcohol<\/h2>\n\n\n\n<p>This medicine contains 50 vol%\u00a0ethanol\u00a0(alcohol) ie up to 20 g per\u00a0dose, equivalent to 52 cl beer or 21 cl wine per\u00a0dose.\u00a0Harmful to people suffering from alcoholism.\u00a0Attention should be paid to pregnant or lactating women, children, and high-risk groups such as patients with liver disease or\u00a0epilepsy.\u00a0The amount of alcohol in this medicine may affect the effectiveness of other medicines.\u00a0Paclitaxel Pfizer contains macrogol glycerol ricinoleate which may cause severe allergic reactions.<\/p>\n\n\n\n<p><strong>Paclitaxel Pfizer contains macrogol glycerol castor oil (polyoxyethylated castor oil)<\/strong>\u00a0which may cause severe allergic reactions.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Paclitaxel Pfizer<\/h2>\n\n\n\n<p>Your doctor has decided which\u00a0dose\u00a0and how many\u00a0doses\u00a0you should receive.\u00a0Paclitaxel Pfizer is given under the supervision of a doctor, who can give you more information.\u00a0Dose\u00a0one depends on the type and severity of cancer.\u00a0The drug is given as an\u00a0intravenous\u00a0infusion\u00a0(drip) for about three hours.\u00a0The treatment is normally repeated after a treatment-free interval of 3 weeks.<\/p>\n\n\n\n<p>You will also receive a special premedication (pre-treatment) with several different medicines (both those taken by mouth and injected into a blood vessel) before each treatment with Paclitaxel Pfizer.\u00a0Premedication is necessary to reduce the risk of severe\u00a0hypersensitivity reactions\u00a0(see section 4. Possible\u00a0side effects,\u00a0<em>Uncommon<\/em>\u00a0).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children<\/h2>\n\n\n\n<p>Paclitaxel is not recommended for use in children under 18 years of age as safety and data have not been adequately studied.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, Paclitaxel Pfizer can cause\u00a0side effects, although not everybody gets them.\u00a0The most common\u00a0side effects\u00a0are hair loss and a reduced number of blood cells.\u00a0After finishing the treatment, your hair should grow back and your blood values \u200b\u200bbecome normal again.<\/p>\n\n\n\n<p><em>Very common (affects more than 1 user in 10):<\/em>\u00a0Bone marrow suppression, leading to a decrease in the number of blood cells, often with\u00a0infections\u00a0(mainly\u00a0urinary\u00a0tract and upper respiratory tract infections) as a result, and\u00a0anemia\u00a0(\u00a0anemia\u00a0).\u00a0Mild\u00a0hypersensitivity reactions\u00a0such as hot flashes and rash.\u00a0Nerve effects in the hands and\/or feet (\u00a0peripheral\u00a0neuropathy\u00a0), which are characterized by ant crawling, numbness, and \/ or pain (may persist for more than six months after stopping paclitaxel use).\u00a0Low\u00a0blood pressure.\u00a0Bleeding.\u00a0Nausea, vomiting, diarrhea.\u00a0Hair loss (most cases of hair loss occurred less than a month after paclitaxel insertion. When this happens, hair loss is pronounced (over 50%) in most patients).\u00a0Muscle or joint pain.\u00a0Mucositis.<\/p>\n\n\n\n<p><em>Common (affects more than 1 user in 100):<\/em>\u00a0Slow heartbeat (\u00a0pulse\u00a0).\u00a0Transient minor nail and skin changes.\u00a0Injection site reactions (local swelling, pain,\u00a0redness, tissue hardening, sometimes\u00a0cellulite, thickening of the skin, tissue death in the skin).\u00a0Elevated levels of liver enzyme.<\/p>\n\n\n\n<p><em>Uncommon (affects less than 1 user in 100):<\/em>\u00a0Shock condition due to blood poisoning.\u00a0Severe\u00a0hypersensitivity reaction requiring\u00a0treatment with the drop in blood pressure, swelling of the face, shortness of breath, and hives.\u00a0Chills, back pain, chest pain, rapid heartbeat, abdominal pain, pain in arms and legs, profuse sweating, and high\u00a0blood pressure\u00a0in connection with\u00a0a hypersensitivity reaction\u00a0.\u00a0Severe heart problems such as myocardial infarction,\u00a0ventricular fibrillation,\u00a0or ceased impulse conduction between the atria of the heart and ventricles.\u00a0Fainting.\u00a0Myocardial infarction.\u00a0High\u00a0blood pressure.\u00a0Blood clots.\u00a0Inflammation\u00a0of a vein in connection with a blood clot.\u00a0Elevated blood levels of\u00a0bilirubin, a yellow decomposing substance of bile.<\/p>\n\n\n\n<p><em>Rare (affects less than 1 in 1,000 people):<\/em>\u00a0Decreased number of\u00a0white blood cell\u00a0types (neutrophilic\u00a0granulocytes\u00a0) with fever.\u00a0Severe\u00a0allergic reaction\u00a0(\u00a0anaphylactic reaction\u00a0).\u00a0Impact on nerves that control the muscles, with muscle weakness in the arms and legs as a result.\u00a0Shortness of breath, fluid accumulation in the lungs, a special type of\u00a0pneumonia\u00a0(interstitial\u00a0pneumonia\u00a0),\u00a0pulmonary fibrosis, blood clots in the lungs, respiratory problems.\u00a0Peritonitis.\u00a0Itching, rash \/\u00a0redness.\u00a0Weakness, malaise, fever, dehydration.\u00a0Pneumonia, blood poisoning.\u00a0Accumulation of fluid throughout the body (fluid swelling).\u00a0Elevated blood levels of\u00a0creatinine\u00a0(a breakdown product of muscle tissue).