{"id":20067,"date":"2022-03-24T11:26:22","date_gmt":"2022-03-24T11:26:22","guid":{"rendered":"https:\/\/zeepedia.com\/?p=20067"},"modified":"2022-03-25T12:43:37","modified_gmt":"2022-03-25T12:43:37","slug":"ovitrelle","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/ovitrelle\/","title":{"rendered":"Ovitrelle &#8211; Chorionic gonadotropin alfa uses, dose and side effects"},"content":{"rendered":"\n<p>250 micrograms&nbsp;solution for injection&nbsp;in a pre-filled&nbsp;pen<br>chorionic gonadotropin alfa<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Ovitrelle is and what it is used for<\/h2>\n\n\n\n<p><strong>What Ovitrelle is<\/strong><\/p>\n\n\n\n<p>Ovitrelle contains the drug &#8220;chorionic gonadotropin alfa&#8221; which is produced in a laboratory using a special\u00a0recombinant DNA\u00a0technology.\u00a0Chorionic gonadotropin alfa is like a\u00a0hormone\u00a0found naturally in the body, called chorionic gonadotropin, which is involved in reproduction and\u00a0fertility.<\/p>\n\n\n\n<p><strong>What Ovitrelle is used for<\/strong><\/p>\n\n\n\n<p>Ovitrelle is used with other medicines:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>To cause&nbsp;follicles&nbsp;(each containing an egg) to develop and mature in women undergoing assisted reproductive technology (a method that can help you conceive) such as &#8221;&nbsp;<em>in vitro<\/em>&nbsp;fertilization&#8221;.&nbsp;Other drugs will be given first to make more&nbsp;follicles&nbsp;grow.<\/li><li>To get the ovary to release an egg (ovulation) in women who can not produce eggs (&#8220;anovulation&#8221;) or women who produce too few eggs (&#8220;oligo-ovulation&#8221;).&nbsp;Other drugs will be given first for&nbsp;follicles&nbsp;to develop and mature.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you use Ovitrelle<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Ovitrelle<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to chorionic gonadotropin alfa or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you have a&nbsp;tumor&nbsp;in the&nbsp;hypothalamus&nbsp;or&nbsp;pituitary gland&nbsp;one (both are parts of the brain).<\/li><li>if you have enlarged ovaries or fluid-filled blisters on the ovaries (ovarian cysts) of unknown origin.<\/li><li>if you have unexplained vaginal bleeding.<\/li><li>if you have cancer of the ovaries, uterus or breasts.<\/li><li>if you have severe&nbsp;inflammation&nbsp;or blood clots in the veins (active thromboembolic diseases).<\/li><li>if you have any other disorder that usually makes a normal pregnancy impossible, e.g.&nbsp;menopause or early menopause (ovarian failure) or malformations of the reproductive organs.<\/li><\/ul>\n\n\n\n<p>Do not use Ovitrelle if any of the above apply to you.&nbsp;If you are not sure, talk to your doctor before taking this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Before starting treatment, your and your partner&#8217;s fertility\u00a0should be examined by a doctor who has experience in treating fertility problems.<\/p>\n\n\n\n<p>Ovarian overstimulation syndrome (OHSS)<\/p>\n\n\n\n<p>This medicine may increase the risk of you developing OHSS.&nbsp;This means that the follicles develop too much and become large cysts.<\/p>\n\n\n\n<p>If you experience lower abdominal pain, weight gain rapidly, nausea or vomiting, or difficulty breathing, do not inject yourself with&nbsp;Ovitrelle&nbsp;but talk to your doctor immediately (see section 4).&nbsp;If you develop OHSS, your doctor may tell you to abstain from sex or use a barrier contraceptive for at least four days.<\/p>\n\n\n\n<p>The risk of OHSS is reduced if the recommended&nbsp;dose&nbsp;of Ovitrelle is used and if you are closely monitored throughout the treatment (eg measurement of estradiol levels in blood tests and ultrasound examination).<\/p>\n\n\n\n<p>Multiple pregnancies and\/or birth defects<\/p>\n\n\n\n<p>When you use Ovitrelle, you are more likely to become pregnant with more than one child at a time (&#8220;multiple pregnancies&#8221;, usually twins) than if you were pregnant naturally.\u00a0Multiple pregnancies can lead to medical complications for you and your children.\u00a0When using assisted reproduction technology, the risk of multiple pregnancies is related to your age, the quality, and the number of fertilized eggs or embryos placed in the uterus.