{"id":20123,"date":"2022-03-26T07:39:17","date_gmt":"2022-03-26T07:39:17","guid":{"rendered":"https:\/\/zeepedia.com\/?p=20123"},"modified":"2022-03-28T08:25:34","modified_gmt":"2022-03-28T08:25:34","slug":"oxycodone-depot-acino","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/oxycodone-depot-acino\/","title":{"rendered":"Oxycodone Depot Acino &#8211; Oxycodone hydrochloride uses, dose and side effects"},"content":{"rendered":"\n<p>10 mg&nbsp;prolonged-release tablet&nbsp;is<br>oxycodone hydrochloride<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Oxikodon Depot Acino is and what it is used for<\/h2>\n\n\n\n<p>Oxycodone\u00a0Depot\u00a0Acino\u00a0prolonged-release tablets\u00a0are a centrally acting, strong painkiller from the\u00a0opioid\u00a0group.<\/p>\n\n\n\n<p>Oxycodone&nbsp;Depot&nbsp;Acino&nbsp;prolonged-release tablets&nbsp;are used to treat severe pain which can only be treated satisfactorily with opioid painkillers.<\/p>\n\n\n\n<p>Oxycodone hydrochloride contained in Oxycodone\u00a0Depot\u00a0Acino\u00a0prolonged-release tablets\u00a0may also be approved for the treatment of other conditions not mentioned in this leaflet.\u00a0Ask your doctor, pharmacist, or another healthcare professional if you have any further questions, and always follow their instructions.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before taking Oxycodone Deopt Acino prolonged-release tablets<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Oxycodone Depot Acino prolonged-release tablets<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to oxycodone or any of the other ingredients of this medicine, (listed in section 6)<\/li><li>if you suffer from severe respiratory distress (\u00a0respiratory depression\u00a0) with too little oxygen in the blood (\u00a0hypoxia\u00a0) and\/or too much\u00a0carbon dioxide\u00a0in the blood,<\/li><li>if you suffer from severe\u00a0chronic obstructive pulmonary disease, cor pulmonale (heart changes due to constant congestion of the circulation in the lungs) or, severe\u00a0bronchial asthma,<\/li><li>if you suffer from intestinal obstruction (paralytic\u00a0ileus\u00a0),<\/li><li>if you have severe abdominal pain or suffer from delayed emptying of the stomach,<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before taking Oxikodon\u00a0Depot\u00a0Acino\u00a0prolonged-release tablets<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are elderly or debilitated,<\/li><li>if your lung, liver, or kidney function is severely impaired,<\/li><li>if you suffer from\u00a0myxedema\u00a0(a certain disease of the thyroid gland), impaired function of the thyroid gland,<\/li><li>if you suffer from insufficient adrenal function (\u00a0Addison&#8217;s disease\u00a0),<\/li><li>if you suffer from prostate\u00a0hypertrophy,<\/li><li>if you suffer from adrenal insufficiency,<\/li><li>if you suffer from alcoholism or undergo alcohol withdrawal,<\/li><li>if you suffer from a known opioid addiction,<\/li><li>if you suffer from\u00a0inflammation\u00a0of the pancreas (pancreatitis),<\/li><li>in conditions with increased pressure in the brain, (eg after head injury)<\/li><li>if you suffer from disorders of the regulation of blood circulation,<\/li><li>if you suffer from\u00a0colic\u00a0in the bile ducts and ureter,<\/li><li>if you suffer from\u00a0inflammatory\u00a0bowel disease,<\/li><li>if you have low\u00a0blood pressure, (\u00a0hypotension\u00a0)<\/li><li>if you suffer from decreased blood volume, (\u00a0hypovolemia\u00a0)<\/li><li>if you suffer from\u00a0epilepsy\u00a0or tend to have seizures,<\/li><li>if you are taking\u00a0MAOIs\u00a0(to treat depression).<\/li><\/ul>\n\n\n\n<p>Oxycodone should be used with caution in patients who have undergone abdominal surgery as opiates are known to reduce bowel motility.<\/p>\n\n\n\n<p>Oxycodone&nbsp;Depot&nbsp;Acino&nbsp;prolonged-release tablets&nbsp;are not recommended before or within 12-24 hours after surgery.