{"id":20125,"date":"2022-03-26T07:40:34","date_gmt":"2022-03-26T07:40:34","guid":{"rendered":"https:\/\/zeepedia.com\/?p=20125"},"modified":"2022-03-28T08:25:29","modified_gmt":"2022-03-28T08:25:29","slug":"oxycodone-depot-actavis","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/oxycodone-depot-actavis\/","title":{"rendered":"Oxycodone Depot Actavis &#8211; Oxycodone hydrochloride uses, dose and side effects"},"content":{"rendered":"\n<p>5 mg, 10 mg, 15 mg, 20 mg, 30 mg, 40 mg, 60 mg, 80 mg&nbsp;prolonged-release tablet&nbsp;is<br>oxycodone hydrochloride<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Oxikodon Depot Actavis is and what it is used for<\/h2>\n\n\n\n<p>Oxycodone&nbsp;Depot&nbsp;Actavis contains the active substance oxycodone hydrochloride, which belongs to a group of medicines called opioids.&nbsp;These are strong painkillers.<\/p>\n\n\n\n<p>Oxycodone&nbsp;Depot&nbsp;Actavis is used to treat severe pain that can only be alleviated with enough painkillers opioid drugs in adults and children from 12 years of age.<\/p>\n\n\n\n<p>Oxycodone hydrochloride contained in Oxycodone\u00a0Depot\u00a0Actavis may also be approved for the treatment of other conditions not mentioned in this product information.\u00a0Ask your doctor, pharmacist, or other healthcare professionals if you have any further questions, and always follow their instructions.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you use Oxikodon Depot Actavis<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Oxycodone Depot Actavis<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to oxycodone hydrochloride or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you have severe respiratory distress (\u00a0respiratory depression\u00a0) with too low oxygen levels in the blood (\u00a0hypoxia\u00a0) and\/or too high carbon dioxide concentrations in the blood.<\/li><li>if you have severe\u00a0chronic obstructive pulmonary disease\u00a0(COPD), cor pulmonale (changes in the heart due to\u00a0chronic\u00a0congestion of the pulmonary circulation), or\u00a0acute, severe\u00a0asthma.<\/li><li>if you have intestinal upset.<\/li><li>if you have acute severe abdominal pain or delayed emptying of the stomach.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before taking Oxikodon&nbsp;Depot&nbsp;Actavis:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are elderly or debilitated.<\/li><li>if your lung, liver, or kidney function is severely impaired.<\/li><li>if you have thyroid disease or impaired thyroid function.<\/li><li>if you have impaired adrenal function, e.g.\u00a0Addison&#8217;s disease.<\/li><li>if you have an enlarged\u00a0prostate.<\/li><li>if you are an alcoholic or undergoing treatment for alcohol dependence.<\/li><li>if you know you are addicted to\u00a0opioids.<\/li><li>if you have\u00a0inflammation\u00a0of the pancreas.<\/li><li>in conditions with increased pressure in the brain, e.g.\u00a0in the event of a head injury.<\/li><li>if you have circulatory disorders.<\/li><li>if you have\u00a0colic\u00a0in the bile duct and ureter.<\/li><li>if you have low\u00a0blood pressure\u00a0or low blood volume.<\/li><li>if you have\u00a0epilepsy\u00a0or a tendency to seizures.<\/li><li>if you are taking\u00a0MAOIs\u00a0(to treat depression).<\/li><li>if you have an\u00a0inflammatory\u00a0bowel disease.<\/li><li>if you have recently undergone abdominal surgery.<\/li><\/ul>\n\n\n\n<p>Tell your doctor if any of the above apply to you or if you have had any of the above before.<\/p>\n\n\n\n<p>Oxycodone\u00a0Depot\u00a0Actavis has primary addiction potential.\u00a0When used for a long time, tolerance to the effects may mean that an increased\u00a0dose\u00a0is required to maintain pain relief.<\/p>\n\n\n\n<p>Chronic\u00a0use of Oxycodone\u00a0Depot\u00a0Actavis may lead to physical dependence and withdrawal symptoms may occur with abrupt discontinuation of treatment.