\u00a0Multiple pregnancies and special characteristics of the couple with fertility problems (eg age) may also be associated with an increased risk of malformations.<\/p>\n\n\n\n<p>The risk of multiple pregnancies decreases if you are carefully monitored throughout the treatment (eg measurement of estradiol levels in blood tests and ultrasound examination).<\/p>\n\n\n\n<p>Ectopic pregnancy<\/p>\n\n\n\n<p>Ectopic pregnancy (ectopic pregnancy) can occur in women with damaged fallopian tubes (the tubes that carry the egg from the ovary to the uterus).&nbsp;Therefore, your doctor should perform an early ultrasound examination to rule out the possibility of ectopic pregnancy.<\/p>\n\n\n\n<p>Miscarriage<\/p>\n\n\n\n<p>When using assisted reproductive technology or when the ovaries are stimulated to produce eggs, the risk of miscarriage is greater than for the average woman.<\/p>\n\n\n\n<p>Blood clots (thromboembolic event)<\/p>\n\n\n\n<p>Talk to your doctor before using Ovitrelle if you or a family member have ever had a blood clot in your leg or lung or a heart attack or\u00a0stroke.\u00a0You may be at greater risk of getting severe blood clots or existing blood clots may worsen with treatment with Ovitrelle.<\/p>\n\n\n\n<p>A tumor\u00a0is in the genitals<\/p>\n\n\n\n<p>There have been reports of\u00a0tumors\u00a0in the ovaries and other genitals, both benign and malignant, in women who have undergone several treatments for\u00a0infertility.<\/p>\n\n\n\n<p>Pregnancy tests<\/p>\n\n\n\n<p>You may get a false-positive test result if you take a pregnancy test on\u00a0serum\u00a0or urine for up to 10 days after taking Ovitrelle.\u00a0Talk to your doctor if you are unsure.<\/p>\n\n\n\n<p><strong>Children and young people<\/strong><\/p>\n\n\n\n<p>Ovitrelle is not intended for use in children and adolescents.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Ovitrelle<\/h2>\n\n\n\n<p>Tell your doctor if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>Do not use Ovitrelle if you are pregnant or breastfeeding.<\/p>\n\n\n\n<p>If you are pregnant or breastfeeding, talk to your doctor before using this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Ovitrelle is not expected to affect your ability to drive or use machines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Ovitrelle contains sodium<\/h2>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg)\u00a0sodium\u00a0per\u00a0dose, ie essentially &#8216;sodium-free&#8217;.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">3. How to use Ovitrelle<\/h2>\n\n\n\n<p>Always use this medicine exactly as your doctor has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p><strong>How much to use<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The recommended&nbsp;dose&nbsp;is 1 pre-filled&nbsp;pen&nbsp;(250 micrograms \/ 0.5 ml) taken as an&nbsp;injection&nbsp;.<\/li><li>Your doctor has explained exactly when to&nbsp;inject&nbsp;one.<\/li><\/ul>\n\n\n\n<p><strong>How to use this medicine<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you give yourself Ovitrelle, carefully read and follow the separate &#8220;Instructions for Use&#8221; in the box.<\/li><li>Ovitrelle is for injection under the skin (&nbsp;subcutaneously&nbsp;).<\/li><li>Each pre-filled&nbsp;pen&nbsp;is for single use only.<\/li><li>Your doctor or nurse will show you how to use the pre-filled Ovitrelle pen to inject the medicine.<\/li><li>Inject Ovitrelle exactly as your doctor or nurse has told you.<\/li><li>After&nbsp;injection&nbsp;, discard the used needle safely and discard the pen.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">If you use more Ovitrelle than you should&nbsp;<\/h2>\n\n\n\n<p>The effects of an overdose of Ovitrelle are unknown but ovarian hyperstimulation syndrome (OHSS) may occur.\u00a0This is described in section 4.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use Ovitrelle<\/h2>\n\n\n\n<p>If you forget to use Ovitrelle, talk to your doctor as soon as you find out.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Stop using Ovitrelle and see a doctor immediately if you notice any of the following serious&nbsp;side effects&nbsp;&#8211; you may need&nbsp;urgent&nbsp;medical attention:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Allergic reactions such as rash, rapid or uneven&nbsp;pulse&nbsp;, swelling of the tongue and throat, sneezing, wheezing or severe breathing problems are very rare (may affect up to 1 in 10,000 people).