{"id":20211,"date":"2022-03-28T10:53:41","date_gmt":"2022-03-28T10:53:41","guid":{"rendered":"https:\/\/zeepedia.com\/?p=20211"},"modified":"2022-03-29T11:32:51","modified_gmt":"2022-03-29T11:32:51","slug":"pacligen","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/pacligen\/","title":{"rendered":"Pacligen &#8211; Paclitaxel uses, dose and side effects"},"content":{"rendered":"\n<p>6 mg \/ ml&nbsp;concentrate for&nbsp;solution for&nbsp;infusion<br>paclitaxel<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Pacligen is and what it is used for<\/h2>\n\n\n\n<p>Paclitaxel is a cancer medicine.&nbsp;It inhibits the growth and division of cancer cells.<\/p>\n\n\n\n<p>Pacligen is used to treat different types of cancer ie:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Breast cancer:<ul><li>Treatment of early breast cancer after surgery when the primary\u00a0tumor\u00a0has been removed, followed by additional treatment with\u00a0anthracycline\u00a0and cyclophosphamide (AC).<\/li><li>As a first-line treatment for advanced breast cancer or for breast cancer that has spread to other parts of the body.\u00a0Pauly is combined either with\u00a0anthracycline\u00a0(eg doxorubicin) or with a substance called <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/trazimera\/\">trastuzumab<\/a> (for patients for whom\u00a0an anthracycline\u00a0is not suitable and for patients whose cancer cells have a\u00a0protein\u00a0on their surface called\u00a0HER2, see the package leaflet for trastuzumab).<\/li><li>As secondary treatment for patients who have not responded to standard\u00a0anthracycline therapy\u00a0or where such treatment should not be used<\/li><\/ul><\/li><li>Ovarian cancer:<ul><li>As a first-line treatment for advanced ovarian cancer or in patients with a residual\u00a0tumor\u00a0larger than 1 cm after an initial operation, in combination with cisplatin.<\/li><li>After standard treatment with platinum-containing drugs has been tried but has not given effect.<\/li><\/ul><\/li><li>A type of lung cancer (advanced non-small cell lung cancer):<ul><li>In combination with cisplatin when surgery and\/or radiation therapy are not appropriate.<\/li><\/ul><\/li><\/ul>\n\n\n\n<p>It is also used to treat a specific\u00a0AIDS-related form of cancer that develops in the connective tissue (\u00a0Kaposi&#8217;s sarcoma\u00a0) when other treatments (ie liposomal\u00a0anthracyclines\u00a0) have been tried but have not yielded results.<\/p>\n\n\n\n<p>Paclitaxel contained in Pacligen may also be approved for the treatment of other conditions not mentioned in this product information.\u00a0Ask your doctor, pharmacist, or other healthcare professional if you have any further questions, and always follow their instructions.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using Pacligen<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Pacligen<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are\u00a0<strong>allergic<\/strong>\u00a0to paclitaxel or any of the other ingredients of this medicine (listed in section 6), especially macrogol glycerol ricinoleate.<\/li><li>if you are breast-feeding<\/li><li>if the number of\u00a0white blood cells\u00a0(\u00a0neutrophils\u00a0) is below 1500 cells per microliter (for cancer patients) or below 1000 cells per microliter (for patients with\u00a0Kaposi&#8217;s sarcoma\u00a0).\u00a0This is measured by healthcare.<\/li><li>if you have a severe and uncontrolled\u00a0infection\u00a0and Pacligen is used to treat\u00a0Kaposi&#8217;s sarcoma<\/li><li>if you suffer from severe liver disease<\/li><\/ul>\n\n\n\n<p>If any of these apply to you,&nbsp;<strong>talk to your doctor before starting Pacligen.<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p><strong>To reduce the risk of allergic reactions<\/strong>, you will be pre-treated with other medicines before receiving Pacligen.