How long does the treatment last<\/strong><\/p>\n\n\n\nYour doctor will decide how long the treatment should last.<\/p>\n\n\n\n
If your original tumor has been removed, the treatment will last for a maximum of 6 months.<\/p>\n\n\n\n
If you take more Oxaliplatin Accord than you should<\/h2>\n\n\n\n
The medicine is given by healthcare professionals and it is very unlikely that you will receive too much or too little medicine.<\/p>\n\n\n\n
If overdose nevertheless occurs, you may experience more and more severe\u00a0side effects.\u00a0Your doctor may give you appropriate treatment for the\u00a0side effects.<\/p>\n\n\n\n
If you have any further questions on the use of this product, ask your doctor, healthcare professional, or pharmacist.<\/p>\n\n\n\n
Possible side effects<\/h2>\n\n\n\n
Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n
If you experience any\u00a0side effects, you must tell your doctor before the next treatment.<\/p>\n\n\n\n
You may experience any of the side effects listed below.<\/p>\n\n\n\n
The most serious side effects<\/strong><\/p>\n\n\n\nContact a doctor immediately<\/strong> if you get any of the following symptoms:<\/p>\n\n\n\nVery common<\/strong> (may affect more than 1 user in 10):<\/p>\n\n\n\n- Allergies \/ allergic reactions, occur mainly during infusion one, sometimes with fatal outcome.<\/li>
- Sore lips or sores in the mouth ( stomatitis or mucositis ).<\/li>
- Low platelet count , abnormal bruising (thromocytopenia). Your doctor will take blood samples to check that you have a sufficient amount of blood cells before starting treatment and before each treatment cycle.<\/li>
- Unexplained respiratory problems such as dry cough, difficulty breathing or wheezing.<\/li><\/ul>\n\n\n\n
Common<\/strong> (may affect up to 1 in 10 people):<\/p>\n\n\n\n- Serious infection in the blood in combination with a decrease in the number of white blood cells ( neutropenic sepsis ) which can be fatal.<\/li>
- Decreased white blood cell count accompanied by fever above 38.3 \u00b0 C or prolonged fever above 38 \u00b0 C for more than one hour (febrile neutropenia ).<\/li>
- Symptoms of an allergic or anaphylactic reaction with sudden signs such as rash, itching or hives on the skin, difficulty swallowing, swelling of the face, lips, tongue or other parts of the body, shortness of breath, wheezing or difficulty breathing, extreme fatigue (it may feel like that you will faint). In most cases, these symptoms occur during infusion one or immediately after, but delayed allergic reactions have also been observed hours or even days after infusion one.<\/li>
- Pain in the chest or upper back, difficulty breathing and coughing up blood (signs of blood clot in the lung).<\/li><\/ul>\n\n\n\n
Uncommon<\/strong> (may affect up to 1 in 100 people):<\/p>\n\n\n\n- Serious infection in the blood ( sepsis ), which can be fatal.<\/li>
- Stopping or swelling in the intestine<\/li>
- Difficulty hearing, dizziness, ringing in the ears.<\/li><\/ul>\n\n\n\n
Rare<\/strong> (may affect up to 1 in 1,000 people):<\/p>\n\n\n\n- Unexpected bleeding or bruising due to extensive blood clots in the body’s small blood vessels (disseminated intravascular coagulation ), which can be fatal.<\/li>
- Abnormal bruising, bleeding or signs of infection such as sore throat and fever.<\/li>
- Persistent or severe diarrhea or vomiting.<\/li>
- Transient temporary loss of vision<\/li>
- A group of symptoms such as headache, altered mental functions, seizures and visual disturbances from blurring to loss of vision (symptoms of reversible posterior leukoencephalopathy syndrome, an unusual neurological disease).<\/li>
- Extreme fatigue with decreased red blood cell count and shortness of breath ( haemolytic anemia ), alone or together with low platelet counts , abnormal bruising ( thrombocytopenia ) and kidney disease that means you urinate little or not at all (symptoms of haemolytic uremic syndrome ).<\/li>
- Scarring and thickening of the lungs with difficulty breathing, sometimes with fatal outcome (interstitial lung disease).<\/li>
- Upper abdominal pain and back pain along with nausea and vomiting.<\/li><\/ul>\n\n\n\n
Very rare<\/strong> (may affect up to 1 in 10,000 people):<\/p>\n\n\n\n- Kidney disease which means that you urinate a little or not at all (symptoms of acute kidney failure ).<\/li>
- Disease of the blood vessels of the liver (symptoms that include abdominal pain and swelling, weight gain and swelling of the feet, ankles or other parts of the body).<\/li><\/ul>\n\n\n\n
Has been reported (occurs in an unknown number of users):<\/strong><\/p>\n\n\n\n- Severe infection in the blood and low blood pressure ( septic shock ), which can be fatal.<\/li>
