{"id":20136,"date":"2022-03-26T07:50:56","date_gmt":"2022-03-26T07:50:56","guid":{"rendered":"https:\/\/zeepedia.com\/?p=20136"},"modified":"2022-03-28T08:23:26","modified_gmt":"2022-03-28T08:23:26","slug":"oxycodone-depot-orion","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/oxycodone-depot-orion\/","title":{"rendered":"Oxycodone Depot Orion &#8211; Oxycodone hydrochloride uses, dose and side effects"},"content":{"rendered":"\n<p>5 mg, 10 mg, 15 mg, 20 mg, 30 mg, 40 mg, 60 mg, 80 mg&nbsp;prolonged-release tablet&nbsp;is<br>oxycodone hydrochloride<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Oxycodone Depot Orion is and what it is used for<\/h2>\n\n\n\n<p>Oxycodone\u00a0Depot\u00a0Orion\u00a0prolonged-release tablets\u00a0are a centrally acting, strong painkiller of the\u00a0opioid\u00a0group.<\/p>\n\n\n\n<p>Oxycodone&nbsp;Depot&nbsp;Orion&nbsp;prolonged-release tablets&nbsp;are used to treat severe pain which can only be treated satisfactorily with opioid painkillers.<\/p>\n\n\n\n<p>Oxycodone&nbsp;Depot&nbsp;Orion&nbsp;prolonged-release tablets&nbsp;are intended for adults and adolescents over 12 years of age.<\/p>\n\n\n\n<p>Oxycodone hydrochloride contained in Oxycodone\u00a0Depot\u00a0Orion\u00a0prolonged-release tablets\u00a0may also be approved for the treatment of other conditions not mentioned in this leaflet.\u00a0Ask your doctor, pharmacist, or other healthcare professionals if you have any further questions, and always follow their instructions.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using Oxycodone Depot Orion<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Oxycodone Depot Orion<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to oxycodone or any of the other ingredients of this medicine (listed in section 6),<\/li><li>if you suffer from severe respiratory distress (\u00a0respiratory depression\u00a0) with too little oxygen in the blood (\u00a0hypoxia\u00a0) and\/or too much\u00a0carbon dioxide\u00a0(\u00a0hypercapnia\u00a0) in the blood,<\/li><li>if you suffer from severe\u00a0chronic obstructive pulmonary disease, cor pulmonale (heart changes due to constant congestion of the circulation in the lungs) or\u00a0acute, severe\u00a0bronchial asthma,<\/li><li>if you suffer from intestinal obstruction (paralytic\u00a0ileus\u00a0),<\/li><li>if you have severe abdominal pain or suffer from delayed emptying of the stomach.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your&nbsp;doctor or pharmacist before taking Oxycodone&nbsp;Depot&nbsp;Orion&nbsp;prolonged-release tablets<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are elderly or debilitated,<\/li><li>if your lung, liver, or kidney function is severely impaired,<\/li><li>if you suffer from\u00a0myxedema\u00a0(a certain disease of the thyroid gland), impaired function of the thyroid gland,<\/li><li>if you suffer from insufficient adrenal function (\u00a0Addison&#8217;s disease\u00a0),<\/li><li>if you suffer from prostate\u00a0hypertrophy,<\/li><li>if you suffer from alcoholism or undergo alcohol withdrawal,<\/li><li>if you suffer from a known opioid addiction,<\/li><li>if you suffer from\u00a0inflammatory\u00a0bowel disease,<\/li><li>if you suffer from\u00a0inflammation\u00a0of the pancreas (\u00a0pancreatitis\u00a0),<\/li><li>in conditions with increased pressure in the brain,<\/li><li>if you suffer from disorders of the regulation of blood circulation,<\/li><li>if you suffer from\u00a0colic\u00a0in the bile ducts and ureters,<\/li><li>if you suffer from\u00a0epilepsy\u00a0or tend to have seizures,<\/li><li>if you are taking\u00a0MAOIs\u00a0(monoamine oxidase inhibitors) (to treat depression).<\/li><\/ul>\n\n\n\n<p>Talk to your doctor if any of these apply to you or if you have had any of these conditions before.<\/p>\n\n\n\n<p><strong>Dependence and tolerance<\/strong><\/p>\n\n\n\n<p>Oxycodone\u00a0Depot\u00a0Orion\u00a0prolonged-release tablets\u00a0have a primary addictive potential.\u00a0When used for a long time, tolerance to the effect may arise, which means that an increased\u00a0dose\u00a0is required to maintain control over the pain.