<\/li><li>Lower abdominal pain, distended abdomen or abdominal discomfort in combination with nausea or vomiting may be symptoms of ovarian hyperstimulation syndrome (OHSS).&nbsp;This may indicate that the ovaries are overreacting to the treatment and that large ovarian cysts have developed (see also section 2, under \u201cOvarian overstimulation syndrome (OHSS).\u201d This is a common reaction (may affect up to 1 in 10 people).<\/li><li>OHSS can become serious with clearly enlarged ovaries, decreased urine production, weight gain, difficulty breathing and possible fluid accumulation in the stomach or chest.&nbsp;This is less common (may affect up to 1 in 100 people).<\/li><li>Severe thrombotic complications (thromboembolic events) sometimes independent of OHSS can occur in very rare cases.&nbsp;This may cause chest pain, shortness of breath,&nbsp;stroke&nbsp;or heart attack (see also section 2, under &#8220;Blood clot formation (thromboembolic event)&#8221;.<\/li><\/ul>\n\n\n\n<p><strong>Other&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>Common (may affect up to 1 in 10 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Headache.<\/li><li>Local reactions at the injection site, such as pain,&nbsp;redness&nbsp;or swelling.<\/li><\/ul>\n\n\n\n<p>Uncommon (may affect up to 1 in 100 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Diarrhea.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Ovitrelle<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the label and carton after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Store in a refrigerator (2 \u00b0 C-8 \u00b0 C).&nbsp;Do not freeze.<\/p>\n\n\n\n<p>Do not use Ovitrelle if you see visible signs of deterioration if the solution contains particles or is not clear.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the package and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is chorionic gonadotropin alfa produced by&nbsp;recombinant DNA&nbsp;technology.<\/li><li>Each pre-filled&nbsp;pen&nbsp;contains 250 micrograms of chorionic gonadotropin alfa in 0.5 ml (equivalent to approximately 6,500 international units, IU).<\/li><li>The other ingredients are mannitol, methionine, disodium phosphate dihydrate, sodium dihydrogen phosphate monohydrate, poloxamer 188,&nbsp;phosphoric acid&nbsp;(for&nbsp;pH&nbsp;adjustment), sodium hydroxide (for&nbsp;pH&nbsp;adjustment) and water for injections.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Ovitrelle is supplied as a clear, colorless to yellowish&nbsp;solution for injection&nbsp;in a pre-filled&nbsp;pen&nbsp;.<\/li><li>Each&nbsp;pen&nbsp;contains 0.5 ml of solution.<\/li><li>The product is supplied in packs of 1 pre-filled pen and 2&nbsp;injection&nbsp;needles (one extra).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Merck Europe BV, Gustav Mahlerplein 102, 1082 MA Amsterdam, The Netherlands<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Merck Serono SpA, Via delle Magnolie 15, 70026 Modugno (Bari), Italy<\/p>\n\n\n\n<p>This leaflet was last modified 10\/on 2021.\u00a0Further information on this medicine is available on the European Medicines Agency website: http:\/\/www.ema.europa.eu.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Instructions for use<\/h2>\n\n\n\n<p><strong>OVITRELLE 250 micrograms&nbsp;solution for injection&nbsp;in a pre-filled&nbsp;pen<\/strong><\/p>\n\n\n\n<p>chorionic gonadotropin alpha<\/p>\n\n\n\n<p><strong>CONTENT<\/strong><\/p>\n\n\n\n<ol class=\"wp-block-list\"><li><strong>How to use Ovitrelle pre-filled&nbsp;pen<\/strong><\/li><li><strong>Before you use Ovitrelle pre-filled&nbsp;pen<\/strong><\/li><li><strong>Prepare Ovitrelle pre-filled&nbsp;pen&nbsp;for&nbsp;injection<\/strong><\/li><li><strong>Setting&nbsp;dose&nbsp;one &#8211; &#8220;How to set&nbsp;dose&nbsp;one to 250&#8221;<\/strong><\/li><li><strong>Inject&nbsp;dos&nbsp;en<\/strong><\/li><li><strong>After&nbsp;injection&nbsp;one<\/strong><\/li><\/ol>\n\n\n\n<p><strong>Warning!\u00a0<\/strong>Read this manual before using the Ovitrelle pre-filled\u00a0pen.