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you experience severe allergic reactions (eg difficulty breathing, shortness of breath, chest tightness, drop in blood pressure, dizziness, skin reactions such as rash or swelling).<\/li><li>If you have a\u00a0<strong>fever, severe chills, sore throat,<\/strong> or sore mouth\u00a0(signs of bone marrow suppression).<\/li><li>If you have conduction disturbance in the heart.<\/li><li>If you have severe liver disease.<\/li><li>If you have previously had problems with your arms and legs such as loss of sensation, weakness, stinging, or burning sensation (signs of\u00a0peripheral\u00a0neuropathy\u00a0).\u00a0A dose\u00a0reduction\u00a0may need to be made.<\/li><li>If your\u00a0<strong>chest has previously been irradiated<\/strong>\u00a0(as this may increase the risk of\u00a0pneumonia\u00a0).<\/li><li>If you develop severe or persistent diarrhea with fever and stomach pain during or shortly after treatment with Pacligen.\u00a0Your bowel may then be inflamed (pseudomembranous\u00a0colitis\u00a0).<\/li><li>If your mouth is sore and red (signs of mucositis) and you are being treated for\u00a0Kaposi&#8217;s sarcoma.\u00a0You may need a lower\u00a0dose.<\/li><\/ul>\n\n\n\n<p>Tell your doctor immediately if any of these apply to you.<\/p>\n\n\n\n<p><strong>Pacligen should always be given\u00a0intravenously<\/strong>.\u00a0If Pacligen is given in the\u00a0arteries, it can cause\u00a0inflammation\u00a0in them, which can cause pain, swelling,\u00a0redness,\u00a0and a feeling of warmth.<\/p>\n\n\n\n<p>Before using Pacligen remember that this medicine contains alcohol (see section \u201cPacligen contains alcohol and macrogol glycerol ricinoleate\u201d).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Pacligen is not recommended for use in children (under 18 years).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other drugs and Pacligen<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>Talk to your doctor while taking paclitaxel while taking any of the following:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>medicines to treat your\u00a0infections\u00a0(ie\u00a0antibiotics\u00a0such as erythromycin, rifampicin, etc., ask your doctor, nurse, or pharmacist if you are unsure whether the medicine you are taking are\u00a0antibiotics\u00a0), and medicines to treat fungal infections (eg\u00a0ketoconazole\u00a0)<\/li><li>drugs used to help stabilize your mood, also called antidepressants (eg\u00a0fluoxetine\u00a0)<\/li><li>medicines for seizures (\u00a0epilepsy\u00a0) (eg carbamazepine,\u00a0phenytoin\u00a0)<\/li><li>drugs used to help lower blood lipid levels (eg gemfibrozil)<\/li><li>medicines used to treat heartburn or\u00a0stomach ulcers\u00a0(eg cimetidine)<\/li><li>medicines for\u00a0HIV\u00a0and\u00a0AIDS\u00a0(eg ritonavir, saquvinavir, indinavir, nelfinavir, efavirenz, nevirapine)<\/li><li>a drug called clopidogrel, which is used to prevent blood clots.<\/li><\/ul>\n\n\n\n<p>Pacligen must be given<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>before cisplatin<\/strong>&nbsp;(for the treatment of cancer) in combination therapy.&nbsp;Your kidney function may need to be checked more often.<\/li><li>24 hours&nbsp;<strong>after doxorubicin<\/strong>&nbsp;(for the treatment of cancer) to avoid high levels of doxorubicin in the body.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n<p><strong>Pregnancy<\/strong><\/p>\n\n\n\n<p><strong>Tell your doctor if you are pregnant<\/strong>\u00a0or think you may be pregnant before receiving Pacligen treatment.\u00a0If there is a risk that you may become pregnant,\u00a0<strong>use an effective and safe method of contraception during treatment.\u00a0<\/strong>Pacligen should not be used during pregnancy unless necessary.<\/p>\n\n\n\n<p>Women and men of&nbsp;childbearing potential&nbsp;and their partners should use effective contraception for at least 6 months after stopping paclitaxel treatment.<\/p>\n\n\n\n<p>Men should seek advice on freezing semen before treatment with paclitaxel as there is a risk of sterility.