\u00a0When a patient no longer needs oxycodone treatment, it is advisable to reduce the\u00a0dose\u00a0gradually to prevent withdrawal symptoms.<\/p>\n\n\n\n<p>The risk of developing physical or mental dependence is small when the drug is used as&nbsp;prescribed&nbsp;by patients suffering from&nbsp;chronic&nbsp;pain, and this risk must be weighed against the possible benefit.&nbsp;Discuss this with your doctor.<\/p>\n\n\n\n<p>An increased sensitivity to pain, which does not respond to a dose increase of oxycodone, may occur during treatment with Oxycodone&nbsp;Depot&nbsp;Actavis.&nbsp;This is unusual, but if it does, your doctor may reduce your&nbsp;dose&nbsp;or switch to another opioid.<\/p>\n\n\n\n<p>Oxycodone&nbsp;Depot&nbsp;Actavis is not recommended before surgery or up to 24 hours after.<\/p>\n\n\n\n<p>Oxycodone&nbsp;Depot&nbsp;Actavis should be used with special caution by people with a history of alcohol or drug addiction.<\/p>\n\n\n\n<p>Like other\u00a0opioids, Oxikodon\u00a0Depot\u00a0Actavis can affect the normal production of\u00a0hormones\u00a0in your body, such as\u00a0cortisol\u00a0or sex hormones.\u00a0This is especially true if you are taking high\u00a0doses\u00a0for a long time.\u00a0Symptoms may include nausea or vomiting, loss of appetite, fatigue, dizziness, altered sexual ability, changes in the menstrual cycle, or\u00a0impotence.\u00a0Discuss this with your doctor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Oxycodone has not been studied in children under 12 years of age.\u00a0Safety and efficacy have not been established and therefore use in children under 12 years of age are not recommended.<\/p>\n\n\n\n<p><strong>Elderly patients<\/strong><\/p>\n\n\n\n<p>In elderly patients without renal and\/or hepatic impairment, no dose adjustment is usually required.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Oxikodon Depot Actavis<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>If you take these tablets with other medicines, the effect of these tablets or the other medicine may increase or decrease.&nbsp;The risk of&nbsp;side effects&nbsp;can also increase.&nbsp;Tell your doctor or pharmacist if you are taking:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>a type of medicine called a\u00a0monoamine oxidase inhibitor\u00a0(\u00a0MAOIs, such as moclobemide, phenelzine, isoniazid, <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/tranylcypromine-glenmark\/\">tranylcypromine<\/a>, or\u00a0selegiline\u00a0), or if you have taken this type of medicine in the last two weeks (see section \u201cWarnings and precautions\u201d),<\/li><li>medicines that help you sleep or stay calm (eg\u00a0hypnotics\u00a0or\u00a0sedatives, including\u00a0benzodiazepines\u00a0),<\/li><li>medicines used to treat depression (eg\u00a0paroxetine\u00a0or\u00a0fluoxetine\u00a0),<\/li><li>medicines used to treat psychiatric or mental illnesses (such as phenothiazines or neuroleptic medicines),<\/li><li>other strong painkillers (\u00a0opioids\u00a0),<\/li><li>muscle relaxants,<\/li><li>quinidine\u00a0(a drug used to treat rapid heartbeat),<\/li><li>cimetidine (a medicine used to\u00a0treat stomach ulcers, indigestion, or heartburn),<\/li><li>medicines used to treat fungal infections (such as\u00a0ketoconazole\u00a0, voriconazole, itraconazole or posaconazole),<\/li><li>drugs used to treat bacterial infections (such as clarithromycin, erythromycin, or telithromycin),<\/li><li>a specific drug called\u00a0protease inhibitor\u00a0used to treat\u00a0HIV\u00a0(eg boceprevir, ritonavir, indinavir, nelfinavir, saquinavir),<\/li><li>rifampicin to treat\u00a0tuberculosis,<\/li><li>carbamazepine (a medicine for seizures, seizures, tremors, and certain pain conditions),<\/li><li>phenytoin\u00a0(a medicine for seizures, seizures, and tremors),<\/li><li>St. John&#8217;s wort, a traditional herbal medicine (Hypericum Perforatum),<\/li><li>medicines used to treat\u00a0allergies\u00a0(\u00a0antihistamines\u00a0) or vomiting (antiemetics),<\/li><li>medicines used to treat\u00a0Parkinson&#8217;s disease,<\/li><li>coumarin-type anticoagulants\u00a0(medicines that reduce the blood&#8217;s ability to clot).