<\/p>\n\n\n\n<p>Chronic&nbsp;use of Oxycodone&nbsp;Depot&nbsp;Orion&nbsp;prolonged-release tablets&nbsp;can lead to physical dependence and withdrawal symptoms may occur with abrupt discontinuation of treatment.&nbsp;When a patient no longer needs treatment with oxycodone hydrochloride, it is advisable to reduce the&nbsp;dose&nbsp;gradually to prevent withdrawal symptoms.<\/p>\n\n\n\n<p>When used as\u00a0prescribed, in patients with\u00a0chronic\u00a0pain, the risk of developing physical or mental dependence is small and this risk must be weighed against the potential benefits.\u00a0Discuss this with your doctor.<\/p>\n\n\n\n<p>Oxycodone\u00a0Depot\u00a0Orion\u00a0prolonged-release tablets\u00a0are for\u00a0oral\u00a0use only.\u00a0In case of\u00a0intravenous\u00a0abuse (\u00a0injection\u00a0via a blood vessel) of the tablets, excipients (especially talc) can lead to damage (\u00a0necrosis\u00a0) of local\u00a0tissue, alteration of lung tissue, (granuloma of the lungs), or other serious potentially fatal events.<\/p>\n\n\n\n<p>This medicine should not be given to patients with known alcohol and drug abuse.<\/p>\n\n\n\n<p><strong>Doping warning<\/strong><\/p>\n\n\n\n<p>Athletes should be aware that this drug may give a positive result in &#8220;anti-doping tests&#8221;.<\/p>\n\n\n\n<p>Using Oxycodone&nbsp;Depot&nbsp;Orion&nbsp;prolonged-release tablets&nbsp;as a doping substance can be a health risk.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Oxycodone\u00a0Depot\u00a0Orion\u00a0prolonged-release tablets\u00a0have not been studied in children under 12 years of age.\u00a0Safety and efficacy have not been established and therefore use in children under 12 years of age are not recommended.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Oxycodone Depot Orion<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.&nbsp;If you take the tablets with other medicines, the effect of the tablets or the other medicine may be affected.<\/p>\n\n\n\n<p>The tablets must not be taken with&nbsp;monoamine oxidase&nbsp;inhibitors or if you have taken this type of medicine in the last two weeks.&nbsp;(see section 2 Do not take Oxycodone&nbsp;Depot&nbsp;Orion)<\/p>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Sedatives or hypnotic drugs (eg\u00a0sedatives,\u00a0hypnotics\u00a0)<\/li><li>Antidepressants (eg\u00a0paroxetine\u00a0)<\/li><li>Drugs designed to treat mental or mental disorders (eg phenothiazines, or\u00a0neuroleptics\u00a0)<\/li><li>Other strong painkillers (\u00a0analgesics\u00a0)<\/li><li>Muscle relaxants<\/li><li>Quinidine\u00a0(a drug for calming fast heartbeats)<\/li><li>Cimetidine (a medicine for\u00a0stomach ulcers, indigestion, heartburn)<\/li><li>Medicines intended to treat fungal infections (eg\u00a0ketoconazole\u00a0, voriconazole, itraconazole or posaconazole)<\/li><li>Drugs intended to treat\u00a0infections\u00a0(eg clarithromycin, erythromycin, or telithromycin)<\/li><li>A special type of medicine known as a protease inhibitor (\u00a0protease inhibitor\u00a0) for the treatment of\u00a0HIV\u00a0(eg boceprevir, ritonavir, indinavir, nelfinavir, or saquinavir)<\/li><li>Rifampicin to treat\u00a0tuberculosis<\/li><li>Carbamazepine (a medicine used to treat seizures, convulsions, or certain pain conditions)<\/li><li>Phenytoin\u00a0(a medicine used to treat seizures, seizures, or convulsions)<\/li><li>An herbal remedy from the plant kingdom,\u00a0St. John&#8217;s wort\u00a0(Hypericum perforatum)<\/li><\/ul>\n\n\n\n<p>Also, tell your doctor if you have recently been given an anesthetic.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Oxycodone Depot Orion with food, drink, and alcohol<\/h2>\n\n\n\n<p>Drinking alcohol while taking Oxycodone\u00a0Depot\u00a0Orion\u00a0prolonged-release tablets\u00a0makes you feel more sleepy or increases the risk of serious\u00a0side effects\u00a0such as shallow breathing with a risk of respiratory arrest and thereby losing consciousness.