<\/p>\n\n\n\n<p><strong>Breast-feeding<\/strong><\/p>\n\n\n\n<p>Do not use Pacligen if you are breastfeeding.\u00a0Tell your doctor if you abreastfeedinging.\u00a0If you are using Pacligen, stop breastfeeding.\u00a0Do not resume breastfeeding until your doctor has permitted you to do so.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>This medicine contains alcohol.&nbsp;Therefore, you should not drive immediately after a course of treatment.<\/p>\n\n\n\n<p>The amount of alcohol in this medicine may also affect your ability to use tools and machines.&nbsp;Refrain from driving or using tools or machines if you feel dizzy or unsure if you can.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0Descriptions of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pacligen contains alcohol and macrogol glycerol ricinoleate<\/h2>\n\n\n\n<p>Pacligen contains 50%\u00a0ethanol\u00a0(volume) ie.\u00a0up to 20 g per\u00a0dose\u00a0corresponding to 520 ml beer or 210 ml wine per\u00a0dose.\u00a0This can be harmful to people suffering from alcoholism.\u00a0Should be observed by pregnant and lactating women, child,ren and high-risk groups such as patients with liver disease or\u00a0epilesy\u00a0.<\/p>\n\n\n\n<p>The amount of alcohol in this medicine may also affect teffectivenessect of other medicines.<\/p>\n\n\n\n<p>Pacligen also contains macrogol glycerol ricinoleate which may cause severe allergic reactions.\u00a0If you are allergic to macrogol glycerol ricinoleate,\u00a0<strong>tell your doctor before using Pacligen.<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How Pacligen is given<\/h2>\n\n\n\n<p>Pacligen should only be administered under the supervision of a qualified oncologist at clinics specializing in the&nbsp;administration&nbsp;of cytotoxic agents.<\/p>\n\n\n\n<p><strong>To reduce the risk of allergic reactions<\/strong>, you will be pre-treated with other medicines before receiving Pacligen.\u00a0These drugs can be given as tablets or as an\u00a0infusion\u00a0into a vein, or both.<\/p>\n\n\n\n<p>The infusion solution has been prepared by mixing the product with&nbsp;glucose&nbsp;solution or sodium chloride solution, see information for healthcare professionals only in this leaflet.<\/p>\n\n\n\n<p>Pacligen will be given as a drip into one of your veins (&nbsp;intravenous&nbsp;infusion&nbsp;) via a filter.<\/p>\n\n\n\n<p>Your doctor will decide which&nbsp;dose&nbsp;and how many&nbsp;doses&nbsp;of Pacligen you need.&nbsp;The amount (&nbsp;dose&nbsp;one) that you should have is based on your body surface area in square meters (m&nbsp;<sup>2<\/sup>&nbsp;) and the results from the blood tests.&nbsp;Depending on the type and severity of your cancer, you will be treated with Pacligen alone or in combination with other cancer drugs.<\/p>\n\n\n\n<p>Pacligen should always be given in one of your veins for 3-24 hours.&nbsp;Pacligen is usually given every two or three weeks unless your doctor decides otherwise.&nbsp;Your doctor will inform you about how many courses of Pacligen you need.<\/p>\n\n\n\n<p>You may feel discomfort or pain if the needle comes loose or is disturbed or if the solution reaches the surrounding\u00a0tissue.\u00a0Contact a doctor or nurse immediately if this happens.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you take more Pacligen than you should<\/h2>\n\n\n\n<p>There is no known&nbsp;antidote&nbsp;for paclitaxel overdose.&nbsp;You will receive treatment for your symptoms.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use Pacligen<\/h2>\n\n\n\n<p>Paclitaxel needs to be given regularly.\u00a0Be sure to keep all appointments and inform doctors if you have missed a\u00a0dse\u00a0.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop using Pacligen<\/h2>\n\n\n\n<p>Stopping using paclitaxel may cause the effect on tumor growth to cease.&nbsp;Do not stop treatment with Pacligen unless you have discussed it with your doctor.