\u00a0Follow the instructions exactly as they may differ from your previous experience.<\/p>\n\n\n\n<p><strong>1. How to use the Ovitrelle pre-filled&nbsp;pen<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The pen is for&nbsp;subcutaneous&nbsp;injection&nbsp;only .<\/li><li>Inject Ovitrelle exactly as your doctor or nurse has told you.<\/li><li><strong>This&nbsp;pen&nbsp;is for single use only.&nbsp;<\/strong>Do not share the pen with anyone else.<\/li><\/ul>\n\n\n\n<p><strong>Before you use Ovitrelle pre-filled\u00a0pen<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>Wash your hands with soap and water.<\/td><td><\/td><\/tr><tr><td><br>Find a clean and <strong>flat surface<\/strong>.<\/td><td><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20100211000012#\" rel=\"noopener\"><\/a><\/td><\/tr><tr><td>Check the&nbsp;<strong>expiration date<\/strong>&nbsp;on the pen label.<\/td><td><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20100211000012#\" rel=\"noopener\"><\/a><\/td><\/tr><tr><td>Gather everything you need and post it:<\/td><td><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20100211000012#\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.fass.se\/imaging\/resources\/ab8b22ea-8ca9-4a65-9cf0-fe43988dd5b4\" alt=\"The pen and the designations of the components.\" title=\"The pen and the designations of the components.\"\/><\/a><\/figure>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>1. dose setting button2. dosdisplay3rd piston4. container5. threaded needle connection6. protection for&nbsp;pen<\/td><td>7. peelable seal8. removable needle9. inner needle guard10. outer needle guard11. alcohol swabs12. containers for sharp objects<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>Note!&nbsp;Alcohol wipes and containers for sharp objects are not included in the packaging.<\/p>\n\n\n\n<p><strong>3. Prepare Ovitrelle pre-filled&nbsp;pen&nbsp;for&nbsp;injection<\/strong><\/p>\n\n\n\n<p><strong>3.1 Remove the cover on the pen<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20100211000012#\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.fass.se\/res\/RootMedia\/Merck\/Media\/Gonal2df202011\/220ta20av20skyddet.jpg\" alt=\"Remove the cover of the pen\" title=\"Remove the cover of the pen\"\/><\/a><\/figure>\n\n\n\n<p><strong>3.2 Prepare the needle for\u00a0injection<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>Develop a new needle &#8211; use only the disposable needle provided.<\/td><td>&nbsp;<\/td><\/tr><tr><td>Hold the outer needle guard firmly.<\/td><td>&nbsp;<\/td><\/tr><tr><td>Check that the peelable seal on the outer needle cover is not damaged or loose.<\/td><td><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20100211000012#\" rel=\"noopener\"><\/a><\/td><\/tr><tr><td>Remove the pull-off seal.<\/td><td><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20100211000012#\" rel=\"noopener\"><\/a><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Warning: <\/strong><em>If the pull-off seal is damaged or loose, do not use the needle.\u00a0Throw it in a container for sharp objects.\u00a0Ask your doctor or pharmacist how to get a new needle.<\/em><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><strong>3.3 Connect the needle<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>Screw the threaded tip of the Ovitrelle pre-filled pen\u00a0to\u00a0the outer needle guard until you feel a slight resistance.\u00a0<strong>Warning!\u00a0<\/strong>Do not tighten the needle too hard.\u00a0The needle may be difficult to remove after\u00a0injection.<\/td><td><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20100211000012#\" rel=\"noopener\"><\/a><\/td><\/tr><tr><td>Remove the outer needle cover by gently pulling it.<\/td><td><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20100211000012#\" rel=\"noopener\"><\/a><\/td><\/tr><tr><td><strong>Set it aside for later use.<\/strong><\/td><td><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20100211000012#\" rel=\"noopener\"><\/a><\/td><\/tr><tr><td>Hold the Ovitrelle pre-filled pen\u00a0with\u00a0the needle pointing upwards. Carefully remove the green inner cover and discard it.