\u00a0The recommendation is not to drink alcohol when using Oxycodone\u00a0Depot\u00a0Orion\u00a0prolonged-release tablets.\u00a0You should avoid drinking grapefruit juice when using Oxycodone\u00a0Depot\u00a0Orion\u00a0prolonged-release tablets.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n<p><em>Pregnancy<\/em><\/p>\n\n\n\n<p>Oxycodone\u00a0Depot\u00a0Orion\u00a0prolonged-release tablets\u00a0should not be used during pregnancy unless necessary.\u00a0There are very little data from the use of oxycodone in pregnant women.<\/p>\n\n\n\n<p>Oxycodone passes through the placenta and into the baby&#8217;s bloodstream.<\/p>\n\n\n\n<p>Long-term use of oxycodone during pregnancy may cause withdrawal symptoms in newborns.\u00a0The use of oxycodone during childbirth may cause\u00a0respiratory depression\u00a0in the newborn.<\/p>\n\n\n\n<p><em>Breast-feeding<\/em><\/p>\n\n\n\n<p>Do not use Oxycodone\u00a0Depot\u00a0Orion\u00a0prolonged-release tablets\u00a0while breastfeeding as oxycodone passes into breast milk.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Oxycodone hydrochloride impairs alertness and responsiveness to such an extent that the ability to drive and use machines is affected or ceases altogether.&nbsp;To see the&nbsp;side effects&nbsp;that affect motor skills and concentration (see section 4).<\/p>\n\n\n\n<p>In the case of stable treatment, a general ban on driving does not have to be necessary.&nbsp;The attending physician must assess the individual situation.&nbsp;Discuss with your doctor if and under what circumstances you can drive a vehicle.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0Descriptions of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<p><strong>Oxycodone&nbsp;Depot&nbsp;Orion&nbsp;prolonged-release tablets&nbsp;contain&nbsp;lactose<\/strong><\/p>\n\n\n\n<p>If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.<br><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to use Oxycodone Depot Orion<\/h2>\n\n\n\n<p>Always take this medicine exactly as your doctor has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p><strong>The recommended&nbsp;dose&nbsp;is:<\/strong><\/p>\n\n\n\n<p><em>Adults and adolescents (over 12 years of age)<\/em><\/p>\n\n\n\n<p>The usual starting dose is 10 mg oxycodone hydrochloride at 12-hour intervals.\u00a0Your doctor will prescribe the\u00a0dose\u00a0needed to treat the pain.<\/p>\n\n\n\n<p>Patients who have already received&nbsp;opioids&nbsp;can start with a higher&nbsp;dose&nbsp;because they have experience with opioid treatment.<\/p>\n\n\n\n<p>For the treatment of non-cancer patients, a daily&nbsp;dose&nbsp;of 40 mg is generally sufficient, but a higher&nbsp;dose&nbsp;may be needed.<\/p>\n\n\n\n<p>Patients with cancer pain usually require a&nbsp;dose&nbsp;of 80 mg to 120 mg of oxycodone hydrochloride, which can be increased to 400 mg in individual cases.<\/p>\n\n\n\n<p>For\u00a0doses\u00a0that are not possible\/practical to obtain, additional strengths of this drug are available.<\/p>\n\n\n\n<p><em>At-risk patients<\/em><\/p>\n\n\n\n<p>If you have impaired kidney and\/or liver function or if you have low body weight, your doctor may prescribe a lower starting dose.<\/p>\n\n\n\n<p><strong>Method of administration<\/strong><\/p>\n\n\n\n<p>The prolonged-release tablets\u00a0should be swallowed whole with a sufficient amount of liquid (\u00bd glass of water) with or without food in the morning and the evening according to a fixed schedule (eg 8.00 in the morning and 20.00 in the evening).<\/p>\n\n\n\n<p>The prolonged-release tablets\u00a0should be swallowed whole, not crushed or chewed as this will lead to too rapid\u00a0release\u00a0of oxycodone due to damage to the sustained\u00a0release\u00a0properties.\u00a0Ingestion of chewed or crushed Oxycodone\u00a0Depot\u00a0Orion\u00a0prolonged-release tablets\u00a0leads to rapid\u00a0release\u00a0and rapid uptake of a potentially lethal\u00a0dose of\u00a0oxycodone (see section \u201cIf you have taken too much Oxycodone\u00a0Depot\u00a0Orion prolonged-release tablets\u201d).