<\/li><\/ul>\n\n\n\n<p>You should also tell your doctor if you have recently been anesthetized.<\/p>\n\n\n\n<p>Concomitant use of Oxycodone Depot Actavis with sedatives or medicines for sleep disorders such as\u00a0benzodiazepines\u00a0or similar medicines increases the risk of drowsiness, difficulty breathing (\u00a0respiratory depression\u00a0),\u00a0coma\u00a0and may be life-threatening.\u00a0Due to this, concomitant use should only be considered when other treatment options are not possible.<\/p>\n\n\n\n<p>If your doctor prescribes Oxikodon&nbsp;Depot&nbsp;Actavis at the same time as sedatives, the&nbsp;dose&nbsp;and treatment time should be limited by your doctor.<\/p>\n\n\n\n<p>Tell your doctor if you are taking any sedatives and carefully follow your doctor&#8217;s dose recommendations.&nbsp;It may be helpful to inform friends or relatives about paying attention to the signs and symptoms described above.&nbsp;Contact a doctor if you experience any of these symptoms.<\/p>\n\n\n\n<p>The risk of\u00a0side effects\u00a0is increased if you take antidepressant drugs (for example,\u00a0citalopram, duloxetine, escitalopram,\u00a0fluoxetine, fluvoxamine,\u00a0paroxetine,\u00a0sertraline,\u00a0venlafaxine\u00a0).\u00a0These drugs can affect or be affected by oxycodone, and you may experience symptoms such as involuntary, rhythmic muscle contractions, including in the muscles that control eye movements, sudden movements, heavy sweating, tremors, excessive reflexive movements, increased muscle tension, body temperature above 38 \u00b0 C.\u00a0Contact your doctor if you experience these symptoms.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Oxycodone Depot Actavis with food, drink, and alcohol<\/h2>\n\n\n\n<p>You should not drink alcohol while taking Oxikodon&nbsp;Depot&nbsp;Actavis.&nbsp;Drinking alcohol while taking Oxikodon&nbsp;Depot&nbsp;Actavis may make you feel sleepy or increase the risk of serious&nbsp;side effects&nbsp;such as weak breathing with the risk of respiratory arrest and unconsciousness.<\/p>\n\n\n\n<p>Grapefruit juice can\u00a0inhibit\u00a0the breakdown of oxycodone which leads to an increased effect.\u00a0Therefore, you should avoid drinking grapefruit juice while taking Oxikodon\u00a0Depot\u00a0Actavis.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n<p><strong>Pregnancy<\/strong><\/p>\n\n\n\n<p>There is insufficient experience with oxycodone treatment in pregnant women.&nbsp;Oxycodone passes through the placenta into the bloodstream of the fetus.<\/p>\n\n\n\n<p>The use of oxycodone during pregnancy may cause withdrawal symptoms in the newborn.\u00a0Newborns of mothers who have received oxycodone during the last 3 to 4 weeks before delivery is at risk of severe respiratory distress (\u00a0respiratory depression\u00a0).\u00a0The use of oxycodone during labor can cause severe breathing problems in the newborn.<\/p>\n\n\n\n<p>Oxycodone&nbsp;Depot&nbsp;Actavis should only be used during pregnancy if the benefit outweighs the risk to the baby.<\/p>\n\n\n\n<p><strong>Breast-feeding<\/strong><\/p>\n\n\n\n<p>You should not take Oxycodone\u00a0Depot\u00a0Actavis during the breastfeeding period as oxycodone may pass into breast milk and may cause breathing difficulties in the newborn baby.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Oxycodone can affect the ability to drive or use machines.<\/p>\n\n\n\n<p>During stable treatment, it is not necessary to ban driving in general.&nbsp;The treating physician must evaluate the individual situation.&nbsp;Discuss with your doctor if and under what circumstances you can drive.