<\/td><td><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20100211000012#\" rel=\"noopener\"><\/a><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20100211000012#\" rel=\"noopener\"><\/a><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><strong>3.4 Look closely at the tip of the needle for a small drop\/drops of liquid<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>If you notice a small drop (s) of fluid go on to&nbsp;<strong>Section 4: Set&nbsp;dose&nbsp;one to 250.<\/strong><\/td><td><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20100211000012#\" rel=\"noopener\"><\/a><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Warning:<\/strong>\u00a0<em>If you do not see a small drop\/drop at or near the tip of the needle, follow the steps on the next page.<\/em><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><strong>If you do not see a small drop\/drops at or near the tip of the needle:<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20100211000012#\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.fass.se\/res\/RootMedia\/Merck\/Media\/Ovitrelle\/Ovitrelle20bild205202d20Vrid20dosinste4llningsknappen20medurs.jpg\" alt=\"Carefully turn the dose setting knob clockwise until you see a dot on the dose display\" title=\"Carefully turn the dose setting knob clockwise until you see a dot on the dose display\"\/><\/a><\/figure>\n\n\n\n<ol class=\"wp-block-list\"><li>Carefully turn the dose setting knob clockwise until you see a dot (\u25cf) on the dose display.&nbsp;If you pass this mode, simply turn the dose setting knob back to the point (\u25cf).<\/li><li>Hold the pen with the needle pointing upwards.<\/li><li>Gently tap the container.<\/li><li>Press the dose setting button&nbsp;<strong>as far as it will go<\/strong>&nbsp;.&nbsp;A small drop of liquid is visible on the tip of the needle.&nbsp;This indicates that your pre-filled pen&nbsp;is ready&nbsp;for&nbsp;injection&nbsp;.<a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20100211000012#\" rel=\"noopener\"><\/a><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20100211000012#\" rel=\"noopener\"><\/a><\/li><li>If you do not see any liquid, you can try a second time (you can do this no more than twice) by starting from step 1 in the section &#8220;If you do not see a small drop \/ drops at or near the tip of the needle&#8221; above.<\/li><\/ol>\n\n\n\n<p><strong>4. Set&nbsp;dose&nbsp;one to 250<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Carefully turn the dose setting knob clockwise.&nbsp;The dose display shows a straight line and you must continue to turn until you can read the number &#8221;&nbsp;<strong>250<\/strong>&nbsp;&#8220;.<\/li><li>Do not press or pull the dose setting knob when turning it.<\/li><\/ul>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20100211000012#\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.fass.se\/res\/RootMedia\/Merck\/Media\/Ovitrelle\/Ovitrelle20bild208202d20ste4lla20in20dosen.jpg\" alt=\"Adjust the dose\" title=\"Adjust the dose\"\/><\/a><\/figure>\n\n\n\n<ul class=\"wp-block-list\"><li>The dose display should show \u201c250\u201d as shown in the figure below.<\/li><\/ul>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20100211000012#\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.fass.se\/res\/RootMedia\/Merck\/Media\/Ovitrelle\/Ovitrelle20bild209202d20ordinerad20dos.jpg\" alt=\"The dose display should show &quot;250&quot;\" title=\"The dose display should show &quot;250&quot;\"\/><\/a><\/figure>\n\n\n\n<p><strong>5. Inject&nbsp;dos&nbsp;en<\/strong><\/p>\n\n\n\n<p><strong>5.1<\/strong>&nbsp;Choose an injection site in the area where your doctor or nurse has told you to&nbsp;inject&nbsp;one.<\/p>\n\n\n\n<p><strong>5.2<\/strong>&nbsp;Clean the skin at the injection site by wiping it with an alcohol swab.<\/p>\n\n\n\n<p><strong>5.3<\/strong>\u00a0Check again that the number on the\u00a0<strong>dose display is &#8220;250&#8221;.\u00a0<\/strong>If it does not show this, you must adjust it (see the step &#8220;4. Set\u00a0dose\u00a0one to 250&#8221;).<\/p>\n\n\n\n<p><strong>5.4\u00a0Inject a\u00a0dose\u00a0that your doctor or nurse has taught you<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>Slowly push the entire needle into the skin (1). Press and hold the dose button as far as it will go\u00a0to\u00a0complete the complete\u00a0injection. Hold down the dose knob for at least 5 seconds to ensure that you have injected the entire\u00a0dose\u00a0one (2). The number shown in the dose display returns to 0. This indicates that the entire\u00a0dose\u00a0has been given. After at least 5 seconds, pull the needle out of the skin while holding down the dose setting button (3). Release the dose setting button.