<\/p>\n\n\n\n<p>The prolonged-release tablets&nbsp;should be taken with or without food with a sufficient amount of liquid.<\/p>\n\n\n\n<p>Oxycodone&nbsp;Depot&nbsp;Orion&nbsp;prolonged-release tablets&nbsp;must not be taken with alcoholic beverages.<\/p>\n\n\n\n<p><strong>Instructions for opening the blister:<\/strong><\/p>\n\n\n\n<p>This medicine is supplied in a child-resistant package.&nbsp;The prolonged-release tablets&nbsp;cannot be squeezed through the blister.&nbsp;Follow these instructions when opening the blister.<\/p>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20120830000019#\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.fass.se\/imaging\/resources\/12e79049-844e-4c04-ada7-8b9fdb2f5ced\" alt=\"Instructions for opening the blister\" title=\"Instructions for opening the blister\"\/><\/a><\/figure>\n\n\n\n<p>Tear off a&nbsp;dose&nbsp;along the perforated line on the blister card.<\/p>\n\n\n\n<p>2. An unsealed area becomes visible where the perforated lines intersect.<\/p>\n\n\n\n<p>3. Remove the cover foil from the bottom foil at the unsealed tab.<\/p>\n\n\n\n<p>Additional information on the daily\u00a0dosage\u00a0one, the division into single doses, and dose adjustment during the current treatment is made by the attending physician and depends on the previous\u00a0dosage.<\/p>\n\n\n\n<p>Some patients who receive Oxycodone&nbsp;Depot&nbsp;Orion&nbsp;prolonged-release tablets&nbsp;according to a fixed schedule need fast-acting pain relievers to treat breakthrough pain.&nbsp;Oxycodone&nbsp;Depot&nbsp;Orion&nbsp;prolonged-release tablets&nbsp;are not suitable for the treatment of breakthrough pain.<\/p>\n\n\n\n<p>The treatment needs to be followed regularly about pain relief and other effects to achieve the best pain treatment possible as well as to be able to treat any side effect in good time and to decide whether the treatment should continue.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Use for children and adolescents<\/h2>\n\n\n\n<p>Oxycodone&nbsp;Depot&nbsp;Orion&nbsp;prolonged-release tablets&nbsp;are not recommended for children under 12 years of age.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you use more Oxycodone Depot Orion then you should \u00a0<\/h2>\n\n\n\n<p>If you have ingested too much medicine or if e.g.\u00a0If a child has accidentally ingested the medicine, contact a doctor or hospital immediately for assessment of the risk and advice.<\/p>\n\n\n\n<p>The following symptoms may occur constricted\u00a0pupils\u00a0(\u00a0miosis\u00a0), impaired breathing (respiratory depression), drowsiness, skeletal muscle weakness, and a drop in blood pressure.\u00a0In severe cases, circulatory collapse, mental and physical inactivity (dormancy), unconsciousness (\u00a0coma\u00a0), decrease in heart rate, and accumulation of water in the lungs (non-cardiogenic\u00a0pulmonary edema\u00a0) may occur;\u00a0abuse of high\u00a0doses\u00a0of strong\u00a0opioids\u00a0such as oxycodone can be fatal.\u00a0Under no circumstances should you be\u00a0exposed\u00a0to situations that require increased concentration, such as driving a car.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use Oxycodone Depot Orion<\/h2>\n\n\n\n<p>If you have taken a smaller\u00a0dose\u00a0of Oxycodone\u00a0Depot\u00a0Orion\u00a0prolonged-release tablets\u00a0than you were prescribed or if you missed a\u00a0dose, the pain relief will be insufficient or stop completely.<\/p>\n\n\n\n<p>You can make up for a missed&nbsp;dose&nbsp;if the next regular intake is not to take place until at least 8 hours.&nbsp;You can then continue to take the medicine as instructed.<\/p>\n\n\n\n<p>You can also take the medicine if the time to the next regular intake is shorter, but postpone the next intake by 8 hours.&nbsp;In principle, you should not take Oxycodone&nbsp;Depot&nbsp;Orion&nbsp;prolonged-release tablets&nbsp;more than once every 8 hours.<\/p>\n\n\n\n<p>Do not take a double\u00a0dose\u00a0to make up for a forgotten\u00a0dose.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop using Oxycodone Depot Orion<\/h2>\n\n\n\n<p>Do not stop treatment without informing your doctor.