{"id":20199,"date":"2022-03-28T10:35:10","date_gmt":"2022-03-28T10:35:10","guid":{"rendered":"https:\/\/zeepedia.com\/?p=20199"},"modified":"2022-03-29T11:33:57","modified_gmt":"2022-03-29T11:33:57","slug":"oxynorm","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/oxynorm\/","title":{"rendered":"OxyNorm &#8211; Oxycodone hydrochloride uses, dose and side effects"},"content":{"rendered":"\n<p>10 mg \/ ml solution for injection<br>oxycodone hydrochloride<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What OxyNorm solution for injection is and what it is used for<\/h2>\n\n\n\n<p>OxyNorm&nbsp;solution for injection&nbsp;contains oxycodone hydrochloride, which belongs to a group of medicines called&nbsp;opioids&nbsp;and has a strong analgesic effect.<\/p>\n\n\n\n<p>OxyNorm&nbsp;solution for injection&nbsp;is used for severe pain such as cancer pain.<\/p>\n\n\n\n<p>Oxycodone hydrochloride contained in OxyNorm\u00a0solution for injection\u00a0may also be approved for the treatment of other conditions not mentioned in this product information.\u00a0Ask your doctor or another healthcare professional if you have any further questions and always follow their instructions.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know about OxyNorm solution for injection<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">You should not be treated with OxyNorm solution for injection:<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to oxycodone hydrochloride or any of the other ingredients of this medicine (listed in section 6)<\/li><li>if you have severely impaired breathing (\u00a0respiratory depression\u00a0) with too little oxygen in the blood (\u00a0hypoxia\u00a0) and\/or too much\u00a0carbon dioxide\u00a0(\u00a0hypercapnia\u00a0) in the blood<\/li><li>if you have severe\u00a0chronic\u00a0lung disease (COPD =\u00a0chronic obstructive pulmonary disease\u00a0), heart disease due to\u00a0chronic\u00a0congestion of the pulmonary circulation (cor pulmonale), or\u00a0acute\u00a0, severe tracheal asthma<\/li><li>if you have a certain type of blockage in the intestine (paralytic\u00a0ileus\u00a0).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or nurse before being treated with OxyNorm&nbsp;solution for injection&nbsp;if you:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>is older<\/li><li>has impaired lung function<\/li><li>has impaired renal function<\/li><li>has impaired liver function<\/li><li>have repeated pauses in breathing while sleeping (\u00a0sleep apnea\u00a0), as this condition may worsen<\/li><li>has impaired thyroid function (\u00a0hypothyroidism\u00a0)<\/li><li>has impaired adrenal function (eg\u00a0Addison&#8217;s disease\u00a0)<\/li><li>have prostate enlargement (\u00a0prostate hypertrophy\u00a0)<\/li><li>is or has previously been addicted to alcohol<\/li><li>is or has previously been addicted to strong painkillers (\u00a0opioids\u00a0)<\/li><li>suffers from mental illness due to an overdose of another drug (toxic\u00a0psychosis\u00a0)<\/li><li>have pancreatitis (\u00a0pancreatitis\u00a0)<\/li><li>has a head injury or increased pressure in the brain<\/li><li>have low\u00a0blood pressure\u00a0(\u00a0hypotension\u00a0)<\/li><li>have diseases of the bile duct<\/li><li>have inflammatory bowel disease<\/li><li>have or usually have constipation<\/li><li>have\u00a0hypovolemia\u00a0(decreased blood volume)<\/li><li>take drugs that affect brain function, see section 2 &#8220;Other drugs and OxyNorm solution for injection&#8221;<\/li><li>take, or have recently (within 2 weeks) taken,\u00a0MAO inhibitors\u00a0(for the treatment of depression).<\/li><\/ul>\n\n\n\n<p>Tell your doctor that you are being treated with OxyNorm\u00a0solution for injection.<\/p>\n\n\n\n<p>When OxyNorm is used for a long time, tolerance to the effects may mean that an increased\u00a0dose\u00a0is required to maintain pain control.