{"id":20063,"date":"2022-03-24T11:15:00","date_gmt":"2022-03-24T11:15:00","guid":{"rendered":"https:\/\/zeepedia.com\/?p=20063"},"modified":"2022-12-25T10:45:55","modified_gmt":"2022-12-25T10:45:55","slug":"ovesterin","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/ovesterin\/","title":{"rendered":"Ovesterin &#8211; Estriol Uses, Dose, And Side Effects"},"content":{"rendered":"\n<p>1 mg \/ g&nbsp;vaginal cream<br>estriol<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Ovesterin Is And What Ovesterin Used For<\/h2>\n\n\n\n<p>Ovesterine belongs to a group of medicines called&nbsp;Hormone&nbsp;Replacement&nbsp;Therapy&nbsp;(&nbsp;HRT&nbsp;) and is for&nbsp;vaginal&nbsp;use.&nbsp;Ovesterine contains the female sex hormone estriol, a so-called&nbsp;estrogen.<\/p>\n\n\n\n<p>Ovesterine is used for topical treatment of ailments such as dryness or irritation of the vagina in women after the last regular period (\u00a0menopause\u00a0).\u00a0The medical term for this is &#8220;vaginal atrophy.&#8221;\u00a0Declining estrogen levels in the body cause it after\u00a0menopause.<\/p>\n\n\n\n<p>\u00d6striol helps to keep the genital mucosa elastic and resistant to both mechanical influences and&nbsp;infection.<\/p>\n\n\n\n<p>Ovesterine works by replacing the&nbsp;estrogen&nbsp;that is normally produced in a woman&#8217;s ovaries.&nbsp;Ovesterin is inserted into the vagina to release the hormone where it is needed.&nbsp;This can relieve the feeling of discomfort in the vagina.<\/p>\n\n\n\n<p>A doctor must first diagnose estrogen deficiency to ensure the correct diagnosis.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What You Need To Know Before Using Ovesterin<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do Not Use Ovesterin<\/h2>\n\n\n\n<p><strong>Medical background and regular check-ups<\/strong><\/p>\n\n\n\n<p>The use of&nbsp;HRT&nbsp;involves risks that must be considered when deciding to start or continue an ongoing treatment.&nbsp;Consult a physician before starting a treatment or to discuss whether to continue treatment<\/p>\n\n\n\n<p>Experience is limited for treating women whose menstruation has stopped prematurely (when the ovaries have stopped working or due to surgery).&nbsp;If your period has stopped prematurely, HRT&#8217;s risks may differ.&nbsp;Talk to your doctor.<\/p>\n\n\n\n<p>Before starting treatment (or resuming treatment), your doctor will ask about your and your family&#8217;s medical background.\u00a0Your doctor may do a general medical and gynecological examination, including an examination of your breasts.<\/p>\n\n\n\n<p>Once you have started treatment, you should go for regular medical check-ups at least once a year.&nbsp;During these check-ups, you should discuss with your doctor the benefits and risks of continued treatment.<\/p>\n\n\n\n<p>Perform regular examinations of the breasts according to the doctor&#8217;s recommendations.<\/p>\n\n\n\n<p><strong>Do not use Ovesterin<\/strong><\/p>\n\n\n\n<p>if any of the following apply to you.&nbsp;If you are not sure, talk to your doctor before taking Ovesterin.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you are allergic to\u00a0estriol\u00a0or any of the other ingredients of this medicine (listed in section 6).<\/li><li>If you have or have had\u00a0breast <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/getting-a-cancer-message\/\">cancer<\/a>\u00a0or there is a suspicion that you may have it<\/li><li>If you have or have had\u00a0estrogen-dependent\u00a0cancer, such as cancer of the uterine lining (endometrium), or if there is a suspicion of such cancer.<\/li><li>If you have\u00a0unexpected\u00a0genital bleeding\u00a0that a doctor has not investigated.<\/li><li>If you have\u00a0<strong>endometrial hyperplasia<\/strong>\u00a0(severe thickening of the uterine lining) and are not being treated for it.