&nbsp;<\/p>\n\n\n\n<p>When a patient no longer needs to be treated with Oxycodone\u00a0Depot\u00a0Orion\u00a0prolonged-release tablets, it is advisable to reduce the daily\u00a0dose\u00a0gradually to avoid withdrawal symptoms.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist<strong>.<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Important serious&nbsp;side effects&nbsp;or symptoms that you should be aware of and actions to take when these&nbsp;side effects&nbsp;or symptoms occur:<\/strong><\/p>\n\n\n\n<p>If you get any of the following\u00a0side effects, stop taking Oxycodone\u00a0Depot\u00a0Orion\u00a0prolonged-release tablets\u00a0and contact your doctor immediately.<\/p>\n\n\n\n<p>Respiratory depression\u00a0is the most significant risk posed by opioids and is most likely to occur in elderly or debilitated patients.\u00a0As a result,\u00a0opioids\u00a0can cause a sharp drop in blood pressure in patients prone to low blood pressure.<\/p>\n\n\n\n<p>In addition to this, oxycodone can cause constricted\u00a0pupils, tracheal spasms, and\u00a0spasms\u00a0in the smooth muscles and dampen the cough reflex.<\/p>\n\n\n\n<p><strong>Other possible&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p><em>Very common (may affect more than 1 user in 10):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Sedation\u00a0(fatigue to drowsiness);\u00a0dizziness;\u00a0headache;\u00a0constipation;\u00a0nausea;\u00a0vomiting;\u00a0itching.<\/li><\/ul>\n\n\n\n<p><em>Common (may affect up to 1 in 10 people):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Several psychological\u00a0side effects\u00a0are such as changes in mood (eg anxiety, depression), changes in activity (usually\u00a0sedation, sometimes accompanied by drowsiness, temporary increase in activity with nervousness and sleep disorders), and changes in behavior (difficulty with the thought process, confusion, individual cases of speech disorders ).<\/li><li>Feeling weak (\u00a0asthenia\u00a0);\u00a0tremors,\u00a0fainting.<\/li><li>Heavy breathing, difficulty breathing, or wheezing (\u00a0dyspnoea,\u00a0bronchospasm\u00a0).<\/li><li>Dry mouth, rarely accompanied by thirst and difficulty swallowing, stomach upset, such as stomach pain, diarrhea, upset stomach (\u00a0dyspepsia\u00a0), no appetite.<\/li><li>Skin problems such as rash, in rare cases, increased photosensitivity (\u00a0photosensitivity\u00a0), in some cases\u00a0itching\u00a0(\u00a0urticaria\u00a0) or flaking skin (exfoliative\u00a0dermatitis\u00a0).<\/li><li>Constipation (increased frequency of urination), heavy sweating (\u00a0hyperhidrosis\u00a0), weakness (\u00a0asthenia\u00a0).<\/li><\/ul>\n\n\n\n<p><em>Uncommon (may affect up to 1 in 100 people):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>A condition that causes abnormal production of a\u00a0hormone\u00a0that reduces the amount of urine (syndrome of insufficient secretion of\u00a0antidiuretic hormone\u00a0).<\/li><li>Changes in perception such as loss of personality, hallucinations (the experience of things that do not exist), emotional instability, changes in the sense of taste, visual disturbances, abnormal\u00a0acute\u00a0increased sensitivity to sound (hyperacusis),\u00a0euphoria, restlessness.<\/li><li>Increased and decreased muscle tension, involuntary muscle twitching, memory disorders (\u00a0amnesia\u00a0), seizures, speech disorders, decreased sensitivity to touch (\u00a0hypesthesia\u00a0), coordination disorders, malaise, and crawling (\u00a0paresthesia\u00a0), fainting (\u00a0vertigo\u00a0).<\/li><li>Increased\u00a0heart rate, rapid or irregular\u00a0heartbeat\u00a0(supraventricular\u00a0tachycardia\u00a0), palpitations (associated with withdrawal symptoms), dilated blood vessels (\u00a0vasodilation\u00a0).<\/li><li>Increased cough,\u00a0inflammation\u00a0of the throat (\u00a0pharyngitis\u00a0), runny nose, voice changes.<\/li><li>Cold sores, gingivitis,\u00a0inflammation\u00a0of the mouth (\u00a0stomatitis\u00a0), decreased ability to swallow (\u00a0dysphagia\u00a0), flatulence.