{"id":20207,"date":"2022-03-28T10:44:36","date_gmt":"2022-03-28T10:44:36","guid":{"rendered":"https:\/\/zeepedia.com\/?p=20207"},"modified":"2022-09-06T06:46:09","modified_gmt":"2022-09-06T06:46:09","slug":"ozurdex","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/ozurdex\/","title":{"rendered":"OZURDEX &#8211; Dexamethasone uses, dose and side effects"},"content":{"rendered":"\n<p>700 micrograms&nbsp;intravitreal&nbsp;implant&nbsp;in&nbsp;applicator<br><a href=\"https:\/\/zeepedia.com\/medical\/medicines\/toflacort\/\">dexamethasone<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What OZURDEX is and what it is used for<\/h2>\n\n\n\n<p>The active substance in OZURDEX is dexamethasone.&nbsp;Dexamethasone belongs to a group of medicines called&nbsp;corticosteroids.<\/p>\n\n\n\n<p>OZURDEX is used to treat adult patients with:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Loss of vision due to diabetic macular edema (DME) if you have already had cataract surgery or if you have not previously responded or are not suitable for other treatments.&nbsp;Diabetic macular edema is a swelling in the photosensitive layer in the back of the eye called the&nbsp;macula.&nbsp;DME is a condition that affects some people with&nbsp;diabetes.<\/li><li>Loss of vision in adults is caused by blockage of veins in the eye.&nbsp;This blockage causes fluid to accumulate, leading to swelling of the part of the retina (the light-sensitive layer at the back of the eye) called the&nbsp;macula.<br>Swelling in the&nbsp;macula&nbsp;can lead to injuries, which can affect the central vision that you use e.g.&nbsp;when reading.&nbsp;OZURDEX works by reducing the swelling in the macula and thus helps to reduce or prevent damage to it.<\/li><li>Inflammation&nbsp;of the back of the eye.&nbsp;This&nbsp;inflammation&nbsp;leads to impaired vision and\/or the presence of liquid clouding in the eye (black dots or tangled lines moving across the&nbsp;visual field&nbsp;).&nbsp;OZURDEX works by reducing this&nbsp;inflammation.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using OZURDEX<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use OZURDEX<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to dexamethasone or any of the other ingredients of this medicine (listed in section 6)<\/li><li>if you have an&nbsp;infection&nbsp;of any kind in or around the eye (bacteria,&nbsp;virus,&nbsp;or fungus)<\/li><li>if you have&nbsp;glaucoma&nbsp;or high pressure in the eye that cannot be treated properly with the medicines you may be using.<\/li><li>if the eye to be treated lacks a lens and if the back of the lens capsule has ruptured<\/li><li>if the eye to be treated has undergone cataract surgery and has an artificial lens, which is implanted in the anterior cavity of the eye (&nbsp;intraocular&nbsp;lens in the anterior chamber) or has been fixed to the white part of the eye (sclera) or the colored part of the eye (&nbsp;iris&nbsp;) and the back of the lens capsule has burst<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Before&nbsp;injecting&nbsp;one with OZURDEX, tell your doctor about:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>you have undergone cataract surgery, iris surgery (the colored part of the eye that controls the amount of light that enters the eye), or surgery to remove the fluid inside the eye (&nbsp;vitreous&nbsp;one)<\/li><li>you are taking some blood thinners<\/li><li>you are taking any&nbsp;steroid&nbsp;or non-steroidal anti-inflammatory drugs that are taken by mouth or applied to the eye<\/li><li>you have previously had a&nbsp;herpes&nbsp;simplex&nbsp;infection&nbsp;in the eye (a wound on the eye that has been there for a long time, or a red and inflamed eye)<\/li><\/ul>\n\n\n\n<p>Occasionally,&nbsp;injection&nbsp;of OZURDEX may cause an infection inside the eye, pain in the eye or red eye, or a rupture or loosening of the retina.