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0The description of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Oxycodone Depot Actavis contains lactose<\/h2>\n\n\n\n<p>This medicine contains\u00a0lactose.\u00a0If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Oxycodone Depot Actavis<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Use for children and adolescents<\/h2>\n\n\n\n<p>Always take this medicine exactly as your doctor or pharmacist has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p><strong>Adults and adolescents (12 years or older)<\/strong><\/p>\n\n\n\n<p>The usual starting dose is 5 or 10 mg oxycodone hydrochloride at 12-hour intervals.\u00a0Your doctor will prescribe the\u00a0dose\u00a0needed to treat the pain.<\/p>\n\n\n\n<p>Further determination of the daily\u00a0dose\u00a0one, the division of the\u00a0doses,\u00a0and all dose adjustments during treatment are carried out by the treating physician and depend on the previous\u00a0dose\u00a0one.<\/p>\n\n\n\n<p>Patients who have previously taken\u00a0opioids\u00a0can start treatment with higher\u00a0doses, taking into account their previous experience with opioid treatment.<\/p>\n\n\n\n<p>Some patients receiving Oxikodon&nbsp;Depot&nbsp;Actavis on an established schedule need fast-acting analgesics such as emergency medicine to control breakthrough pain.&nbsp;Oxycodone&nbsp;Depot&nbsp;Actavis is not indicated for the treatment of breakthrough pain.<\/p>\n\n\n\n<p>In the treatment of non-cancer-related pain, a\u00a0dose\u00a0of 20 mg oxycodone hydrochloride twice daily is usually sufficient, but a higher\u00a0dose\u00a0may be needed.\u00a0Patients with cancer pain usually need higher\u00a0doses, from 80 mg to 120 mg oxycodone hydrochloride, which can be increased to 400 mg oxycodone hydrochloride in individual cases.<\/p>\n\n\n\n<p>The treatment needs to be checked regularly about pain relief and other effects to achieve the best possible pain treatment as well as the possibility of treating all\u00a0side effects\u00a0that occur in good time and deciding whether to continue the treatment.<\/p>\n\n\n\n<p><strong>Impaired kidney or liver function or low body weight<\/strong><\/p>\n\n\n\n<p>If you have impaired kidney and\/or liver function or if you have low body weight, your doctor may prescribe a lower starting dose.<\/p>\n\n\n\n<p><strong>How to take the medicine and the duration of treatment<\/strong><\/p>\n\n\n\n<p>Swallow\u00a0the prolonged-release tablet\u00a0whole with a sufficient amount of liquid (\u00bd glass of water), with or without food, in the morning and evening according to a set schedule (eg 8.00 am and 8.00 pm).<\/p>\n\n\n\n<p>The prolonged-release tablet\u00a0must not be broken, crushed, or chewed as this will lead to rapid\u00a0release\u00a0of oxycodone due to damage to the tablet&#8217;s sustained-release\u00a0properties.\u00a0If you swallow a\u00a0prolonged-release\u00a0or chewed prolonged-release tablet, this will lead to rapid\u00a0release\u00a0and absorption of a lethal\u00a0dose of\u00a0oxycodone (see section \u201cIf you have taken too much Oxycodone\u00a0Depot\u00a0Actavis\u201d).<\/p>\n\n\n\n<p>Oxycodone\u00a0Depot\u00a0Actavis\u00a0prolonged-release tablets\u00a0are for oral use only.\u00a0In the case of drug injection (\u00a0injection\u00a0into a vein), the ingredients of the tablet may lead to degeneration (\u00a0necrosis\u00a0) of the nearby\u00a0tissue, alteration of lung tissue (lung granuloma), or other serious events that can be fatal.<\/p>\n\n\n\n<p><em>Instructions for use of child-resistant blister packs:<\/em><\/p>\n\n\n\n<p>1. Do not attempt to push the tablet directly out of the tablet compartment.&nbsp;You can not push the tablet out through the foil.&nbsp;Instead, the foil must be removed.<\/p>\n\n\n\n<p>2. First separate a&nbsp;dose&nbsp;from the rest of the strip at the perforations.<a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20120926000039#\" rel=\"noopener\"><\/a><\/p>\n\n\n\n<p>Then gently pull off the back to open the tablet compartment.