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Tell your doctor immediately<\/strong>&nbsp;if you notice any&nbsp;<strong>signs of allergic reactions.&nbsp;<\/strong>Which may include one or more of the following symptoms:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Hot flashes<\/li><li>Rash<\/li><li>Itching<\/li><li>Pressure over the chest<\/li><li>Shortness of breath or difficulty breathing<\/li><li>Swelling<\/li><\/ul>\n\n\n\n<p>These symptoms may be signs of serious\u00a0side effects.<\/p>\n\n\n\n<p><strong>Tell your doctor immediately if you:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>have a\u00a0<strong>fever, severe chills, sore throat,<\/strong> or sore mouth\u00a0(signs of bone marrow suppression)<\/li><li>have\u00a0a <strong>loss of sensation or experience weakness in arms and legs<\/strong>\u00a0(signs of\u00a0peripheral\u00a0neuropathy\u00a0) *<\/li><li>gets\u00a0<strong>severe\u00a0or persistent diarrhea<\/strong>\u00a0with fever and stomach pain<\/li><\/ul>\n\n\n\n<p>* May persist for more than six months after stopping paclitaxel use.<\/p>\n\n\n\n<p><em>Very common (may affect more than 1 user in 10):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Infection\u00a0(mainly upper\u00a0respiratory\u00a0tract and urinary tract infection) If you have a fever or other signs of\u00a0infection, tell your doctor immediately<\/li><li>Respiratory distress<\/li><li>Studies can show a decrease in\u00a0platelets, white and\u00a0red blood cells<\/li><li>Fever, severe chills, headache, dizziness, tiredness, pallor, bleeding, if you get bruises more easily than normal<\/li><li>Mild\u00a0hypersensitivity reactions\u00a0such as hot flashes, rash, and\u00a0itching.<\/li><li>Damage to peripheral nerves characterized by ant crawling, loss of sensation, and\/or pain in arms and\/or legs (symptoms of\u00a0peripheral\u00a0neuropathy\u00a0) *<\/li><li>Low\u00a0blood pressure<\/li><li>Nausea, vomiting, diarrhea<\/li><li>Sore throat or sore mouth, sore and red mouth<\/li><li>Hair loss (most cases of hair loss occurred less than a month after paclitaxel insertion. When this happens, hair loss is pronounced (over 50%) in most patients).<\/li><li>Muscle pain or joint pain, cramps<\/li><\/ul>\n\n\n\n<p>* May persist for more than six months after stopping paclitaxel use.<\/p>\n\n\n\n<p><em>Common (may affect up to 1 in 10 people):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Slow heartbeat (\u00a0pulse\u00a0)<\/li><li>Transient minor nail and skin changes.<\/li><li>Injection site reactions (local swelling, pain,\u00a0redness, hardening of\u00a0tissue, sometimes\u00a0cellulite, thickening of the skin (skin fibrosis), tissue death (\u00a0necrosis\u00a0))<\/li><li>Investigations may show: Slow heart rate (\u00a0pulse\u00a0), severely elevated levels of liver enzymes (alkaline phosphatases and\u00a0AST\u00a0) indicating impaired liver function.<\/li><\/ul>\n\n\n\n<p><em>Uncommon&nbsp;<\/em>&nbsp;<em>(may affect up to 1 in 100 people):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Shock condition due to blood poisoning (known as\u00a0septic\u00a0shock\u00a0).<\/li><li>Severe\u00a0hypersensitivity reactions\u00a0such as<ul><li>drop in blood pressure, swelling of the face, lips, mouth, tongue, or throat and shortness of breath, and hives;\u00a0<strong>these reactions require medical treatment<\/strong><\/li><li>overindulge<\/li><li>back pain<\/li><li>chest pain<\/li><li>palpitation<\/li><li>abdominal pain<\/li><li>pain in hands and feet<\/li><\/ul><\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li>Sweating<\/li><li>Fatigue<\/li><li>High&nbsp;blood pressure<\/li><li>Inflammation&nbsp;in a friend<\/li><li>Blood clot<\/li><li>Respiratory distress<\/li><li>Fast heartbeat<\/li><li>Ventricular fibrillation&nbsp;or cessation of impulse conduction between the atria of the heart and ventricles<\/li><li>Fainting<\/li><li>Myocardial infarction<\/li><li>Tests may