<\/li><li>Belching, intestinal obstruction (\u00a0ileus\u00a0), taste disturbances, increased liver enzymes,<\/li><li>Dry skin.<\/li><li>Urinary retention.<\/li><li>Disorder of sexual function (decreased sexual desire and\u00a0impotence\u00a0).<\/li><li>Accidental damage;\u00a0pain (eg chest pain);\u00a0accumulation of fluid in the\u00a0tissues\u00a0(\u00a0edema\u00a0);\u00a0migraine;\u00a0physically dependent with withdrawal symptoms;\u00a0allergic reactions.<\/li><li>Lack of water in the body (\u00a0dehydration\u00a0).<\/li><li>Hypersensitivity (\u00a0allergic reaction\u00a0).<\/li><li>Thirst, changes in tear secretion.<\/li><li>Overindulge.<\/li><li>A ringing tone in the ear (\u00a0tinnitus\u00a0).<\/li><li>Drug tolerance (an increasing\u00a0dose\u00a0is required to achieve the same effect).<\/li><\/ul>\n\n\n\n<p><em>Rare (may affect up to 1 in 1,000 people):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Lymph node disease (\u00a0lymphadenopathy\u00a0).<\/li><li>Seizures, especially in patients with\u00a0epilepsy, muscle spasms (involuntary<\/li><li>contraction\u00a0is of the muscles).<\/li><li>Lowering of\u00a0blood pressure, rarely accompanied by symptoms such as throbbing or<\/li><li>a very fast heartbeat.<\/li><li>Bleeding in the gums, increased appetite, dark-colored stools, tooth discoloration and<\/li><li>tooth damage.<\/li><li>Herpes\u00a0simplex (disease of the skin and mucous membranes), hives (\u00a0urticaria\u00a0).<\/li><li>Change in body weight (increase or decrease),\u00a0cellulite.<\/li><\/ul>\n\n\n\n<p><em>Unknown frequency (frequency can not be calculated from known data)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Anaphylactic reaction.<\/li><li>Aggression.<\/li><li>Increased sensitivity to pain (hyperalgesia).<\/li><li>Dental caries.<\/li><li>Bile duct stasis, gallstone attack.<\/li><li>No menstruation (\u00a0amenorrhea\u00a0).<\/li><\/ul>\n\n\n\n<p><em>Withdrawal syndrome&nbsp;with&nbsp;opioids<\/em><\/p>\n\n\n\n<p>As oxycodone hydrochloride may lead to drug addiction, there is a risk of developing\u00a0opioid\u00a0withdrawal or\u00a0withdrawal\u00a0symptoms characterized by one or all of the following;\u00a0restlessness, watery eyes (\u00a0lacrimation\u00a0), runny nose, yawning, sweating, chills, muscle pain, pupil dilation, and irregular heartbeat (\u00a0palpitation\u00a0).\u00a0Other symptoms may include irritability, anxiety, back pain, joint pain, abdominal cramps, insomnia, nausea,\u00a0anorexia, vomiting, diarrhea or increased\u00a0blood pressure, respiratory rate, or heart rate.<\/p>\n\n\n\n<p><em>Countermeasures<\/em><\/p>\n\n\n\n<p>If you notice any of the\u00a0side effects\u00a0described above, your doctor will usually take appropriate action.<\/p>\n\n\n\n<p>Constipation can be prevented by a high-fiber diet and increased water intake.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Oxycodone Depot Orion<\/h2>\n\n\n\n<p>Keep out of sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the blister \/ can and on the carton after \u201cEXP\u201d.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p><strong>Oxycodone&nbsp;<\/strong><strong>Depot&nbsp;Orion 5 mg prolonged-release tablets:<\/strong><\/p>\n\n\n\n<p>Do not store above 25 \u00b0 C.<\/p>\n\n\n\n<p><strong>Oxycodone&nbsp;Depot&nbsp;Orion 10 mg prolonged-release tablets:<\/strong><\/p>\n\n\n\n<p>Do not store above 30 \u00b0 C.<\/p>\n\n\n\n<p><strong>Oxycodone&nbsp;Depot&nbsp;Orion 15 mg \/ 20 mg \/ 30 mg \/ 40 mg \/ 60 mg \/ 80 mg:<\/strong><\/p>\n\n\n\n<p>This medicine does not require any special storage instructions.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<p><em>Oxycodone Orion&nbsp;Depot&nbsp;prolonged-release tablet&nbsp;contains<\/em><\/p>\n\n\n\n<p>The active substance is oxycodone hydrochloride.<\/p>\n\n\n\n<p><strong>5 mg:<\/strong><\/p>\n\n\n\n<p>Each&nbsp;prolonged-release tablet&nbsp;contains 5 mg oxycodone hydrochloride equivalent to 4.5 mg oxycodone.