{"id":20193,"date":"2022-03-28T10:28:26","date_gmt":"2022-03-28T10:28:26","guid":{"rendered":"https:\/\/zeepedia.com\/?p=20193"},"modified":"2022-03-29T11:34:14","modified_gmt":"2022-03-29T11:34:14","slug":"oxycodone-orion","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/oxycodone-orion\/","title":{"rendered":"Oxycodone Orion &#8211; Oxycodone hydrochloride uses, dose and side effects"},"content":{"rendered":"\n<p>10 mg \/ ml&nbsp;solution for injection \/ infusion<br>oxycodone hydrochloride<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Oxycodone Orion is and what it is used for<\/h2>\n\n\n\n<p>This solution for\u00a0injection\u00a0and\u00a0infusion\u00a0contains the active ingredient oxycodone, which belongs to a group of medicines called\u00a0opioids.<\/p>\n\n\n\n<p>This medicine has been prescribed for you by your doctor to relieve severe pain that can only be controlled with opioid analgesics.<\/p>\n\n\n\n<p>Oxycodone hydrochloride contained in Oxycodone Orion may also be approved for the treatment of other conditions not mentioned in this leaflet.\u00a0Ask your doctor, pharmacist, or other healthcare professionals if you have any further questions, and always follow their instructions.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using Oxycodone Orion<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Oxycodone Orion<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to oxycodone or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you have severe breathing problems<\/li><li>if you have problems clearing mucus from the airways<\/li><li>if you have seizures<\/li><li>if you have&nbsp;a coma<\/li><li>if you have&nbsp;acute&nbsp;abdominal pain<\/li><li>if you have severe hepatic impairment<\/li><li>if you have previously had anxiety under the influence of alcohol or sedatives<\/li><li>if you have intestinal upset<\/li><li>if you have too high a concentration of&nbsp;carbon dioxide&nbsp;in your blood<\/li><li>if you have a disease that affects both the heart and lungs and is called cor pulmonale<\/li><li>if you have severe&nbsp;chronic&nbsp;asthma&nbsp;or severe&nbsp;chronic obstructive pulmonary disease<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p><strong>Talk to your doctor before receiving Oxycodone Orion<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have severe lung function<\/li><li>if you have\u00a0myxedema\u00a0(diseases of the thyroid gland with symptoms such as dry, waxy swelling of the skin, low metabolism)<\/li><li>impaired thyroid function<\/li><li>if you have impaired adrenal function (your\u00a0adrenal cortex\u00a0does not work properly) for example\u00a0Addison&#8217;s disease<\/li><li>if you have\u00a0psychosis\u00a0caused by toxic substances<\/li><li>if you have an enlarged\u00a0prostate\u00a0(\u00a0prostate hypertrophy\u00a0)<\/li><li>if you are or have been addicted to alcohol or drugs<\/li><li>if you suffer from\u00a0delirium tremens\u00a0due to alcohol withdrawal<\/li><li>if you have a head injury<\/li><li>if you have low\u00a0blood pressure<\/li><li>if you have reduced blood volume<\/li><li>if you have kidney or liver problems<\/li><li>if you have inflammatory bowel disease<\/li><li>if you have a biliary tract disease<\/li><li>if you have\u00a0spasms\u00a0in the gallbladder or urinary tract<\/li><li>if you have\u00a0inflammation\u00a0of the pancreas<\/li><li>if you are using monoamine oxidase (MAO) inhibitors (used to treat depression or\u00a0Parkinson&#8217;s disease\u00a0)<\/li><li>if you are elderly or debilitated<\/li><li>if you have recently undergone an operation or if an operation is planned within the next few days<\/li><\/ul>\n\n\n\n<p><strong>Inform your doctor during treatment:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>when the bowel function does not work properly.&nbsp;This may indicate a blockage in the intestine and then the treatment should be stopped immediately.<\/li><li>if your pain is not relieved even if oxycodone&nbsp;dose&nbsp;one is increased.<\/li><\/ul>\n\n\n\n<p><strong>Long-term treatment<\/strong><\/p>\n\n\n\n<p>Using Oxycodone Orion for long periods may cause physical dependence.\u00a0Therefore,\u00a0dose\u00a0one should be gradually reduced at the end of treatment (see section 3 &#8220;If your treatment with Oxycodone Orion is stopped&#8221;).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>There is not enough information to recommend the use of Oxycodone Orion in children.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Oxycodone Orion<\/h2>\n\n\n\n<p>Tell your doctor if you are taking, have recently taken, or might take any other medicines, including medicines obtained without a prescription.