show elevated levels of&nbsp;bilirubin&nbsp;(a yellow bile degradation product) in the blood (jaundice)<\/li><\/ul>\n\n\n\n<p><em>Rare (may affect up to 1 in 1,000 people):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Blood poisoning (\u00a0sepsis\u00a0)<\/li><li>Peritonitis<\/li><li>Decreased number of\u00a0white blood cell\u00a0types with fever increased risk of\u00a0infection\u00a0(febrile neutropenia)<\/li><li>Life-threatening\u00a0allergic reaction\u00a0(\u00a0anaphylactic reaction\u00a0)<\/li><li>Effects on nerves that control the muscles, with muscle weakness in the arms and legs as a result (motor\u00a0neuropathy\u00a0)<\/li><li>Shortness of breath, blood clots in the lungs,\u00a0pulmonary fibrosis, interstitial\u00a0pneumonia, shortness of breath, pleural effusion<\/li><li>Armored<\/li><li>Holes in the intestine<\/li><li>Inflammation\u00a0of the colon (ischemic\u00a0colitis\u00a0)<\/li><li>Inflammation\u00a0of the pancreas (\u00a0pancreatitis\u00a0)<\/li><li>Itching, rash,\u00a0redness\u00a0(\u00a0erythema\u00a0)<\/li><li>The elevated level of\u00a0creatinine\u00a0in the blood, may indicate impaired renal function<\/li><li>Impact on the nerves with the feeling of muscle weakness in arms and legs<\/li><li>Fever, dehydration, weakness, fluid swelling, malaise<\/li><li>Heart problems that can cause shortness of breath or swollen ankles<\/li><\/ul>\n\n\n\n<p><em>Very rare (may affect up to 1 in 10,000 people)<\/em>&nbsp;:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Sudden disturbance in the blood-forming cells (\u00a0acute\u00a0leukemia,\u00a0myelodysplastic syndrome\u00a0).<\/li><li>Life-threatening\u00a0allergic reaction\u00a0with\u00a0shock\u00a0(anaphylactic\u00a0shock\u00a0)<\/li><li>Loss of appetite (\u00a0anorexia\u00a0)<\/li><li>Confusion state<\/li><li>Visual disturbance and\/or visual disturbances (fibrillation scotoma)<\/li><li>Hearing loss or hearing loss (ototoxicity),\u00a0tinnitus, dizziness<\/li><li>Irregular, rapid heartbeat (\u00a0atrial fibrillation,\u00a0supraventricular\u00a0tachycardia\u00a0)<\/li><li>Blood clots (thrombosis) in the blood vessels of the abdominal cavity and intestines<\/li><li>Inflammation\u00a0of the colon, sometimes with persistent, severe diarrhea (pseudomembranous\u00a0colitis,\u00a0neutropenic\u00a0colitis\u00a0), accumulation of fluid in the abdomen (\u00a0ascites\u00a0),\u00a0inflammation\u00a0of the esophagus, constipation.<\/li><li>Failure of liver function (tissue death in the liver, effects on the brain due to impaired liver function) Fatal cases were reported for both conditions<\/li><li>Severe allergic reactions include fever, skin redness, joint pain and\/or\u00a0inflammation\u00a0of the eyes (\u00a0Stevens-Johnson syndrome\u00a0), localized skin redness (\u00a0epidermal\u00a0necrolysis\u00a0),\u00a0redness\u00a0with irregular red (fluid-filled) spots (erythema multiforme), skin inflammation with blisters and flaking skin (exfoliative\u00a0dermatitis\u00a0), hives, nail solution (hands and feet should be protected from sunlight during treatment)<\/li><\/ul>\n\n\n\n<p><em>Has been reported (may occur in an unknown number of users)<\/em>\u00a0:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Tumor light syndrome that caused:<\/li><li>High levels of\u00a0potassium\u00a0in the blood, can cause abnormal heart rhythm (hyperkalemia),<\/li><li>Skeletal muscle spasm (\u00a0tetany\u00a0), seizures, developmental disorders, movement disorders, emotional instability\/anxiety\/worry, pain or weakness in muscles (hypocalcemia)<\/li><li>Fatigue, loss of appetite, headache, accumulation of fluid in arms, legs, and lungs (\u00a0kidney failure\u00a0)<\/li><li>Swelling in the back of the eye (macular edema) that has distorted the central\u00a0visual\u00a0field<\/li><li>Photopsia\u00a0that caused perceived flashes in the\u00a0field\u00a0of view.<\/li><li>Vitreous clouding appears as spots, threads, or fragments of cobwebs that slowly flow past the observer&#8217;s eyes.