\u00a0Armored.\u00a0Holes in the intestine.\u00a0Inflammation\u00a0of the colon.\u00a0Inflammation\u00a0of the pancreas.\u00a0Heart failure.<\/p>\n\n\n\n<p><em>Very rare (affects less than 1 in 10,000 people):\u00a0<\/em>Acute\u00a0leukemia\u00a0(blood cancer) or similar conditions (\u00a0myelodysplastic syndrome\u00a0).\u00a0Life-threatening\u00a0allergic reaction\u00a0(anaphylactic\u00a0shock\u00a0).\u00a0Loss of appetite.\u00a0Confusion state.\u00a0Impact on the so-called\u00a0autonomic nervous system\u00a0(with intestinal paralysis and drop in blood pressure when the body changes position), epileptic seizures, seizures, effects on the brain, dizziness, dizziness, headache, difficulty coordinating movements.\u00a0Visual impairment and\/or visual disturbances in patients who have received a\u00a0dose\u00a0higher than those recommended.\u00a0Impact on the sense of hearing and balance.\u00a0Hearing loss,\u00a0tinnitus), dizziness.\u00a0Flickering in the atrium of the heart.\u00a0Increased stroke rate in the atrium of the heart.\u00a0Shock condition due to drop in blood pressure.\u00a0Cough.\u00a0Inflammation\u00a0of the esophagus.\u00a0Constipation.\u00a0Accumulation of fluid in the abdomen.\u00a0Tissue death in the liver, affects on the brain due to impaired liver function.\u00a0Severe skin reactions with\u00a0inflammation, such as\u00a0Stevens-Johnson\u00a0syndrome or\u00a0epidermal\u00a0necrolysis, skin inflammation with flaking skin, hives, nail dissolution (hands and feet should be protected from sunlight during treatment).<\/p>\n\n\n\n<p><em>Has been reported (\u00a0occurs in an unknown number of users):<\/em>\u00a0Tumor light syndrome (may cause symptoms such as decreased or stopped urine production, muscle cramps, irregular heartbeat).\u00a0Eye side effects such as swelling of the\u00a0macula\u00a0(macular edema), the appearance of flashes of light (\u00a0photos\u00a0) and dots\/spots in the\u00a0field\u00a0of vision.\u00a0Inflammation\u00a0of the vein (\u00a0phlebitis\u00a0), connective tissue disease that makes the skin hard and thickened (\u00a0scleroderma\u00a0),\u00a0inflammatory\u00a0connective tissue disease (systemic lupus erythematosus,\u00a0SLE\u00a0).\u00a0Spasm of the tracheal muscles that can cause breathing difficulties (\u00a0bronchospasm\u00a0).\u00a0Disseminated intravascular coagulation\u00a0or \u201cDIC\u201d has been reported.\u00a0This is a serious condition that causes people to bleed too easily, get blood clots too easily or both.\u00a0Redness\u00a0and swelling of the palms and soles of the feet, can lead to the skin flaking.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Paclitaxel Pfizer<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not store above 25 \u00b0 C.&nbsp;Store in the outer carton.&nbsp;Sensitive to light.&nbsp;Freezing has no negative effect on the product.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the label after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>The medicine should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is paclitaxel 6 mg\/ml.<\/li><li>The other ingredients are macrogol glycerol castor oil (polyoxyethylated castor oil), anhydrous\u00a0ethanol,\u00a0and anhydrous citric acid.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Clear, colorless to the pale yellow\u00a0viscous\u00a0solution.<\/p>\n\n\n\n<p>Pack sizes:<\/p>\n\n\n\n<p>1 x 5 ml (30 mg paclitaxel)<\/p>\n\n\n\n<p>1 x 16.7 ml (100 mg paclitaxel)<\/p>\n\n\n\n<p>1 x 25 ml (150 mg paclitaxel)<\/p>\n\n\n\n<p>1 x 50 ml (300 mg paclitaxel)<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p>Holder of approval for sale:: Pfizer AB, 191 90 Sollentuna, Telephone: 08-550 520 00, E-mail: eumedinfo@pfizer.com<\/p>\n\n\n\n<p>Manufacturer:<\/p>\n\n\n\n<p>Pfizer Service Company BVBA, Hoge Wei 10, 1930 Zaventem, Belgium<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Paclitaxel Pfizer prevents the growth of certain cancer cells, especially in special cancers of the breast, ovaries and lungs, as well as a special AIDS -related cancer that originates in the connective tissue ( Kaposi&#8217;s sarcoma ).<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18527],"tags":[20745,20741,20747,20744,20746,20748,20742,20743],"class_list":["post-20266","post","type-post","status-publish","format-standard","hentry","category-medicines","category-p","tag-benefits-of-paclitaxel-pfizer","tag-paclitaxel-pfizer","tag-paclitaxel-pfizer-dosage","tag-paclitaxel-pfizer-side-effects","tag-paclitaxel-pfizer-usage","tag-side-effects-of-paclitaxel-pfizer","tag-what-is-paclitaxel-pfizer","tag-what-paclitaxel-pfizer-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20266","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=20266"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20266\/revisions"}],"predecessor-version":[{"id":20327,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20266\/revisions\/20327"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=20266"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=20266"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=20266"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}