<\/td><td><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20100211000012#\" rel=\"noopener\"><\/a><br><br><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20100211000012#\" rel=\"noopener\"><\/a><\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p><strong>6. After&nbsp;injection&nbsp;a<\/strong><\/p>\n\n\n\n<p><strong>6.1 Check that the dose display shows 0.<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>This confirms that the entire&nbsp;dose&nbsp;has been injected.&nbsp;<strong>Do not try to inject a second time.<\/strong><\/li><li>If the dose display does not show 0, contact your doctor or pharmacist.<\/li><\/ul>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20100211000012#\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.fass.se\/res\/RootMedia\/Merck\/Media\/Gonal2df202011\/1120efter20injektionen.jpg\" alt=\"After the injection\" title=\"After the injection\"\/><\/a><\/figure>\n\n\n\n<p><strong>6.2 Remove the needle after&nbsp;injection<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Hold the pre-filled pen firmly in the container.<\/li><li>Carefully attach the outer needle cover to the needle.<\/li><\/ul>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20100211000012#\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.fass.se\/res\/RootMedia\/Merck\/Media\/Ovitrelle\/Ovitrelle20bild2012202d20se4tt20ne5lskyddet20pe520ne5len.jpg\" alt=\"Carefully attach the outer needle cover to the needle\" title=\"Carefully attach the outer needle cover to the needle\"\/><\/a><\/figure>\n\n\n\n<ul class=\"wp-block-list\"><li>Grasp the outer needle cover and unscrew the needle.<\/li><\/ul>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20100211000012#\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.fass.se\/res\/RootMedia\/Merck\/Media\/Ovitrelle\/Ovitrelle20bild2013202d20skruva20av20ne5len.jpg\" alt=\"Grasp the outer needle cover and unscrew the needle\" title=\"Grasp the outer needle cover and unscrew the needle\"\/><\/a><\/figure>\n\n\n\n<ul class=\"wp-block-list\"><li>Be careful not to stick it on the needle.<\/li><li>Now put the cover back on the pen.<\/li><\/ul>\n\n\n\n<p><strong>6.3 Disposal<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>Use the needle and pen only once. When you have finished your\u00a0injection, discard the used needle safely. Discard the pen.\u00a0It is best to put it back in its original packaging. When the pen is empty, ask your pharmacist how to dispose of it.<\/td><td><\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Ovitrelle contains the drug &#8220;chorionic gonadotropin alfa&#8221; which is produced in a laboratory using a special recombinant DNA technology. Chorionic gonadotropin alfa is like a hormone found naturally in the body, called chorionic gonadotropin, which is involved in reproduction and fertility .<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18526],"tags":[20437,20442,20433,20436,20438,20441,20435,20434,20439,20440],"class_list":["post-20067","post","type-post","status-publish","format-standard","hentry","category-medicines","category-o","tag-benefits-of-chorionic-gonadotropin-alfa","tag-benefits-of-ovitrelle","tag-chorionic-gonadotropin-alfa","tag-chorionic-gonadotropin-alfa-side-effects","tag-ovitrelle","tag-ovitrelle-side-effects","tag-what-chorionic-gonadotropin-alfa-is-used-for","tag-what-is-chorionic-gonadotropin-alfa","tag-what-is-ovitrelle","tag-what-ovitrelle-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20067","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=20067"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20067\/revisions"}],"predecessor-version":[{"id":20110,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20067\/revisions\/20110"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=20067"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=20067"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=20067"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}