<\/p>\n\n\n\n<p>Prolonged use of OxyNorm may lead to physical dependence and withdrawal symptoms may occur with abrupt discontinuation of treatment.&nbsp;When a patient no longer needs oxycodone treatment, it is advisable to reduce the&nbsp;dose&nbsp;gradually to prevent withdrawal symptoms (see section 3 \u201cIf treatment is discontinued\u201d).<\/p>\n\n\n\n<p>The risk of developing physical or psychological dependence is small when used as directed by patients suffering from long-term pain and this risk must be weighed against the potential benefit.&nbsp;Discuss this with your doctor.<\/p>\n\n\n\n<p>Opioids\u00a0are not the first-line treatment for long-term pain that is not caused by cancer and are not recommended as the only treatment.\u00a0If you are taking this medicine for this type of pain, your doctor will monitor you closely and make the necessary dose adjustments to prevent addiction and abuse.<\/p>\n\n\n\n<p>An increased sensitivity to pain, which does not respond to a dose increase of oxycodone, may occur during treatment with OxyNorm.&nbsp;This is unusual, but if it does, your doctor may reduce your&nbsp;dose&nbsp;or switch to another opioid.<\/p>\n\n\n\n<p>OxyNorm can cause sleep-related respiratory disorders such as\u00a0sleep apnea\u00a0(repeated pauses when you sleep) and\u00a0hypoxemia\u00a0(low oxygen content in the blood).\u00a0Symptoms of this can be shortness of breath during sleep, waking up short of breath, difficulty sleeping, or excessive fatigue during the day.\u00a0If you or anyone else observes these symptoms, consult a doctor.\u00a0Your doctor may reduce\u00a0your dose\u00a0one.<\/p>\n\n\n\n<p>OxyNorm\u00a0solution for injection\u00a0should not be used with alcohol.\u00a0Alcohol can increase the risk of serious\u00a0side effects\u00a0such as drowsiness\/drowsiness, impaired and slow breathing, unconsciousness,\u00a0coma\u00a0and can even be life-threatening.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>OxyNorm&nbsp;solution for injection&nbsp;should not be given to children and adolescents under 18 years of age as there is no experience in the treatment of these patient categories.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and OxyNorm solution for injection<\/h2>\n\n\n\n<p>Tell your doctor if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>The risk of\u00a0side effects\u00a0increases if you are treated with OxyNorm\u00a0solution for injection\u00a0and at the same time take medicines that affect brain function.\u00a0In such cases, the\u00a0side effects\u00a0may be exacerbated.\u00a0For example, fatigue\/drowsiness, impaired and slow breathing may worsen and may lead to unconsciousness,\u00a0coma,\u00a0and may even be life-threatening.<\/p>\n\n\n\n<p>Examples of drugs that affect brain function are:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Other strong painkillers (\u00a0opioids\u00a0)<\/li><li>Medicines for\u00a0epilepsy, pain, and anxiety (gabapentin and pregabalin)<\/li><li>Hypnotics and sedatives (\u00a0sedatives\u00a0(including\u00a0benzodiazepines\u00a0),\u00a0hypnotics,\u00a0anxiolytics\u00a0)<\/li><li>Antidepressants<\/li><li>Drugs for mental or mental illness (antipsychotics such as phenothiazines and\u00a0neuroleptics\u00a0)<\/li><li>Medicines used under anesthesia or anesthesia<\/li><li>Muscle relaxants used to relieve muscle cramps<\/li><li>Medicines used to treat\u00a0allergies, motion sickness, or nausea (\u00a0antihistamines\u00a0or antiemetics)<\/li><\/ul>\n\n\n\n<p>Concomitant use of\u00a0opioids, including OxyNorm, and sedatives such as\u00a0benzodiazepines\u00a0or similar drugs increase the risk of drowsiness, difficulty breathing (\u00a0respiratory depression\u00a0), and\u00a0coma\u00a0and can be life-threatening.\u00a0Due to this, concomitant use should only be considered when other treatment options are not possible.