<\/p>\n\n\n\n<p>Other ingredients are:<\/p>\n\n\n\n<p><em>Tablet core:\u00a0<\/em>Lactose monohydrate, ammonium methyl acrylate copolymer (type B), Povidone K29 \/ 32, talc, triacetin, stearyl alcohol, magnesium stearate<\/p>\n\n\n\n<p><em>Tablet coating:<\/em>&nbsp;Hypromellose, talc, macrogol 400, titanium dioxide (E 171), brilliant blue FCF (E133)<\/p>\n\n\n\n<p><strong>10 mg:<\/strong><\/p>\n\n\n\n<p>Each&nbsp;prolonged-release tablet&nbsp;contains 10 mg oxycodone hydrochloride equivalent to 9 mg oxycodone.<\/p>\n\n\n\n<p>Other ingredients are:<\/p>\n\n\n\n<p><em>Tablet core:\u00a0<\/em>Lactose monohydrate, ammonium methyl acrylate copolymer (type B), Povidone K29 \/ 32, talc, triacetin, stearyl alcohol, magnesium stearate<\/p>\n\n\n\n<p><em>Tablet coating:<\/em>&nbsp;Hypromellose, talc, macrogol 400, titanium dioxide (E 171)<\/p>\n\n\n\n<p><strong>15 mg:<\/strong><\/p>\n\n\n\n<p>Each&nbsp;prolonged-release tablet&nbsp;contains 15 mg oxycodone hydrochloride equivalent to 13.5 mg oxycodone.<\/p>\n\n\n\n<p>Other ingredients are:<\/p>\n\n\n\n<p><em>Tablet core:\u00a0<\/em>Lactose monohydrate, ammonium methyl acrylate copolymer (type B), Povidone K29 \/ 32, talc, triacetin, stearyl alcohol,\u00a0magnesium\u00a0stearate<\/p>\n\n\n\n<p><em>Tablet coating:<\/em>&nbsp;Hypromellose, talc, macrogol 400, titanium dioxide (E 171), black iron oxide (E172)<\/p>\n\n\n\n<p><strong>20 mg:<\/strong><\/p>\n\n\n\n<p>Each&nbsp;prolonged-release tablet&nbsp;contains 20 mg oxycodone hydrochloride equivalent to 17.9 mg oxycodone.<\/p>\n\n\n\n<p>Other ingredients are:<\/p>\n\n\n\n<p><em>Tablet core:\u00a0<\/em>Lactose monohydrate, ammonium methyl acrylate copolymer (type B), Povidone K29 \/ 32, talc, triacetin, stearyl alcohol, magnesium stearate<\/p>\n\n\n\n<p><em>Tablet coating:<\/em>&nbsp;Hypromellose, talc, macrogol 400, titanium dioxide (E 171), red iron oxide (E172)<\/p>\n\n\n\n<p><strong>30 mg:<\/strong><\/p>\n\n\n\n<p>Each&nbsp;prolonged-release tablet&nbsp;contains 30 mg oxycodone hydrochloride equivalent to 26.9 mg oxycodone.<\/p>\n\n\n\n<p>Other ingredients are:<\/p>\n\n\n\n<p><em>Tablet core:\u00a0<\/em>Lactose monohydrate, ammonium methyl acrylate copolymer (type B), Povidone K29 \/ 32, talc, triacetin, stearyl alcohol, magnesium stearate<\/p>\n\n\n\n<p><em>Tablet coating:<\/em>&nbsp;Hypromellose, talc, macrogol 400, titanium dioxide (E 171), brown iron oxide (E172), black iron oxide (E172)<\/p>\n\n\n\n<p><strong>40 mg:<\/strong><\/p>\n\n\n\n<p>Each&nbsp;prolonged-release tablet&nbsp;contains 40 mg oxycodone hydrochloride equivalent to 35.9 mg oxycodone.<\/p>\n\n\n\n<p>Other ingredients are:<\/p>\n\n\n\n<p><em>Tablet core:\u00a0<\/em>Lactose monohydrate, ammonium methyl acrylate copolymer (type B), Povidone K29 \/ 32, talc, triacetin, stearyl alcohol, magnesium stearate<\/p>\n\n\n\n<p><em>Tablet coating:<\/em>&nbsp;Hypromellose, talc, macrogol 400, titanium dioxide (E 171), red iron oxide (E172), yellow iron oxide (E172)<\/p>\n\n\n\n<p><strong>60 mg:<\/strong><\/p>\n\n\n\n<p>Each&nbsp;prolonged-release tablet&nbsp;contains 60 mg oxycodone hydrochloride equivalent to 53.8 mg oxycodone.<\/p>\n\n\n\n<p>Other ingredients are:<\/p>\n\n\n\n<p><em>Tablet core:\u00a0<\/em>Lactose monohydrate, ammonium methyl acrylate copolymer (type B), Povidone K29 \/ 32, talc, triacetin, stearyl alcohol, magnesium stearate<\/p>\n\n\n\n<p><em>Tablet coating:<\/em>&nbsp;Hypromellose, talc, macrogol 400, titanium dioxide (E 171), red iron oxide (E172), erythrosine (E127)<\/p>\n\n\n\n<p><strong>80 mg:<\/strong><\/p>\n\n\n\n<p>Each&nbsp;prolonged-release tablet&nbsp;contains 80 mg oxycodone hydrochloride equivalent to 71.7 mg oxycodone.<\/p>\n\n\n\n<p>Other ingredients are:<\/p>\n\n\n\n<p><em>Tablet core:\u00a0<\/em>Lactose monohydrate, ammonium methyl acrylate copolymer (type B), Povidone K29 \/ 32, talc, triacetin, stearyl alcohol, magnesium stearate<\/p>\n\n\n\n<p><em>Tablet coating:<\/em>&nbsp;Hypromellose, macrogol 400, titanium dioxide (E 171), indigo carmine aluminum lacquer (E132), yellow iron oxide (E172)<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Oxycodone&nbsp;Depot&nbsp;Orion 5 mg&nbsp;prolonged-release tablet&nbsp;is<\/p>\n\n\n\n<p>Light blue, round biconvex,&nbsp;prolonged-release tablets&nbsp;with a diameter of 6.9\u20137.3 mm and a height of 3.2-3.9 mm.