<\/p>\n\n\n\n<p>Oxycodone&nbsp;Depot&nbsp;Acino&nbsp;prolonged-release tablets&nbsp;have a primary dependence potential.&nbsp;When used for a long time, tolerance to the effect and gradually higher&nbsp;doses&nbsp;may be required to maintain control over the pain.<\/p>\n\n\n\n<p>Chronic\u00a0use of Oxikodon\u00a0Depot\u00a0Acino\u00a0prolonged-release tablets\u00a0can lead to physical dependence and withdrawal syndrome may occur with abrupt discontinuation of treatment.\u00a0These symptoms may include yawning, enlarged\u00a0pupils, increased tear production, runny nose, tremors, increased sweating, anxiety, upset, twitching, and insomnia.\u00a0When a patient no longer needs oxycodone treatment, it is advisable to reduce the\u00a0dose\u00a0gradually to prevent withdrawal symptoms.<\/p>\n\n\n\n<p>When used as directed, in patients with&nbsp;chronic&nbsp;pain, the risk of developing physical or mental dependence is significantly reduced and needs to be weighed against the potential benefits.&nbsp;Discuss this with your doctor.<\/p>\n\n\n\n<p>If you drink alcohol while taking Oxikodon\u00a0Depot\u00a0Acino, it may make you feel more sleepy or increase the risk of serious\u00a0side effects\u00a0such as\u00a0shallow breathing with a risk of respiratory arrest and unconsciousness.\u00a0You should not drink alcohol while taking Oxycodone\u00a0Depot\u00a0Acino.<\/p>\n\n\n\n<p>The prolonged-release tablets&nbsp;should not be given to patients with known alcohol and drug abuse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Oxycodone&nbsp;Depot&nbsp;Acino is not recommended for use in children and adolescents under 18 years of age.<\/p>\n\n\n\n<p><strong>Elderly patients<\/strong><\/p>\n\n\n\n<p>In elderly patients,&nbsp;dose&nbsp;adjustment is usually not necessary.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Oxycodone Depot Acino<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Medicines that suppress the activity of the\u00a0central nervous system\u00a0(eg sleeping pills or sedatives [sedatives,\u00a0hypnotics\u00a0], other medicines that affect the nervous system [phenothiazines,\u00a0neuroleptics\u00a0], medicines used to treat\u00a0allergies\u00a0or vomiting [antihistamines, antiemetics\u00a0], and other\u00a0opioids\u00a0or alcohol may aggravate the\u00a0side effects\u00a0of oxycodone, in particular respiratory depression (\u00a0respiratory depression\u00a0).<\/li><li>Drugs with anticholinergic effects (eg drugs that suppress\u00a0psychosis\u00a0[neuroleptics], drugs used to treat\u00a0allergies\u00a0[antihistamines] or vomiting [antiemetics], drugs used to treat\u00a0Parkinson&#8217;s disease\u00a0) may aggravate some of the\u00a0side effects\u00a0of oxycodone ( eg constipation,\u00a0dry mouth\u00a0or urinary disorders) Cimetidine may\u00a0inhibit\u00a0the breakdown of oxycodone.\u00a0The effects of other drugs that may have a significant effect on the degradation of oxycodone have not been studied.<\/li><li>Monoamine oxidase inhibitors\u00a0(MAOIs) may potentiate the\u00a0side effects\u00a0of oxycodone (eg, stimulation of increased or decreased\u00a0blood pressure\u00a0).\u00a0Oxycodone should be used with caution in patients taking or have taken MAOIs in the last 2 weeks<\/li><li>In individual cases, more or less extensive blood clot formation has been observed when anticoagulant drugs (coumarin-type anticoagulants) are taken with Oxycodone\u00a0Depot\u00a0Acino\u00a0prolonged-release tablets.<\/li><\/ul>\n\n\n\n<p>Concomitant use of the following drugs may lead to reduced degradation of oxycodone in the body, which may lead to increased blood concentrations and the effects of oxycodone:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Medicines for the treatment of\u00a0infections\u00a0caused by bacteria, so-called macrolide antibiotics (eg clarithromycin, erythromycin, and telithromycin)<\/li><li>Medicines for the treatment of fungal infections (eg\u00a0ketoconazole\u00a0, voriconazole, itraconazole and posaconazole)<\/li><li>Drugs called\u00a0protease inhibitors\u00a0and used to treat\u00a0HIV\u00a0(eg boceprevir, ritonavir, indinavir, nelfinavir, and saquinavir).