\u00a0If you use Oxycodone Orion with certain other medicines, the effect of Oxycodone Orion, or the other medicines, may change.<\/p>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>medicines to help you sleep or to treat anxiety (anti-anxiety drugs, sleeping pills, or sedatives)<\/li><li>antidepressants<\/li><li>medicines for the treatment of mental or mental illness (eg phenothiazines or\u00a0neuroleptics\u00a0)<\/li><li>other strong painkillers (eg other\u00a0opioids\u00a0)<\/li><li>medicines to relieve allergic reactions (\u00a0antihistamines\u00a0)<\/li><li>medicines to relieve nausea and vomiting (antiemetics)<\/li><li>drugs for the treatment of\u00a0Parkinson&#8217;s disease<\/li><li>cimetidine, which is used to treat heartburn or\u00a0stomach ulcers<\/li><li>medicines to stop the blood from clotting (\u00a0warfarin\u00a0)<\/li><li>macrolide antibiotics<\/li><li>medicines for fungal infections<\/li><li>medicines for\u00a0HIV\u00a0\/\u00a0AIDS<\/li><li>drugs to treat\u00a0tuberculosis<\/li><li>drugs to treat\u00a0epilepsy<\/li><li>drugs to treat\u00a0cardiac\u00a0arrhythmias<\/li><li>St. John&#8217;s wort<\/li><li>or if you have been taking a\u00a0monoamine oxidase inhibitor\u00a0(MAO) inhibitor in the last two weeks.\u00a0MAO inhibitors\u00a0are used to treat depression or\u00a0Parkinson&#8217;s disease.<\/li><\/ul>\n\n\n\n<p>Concomitant use of Oxycodone Orion with sedatives or sleeping pills such as\u00a0benzodiazepines\u00a0or similar medicines increases the risk of drowsiness, difficulty breathing (\u00a0breathing depression\u00a0),\u00a0coma\u00a0and may be life-threatening.\u00a0Due to this, concomitant use should only be considered when other treatment options are not possible.\u00a0If your doctor prescribes Oxycodone Orion at the same time as sedatives, you should take a\u00a0dose one and the treatment time is limited by the doctor.\u00a0Tell your doctor if you are taking any sedatives and carefully follow your doctor&#8217;s dose recommendations.\u00a0It may be helpful to inform friends or relatives about paying attention to the signs and symptoms listed above.\u00a0Contact a doctor if you experience any of these symptoms.<\/p>\n\n\n\n<p>The risk of\u00a0side effects\u00a0is increased if you take antidepressant drugs (for example,\u00a0citalopram, duloxetine, escitalopram,\u00a0fluoxetine, fluvoxamine,\u00a0paroxetine,\u00a0sertraline,\u00a0venlafaxine\u00a0).\u00a0These drugs can affect or be affected by oxycodone, and you may experience symptoms such as involuntary, rhythmic muscle contractions, including in the muscles that control eye movements, sudden movements, heavy sweating, tremors, excessive reflexive movements, increased muscle tension, body temperature above 38 \u00b0 C.\u00a0Contact your doctor if you experience these symptoms.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Oxycodone Orion with food, drink, and alcohol<\/h2>\n\n\n\n<p>Oxycodone Orion solution for injection or infusion can be used with food and drink.<\/p>\n\n\n\n<p>However, avoid grapefruit juice as it may affect the plasma levels of Oxycodone.<\/p>\n\n\n\n<p><strong>Alcohol<\/strong><\/p>\n\n\n\n<p>Do not drink alcohol during treatment.&nbsp;Alcohol may aggravate certain dangerous&nbsp;side effects&nbsp;of oxycodone, e.g.&nbsp;severe respiratory problems, when used during treatment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n<p>The use of Oxycodone Orion should be avoided as far as possible during pregnancy and lactation.<\/p>\n\n\n\n<p>Pregnancy<\/p>\n\n\n\n<p>There are limited data on the use of oxycodone in pregnant women.\u00a0Oxycodone passes the placenta into the baby&#8217;s bloodstream.\u00a0The use of oxycodone during pregnancy may lead to withdrawal symptoms in the newborn.\u00a0Infants whose mothers have received oxycodone during the last 3-4 weeks before delivery can cause severe breathing problems in newborns.\u00a0Oxycodone Orion should only be used during pregnancy if the benefit outweighs the potential risks to the baby.<\/p>\n\n\n\n<p>Breast-feeding<\/p>\n\n\n\n<p>Oxycodone can pass into breast milk and may cause breathing difficulties in the newborn baby.\u00a0Oxycodone Orion should therefore not be used during breastfeeding.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>This medicine may impair your ability to react and cause\u00a0side effects\u00a0such as dizziness and drowsiness which may affect your ability to drive or use machines.\u00a0These are usually most noticeable when you first start using Oxycodone Orion or when switching to a higher\u00a0dose.\u00a0Do not drive or use tools or machines if you are affected.