<\/p>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20120926000039#\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.fass.se\/res\/RootMedia\/Actavis\/Media\/Oxikodon\/Bild205.jpg\" alt=\"Carefully pull off the back\" title=\"Carefully pull off the back\"\/><\/a><\/figure>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20120926000039#\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.fass.se\/res\/RootMedia\/Actavis\/Media\/Oxikodon\/Bild206.jpg\" alt=\"Carefully pull off the back\" title=\"Carefully pull off the back\"\/><\/a><\/figure>\n\n\n\n<p>4. You can then take the tablet out of the tablet compartment.<\/p>\n\n\n\n<p><em>Instructions for use of child protection cans:<\/em><\/p>\n\n\n\n<p>Press the lid down and turn it to open.<\/p>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20120926000039#\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.fass.se\/res\/RootMedia\/Actavis\/Media\/Oxikodon20depot20Actavis\/Oxikodon20Depot20fig204.jpg\" alt=\"Press the lid down and turn to open.\" title=\"Press the lid down and turn to open.\"\/><\/a><\/figure>\n\n\n\n<p>Your doctor will adjust the&nbsp;dose&nbsp;depending on the&nbsp;intensity&nbsp;of the pain and how you respond to the treatment.&nbsp;Take the number of&nbsp;prolonged-release tablets&nbsp;prescribed by your doctor twice a day.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you take more Oxikodon Depot Actavis then you should<\/h2>\n\n\n\n<p>If you have ingested too much medicine or if e.g.\u00a0If a child has ingested the medicine by mistake, contact a doctor or hospital for risk assessment and advice.<\/p>\n\n\n\n<p>The following symptoms may occur: constricted\u00a0pupils, decreased breathing, muscle weakness, drowsiness, and drop in blood pressure.\u00a0In severe cases, circulatory collapse, mental and motor inactivity, unconsciousness, slow heartbeat and accumulation of water in the lungs, low\u00a0blood pressure,\u00a0or death may occur.\u00a0Abuse of high\u00a0doses\u00a0of strong\u00a0opioids\u00a0such as oxycodone can be fatal.\u00a0Under no circumstances should you be\u00a0exposed\u00a0to situations that require a high ability to concentrate, such as\u00a0driving.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Oxikodon Depot Actavis<\/h2>\n\n\n\n<p>If you take a smaller&nbsp;dose&nbsp;of Oxikodon&nbsp;Depot&nbsp;Actavis than you were instructed to take or if you forget to take a tablet, the pain relief will be insufficient or stop completely.<\/p>\n\n\n\n<p>You can compensate for a forgotten tablet if the next planned regular intake is not to take place until at least 8 hours.&nbsp;Then you can continue to take the tablets according to the instructions.<\/p>\n\n\n\n<p>You should also take&nbsp;prolonged-release tablets&nbsp;if the time to the next regular intake is shorter, but then you should postpone the next intake by 8 hours.&nbsp;In principle, you should not take Oxikodon&nbsp;Depot&nbsp;Actavis more often than every 8 hours.<\/p>\n\n\n\n<p>Do not take a double&nbsp;dose&nbsp;to make up for a forgotten tablet.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking Oxikodon Depot Actavis<\/h2>\n\n\n\n<p>Do not stop treatment without talking to your doctor.<\/p>\n\n\n\n<p>When a patient no longer needs treatment with Oxikodon&nbsp;Depot&nbsp;Actavis, it is advisable to reduce the&nbsp;dose&nbsp;gradually to prevent withdrawal symptoms.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>If you experience any of the following\u00a0side effects, stop using Oxikodon\u00a0Depot\u00a0Actavis immediately and contact your doctor\u00a0or go to the nearest emergency room:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Respiratory depression (shallow breathing)<\/strong>\u00a0is the most serious risk caused by\u00a0opioids\u00a0and is most likely to occur in elderly or debilitated patients.