&nbsp;It is important to ascertain and treat these as soon as possible.&nbsp;Tell your doctor immediately if you experience increased eye pain or increased discomfort in the eye, eye redness that gets worse, flashes of light and a sudden increase in fluid cloudiness in the eye, partially blocked vision, impaired vision, or increased photosensitivity after&nbsp;injection.<\/p>\n\n\n\n<p>In some patients, pressure in the eye may increase and possibly cause&nbsp;glaucoma.&nbsp;This can happen without you noticing and the doctor will therefore examine you regularly and, if necessary, give you treatment to reduce the pressure in your eye.<\/p>\n\n\n\n<p>In most patients who have not yet undergone cataract surgery, a cloudiness of the eye&#8217;s natural lens (&nbsp;cataract&nbsp;) may occur after repeated treatment with OZURDEX.&nbsp;If this happens, your vision will deteriorate and you will probably need to have surgery to remove the&nbsp;cataract.&nbsp;Your doctor will help you decide when it is most appropriate to operate, but you should be aware that until you are ready for your operation, your vision will be as bad or worse than it was before you started receiving your OZURDEX. injection&nbsp;is.<\/p>\n\n\n\n<p>The implant&nbsp;can be moved from the back of the eye to its front in patients with a rupture in the back of the lens capsule and\/or patients who have an opening in the&nbsp;iris.&nbsp;This can lead to swelling in the transparent layer in front of the eye and cause blurred vision.&nbsp;If this continues for a long time and is not treated, it may be necessary to perform tissue transplantation.<\/p>\n\n\n\n<p>Injection&nbsp;of OZURDEX into both eyes at the same time has not been studied and is not recommended.&nbsp;Your doctor should not inject OZURDEX into both eyes at the same time.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and adolescents (under 18 years)<\/h2>\n\n\n\n<p>The use of OZURDEX in children and adolescents has not been studied and is therefore not recommended.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and OZURDEX<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>There is no experience with the use of OZURDEX in pregnant women or during breastfeeding.&nbsp;OZURDEX should not be used during pregnancy or breastfeeding unless your doctor considers it necessary.&nbsp;If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, talk to your doctor before taking OZURDEX.&nbsp;Ask your doctor or pharmacist for advice before taking any medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>After treatment with OZURDEX, your vision may be slightly impaired for a short time.&nbsp;If this happens, do not drive or use any tools or machines until your eyesight has improved.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use OZURDEX<\/h2>\n\n\n\n<p>All OZURDEX&nbsp;injections&nbsp;will be given by an ophthalmologist with appropriate training.<\/p>\n\n\n\n<p>The recommended&nbsp;dose&nbsp;is an&nbsp;implant&nbsp;that is injected into your eye.&nbsp;If the effect of the&nbsp;injection&nbsp;should decrease and if the doctor recommends it, another&nbsp;implant&nbsp;can be injected into the eye.<\/p>\n\n\n\n<p>Your doctor will ask you to use&nbsp;eye drops&nbsp;with&nbsp;antibiotics&nbsp;daily for three days before and after each&nbsp;injection&nbsp;to prevent&nbsp;eye&nbsp;infection.&nbsp;Follow these instructions carefully.<\/p>\n\n\n\n<p>On the day of injection, your doctor may use&nbsp;eye drops&nbsp;with&nbsp;antibiotics&nbsp;to prevent&nbsp;infection.&nbsp;Your doctor will clean your eye and eyelids before&nbsp;injecting&nbsp;one.