<\/li><li>The antidepressant drug\u00a0paroxetine<\/li><li>The antiarrhythmic drug\u00a0quinidine\u00a0and<\/li><li>Grapefruit juice<\/li><\/ul>\n\n\n\n<p>Dose&nbsp;one of oxycodone may need to be adjusted during concomitant treatment.<\/p>\n\n\n\n<p>The following drugs may increase the breakdown of oxycodone in the body, which may lead to a reduction in the effects of oxycodone:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Rifampicin (\u00a0antibiotic\u00a0)<\/li><li>Carbamazepine and\u00a0phenytoin\u00a0(\u00a0antiepileptic drugs\u00a0)<\/li><li>St. John&#8217;s wort (natural remedy)<\/li><\/ul>\n\n\n\n<p>Dose&nbsp;one of oxycodone may need to be adjusted during concomitant treatment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Oxycodone Depot Acino with food, drink, and alcohol<\/h2>\n\n\n\n<p>Alcohol intensifies alertness and reactivity and may potentiate&nbsp;side effects&nbsp;such as drowsiness and shortness of breath.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding, and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n<p><em><strong>Pregnancy<\/strong><\/em><\/p>\n\n\n\n<p>Do not use Oxycodone\u00a0Depot\u00a0Acino\u00a0prolonged-release tablets\u00a0if you are pregnant.\u00a0There are limited data from the use of oxycodone in pregnant women.<\/p>\n\n\n\n<p>Oxycodone passes through the placenta and into the baby&#8217;s bloodstream.<\/p>\n\n\n\n<p>Long-term use of oxycodone during pregnancy may cause withdrawal symptoms in newborns.\u00a0The use of oxycodone during childbirth may cause\u00a0respiratory depression\u00a0in newborns.<\/p>\n\n\n\n<p><strong>Breast-feeding<\/strong><\/p>\n\n\n\n<p>Do not use Oxycodone\u00a0Depot\u00a0Acino\u00a0prolonged-release tablets\u00a0while breastfeeding as oxycodone passes into breast milk and may cause\u00a0respiratory depression\u00a0in newborns.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Oxycodone can impair alertness and responsiveness to such an extent that the ability to drive and use machines is affected or ceases altogether.&nbsp;To see the&nbsp;side effects&nbsp;that affect motor skills and concentration, see section 4 (Possible&nbsp;side effects&nbsp;).<\/p>\n\n\n\n<p>In stable treatment, a general ban on driving is not necessary.&nbsp;The attending physician must assess the individual situation.&nbsp;Discuss with your doctor if and under what circumstances you can drive a vehicle.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened vigilance.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0Descriptions of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Therefore, read all the information in this leaflet<\/p>\n\n\n\n<p>guidance.&nbsp;If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Oxycodone Depot Acino contains excipients<\/h2>\n\n\n\n<p>This medicine contains sugar (sucrose).&nbsp;If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Oxycodone Depot Acino prolonged-release tablets<\/h2>\n\n\n\n<p>Always take this medicine exactly as your doctor has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p>The recommended&nbsp;dose&nbsp;is:<\/p>\n\n\n\n<p><strong>Oxycodone\u00a0Depot\u00a0Acino 10 mg prolonged-release tablets:<\/strong><\/p>\n\n\n\n<p><strong>Adults (over 18 years)<\/strong><\/p>\n\n\n\n<p>The usual starting dose is 10 mg oxycodone hydrochloride (1\u00a0prolonged-release tablet\u00a0) at 12-hour intervals.\u00a0However, your doctor will prescribe the\u00a0dose\u00a0needed to treat the pain.<\/p>\n\n\n\n<p>Further determination of the daily\u00a0dose\u00a0one, division into single doses, and any adjustments during the further treatment is performed by the attending physician and depends on the previous\u00a0dose\u00a0one.