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0Descriptions of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Oxycodone Orion contains sodium<\/h2>\n\n\n\n<p>This medicine contains less than 1 mmol\u00a0sodium\u00a0(23 mg) per\u00a0dose, ie essentially &#8216;sodium-free&#8217;.\u00a0is next to &#8220;sodium-free&#8221;.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Oxycodone Orion<\/h2>\n\n\n\n<p>Your doctor will prescribe an individual\u00a0dose\u00a0for you depending on your age, how severe your pain is, your general condition, any concomitant illnesses, and your previous and concomitant medication.<\/p>\n\n\n\n<p>Healthcare professionals will prepare and give you this medicine either as an\u00a0injection\u00a0(under the skin, in a blood vessel, or a muscle) or as a drip (under the skin or in a blood vessel).<\/p>\n\n\n\n<p>You will be given Oxycodone Orion for as short a time as possible<\/p>\n\n\n\n<p>Instructions for use for healthcare professionals can be found at the end of this leaflet.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you take more Oxycodone Orion than you should<\/h2>\n\n\n\n<p>Oxycodone Orion is given to you by healthcare professionals.&nbsp;An overdose is therefore unlikely.<\/p>\n\n\n\n<p>If you have ingested too much medicine or if e.g.\u00a0If a child has ingested the medicine by mistake, contact a doctor or hospital for risk assessment and advice.<\/p>\n\n\n\n<p>The symptoms of overdose are small\u00a0pupils, severe difficulty breathing, drowsiness, muscle weakness, slow heart rate, and low\u00a0blood pressure.\u00a0In severe cases,\u00a0coma\u00a0and death can also occur.\u00a0When seeking medical attention, bring this leaflet and any remaining solution and show it to your doctor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If your treatment with Oxycodone Orion is stopped<\/h2>\n\n\n\n<p>You should not suddenly stop using this medicine unless your doctor recommends it.\u00a0If you want to stop using the medicine, discuss this with your doctor first.\u00a0Dose\u00a0one is usually reduced gradually so that you do not experience unpleasant effects.\u00a0Abrupt discontinuation of treatment can cause withdrawal symptoms within 24 hours such as restlessness, watery eyes, and nose, sweating, and difficulty sleeping.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p>This medicine can in some rare cases cause serious\u00a0side effects.\u00a0<strong>Stop taking Oxycodone Orion and contact your doctor immediately if the following occur<\/strong>\u00a0:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>respiratory depression, which is most likely in elderly or debilitated patients.\u00a0This medicine can also cause\u00a0bronchospasm, difficulty breathing, and suppress the cough reflex.<\/li><li>dizziness, which may be a symptom of a severe drop in blood pressure<\/li><li>small\u00a0pupils, which may be a symptom of overdose<\/li><li>gallstone attack\u00a0<\/li><li>life-threatening\u00a0allergic reaction\u00a0(anaphylactoid and anaphylactic reaction)\u00a0Oxycodone can also cause the following side effects:<\/li><\/ul>\n\n\n\n<p><em>Very common (may affect more than 1 user in 10):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>dizziness, drowsiness, headache<\/li><li>constipation, nausea, vomiting.\u00a0Your doctor may\u00a0prescribe\u00a0appropriate medications to treat these symptoms.<\/li><li>itching.<\/li><\/ul>\n\n\n\n<p><em>Common (may affect up to 1 in 10 people):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>anxiety, confusion, nervousness, depression, abnormal thoughts, insomnia<\/li><li>tremors<\/li><li>drop in blood pressure when you stand up which can cause dizziness, dizziness or fainting<\/li><li>difficulty breathing<\/li><li>abdominal pain, loss of appetite, diarrhea, digestive problems,&nbsp;dry mouth<\/li><li>skin rash, excessive sweating<\/li><li>fluid retention, dullness<\/li><li>sweating, chills, lack or loss of strength and energy.<\/li><\/ul>\n\n\n\n<p><em>Uncommon (may affect up to 1 in 100 people):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>agitation, hallucinations, memory loss, emotional instability,\u00a0euphoria<\/li><li>cramps, involuntary muscle contractions, excessive muscle tension, decreased sensation of touch, feeling of numbness or tingling in the skin, difficulty speaking, fainting, dizziness<\/li><li>dilation of blood vessels<\/li><li>altered taste buds, gastrointestinal problems, flatulence, difficulty swallowing, intestinal blockage, belching<\/li><li>elevated liver enzyme values<\/li><li>hives, dry skin<\/li><li>difficulty urinating, spasms of the urethra<\/li><li>absence of menstruation, decreased sex drive,\u00a0impotence<\/li><li>swelling of the arms and legs, thirst, withdrawal syndrome, malaise, drug tolerance<\/li><li>hypersensitivity<\/li><li>dehydration<\/li><li>drug addiction<\/li><li>visual disturbances<\/li><li>palpitations (in connection with the\u00a0release\u00a0of oxycodone).