&nbsp;Your doctor will also give you&nbsp;local anesthesia&nbsp;to reduce or prevent any pain when&nbsp;you inject&nbsp;one.&nbsp;You may hear a clicking sound when OZURDEX is injected.&nbsp;This is normal.<\/p>\n\n\n\n<p><strong>Detailed instructions for the doctor on how to&nbsp;inject&nbsp;one of OZURDEX are included in the carton of the medicine.<\/strong><\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects, although not everybody gets them.<\/p>\n\n\n\n<p>The following&nbsp;side effects&nbsp;can be seen with OZURDEX:<\/p>\n\n\n\n<p>Very common (may affect more than 1 in 10 people):<\/p>\n\n\n\n<p>Increased pressure in the eye, cloudy lens (&nbsp;cataract&nbsp;), bleeding on the surface of the eye *<\/p>\n\n\n\n<p>Common (may affect up to 1 in 10 people):<\/p>\n\n\n\n<p>High pressure in the eye, turbidity at the back of the lens, bleeding on the inside of the eye *, impaired vision *, difficulty seeing, discharge of the gelatinous mass inside the eye from the photosensitive layer at the back of the eye (vitreous detachment) *, a feeling of spots in the front eye (including liquid haze) *, a feeling of seeing through haze or fog *,&nbsp;inflammation&nbsp;of the eyelid, eye pain *, flashes of light *, swelling in the layer over the white part of the eye *, redness of the eyes *, headache<\/p>\n\n\n\n<p>Uncommon (may affect up to 1 in 100 people):<\/p>\n\n\n\n<p>A severe&nbsp;inflammation&nbsp;in the back of the eye (usually due to a viral infection), severe&nbsp;infection&nbsp;or&nbsp;inflammation&nbsp;inside the eye *,&nbsp;glaucoma&nbsp;(an eye disease where increased pressure inside the eye is associated with damage to the&nbsp;optic nerve&nbsp;), discharge of the photosensitive layer at the back of the eye (retinal detachment) *, rupture of the photosensitive layer at the back of the eye (retinal rupture) *, decreased pressure in the eye in connection with leakage of the gelled mass (&nbsp;vitreous&nbsp;one) from the inside of the eye *,&nbsp;inflammation&nbsp;inside the front of the eye *, increased amount of&nbsp;protein&nbsp;and cells in the front of the eye due to inflammation *, abnormal sensation in the eye *,&nbsp;itchingon the eyelid,&nbsp;redness&nbsp;in the white part of the eye *, movement of the OZURDEX&nbsp;implant&nbsp;et from the back of the eye to the front part which leads to blurred vision or impaired vision and which may cause swelling in the transparent part of the eye (cornea) *, unintentional incorrect placement of OZURDEX implant *,&nbsp;migraine<\/p>\n\n\n\n<p><em>* These&nbsp;side effects&nbsp;may be due to the injection procedure and not the OZURDEX&nbsp;implant&nbsp;itself.&nbsp;The more&nbsp;injections&nbsp;you receive, the more often these&nbsp;side effects&nbsp;may occur.<\/em><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store OZURDEX<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton and bag after EXP:&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>No special storage instructions.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is dexamethasone.<\/li><li>Each&nbsp;implant&nbsp;contains 700 micrograms of dexamethasone.<\/li><li>The other ingredients are Ester-terminated 50:50 poly D, L-lactide-glycolide copolymer, and acid-terminated 50:50 poly D, L-lactide-glycolide copolymer.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>OZURDEX is a rod-shaped&nbsp;implant&nbsp;that is stored inside a needle in an&nbsp;applicator.&nbsp;The applicator and a pack of desiccants are packed in a sealed foil bag in a carton.&nbsp;A carton contains an&nbsp;applicator&nbsp;with an&nbsp;implant&nbsp;to be used once and then discarded.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p>Allergan Pharmaceuticals Ireland<br>Castlebar Road<br>Westport<\/p>\n\n\n\n<p>Co.