<\/p>\n\n\n\n<p>Patients who have previously taken\u00a0opioids\u00a0can start treatment with higher\u00a0doses, taking into account their previous experience with opioid treatment.<\/p>\n\n\n\n<p>Some patients taking Oxikodon\u00a0Depot\u00a0Acino 10 mg\u00a0prolonged-release tablets\u00a0according to a fixed schedule need fast-acting pain relief when needed to control breakthrough pain.\u00a0Oxycodone Acino 10 mg\u00a0prolonged-release tablets\u00a0are not intended for the treatment of\u00a0acute\u00a0pain and\/or breakthrough pain.<\/p>\n\n\n\n<p>To treat non-cancerous pain, a&nbsp;dose&nbsp;of 2&nbsp;prolonged-release tablets&nbsp;twice daily (40 mg oxycodone hydrochloride daily) is usually sufficient, but a higher&nbsp;dose&nbsp;may be necessary.<\/p>\n\n\n\n<p>Patients with cancer pain usually require a&nbsp;dose&nbsp;of 80 mg to 120 mg of oxycodone hydrochloride, which can be increased to 400 mg in individual cases.<\/p>\n\n\n\n<p>For higher\u00a0doses, Oxikodon\u00a0Depot\u00a0Acino 20 mg, 40 mg, and 80 mg\u00a0prolonged-release tablets\u00a0are available.<\/p>\n\n\n\n<p>The treatment needs to be checked regularly about pain relief and other effects to achieve the best possible pain treatment and to be able to treat any\u00a0side effects\u00a0that occur in good time and to decide whether the treatment should continue.<\/p>\n\n\n\n<p><strong>At-risk patients<\/strong><\/p>\n\n\n\n<p>If you have impaired kidney and\/or liver function, your doctor may prescribe a lower starting dose.<\/p>\n\n\n\n<p>Oxycodone&nbsp;Depot&nbsp;Acino&nbsp;prolonged-release tablets&nbsp;must not be taken with alcoholic beverages.<\/p>\n\n\n\n<p><strong>Method of administration and treatment time<\/strong><\/p>\n\n\n\n<p>The prolonged-release tablets\u00a0should be swallowed (whole or divided) with a sufficient amount of liquid (\u00bd glass of water) with or without food in the morning and the evening according to a fixed schedule (eg 8.00 in the morning and 20.00 in the evening).<\/p>\n\n\n\n<p>The prolonged-release tablets\u00a0must not be crushed or chewed as this will lead to rapid\u00a0release\u00a0of oxycodone due to damage to the sustained\u00a0release\u00a0properties.\u00a0Ingestion of chewed or crushed Oxycodone\u00a0Depot\u00a0Acino\u00a0prolonged-release tablets\u00a0leads to rapid\u00a0release\u00a0and rapid uptake of a potentially lethal\u00a0dose of\u00a0oxycodone (see section\u00a0\u201cIf you have taken too much\u00a0Oxycodone<strong>\u00a0Depot\u00a0Acino prolonged-release tablets\u201d<\/strong>\u00a0).<\/p>\n\n\n\n<p>Oxycodone\u00a0Depot\u00a0Acino\u00a0prolonged-release tablets\u00a0should be swallowed orally.\u00a0When\u00a0used for injection\u00a0(\u00a0injection\u00a0into a vein), the tablet&#8217;s excipients (especially talc) can lead to death (\u00a0necrosis\u00a0) of local\u00a0tissue, changes in the lungs (granulomas in the lungs), or other serious, possibly fatal consequences.<\/p>\n\n\n\n<p><strong>Instructions for opening the blister:<\/strong><\/p>\n\n\n\n<p>This medicine is supplied in a child-resistant package.&nbsp;The film-coated tablets cannot be squeezed through the blister.&nbsp;Follow these instructions when opening the blister.<\/p>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20070730000056#\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.fass.se\/res\/RootMedia\/Orion20Pharma\/Media\/Oxikodon20Acino\/Oxikodon20Acino20bild201.jpg\" alt=\"Instruction childproof blister\" title=\"Instruction childproof blister\"\/><\/a><\/figure>\n\n\n\n<p>Subtract a&nbsp;dose&nbsp;by tearing the blister at the perforated line.<\/p>\n\n\n\n<p>2. An unsealed part of the blister, where the perforated lines meet, then becomes available.<\/p>\n\n\n\n<p>3. Peel off the foil on the unsealed part of the blister.