<\/li><li>Inflammation\u00a0in a friend (\u00a0phlebitis\u00a0)<\/li><li>Symmetrical thickening of the skin (\u00a0scleroderma\u00a0)<\/li><li>Systemic lupus erythematosus has caused fever, malaise, joint pain, muscle aches, fatigue, and temporary loss of\u00a0cognitive\u00a0ability.<\/li><li>Disseminated intravascular\u00a0coagulation\u00a0or \u201cDIC\u201d has been reported.\u00a0This is a serious condition that causes people to bleed too easily, get blood clots too easily or both.<\/li><li>Redness\u00a0and swelling of the palms and soles of the feet can lead to skin flaking.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Pacligen<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Keep the vial (s) in the outer carton.&nbsp;Sensitive to light.&nbsp;No special temperature instructions.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton and vial after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is paclitaxel.\u00a0One milliliter of concentrate contains 6 mg of paclitaxel.One 5 ml\u00a0vial\u00a0contains 30 mg paclitaxelOne\u00a016.7 ml\u00a0vial contains 100 mg paclitaxelOne\u00a025 ml\u00a0vial contains 150 mg paclitaxelOne 50 ml\u00a0vial\u00a0contains 300 mg paclitaxelOne\u00a0100 ml\u00a0vial contains 600 mg paclitaxel<\/li><li>The other ingredients are anhydrous\u00a0ethanol\u00a0(alcohol) and polyoxyethylated castor oil (macrogol glycerol castinoleate).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Pacligen is a clear, colorless to pale yellow,\u00a0viscous\u00a0solution in colorless vials (type I glass) with fluoropolymer-coated halo butyl rubber stopper and corrugated aluminum capsule.<\/p>\n\n\n\n<p>Each&nbsp;vial&nbsp;contains 30 mg, 100 mg, 150 mg, 300 mg or 600 mg of paclitaxel.<\/p>\n\n\n\n<p>Pacligen is available in packs of 1, 5, 10, 20 vials.\u00a0Pack sizes of 1\u00a0vial, 5 vials, and 10 vials are supplied with or without plastic protection (Onco-Safe or protective foil) in a carton.\u00a0Once-Safe and protective foil are not in contact with the medicine and provide increased safety during transport, which increases the safety of pharmacy and healthcare staff.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p><em>Marketing Authorisation Holder<\/em><\/p>\n\n\n\n<p>Sandoz A \/ S, Edvard Thomsens Vej 14, 2300 Copenhagen, Denmark<\/p>\n\n\n\n<p><em>Manufacturer<\/em><\/p>\n\n\n\n<p>Salutas Pharma GmbH, Otto-von-Guericke-Allee 1, 39179 Barleben, Germany<\/p>\n\n\n\n<p>or<\/p>\n\n\n\n<p>Lek Pharmaceuticals dd, Verovskova 57, 1526 Ljubljana, Slovenia<\/p>\n\n\n\n<p>or<\/p>\n\n\n\n<p>Ebewe Pharma Ges.mbH Nfg.&nbsp;KG, Mondseestrasse 11, 4866 Unterach, Austria<\/p>\n\n\n\n<p>or<\/p>\n\n\n\n<p>Fareva Unterach GmbH, Mondseestrasse 11, 4866 Unterach, Austria<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Paclitaxel is a cancer medicine. It inhibits the growth and division of cancer cells.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18527],"tags":[20594,20574,20590,20593,10249,20573,20591,10250,20592,10251],"class_list":["post-20211","post","type-post","status-publish","format-standard","hentry","category-medicines","category-p","tag-benefits-of-pacligen","tag-benefits-of-paclitaxel","tag-pacligen","tag-pacligen-side-effects","tag-paclitaxel","tag-paclitaxel-side-effects","tag-what-is-pacligen","tag-what-is-paclitaxel","tag-what-pacligen-is-used-for","tag-what-paclitaxel-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20211","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=20211"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20211\/revisions"}],"predecessor-version":[{"id":20252,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20211\/revisions\/20252"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=20211"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=20211"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=20211"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}