<\/li><li>If you have or have had a\u00a0<strong>blood clot in a vein<\/strong>\u00a0(venous\u00a0thromboembolism\u00a0), in your legs (deep\u00a0vein thrombosis\u00a0), or in your lungs (\u00a0pulmonary embolism\u00a0).<\/li><li>If you have a\u00a0coagulation disorder, a condition with an increased risk of blood clots (lack of\u00a0protein\u00a0C,\u00a0protein\u00a0S, or antithrombin).<\/li><li>If you have or have recently had a disease caused by a blood clot in the\u00a0arteries, such as a\u00a0heart attack,\u00a0stroke,\u00a0or\u00a0angina.<\/li><li>If you have or have had any\u00a0liver disease\u00a0and still have abnormal liver values.<\/li><li>If you have\u00a0porphyria, a rare inherited blood disorder.<\/li><\/ul>\n\n\n\n<p>If any of the above affects you the first time you use Ovesterin, stop using Ovesterin and contact your doctor immediately.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Ovesterin vaginal&nbsp;cream&nbsp;should not be combined with estrogen preparations with systemic effects, such as tablets, as the estrogen concentrations achieved have not been studied in terms of safety and risks.<\/p>\n\n\n\n<p>Talk to your doctor if you have had any of the following problems before starting treatment, as these may come back or worsen during treatment with Ovesterin.&nbsp;Should this occur, have more frequent check-ups with a doctor.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Muscle knots (\u00a0fibroids\u00a0) in the uterus<\/li><li>Uterine lining tissue that grows outside the uterus (\u00a0endometriosis\u00a0) or has previously had severe thickening of the uterine lining (\u00a0endometrial hyperplasia\u00a0).<\/li><li>Increased risk of getting a blood clot (see below &#8220;Blood clots in a vein (\u00a0thrombosis\u00a0)&#8221;)<\/li><li>Increased risk of getting estrogen-dependent cancer (such as if a close relative has had breast cancer or other estrogen-dependent cancer)<\/li><li>High\u00a0blood pressure<\/li><li>Liver disease, e.g., benign\u00a0tumor<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/diabetes-type-1\/\">Diabetes<\/a><\/li><li>Gallstone disease<\/li><li>Migraine\u00a0or severe headache<\/li><li>An\u00a0autoimmune\u00a0disease that affects many organs in the body (<a href=\"https:\/\/zeepedia.com\/medical\/diseases\/sle\/\">systemic lupus erythematosus<\/a>,\u00a0SLE\u00a0)<\/li><li>Epilepsy<\/li><li>Asthma<\/li><li>Ossification of the middle ear leading to hearing loss (otosclerosis)<\/li><li>Fluid retention due to heart or kidney disease.<\/li><\/ul>\n\n\n\n<p>Tell your doctor if you have&nbsp;hepatitis&nbsp;C and are following a combination regimen of the medicines ombitasvir\/paritaprevir\/ritonavir, with or without dasabuvir.&nbsp;Using a combination of these drugs with certain estrogen-containing products may cause elevated liver function tests (increase in liver enzyme ALT);&nbsp;The risk of this happening with Ovesterin is currently unknown.<\/p>\n\n\n\n<p><strong>You should contact a doctor immediately and discontinue treatment if any of the following occur:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Any of the things mentioned in the section &#8216;Do not use Ovesterin&#8217;<\/li><li>If the skin or whites of the eyes turn yellow (jaundice);\u00a0it may be a symptom of liver disease<\/li><li>If your\u00a0blood pressure\u00a0rises sharply (symptoms may include headache, fatigue, or dizziness)<\/li><li>If you are experiencing migraine-like headaches for the first time<\/li><li>If you become pregnant<\/li><li>If you get symptoms of a blood clot, such as<ul><li>Painful swelling and redness of the legs<\/li><li>Sudden chest <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/brain-and-nerves\/pain\/\">pain<\/a><\/li><li>For breathing difficulties and more information, see below &#8220;Blood clots in a vein (\u00a0thrombosis\u00a0).