\u00a0If your doctor prescribes OxyNorm at the same time as sedatives, the\u00a0dose\u00a0and treatment time should be limited by your doctor.<\/p>\n\n\n\n<p>Tell your doctor if you are taking any sedatives and carefully follow your doctor&#8217;s dose recommendations.&nbsp;It may be helpful to inform friends or relatives about paying attention to the signs and symptoms described above.&nbsp;Contact a doctor if you experience any of these symptoms.<\/p>\n\n\n\n<p>The risk of\u00a0side effects\u00a0is increased if you take antidepressant drugs (for example,\u00a0citalopram, duloxetine, escitalopram,\u00a0fluoxetine, fluvoxamine,\u00a0paroxetine,\u00a0sertraline,\u00a0venlafaxine\u00a0).\u00a0These drugs can affect or be affected by oxycodone, and you may experience symptoms such as involuntary, rhythmic muscle contractions, including in the muscles that control eye movements, sudden movements, heavy sweating, tremors, excessive reflexive movements, increased muscle tension, body temperature above 38 \u00b0 C.\u00a0Contact your doctor if you experience these symptoms.<\/p>\n\n\n\n<p>If you are given OxyNorm\u00a0solution for injection\u00a0at the same time as medicines (coumarin derivatives) that reduce the blood&#8217;s ability to coagulate (clot), the coagulation time may increase or decrease.\u00a0It may be necessary to adjust the OxyNorm\u00a0dose.<\/p>\n\n\n\n<p>Some medicines may increase the effect of OxyNorm and therefore a dose&nbsp;reduction&nbsp;may be necessary:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Certain types of&nbsp;antibiotics&nbsp;(macrolide antibiotics)<\/li><li>Fungicides<\/li><li>Protease inhibitors&nbsp;(used to treat&nbsp;HIV&nbsp;)<\/li><li>Cimetidine (antacid used to treat&nbsp;stomach ulcers&nbsp;and heartburn)<\/li><\/ul>\n\n\n\n<p>Some medicines may reduce the effect of OxyNorm and therefore an increase in&nbsp;dose&nbsp;may be necessary:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Rifampicin (used to treat&nbsp;tuberculosis&nbsp;)<\/li><li>Carbamazepine (used in&nbsp;epilepsy&nbsp;and certain pain conditions)<\/li><li>Phenytoin&nbsp;(used in&nbsp;epilepsy&nbsp;)<\/li><li>St. John&#8217;s wort<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">OxyNorm solution for injection with food, drink, and alcohol<\/h2>\n\n\n\n<p>If you drink alcohol while being treated with OxyNorm\u00a0solution for injection, it may make you feel more sleepy or increase the risk of serious\u00a0side effects\u00a0such as\u00a0shallow breathing with a risk of respiratory arrest and unconsciousness.\u00a0You should not drink alcohol while being treated with OxyNorm.<\/p>\n\n\n\n<p>You should avoid drinking grapefruit juice when you are being treated with OxyNorm&nbsp;solution for injection&nbsp;as it may increase the effect of the medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before taking this medicine.<\/p>\n\n\n\n<p>The use of this product should be avoided if possible in pregnant women.\u00a0Prolonged use of OxyNorm during pregnancy may cause life-threatening withdrawal symptoms in the newborn.\u00a0Symptoms that should be noticed in the infant are irritability, hyperactivity, screaming, shaking, vomiting, and not gaining weight.<\/p>\n\n\n\n<p>OxyNorm\u00a0solution for injection\u00a0should not be used during breastfeeding as oxycodone passes into breast milk and may cause breathing problems in the breast-fed baby.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>OxyNorm impairs the ability to concentrate and react. This should be taken into account when sharper attention is required, e.g.&nbsp;when driving and when handling machines.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0Descriptions of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0If you are not sure, talk to your doctor or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">OxyNorm solution for injection contains sodium<\/h2>\n\n\n\n<p>OxyNorm solution for injection contains less than 1 mmol (23 mg)&nbsp;sodium&nbsp;per ml, ie it is essentially &#8216;sodium-free&#8217;.