\u00a0This can also lead to a sharp drop in blood pressure.<\/li><li><strong>severe allergic reactions (anaphylactic\u00a0shock\u00a0)<\/strong>\u00a0which may cause\u00a0hives, swelling of the face, lips, mouth, tongue, or throat, or difficulty breathing.<\/li><li><strong>reduction in pupil size<\/strong><\/li><li><strong>sudden difficulty breathing<\/strong>\u00a0(\u00a0bronchospasm\u00a0)<\/li><li><strong>abdominal cramps<\/strong>\u00a0(\u00a0spasm\u00a0in the smooth muscles around the intestines)<\/li><li><strong>subdued cough reflex.<\/strong><\/li><\/ul>\n\n\n\n<p><strong>Other possible&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p><strong>Very common (may affect more than 1 user in 10):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>decreased level of consciousness (fatigue to drowsiness).\u00a0This usually occurs at the beginning of your treatment or if you increase the\u00a0dose\u00a0one and usually disappear after a few days.<\/li><li>dizziness.<\/li><li>headache.<\/li><li>constipation.<\/li><li>nausea.<\/li><li>vomiting.<\/li><li>itching.<\/li><\/ul>\n\n\n\n<p><strong>Common (may affect up to 1 in 10 people):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>a feeling of weakness (\u00a0asthenia\u00a0)<\/li><li>various psychological\u00a0side effects\u00a0are such as:<ul><li>mood swings (such as anxiety, depression).<\/li><li>altered activity level (nervousness and sleep disorders).<\/li><li>altered behavior (thought disorders, confusion, memory loss, isolated cases of speech disorders).<\/li><\/ul><\/li><li>tremors or involuntary tremors.<\/li><li>shortness of breath.<\/li><li>difficulty breathing or wheezing.<\/li><li>dry mouth, in rare cases together with thirst, stomach problems such as stomach pain, diarrhea, indigestion, decreased appetite.<\/li><li>skin problems such as rash, in rare cases, increased sensitivity to sunlight (\u00a0photosensitivity\u00a0), in some cases\u00a0itching\u00a0or scaly rash, sweating.<\/li><li>problems urinating (increased need to urinate).<\/li><\/ul>\n\n\n\n<p><strong>Uncommon (may affect up to 1 in 100 people):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>allergic reactions.<\/li><li>dehydration.<\/li><li>the feeling of anxiety or upset.<\/li><li>emotional fluctuations such as unstable emotional state, personality change, an abnormal feeling of happiness and seeing, hearing, or feeling things that are not there (hallucinations), altered taste buds, visual disturbances, unusually sharp hearing, feeling dizzy or dizzy, decreased sex drive;\u00a0dependent (see section 2).<\/li><li>abnormal secretion of\u00a0antidiuretic hormone.<\/li><li>memory gaps, seizures, difficulty stretching muscles, increased or decreased\u00a0muscle tone, ticks, decreased sensitivity to touch, coordination difficulties, speech difficulties, fainting, and crawling.<\/li><li>feeling sick, increased\u00a0heart rate, awareness of the heartbeat.<\/li><li>dilated blood vessels.<\/li><li>cough, sore throat, runny nose, voice changes, difficulty breathing.<\/li><li>cold sores,\u00a0inflammation\u00a0of the gums,\u00a0inflammation\u00a0of the mouth, difficulty swallowing, gas, constipation in the intestine.<\/li><li>elevated liver enzymes.<\/li><li>dry skin.<\/li><li>difficulty urinating.<\/li><li>impaired sexual function,\u00a0impotence.<\/li><li>injuries as a result of accidents.<\/li><li>pain (eg chest pain), too much fluid in the\u00a0tissues\u00a0(\u00a0edema\u00a0), chills, thirst,\u00a0migraine, physical dependence with withdrawal symptoms.<\/li><li>changes in tear flow, contraction of the\u00a0pupils, visual disturbances.<\/li><\/ul>\n\n\n\n<p><strong>Rare (may affect up to 1 in 1,000 people):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>a disease of the lymph nodes.<\/li><li>lowering of\u00a0blood pressure, dizziness when standing up from sitting or lying down.