<\/p>\n\n\n\n<p>Your doctor will adjust your&nbsp;dosage&nbsp;depending on how severe the pain is and how the treatment works for you.&nbsp;Take the number of&nbsp;prolonged-release tablets&nbsp;you have been prescribed by your doctor twice a day.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you take more Oxikodon Depot Acino prolonged-release tablets then you should<\/h2>\n\n\n\n<p>If you have ingested too much medicine or if e.g.\u00a0a child ingested the medicine accidentally contact a doctor or hospital immediately for risk assessment and advice.<\/p>\n\n\n\n<p>The following symptoms may occur constricted\u00a0pupils\u00a0(\u00a0miosis\u00a0), impaired breathing (\u00a0respiratory depression\u00a0), skeletal muscle weakness, and a drop in blood pressure.\u00a0In severe cases, circulatory collapse, mental and physical inactivity (dormancy), unconsciousness (\u00a0coma\u00a0), decrease in heart rate, and accumulation of water in the lungs (non-cardiogenic\u00a0edema\u00a0) may occur;\u00a0abuse of high\u00a0doses\u00a0of strong\u00a0opioids\u00a0such as oxycodone can be fatal.\u00a0Under no circumstances should you be\u00a0exposed\u00a0to situations that require increased concentration, such as driving a car.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Oxikodon Depot Acino prolonged-release tablets<\/h2>\n\n\n\n<p>If you have taken a smaller&nbsp;dose of&nbsp;Oxikodon&nbsp;Depot&nbsp;Acino&nbsp;prolonged-release tablet&nbsp;than instructed or if you miss taking tablets, the pain relief will be insufficient or stop completely.<\/p>\n\n\n\n<p>You can make up for a missed tablet if the next regular intake is not to take place until at least 8 hours.&nbsp;You can then continue to take tablets as instructed,<\/p>\n\n\n\n<p>You can also take a&nbsp;prolonged-release tablet&nbsp;if the time to the next regular intake is shorter, but postpone the next intake by 8 hours.&nbsp;In principle, you should not take Oxikodon&nbsp;Depot&nbsp;Acino&nbsp;prolonged-release tablets&nbsp;more than once every 8 hours.<\/p>\n\n\n\n<p>Do not take a double&nbsp;dose&nbsp;to make up for a forgotten tablet.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking Oxikodon prolonged-release Acino prolonged-release tablets<\/h2>\n\n\n\n<p>Do not stop treatment without informing your doctor.\u00a0When a patient no longer needs to be treated with Oxikodon\u00a0Depot\u00a0Acino\u00a0prolonged-release tablets, it is advisable to reduce the daily\u00a0dose\u00a0gradually to avoid withdrawal symptoms.\u00a0If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Important serious&nbsp;side effects&nbsp;or symptoms that you should be aware of and actions to take when these&nbsp;side effects&nbsp;or symptoms occur:<\/strong><\/p>\n\n\n\n<p>If you get any of the following\u00a0side effects, stop taking Oxikodon\u00a0Depot\u00a0Acino\u00a0prolonged-release tablets\u00a0and contact your doctor immediately.<\/p>\n\n\n\n<p>Respiratory depression\u00a0is the most significant risk posed by opioids and is most likely to occur in elderly or debilitated patients.\u00a0As a result,\u00a0opioids\u00a0can cause a sharp drop in blood pressure in patients prone to low blood pressure.<\/p>\n\n\n\n<p>In addition to this, oxycodone can cause constricted\u00a0pupils, tracheal spasms, and\u00a0spasms\u00a0in the smooth muscles and dampen the cough reflex.