<\/p>\n\n\n\n<p>Oxycodone&nbsp;Depot&nbsp;Orion 10 mg prolonged-release tablets:<\/p>\n\n\n\n<p>White, round biconvex,&nbsp;prolonged-release tablets&nbsp;with a diameter of 6.9\u20137.3 mm and a height of 3.2\u20133.9 mm.<\/p>\n\n\n\n<p>Oxycodone&nbsp;Depot&nbsp;Orion 15 mg prolonged-release tablets:<\/p>\n\n\n\n<p>Gray, round biconvex,&nbsp;prolonged-release tablets&nbsp;with a diameter of 6.9\u20137.3 mm and a height of 3.2\u20133.9 mm.<\/p>\n\n\n\n<p>Oxycodone&nbsp;Depot&nbsp;Orion 20 mg prolonged-release tablets:<\/p>\n\n\n\n<p>Light pink, round biconvex,&nbsp;prolonged-release tablets&nbsp;with a diameter of 6.9\u20137.3 mm and a height of 3.2\u20133.9 mm.<\/p>\n\n\n\n<p>Oxycodone&nbsp;Depot&nbsp;Orion 30 mg prolonged-release tablets:<\/p>\n\n\n\n<p>Brown, round biconvex,&nbsp;prolonged-release tablets&nbsp;with a diameter of 6.9\u20137.3 mm and a height of 3.2\u20133.9 mm.<\/p>\n\n\n\n<p>Oxycodone&nbsp;Depot&nbsp;Orion 40 mg prolonged-release tablets:<\/p>\n\n\n\n<p>Light orange to ocher, round biconvex,&nbsp;prolonged-release tablets&nbsp;with a diameter of 6.9\u20137.3 mm and a height of 3.2\u20133.9 mm.<\/p>\n\n\n\n<p>Oxycodone&nbsp;Depot&nbsp;Orion 60 mg prolonged-release tablets:<\/p>\n\n\n\n<p>Pink-red, round biconvex,&nbsp;prolonged-release tablets&nbsp;with a diameter of 8.6\u20139.0 mm and a height of 4.6\u20135.3 mm.<\/p>\n\n\n\n<p>Oxycodone&nbsp;Depot&nbsp;Orion 80 mg prolonged-release tablets:<\/p>\n\n\n\n<p>Green, round biconvex,&nbsp;prolonged-release tablets&nbsp;with a diameter of 8.6\u20139.0 mm and a height of 5.0\u20135.6 mm.<\/p>\n\n\n\n<p>Pack sizes: 10&#215;1, 14&#215;1, 20&#215;1, 25&#215;1, 28&#215;1, 30&#215;1, 40&#215;1, 50&#215;1, 56&#215;1, 60&#215;1, 98&#215;1 and 100&#215;1&nbsp;prolonged-release tablets&nbsp;in child-resistant single-dose blisters.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p><em>Marketing Authorisation Holder:&nbsp;<\/em><\/p>\n\n\n\n<p>Orion Corporation<\/p>\n\n\n\n<p>Orionintie 1<\/p>\n\n\n\n<p>FI-02200 Espoo<\/p>\n\n\n\n<p>Finland<\/p>\n\n\n\n<p><em>Manufacturer:<\/em><\/p>\n\n\n\n<p>Orion Corporation, Orion Pharma<\/p>\n\n\n\n<p>Orionintie 1<\/p>\n\n\n\n<p>FI-02200 Espoo<\/p>\n\n\n\n<p>Finland<\/p>\n\n\n\n<p>Orion Corporation Orion Pharma<\/p>\n\n\n\n<p>Joensuunkatu 7<\/p>\n\n\n\n<p>FI-24100 Salo<\/p>\n\n\n\n<p>Finland<\/p>\n\n\n\n<p><em>For any information about this medicine, please contact the local representative of the Marketing Authorization Holder:<\/em><\/p>\n\n\n\n<p>Orion Pharma AB<\/p>\n\n\n\n<p>medinfo@orionpharma.com<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Oxycodone Depot Orion prolonged-release tablets are a centrally acting, strong painkiller of the opioid group .<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18526],"tags":[20530,16085,20525,20529,20528,16081,16084,20507,20526,20527,16091],"class_list":["post-20136","post","type-post","status-publish","format-standard","hentry","category-medicines","category-o","tag-benefits-of-oxycodone-depot","tag-benefits-of-oxycodone-hydrochloride","tag-oxycodone-depot","tag-oxycodone-depot-side-effects","tag-oxycodone-depot-tablet","tag-oxycodone-hydrochloride","tag-oxycodone-hydrochloride-side-effects","tag-oxycodone-hydrochloride-tablet","tag-what-is-oxycodone-depot","tag-what-oxycodone-depot-is-used-for","tag-what-oxycodone-hydrochloride-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20136","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=20136"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20136\/revisions"}],"predecessor-version":[{"id":20183,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20136\/revisions\/20183"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=20136"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=20136"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=20136"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}