<\/li><li>muscle spasms (involuntary muscle contractions).<\/li><li>bleeding gums, increased appetite, dark-colored stools, stains on the teeth.<\/li><li>herpes\u00a0simplex (a disease that affects the skin and mucous membranes).<\/li><li>itchy skin rash (hives).<\/li><li>blood in the urine.<\/li><li>changes in body weight (increased or decreased),\u00a0cellulite\u00a0(\u00a0inflammation\u00a0of the subcutaneous tissue).<\/li><\/ul>\n\n\n\n<p><strong>Very rare (may affect up to 1 in 10,000 people):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>severe allergic reactions (anaphylactic reactions).<\/li><li>aggression.<\/li><li>increased pain sensitivity which is not improved by increased\u00a0dosage.<\/li><li>caries.<\/li><li>pain on the right side of the stomach,\u00a0itching,\u00a0and jaundice caused by\u00a0inflammation\u00a0of the gallbladder.<\/li><li>menstrual failure.<\/li><li>Long-term use of Oxycodone\u00a0Depot\u00a0Actavis during pregnancy may cause life-threatening withdrawal symptoms in newborns.\u00a0Symptoms to look out for are e.g.\u00a0irritability, hyperactivity and abnormal sleep patterns, screams, tremors, vomiting, diarrhea, and lack of weight gain.<\/li><\/ul>\n\n\n\n<p><strong>Prevention:<\/strong><\/p>\n\n\n\n<p>If you experience any of the&nbsp;side effects&nbsp;mentioned above, your doctor will usually take the necessary measures.&nbsp;Side effects&nbsp;in the form of constipation can be prevented through a fiber-enriched diet and increased fluid intake.&nbsp;If you suffer from nausea or vomiting, your doctor will prescribe a suitable medicine for this.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Oxikodon Depot Actavis<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the label or carton after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p><em>Blister packs:<\/em><\/p>\n\n\n\n<p>Do not store above 25 \u00b0 C.<\/p>\n\n\n\n<p><em>HDPE can<\/em>&nbsp;:<\/p>\n\n\n\n<p>5 mg, 10 mg, 15 mg: Do not store above 30 \u00b0 C.<\/p>\n\n\n\n<p>20 mg, 30 mg, 40 mg, 60 mg, 80 mg: No special storage instructions.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is oxycodone hydrochloride.\u00a0Each tablet contains 5, 10, 15, 20, 30, 40, 60 or 80 mg of oxycodone hydrochloride.<\/li><li>Other ingredients are Tablet core: Lactose\u00a0monohydrate, hypromellose, povidone, stearic acid, magnesium stearate,\u00a0colloidal\u00a0anhydrous silica. <em>Tablet coating:<\/em>5 mg tablets: polyvinyl alcohol, titanium dioxide (E171), macrogol, talc, blue indigo carmine (E132), yellow iron oxide (E172).10 mg tablets: titanium dioxide (E171), hypromellose, macrogol, polysorbate 80.15 mg tablets: polyvinyl alcohol, titanium dioxide (E171), macrogol, talc, yellow iron oxide (E172), black iron oxide (E172).20 mg tablets: polyvinyl alcohol, titanium dioxide (E171), macrogol, talc, red iron oxide (E172).30 mg tablets: polyvinyl alcohol, macrogol, talc, red iron oxide (E172), black iron oxide (E172), blue indigo carmine (E132).40 mg tablets: polyvinyl alcohol, titanium dioxide (E171), macrogol, talc, yellow iron oxide (E172).60 mg tablets: polyvinyl alcohol, macrogol, talc, red iron oxide (E172), black iron oxide (E172), blue indigo carmine (E132).80 mg tablets: polyvinyl alcohol, titanium dioxide (E171), macrogol, talc, blue indigo carmine (E132), yellow iron oxide (E172).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p>Oxycodone\u00a0Depot\u00a0Actavis 5 mg\u00a0prolonged-release tablets\u00a0are blue, round, biconvex tablets, 7 mm in diameter marked with \u201cOX 5\u201d on one side.<\/p>\n\n\n\n<p>Oxycodone\u00a0Depot\u00a0Actavis 10 mg\u00a0prolonged-release tablets\u00a0are white, round, biconvex tablets, 9 mm in diameter marked with \u201cOX 10\u201d on one side.<\/p>\n\n\n\n<p>Oxycodone\u00a0Depot\u00a0Actavis 15 mg\u00a0prolonged-release tablets\u00a0are gray, round, biconvex tablets, 9 mm in diameter marked with \u201cOX 15\u201d on one side.