&nbsp;Mayo<\/p>\n\n\n\n<p>Ireland<\/p>\n\n\n\n<p>For any information about this medicine, please contact the local representative of the Marketing Authorization Holder:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Belgi\u00eb \/ Belgique \/ Belgien \/<\/strong><strong>Luxembourg \/ Luxemburg<\/strong>Allergan nvTel: +32 (0) 2 351 24 24<\/td><td><strong>Lithuania<\/strong>AbbVie UABTel: +370 5 205 3023<\/td><\/tr><tr><td><strong>Bulgaria<\/strong>Allergan Bulgaria \u0415\u041e\u041e\u0414Tel: +359 (0) 800 20 280<\/td><td><strong>Hungary<\/strong>Allergan Hungary Kft.Tel .: +36 80 100 101<\/td><\/tr><tr><td><strong>Czech Republic<\/strong>Allergan CZ sroTel: +420 800 188 818<\/td><td><strong>The Netherlands<\/strong>Allergan bvTel: +32 (0) 2 351 24 24<\/td><\/tr><tr><td><strong>Denmark<\/strong>Allergan Norden ABTel: + 4580884560<\/td><td><strong>Norway<\/strong>Allergan Norden ABTel: +47 80 01 04 97<\/td><\/tr><tr><td><strong>Germany<\/strong>Allergan GmbHTel: +49 69 92038 1050<\/td><td><strong>Austria<\/strong>&nbsp;Pharm-Allergan GmbHTel: +43 1 99460 6355<\/td><\/tr><tr><td><strong>Eesti<\/strong>AbbVie O\u00dcTel: + 372 623 1011<\/td><td><strong>Poland<\/strong>Allergan Sp.&nbsp;z ooTel .: +48 22 256 3700<\/td><\/tr><tr><td><strong>Greece \/ Cyprus<\/strong>Allergan Hellas Pharmaceuticals SA<br>:\u03b7\u03bb: +30 210 74 73 300<\/td><td><strong>Portugal<\/strong>Profarin Lda.Tel: + 351 21 425 3242<\/td><\/tr><tr><td><strong>Spain<\/strong>Allergan SATel: + 34 91 807 6130<\/td><td><strong>Romania<\/strong>Allergan SRLTel: +40 21 301 53 02<\/td><\/tr><tr><td><strong>France<\/strong>Allergan France SASTel: +33 (0) 1 49 07 83 00<\/td><td><strong>Slovenia<\/strong>AbbVie Biofarmacevtska dru\u017eba dooTel: + 386 (1) 32 08 060<\/td><\/tr><tr><td><strong>Croatia<\/strong>AbbVie dooTel: +385 (0) 1 5625 501<\/td><td><strong>Slovak Republic<\/strong>Allergan SK sroTel: +421 800 221 223<\/td><\/tr><tr><td><strong>Ireland \/ Malta \/ United Kingdom (Northern Ireland)<\/strong>Allergan Pharmaceuticals IrelandTel: +3531800 931 787 (IE)+356 27780331 (MT)+44 (0) 1628 494026 (UK (NI))<\/td><td><strong>Finland \/ Finland<\/strong>Allergan Norden ABPuh \/ Tel: + 358 800 115 003<\/td><\/tr><tr><td><strong>Iceland<\/strong>Teva Pharma Iceland ehf.Phone: +354 550 3300<\/td><td><strong>Sweden<\/strong>Allergan Norden ABTel: + 46859410000<\/td><\/tr><tr><td><strong>Italy<\/strong>Allergan SpATel: + 39 06 509 562 90<\/td><td><strong>Latvia<\/strong>AbbVie SIATel: +371 676 05000<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>The active substance in OZURDEX is dexamethasone. Dexamethasone belongs to a group of medicines called corticosteroids .<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18527],"tags":[18577,13703,5721,5723,20605,20608,12225,5722,20606,20607],"class_list":["post-20207","post","type-post","status-publish","format-standard","hentry","category-medicines","category-p","tag-benefits-of-dexamethasone","tag-benefits-of-v","tag-dexamethasone","tag-dexamethasone-side-effects","tag-ozurdex","tag-ozurdex-side-effects","tag-what-dexamethasone-is-used-for","tag-what-is-dexamethasone","tag-what-is-ozurdex","tag-what-ozurdex-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20207","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=20207"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20207\/revisions"}],"predecessor-version":[{"id":25032,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20207\/revisions\/25032"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=20207"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=20207"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=20207"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}