- Abnormal heart rhythm ( QT prolongation) that can be seen on electrocardiograms ( ECG ), which can be fatal.<\/li>
- Muscle pain and swelling, in combination with weakness, fever or red \u2011 brown urine (symptoms of muscle damage called rhabdomyolysis ), which can be fatal.<\/li>
- Abdominal pain, nausea, bloody vomiting or vomiting that looks like “coffee grounds” or dark, tar-like stools (symptoms of ulcers in the gastrointestinal tract, with the risk of bleeding or perforation ), which can be fatal.<\/li>
- Decreased blood flow to the intestines (intestinal ischemia), which can be fatal.<\/li>
- Spasm of the throat leading to difficulty breathing.<\/li>
- Autoimmune reaction leading to decreased number of all types of blood cells ( autoimmune pancytopenia) (with symptoms such as easy bleeding, bruising, shortness of breath, extreme fatigue and weakness and increased risk of infection due to impaired immune status).<\/li>
- Symptoms of stroke (including severe headache, confusion, visual difficulties in one or both eyes, numbness or weakness of face, arm or leg, usually unilateral, drooping face, difficulty walking, dizziness, loss of balance and difficulty speaking).<\/li>
- Pneumonia (severe pneumonia ) which can be fatal<\/li><\/ul>\n\n\n\n
Other known side effects of Oxaliplatin Accord are:<\/strong><\/p>\n\n\n\nVery common<\/strong> (may affect more than 1 user in 10):<\/p>\n\n\n\n- Oxaliplatin Accord may affect the nervous system ( peripheral neuropathy ) and you may experience tingling and \/ or numbness in the fingers, toes, around the mouth or in the throat. These symptoms can sometimes occur along with seizures.These side effects are often triggered by cold such as. when opening the refrigerator or holding a cold beverage. You may also find it difficult to perform fine motor tasks such as pushing buttons. In most cases, the symptoms subside completely by themselves, but there is a risk of persistent symptoms of this nerve disorder after the end of treatment. Some people experience a stinging, shock-like sensation that moves down the arms or torso when bending the neck.<\/li>
- Oxaliplatin Accord can sometimes give rise to an unpleasant sensation in the throat, especially when swallowing and give a feeling of shortness of breath. If this feeling occurs, it usually occurs during or within a few hours after infusion one and can be triggered by cold. Although the feeling is unpleasant, it does not last long and disappears without treatment. The doctor may decide to change the treatment as a result.<\/li>
- Oxaliplatin Accord may cause diarrhea, mild nausea and vomiting. However, you are usually given medicines that prevent nausea before the treatment and possibly also after the treatment.<\/li>
- Oxaliplatin Accord causes a temporary decrease in the amount of blood cells . The decrease in the amount of red blood cells can cause anemia ( anemia ), abnormal bleeding or bruising (due to a reduced amount of platelets ). Reducing the amount of white blood cells can make you more susceptible to infection . Before starting treatment, and at each subsequent treatment, blood samples are taken to check that you have a sufficient number of blood cells .<\/li>
- A feeling of discomfort near or at the injection site during infusion .<\/li>
- Fever, tremors, mild or severe fatigue, body aches.<\/li>
- Weight changes, loss of appetite, taste changes, constipation.<\/li>
- Headache, back pain.<\/li>
- Abnormal sensation in the tongue that can give rise to speech changes.<\/li>
- Abdominal pain.<\/li>
- Abnormal bleeding such as nosebleeds.<\/li>
- Allergic reactions, skin rash that may be red and itchy, mild hair loss ( alopecia ).<\/li>
- Altered blood counts, including abnormal liver function values.<\/li><\/ul>\n\n\n\n
Common<\/strong> (may affect up to 1 in 10 people):<\/p>\n\n\n\n- Indigestion and heartburn, hiccups, hot flashes, dizziness.<\/li>
- Increased sweating and nail problems, scaly skin.<\/li>
- Chest pain.<\/li>
- Pulmonary problems and runny nose.<\/li>
- Pain in joints and skeleton.<\/li>
- Pain when urinating and altered liver function, changes in urination frequency, dehydration.<\/li>
- Blood in urine or feces, swollen blood vessels, blood clots in the lung.<\/li>
- High blood pressure .<\/li>
- Depression and difficulty sleeping.<\/li>
- Inflammation of the conjunctiva of the eye ( conjunctivitis ) and visual problems.<\/li>
- Decreased calcium levels in the blood.<\/li>
- Swelling of the nerves to your muscles, neck stiffness<\/li>
- Fall accident.<\/li><\/ul>\n\n\n\n
Uncommon<\/strong> (may affect up to 1 in 100 people):<\/p>\n\n\n\n- Nervousness.<\/li><\/ul>\n\n\n\n
Rare<\/strong> (may affect up to 1 in 1,000 people):<\/p>\n\n\n\n- Impaired hearing.<\/li><\/ul>\n\n\n\n