<\/p>\n\n\n\n<p><strong>Other possible&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p><strong>Very common (may affect more than 1 in 10 people):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Drowsiness dizziness;&nbsp;headache<\/li><li>constipation;&nbsp;nausea;&nbsp;vomiting<\/li><li>itching<\/li><\/ul>\n\n\n\n<p><strong>Common (may affect up to 1 in 10 people):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Loss of appetite, anxiety, depression, changes in activation (usually\u00a0sedation, sometimes followed by drowsiness), nervousness, sleep disturbances, difficulty with the thought process, confusion<\/li><li>involuntary muscle contractions (shaking)<\/li><li>bronchial spasms (difficulty breathing or wheezing), shortness of breath (\u00a0dyspnoea\u00a0)<\/li><li>dry mouth, stomach pain, diarrhea, stomach upset (acid regurgitation)<\/li><li>skin rash, increased sweating<\/li><li>a feeling of weakness (\u00a0asthenia\u00a0)<\/li><\/ul>\n\n\n\n<p><strong>Uncommon (may affect up to 1 in 100 people):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Hypersensitivity reactions\u00a0(allergic reactions)<\/li><li>Increased secretion of\u00a0antidiuretic hormone\u00a0(\u00a0ADH\u00a0), less water in the body (dehydration)<\/li><li>Upset, emotional instability,\u00a0euphoria, decreased sex drive, drug abuse<\/li><li>Memory loss (\u00a0amnesia\u00a0), seizures (cramps), increased muscle tension, involuntary muscle twitching, decreased sensitivity to touch (\u00a0hypesthesia\u00a0), language disturbance, fainting, tingling (\u00a0paresthesia\u00a0), taste changes (\u00a0dysgeusia\u00a0)<\/li><li>Changes in tear secretion, visual impairment, pupillary\u00a0contraction.<\/li><li>Dizziness (\u00a0vertigo\u00a0),\u00a0acute\u00a0increased sensitivity to sound (hyperacusis)<\/li><li>Awareness of heartbeat (in connection with withdrawal syndrome)<\/li><li>dilated blood vessels (\u00a0vasodilation\u00a0)<\/li><li>Increased cough;\u00a0inflammation\u00a0of the pharynx;\u00a0Suva;\u00a0voice changes,\u00a0respiratory depression<\/li><li>Gallkolik;\u00a0sores in the mouth;\u00a0gingivitis,\u00a0inflammation\u00a0of the mouth (\u00a0stomatitis\u00a0), difficulty swallowing (\u00a0dysphagia\u00a0), flatulence, belching, blockage in the intestine (\u00a0ileus\u00a0)<\/li><li>Increased liver enzymes<\/li><li>Dry skin, herpes simplex<\/li><li>Difficulty urinating (\u00a0urinary retention\u00a0)<\/li><li>Disorder of sexual function<\/li><li>Injuries due to accidents, pain (eg chest pain),\u00a0migraines, tremors, withdrawal syndrome, malaise, swelling of\u00a0tissue\u00a0due to\u00a0fluid retention\u00a0(\u00a0edema\u00a0), tolerance, thirst<\/li><\/ul>\n\n\n\n<p><strong>Rare (may affect up to 1 in 1,000 people):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Lymph node disease (\u00a0lymphadenopathy\u00a0)<\/li><li>Seizures, especially in patients with\u00a0epilepsy\u00a0or patients with a tendency to seizures<\/li><li>Low\u00a0blood pressure, especially when standing up<\/li><li>Hives<\/li><li>Blood in the urine (\u00a0hematuria\u00a0)<\/li><li>Changes in body weight (increase or decrease),\u00a0cellulite<\/li><\/ul>\n\n\n\n<p><strong>No known frequency (can not be calculated from the available data)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Severe\u00a0hypersensitivity reactions\u00a0(anaphylactic reactions)<\/li><li>Aggression<\/li><li>Increased sensitivity to pain<\/li><li>Bleeding in the gums,\u00a0caries, increased appetite, dark stools<\/li><li>Blockage of the bile ducts, sometimes painful (cholestasis, biliary\u00a0colic\u00a0)<\/li><li>Absence of menstrual bleeding (\u00a0amenorrhea\u00a0)<\/li><\/ul>\n\n\n\n<p><strong>Countervailing measures<\/strong><\/p>\n\n\n\n<p>If you notice any of the\u00a0side effects\u00a0described above, your doctor will take appropriate action.<\/p>\n\n\n\n<p>Constipation side effects can be prevented by a high-fiber diet and increased water intake.<\/p>\n\n\n\n<p>If you suffer from nausea or vomiting, your doctor will prescribe the appropriate medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Oxikodon Depot Acino<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the blister \/ can and on the carton after \u201cEXP\u201d.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Do not store above 30 \u00b0 C.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">6. Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<p><strong>Oxycodone\u00a0Depot\u00a0Acino contains\u00a010 mg\u00a0prolonged-release tablets<\/strong><\/p>\n\n\n\n<p>&#8211; The active substance is oxycodone hydrochloride.&nbsp;Each&nbsp;prolonged-release tablet&nbsp;contains 10 mg oxycodone hydrochloride equivalent to 9 mg oxycodone.<\/p>\n\n\n\n<p>&#8211; The other ingredients are:<\/p>\n\n\n\n<p>Tablet core: Sugar spheres (sucrose, maize starch), hypromellose, macrogol 6000, talc, ethylcellulose, hydroxypropyl cellulose, propylene glycol, magnesium stearate, microcrystalline cellulose, powdered cellulose, silica\u00a0colloidal\u00a0anhydrous.<\/p>\n\n\n\n<p>Tablet coating: Hypromellose, talc, macrogol 6000, titanium dioxide (E171), brown iron oxide (E 172), red iron oxide (E 172).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and the contents of the pack<\/h2>\n\n\n\n<p><strong>Oxycodone\u00a0Depot\u00a0Acino 10 mg\u00a0prolonged-release tablet\u00a0your appearance and pack sizes<\/strong><\/p>\n\n\n\n<p>Oxycodone\u00a0Depot\u00a0Acino 10 mg\u00a0prolonged-release tablets\u00a0are brown-red, biconvex, oblong\u00a0prolonged-release tablets\u00a0with a scoreline on both sides.<\/p>\n\n\n\n<p>Oxycodone&nbsp;Depot&nbsp;Acino 10 mg&nbsp;prolonged-release tablets&nbsp;are available in blister packs, with child-resistant closure, if 10, 14, 20, 25, 28, 30, 40, 50, 56, 60, 98 and 100&nbsp;prolonged-release tablets&nbsp;and in HDPE jars, with PP child-resistant twist-off cap, if 14, 20, 25, 28, 30, 50, 56, 98, 100 and 200&nbsp;prolonged-release tablets&nbsp;.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p>Marketing Authorisation Holder:<\/p>\n\n\n\n<p>Acino AG<\/p>\n\n\n\n<p>Am Windfeld 35<\/p>\n\n\n\n<p>83714 Miesbach<\/p>\n\n\n\n<p>Germany<\/p>\n\n\n\n<p>Manufacturer:<\/p>\n\n\n\n<p>Orion Corporation, Orion Pharma<\/p>\n\n\n\n<p>Orionintie 1<\/p>\n\n\n\n<p>FI-02200 Espoo<\/p>\n\n\n\n<p>Finland<\/p>\n\n\n\n<p>For further information on this medicine, please contact your local representative:<\/p>\n\n\n\n<p>Orion Pharma AB, Danderyd<\/p>\n\n\n\n<p>medinfo@orionpharma.com<\/p>\n\n\n\n<p><strong>This medicinal product is authorized under the European Economic Area under the names:<\/strong><\/p>\n\n\n\n<p>Denmark Oxycodone hydrochloride &#8220;Acino&#8221; 10 mg<\/p>\n\n\n\n<p>Norway Zacrenoxin&nbsp;depot&nbsp;10 mg<\/p>\n\n\n\n<p>Poland Oxycodone Acino 10 mg<\/p>\n\n\n\n<p>Slovakia Oxycodone Acino 10 mg<\/p>\n\n\n\n<p>Germany Oxycodone-&nbsp;HCl&nbsp;-Acino \/ 10 mg<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Oxycodone Depot Acino prolonged-release tablets are a centrally acting, strong painkiller from the opioid group .<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18526],"tags":[20557,16085,20552,20556,20555,16081,16084,20507,20553,16082,20554,16091],"class_list":["post-20123","post","type-post","status-publish","format-standard","hentry","category-medicines","category-o","tag-benefits-of-oxycodone-depot-acino","tag-benefits-of-oxycodone-hydrochloride","tag-oxycodone-depot-acino","tag-oxycodone-depot-acino-side-effects","tag-oxycodone-depot-acino-tablet","tag-oxycodone-hydrochloride","tag-oxycodone-hydrochloride-side-effects","tag-oxycodone-hydrochloride-tablet","tag-what-is-oxycodone-depot-acino","tag-what-is-oxycodone-hydrochloride","tag-what-oxycodone-depot-acino-is-used-for","tag-what-oxycodone-hydrochloride-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20123","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=20123"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20123\/revisions"}],"predecessor-version":[{"id":20190,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20123\/revisions\/20190"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=20123"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=20123"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=20123"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}