<\/li><\/ul>\n\n\n\n<p><em>Rare (may affect up to 1 in 1,000 people):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>allergic reaction, severe\u00a0hypersensitivity reaction<\/li><\/ul>\n\n\n\n<p><em>No known frequency (occurs in an unknown number of users):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>aggression<\/li><li>abnormally increased pain sensation<\/li><li>caries<\/li><li>stop or decrease the flow of bile.<\/li><li>Prolonged use of Oxycodone Orion during pregnancy may cause life-threatening withdrawal symptoms in newborns.\u00a0Symptoms that should be noticed in the infant are irritability, hyperactivity, abnormal sleep patterns, screaming, shaking, vomiting, diarrhea, and not gaining weight.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Oxycodone Orion<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the ampoule label and carton after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>This medicine does not require any specific temperature instructions.&nbsp;Store in the original package.&nbsp;Sensitive to light.<\/p>\n\n\n\n<p>Once the\u00a0ampoule\u00a0has been opened, the solution for injection\/infusion should be used immediately.\u00a0Unused solutions should be discarded.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is oxycodone hydrochloride.&nbsp;Each ml contains 10 mg of oxycodone hydrochloride.<\/li><li>The other ingredients are citric acid monohydrate, sodium citrate, sodium chloride, hydrochloric acid (for&nbsp;pH&nbsp;adjustment), sodium hydroxide (for&nbsp;pH&nbsp;adjustment), water for injections.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Oxycodone Orion solution for injection\/infusion is a clear, colorless solution.<\/p>\n\n\n\n<p>It is delivered in\u00a0glass ampoules\u00a0packaged in cardboard boxes containing 5 x 1 ml, 5 x 2 ml, or 5 x 10 ml.<\/p>\n\n\n\n<p>1 ml liquid in 2 ml\u00a0glass ampoule\u00a0with two yellow rings, 2 ml\u00a0glass ampoule\u00a0with two colored rings where the upper ring is brown and the lower is yellow and 10 ml\u00a0glass ampoule\u00a0with two colored rings where the upper is dark blue and the lower is yellow. \u00a0<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p>Orion Corporation<\/p>\n\n\n\n<p>Orionv\u00e4gen 1<\/p>\n\n\n\n<p>FI-02200 Espoo<\/p>\n\n\n\n<p>Finland<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Orion Corporation Orion Pharma<\/p>\n\n\n\n<p>Orionv\u00e4gen 1<\/p>\n\n\n\n<p>FI-02200 Espoo<\/p>\n\n\n\n<p>Finland<\/p>\n\n\n\n<p>For further information on this medicine, please contact your local representative:<\/p>\n\n\n\n<p>Orion Pharma AB, Danderyd<\/p>\n\n\n\n<p>medinfo@orionpharma.com<\/p>\n\n\n\n<p><strong>This medicinal product is authorized under the European Economic Area under the names:<\/strong><\/p>\n\n\n\n<p>Denmark: Oxycodone Orion 10 mg\/ml solution for injection and infusion<\/p>\n\n\n\n<p>Finland: Oxycodone Orion 10 mg \/ ml injection \/ infusion test, limos<\/p>\n\n\n\n<p>Sweden: Oxycodone Orion 10 mg \/ ml solution for injection \/ infusion<\/p>\n","protected":false},"excerpt":{"rendered":"<p>This solution for injection and infusion contains the active ingredient oxycodone, which belongs to a group of medicines called opioids .<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18526],"tags":[16085,20654,16081,16084,20650,20653,16082,20651,16091,20652],"class_list":["post-20193","post","type-post","status-publish","format-standard","hentry","category-medicines","category-o","tag-benefits-of-oxycodone-hydrochloride","tag-benefits-of-oxycodone-orion","tag-oxycodone-hydrochloride","tag-oxycodone-hydrochloride-side-effects","tag-oxycodone-orion","tag-oxycodone-orion-side-effects","tag-what-is-oxycodone-hydrochloride","tag-what-is-oxycodone-orion","tag-what-oxycodone-hydrochloride-is-used-for","tag-what-oxycodone-orion-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20193","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=20193"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20193\/revisions"}],"predecessor-version":[{"id":20263,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20193\/revisions\/20263"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=20193"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=20193"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=20193"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}