Has been reported (occurs in an unknown number of users):<\/strong><\/p>\n\n\n\n- Allergic vasculitis ( inflammation of blood vessels).<\/li>
- Cramps (uncontrolled shaking of the body).<\/li>
- Myocardial infarction, angina pectoris (pain or discomfort in the chest).<\/li>
- Esophagitis ( inflammation (angina) in the esophagus – the tube that connects your mouth to the stomach – which leads to pain and difficulty swallowing).<\/li>
- Risk of new cancer. Leukemia , a form of blood cancer, has been reported in patients following the use of Oxaliplatin Accord in combination with certain other medicines. Talk to your doctor about the increased risk of this type of cancer when using Oxaliplatin Accord and some other medicines.<\/li><\/ul>\n\n\n\n
How to store Oxaliplatin Accord<\/h2>\n\n\n\n
Keep out of sight and reach of children.<\/p>\n\n\n\n
Keep the vial in the outer carton. Sensitive to light. Do not freeze. <\/p>\n\n\n\n
Do not use this medicine after the expiry date which is stated on the outer carton and vial label after EXP. The expiration date is the last day of a specified month.<\/p>\n\n\n\n
Chemical and physical in-use stability has been demonstrated for 48 hours at +2 to + 8 \u00b0 C and for 24 hours at + 25 \u00b0 C. From a microbiological perspective, the infusion preparation should be used immediately. If the reconstituted product is not used immediately, the user is responsible for the storage time and storage conditions before use. Normally the product should not be stored for longer than 24 hours at +2 to + 8 \u00b0 C, unless diluted under controlled and validated aseptic conditions.<\/p>\n\n\n\n
Only clear solutions without particles should be used.<\/p>\n\n\n\n
The medicine should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.<\/p>\n\n\n\n
Avoid contact with eyes and skin. In case of splashes or spills, contact a doctor or healthcare professional immediately.<\/p>\n\n\n\n
After completion of the\u00a0infusion, doctors or healthcare professionals will discard the medicine by taking appropriate precautions.<\/p>\n\n\n\n
Contents of the package and other information<\/h2>\n\n\n\nContent declaration<\/h2>\n\n\n\n
The active substance is oxaliplatin.<\/p>\n\n\n\n
Other ingredients are water for injections.<\/p>\n\n\n\n
What the medicine looks like and contents of the pack<\/h2>\n\n\n\n
1 ml concentrate for solution for infusion contains 5 mg oxaliplatin.<\/p>\n\n\n\n
Oxaliplatin Accord is a clear, colorless liquid, with no visible particles.<\/p>\n\n\n\n
Each carton contains one\u00a0vial.<\/p>\n\n\n\n
10 ml concentrate for solution for infusion contains 50 mg oxaliplatin.<\/p>\n\n\n\n
20 ml concentrate for solution for infusion contains 100 mg oxaliplatin.<\/p>\n\n\n\n
40 ml concentrate for solution for infusion contains 200 mg oxaliplatin.<\/p>\n\n\n\n
Not all pack sizes may be marketed.<\/p>\n\n\n\n
Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n
Marketing Authorisation Holder<\/em> <\/p>\n\n\n\nAccord Healthcare BV<\/p>\n\n\n\n
Winthontlaan 200<\/p>\n\n\n\n
3526 kV Utrecht<\/p>\n\n\n\n
Netherlands<\/p>\n\n\n\n
Manufacturer<\/em><\/p>\n\n\n\nAccord Healthcare Limited<\/p>\n\n\n\n
Sage House, 319 Pinner Road<\/p>\n\n\n\n
North Harrow HA1 4HF, United Kingdom <\/p>\n\n\n\n
Accord Healthcare Polska Sp.z oo,<\/p>\n\n\n\n
ul. Lutomierska 50,95-200 Pabianice, Poland<\/p>\n\n\n\n
Accord Healthcare BV<\/p>\n\n\n\n
Winthontlaan 200<\/p>\n\n\n\n
3526 kV Utrecht<\/p>\n\n\n\n
Netherlands<\/p>\n","protected":false},"excerpt":{"rendered":"
This medicine is called Oxaliplatin Accord 5 mg \/ ml concentrate for solution for infusion , but in the rest of the package leaflet it is called Oxaliplatin Accord.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18526],"tags":[20411,20426,20407,20422,20425,20410,20408,20423,20424,20409],"class_list":["post-20071","post","type-post","status-publish","format-standard","hentry","category-medicines","category-o","tag-benefits-of-oxaliplatin","tag-benefits-of-oxaliplatin-accord","tag-oxaliplatin","tag-oxaliplatin-accord","tag-oxaliplatin-accord-side-effects","tag-oxaliplatin-side-effects","tag-what-is-oxaliplatin","tag-what-is-oxaliplatin-accord","tag-what-oxaliplatin-accord-is-used-for","tag-what-oxaliplatin-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20071","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=20071"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20071\/revisions"}],"predecessor-version":[{"id":20108,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20071\/revisions\/20108"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=20071"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=20071"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=20071"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}