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to be treated with OxyNorm solution for injection<\/h2>\n\n\n\n<p>Your doctor will tell you what&nbsp;dose&nbsp;you are taking and how to get it.&nbsp;If you have any further questions, ask your doctor or healthcare professional.<\/p>\n\n\n\n<p>Dose\u00a0one is determined individually for each patient and is tailored to your pain.\u00a0You will normally be given OxyNorm\u00a0solution for injection\u00a0by a doctor or nurse.<\/p>\n\n\n\n<p>For information on handling, see information for physicians and healthcare professionals.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you take more OxyNorm than you should<\/h2>\n\n\n\n<p>OxyNorm\u00a0solution for injection\u00a0will be given to you by a doctor or other healthcare professional and it is, therefore, unlikely that you will receive too much.\u00a0If you think you have ingested too much medicine or if e.g.\u00a0If a child has ingested the medicine by mistake, contact a doctor at the hospital for an assessment of the risk and advice.<\/p>\n\n\n\n<p>The following symptoms may occur with overdose: decreased pupil size, impaired breathing (\u00a0respiratory depression,\u00a0pulmonary edema\u00a0), muscle weakness, slow\u00a0heart rate,\u00a0and drop in blood pressure.\u00a0In severe cases, drowsiness and unconsciousness (\u00a0coma\u00a0) may occur.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If a dose has been missed<\/h2>\n\n\n\n<p>Ask your doctor or healthcare professional if you think you have not received OxyNorm.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If treatment is stopped<\/h2>\n\n\n\n<p>Contact your doctor if you wish to discontinue treatment with OxyNorm.<\/p>\n\n\n\n<p>If use is stopped abruptly after a long period of treatment, withdrawal symptoms such as restlessness, anxiety, anxiety, insomnia, involuntary muscle contractions, tremors, and gastrointestinal problems may occur.\u00a0Your doctor will tell you how to stop the treatment to reduce the risk of withdrawal symptoms, usually done by\u00a0gradually reducing the\u00a0dose.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p>The following frequency data are used to evaluate the side effects:<\/p>\n\n\n\n<p>Very common: May affect more than 1 user in 10<\/p>\n\n\n\n<p>Common: May affect up to 1 in 10 people<\/p>\n\n\n\n<p>Uncommon: May affect up to 1 in 100 people<\/p>\n\n\n\n<p>Rare: May affect up to 1 in 1,000 people<\/p>\n\n\n\n<p>Very rare: May affect up to 1 in 10,000 people<\/p>\n\n\n\n<p>Has been reported: Occurs in an unknown number of users<\/p>\n\n\n\n<p><strong>Contact a doctor immediately if any of the following symptoms occur:<\/strong><\/p>\n\n\n\n<p>Very slow or weak breathing (\u00a0respiratory depression\u00a0).\u00a0This is the most serious risk with medicines such as OxyNorm\u00a0solution for injection\u00a0(\u00a0opioids\u00a0) and can even be life-threatening.<\/p>\n\n\n\n<p><strong>Very common<\/strong><\/p>\n\n\n\n<p>Drowsiness, dizziness, headache, constipation, nausea, vomiting,\u00a0itching.<\/p>\n\n\n\n<p><strong>Usual<\/strong><\/p>\n\n\n\n<p>Decreased appetite, anxiety, confusion, depression, insomnia, nervousness, abnormal thinking, tremors, drowsiness (\u00a0lethargy\u00a0), impaired breathing, tracheal cramps, abdominal pain, diarrhea,\u00a0dry mouth, indigestion, rash, sweating, feeling weak.