<\/p>\n\n\n\n<p>Oxycodone\u00a0Depot\u00a0Actavis 20 mg\u00a0prolonged-release tablets\u00a0are pink, round, biconvex tablets, 7 mm in diameter marked with \u201cOX 20\u201d on one side.<\/p>\n\n\n\n<p>Oxycodone&nbsp;Depot&nbsp;Actavis 30 mg&nbsp;prolonged-release tablets&nbsp;are brown, round, biconvex tablets, 9 mm in diameter marked with \u201cOX 30\u201d on one side.<\/p>\n\n\n\n<p>Oxycodone\u00a0Depot\u00a0Actavis 40 mg\u00a0prolonged-release tablets\u00a0are yellow, round, biconvex tablets, 7 mm in diameter marked with \u201cOX 40\u201d on one side.<\/p>\n\n\n\n<p>Oxycodone&nbsp;Depot&nbsp;Actavis 60 mg&nbsp;prolonged-release tablets&nbsp;are red, round, biconvex tablets, 9 mm in diameter marked with \u201cOX 60\u201d on one side.<\/p>\n\n\n\n<p>Oxycodone&nbsp;Depot&nbsp;Actavis 80 mg&nbsp;prolonged-release tablets&nbsp;are green, round, biconvex tablets, 9 mm in diameter marked with \u201cOX 80\u201d on one side.<\/p>\n\n\n\n<p>Oxycodone&nbsp;Depot&nbsp;Actavis is available in blister packs for:<\/p>\n\n\n\n<p>5 mg: 1, 20, 28, 30, 50, 56, 60 and 100&nbsp;prolonged-release tablets&nbsp;.<\/p>\n\n\n\n<p>10 mg, 20 mg, 40 mg, 80 mg: 1, 20, 28, 30, 50, 56, 60, 98 and 100&nbsp;prolonged-release tablets&nbsp;.<\/p>\n\n\n\n<p>15 mg: 1, 20, 28, 30, 50, 56, 98 and 100&nbsp;prolonged-release tablets&nbsp;.<\/p>\n\n\n\n<p>30 mg, 60 mg: 1, 20, 28, 30, 50, 56, 98 and 100&nbsp;prolonged-release tablets&nbsp;.<\/p>\n\n\n\n<p>Oxycodone&nbsp;Depot&nbsp;Actavis is available in child-resistant blister packs for:<\/p>\n\n\n\n<p>5 mg: 1, 20, 28, 30, 50, 56, 60 and 100&nbsp;prolonged-release tablets&nbsp;.<\/p>\n\n\n\n<p>10 mg, 20 mg, 40 mg, 80 mg: 1, 20, 28, 30, 50, 56, 60, 98 and 100&nbsp;prolonged-release tablets&nbsp;.<\/p>\n\n\n\n<p>15 mg: 1, 20, 28, 30, 50, 56, 98 and 100&nbsp;prolonged-release tablets&nbsp;.<\/p>\n\n\n\n<p>30 mg, 60 mg: 1, 20, 28, 30, 50, 56, 98 and 100&nbsp;prolonged-release tablets&nbsp;.<\/p>\n\n\n\n<p>Oxycodone\u00a0Depot\u00a0Actavis is also available in white, round, child-resistant HDPE jars with PP lids containing 98 or 100\u00a0prolonged-release tablets.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Actavis Group PTC EHF<\/p>\n\n\n\n<p>Reykjav\u00edkurvegur 76 78<\/p>\n\n\n\n<p>220 Hafnarfj\u00f6r\u00f0ur<\/p>\n\n\n\n<p>Iceland<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Balkanpharma Dupnitsa AD<\/p>\n\n\n\n<p>3 Samokovsko Shosse Str.<\/p>\n\n\n\n<p>Dupnitsa 2600<\/p>\n\n\n\n<p>Bulgaria<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Oxycodone Depot Actavis contains the active substance oxycodone hydrochloride, which belongs to a group of medicines called opioids. These are strong painkillers.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18526],"tags":[20530,16085,20525,20529,20528,16081,16084,20507,20526,16082,20527,16091],"class_list":["post-20125","post","type-post","status-publish","format-standard","hentry","category-medicines","category-o","tag-benefits-of-oxycodone-depot","tag-benefits-of-oxycodone-hydrochloride","tag-oxycodone-depot","tag-oxycodone-depot-side-effects","tag-oxycodone-depot-tablet","tag-oxycodone-hydrochloride","tag-oxycodone-hydrochloride-side-effects","tag-oxycodone-hydrochloride-tablet","tag-what-is-oxycodone-depot","tag-what-is-oxycodone-hydrochloride","tag-what-oxycodone-depot-is-used-for","tag-what-oxycodone-hydrochloride-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20125","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=20125"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20125\/revisions"}],"predecessor-version":[{"id":20189,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20125\/revisions\/20189"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=20125"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=20125"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=20125"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}