<\/p>\n\n\n\n<p><strong>Less common<\/strong><\/p>\n\n\n\n<p>Allergic reactions, dehydration, restlessness, gloom, elation, mood swings, hallucinations, decreased sexual desire, drug dependence, memory loss, seizures, high\u00a0blood pressure, loss of sensation, involuntary muscle movements, speech disorders, fainting, and crawling,\u00a0dizziness, puffiness,\u00a0puffiness\u00a0dizziness), palpitations (associated with\u00a0abstinence\u00a0), dilation of blood vessels, very slow or weak breathing, difficulty swallowing, gas in the stomach, belching, intestinal upset, elevated liver enzyme levels, urethral spasm, dry skin, difficulty urinating,\u00a0impotence, decreased hormone production in testicles\/ovaries (\u00a0hypogonadism\u00a0), increased\u00a0ADH\u00a0-release, chills,\u00a0abstinence, malaise, accumulation of fluid in the\u00a0tissues\u00a0(\u00a0edema\u00a0), swelling in the arms and legs due to fluid accumulation, drug tolerance, thirst.<\/p>\n\n\n\n<p><strong>Rare<\/strong><\/p>\n\n\n\n<p>Low\u00a0blood pressure, tendency to faint standing up, hives.<\/p>\n\n\n\n<p><strong>Has been reported (occurs in an unknown number of users)<\/strong><\/p>\n\n\n\n<p>Anaphylactic reactions, anaphylactoid reaction, aggression, increased sensitivity to pain (hyperalgesia), repeated pauses in breathing during sleep (&nbsp;sleep apnea&nbsp;) (see section 2 \u201cWarnings and precautions\u201d), dental problems, bile arrest (cholestasis), biliary spasm, missed menstruation, neonatal abstinence.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store OxyNorm solution for injection<\/h2>\n\n\n\n<p>No special storage instructions for unopened packaging.&nbsp;For further information on use after opening the package, see information for physicians and healthcare professionals.<\/p>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>The medicine should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<p>The active substance is oxycodone hydrochloride.<\/p>\n\n\n\n<p>Other ingredients are:<\/p>\n\n\n\n<p>\u2022 Citric acid monohydrate<\/p>\n\n\n\n<p>\u2022 Sodium citrate<\/p>\n\n\n\n<p>\u2022 Sodium chloride<\/p>\n\n\n\n<p>Hydrochloric&nbsp;acid&nbsp;(&nbsp;pH&nbsp;adjuster)<\/p>\n\n\n\n<p>\u2022 Sodium hydroxide (&nbsp;pH&nbsp;adjuster)<\/p>\n\n\n\n<p>Water for injections<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>OxyNorm&nbsp;solution for injection&nbsp;is a clear, colorless solution.<\/p>\n\n\n\n<p>OxyNorm&nbsp;solution for injection&nbsp;is supplied in packs of 5 x 1 ml, 5 x 2 ml or 4 x 20 ml&nbsp;ampoules&nbsp;.&nbsp;<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p>Mundipharma AB<\/p>\n\n\n\n<p>M\u00f6lndalsv\u00e4gen 30 B<\/p>\n\n\n\n<p>412 63 Gothenburg<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Mundipharma DC BV<\/p>\n\n\n\n<p>Listening 16<\/p>\n\n\n\n<p>3832 RC Leusden<\/p>\n\n\n\n<p>Holland<\/p>\n","protected":false},"excerpt":{"rendered":"<p>OxyNorm solution for injection contains oxycodone hydrochloride, which belongs to a group of medicines called opioids and has a strong analgesic effect.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18526],"tags":[16085,20639,16081,16084,20635,20638,16082,20636,16091,20637],"class_list":["post-20199","post","type-post","status-publish","format-standard","hentry","category-medicines","category-o","tag-benefits-of-oxycodone-hydrochloride","tag-benefits-of-oxynorm","tag-oxycodone-hydrochloride","tag-oxycodone-hydrochloride-side-effects","tag-oxynorm","tag-oxynorm-side-effects","tag-what-is-oxycodone-hydrochloride","tag-what-is-oxynorm","tag-what-oxycodone-hydrochloride-is-used-for","tag-what-oxynorm-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20199","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=20199"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20199\/revisions"}],"predecessor-version":[{"id":20257,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20199\/revisions\/20257"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=20199"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=20199"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=20199"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}