&#8221;<\/li><\/ul><\/li><\/ul>\n\n\n\n<p>Note: Ovesterin is not a contraceptive.&nbsp;If it is less than 12 months since your last period, or if you are under 50, you may still need to use contraception to avoid pregnancy.&nbsp;Consult your doctor.<\/p>\n\n\n\n<p><strong>Hormone therapy&nbsp;<\/strong><strong>and cancer<\/strong><\/p>\n\n\n\n<p><strong>Severe thickening of the uterine lining (&nbsp;endometrial hyperplasia&nbsp;) and cancer of the uterine lining (endometrial cancer)<\/strong><\/p>\n\n\n\n<p>Using&nbsp;HRT&nbsp;tablets with&nbsp;estrogen&nbsp;alone for a long time may increase the risk of developing cancer of the uterine lining (endometrium).<\/p>\n\n\n\n<p>It is unclear if there is a similar risk with Ovesterin when used for repeated treatment or for a long time (over a year).\u00a0However, the uptake of Ovesterin into the blood is very low, so adding progestogens is unnecessary.<\/p>\n\n\n\n<p>If you experience breakthrough bleeding or splashing bleeding, there is usually nothing to worry about, but you should make an appointment with your doctor.&nbsp;It may be a sign that your uterine lining has become thicker.<\/p>\n\n\n\n<p>To prevent overstimulation of the uterine lining, the maximum&nbsp;dose should not exceed 1 application (0.5 mg), and the maximum&nbsp;dose&nbsp;should not be&nbsp;used for more than a few weeks (maximum 4 weeks).<\/p>\n\n\n\n<p><em>The following risks apply to hormone replacement therapy (&nbsp;HRT&nbsp;) circulating in the blood.&nbsp;Ovesterin 1 mg \/ g&nbsp;vaginal cream<\/em>, on the other hand, is used topically in the vagina, and the uptake into the blood is very low.&nbsp;The conditions described below are unlikely to worsen or recur during treatment with Ovesterin 1 mg \/ g&nbsp;vaginal cream<em>, but you should consult a doctor if you are concerned.<\/em><\/p>\n\n\n\n<p><strong>Breast cancer<\/strong><\/p>\n\n\n\n<p>There are indications that the use of Ovesterin 1 mg \/ g&nbsp;vaginal cream&nbsp;does not increase the risk of breast cancer in women who have not had breast cancer before.&nbsp;It is unknown whether Ovesterin 1 mg \/ g&nbsp;vaginal cream&nbsp;can be used safely in women with breast cancer.<\/p>\n\n\n\n<p><strong>Check your breasts regularly.&nbsp;Contact a doctor if you notice changes such as:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Indentations or pits<\/li><li>Changes in the nipple<\/li><li>Nodules you can see or feel.<\/li><\/ul>\n\n\n\n<p>You are also recommended to participate in a mammogram when you are called.<\/p>\n\n\n\n<p><strong>Ovarian cancer (&nbsp;ovarian cancer&nbsp;)<\/strong><\/p>\n\n\n\n<p>Ovarian cancer is rare &#8211; much rare than breast cancer.&nbsp;Estrogen-only&nbsp;use of&nbsp;HRT&nbsp;has been associated with a slightly increased risk of ovarian cancer.<\/p>\n\n\n\n<p>The risk of ovarian cancer varies with age.\u00a0For example, about 2 women out of 2,000 aged 50 to 54 who do not receive\u00a0HRT\u00a0will be diagnosed with ovarian cancer over 5 years.\u00a0For women who have had\u00a0HRT\u00a0for 5 years, there will be about 3 cases per 2,000 users (i.e., about 1 extra case).<\/p>\n\n\n\n<p><strong>How&nbsp;HRT&nbsp;affects the heart and blood circulation<\/strong><\/p>\n\n\n\n<p><strong>Blood clots in a vein (&nbsp;thrombosis&nbsp;)<\/strong><\/p>\n\n\n\n<p>The risk of&nbsp;<strong>blood clots in the veins<\/strong>&nbsp;is 1.3-3 times higher for women who take&nbsp;HRT&nbsp;than for those who do not.&nbsp;It is unknown whether Ovesterin presents the same risk.<\/p>\n\n\n\n<p>Blood clots can be serious.&nbsp;If a blood clot ends up in the lungs, it can cause chest pain, shortness of breath, collapse or even lead to death.<\/p>\n\n\n\n<p>You are more likely to get a blood clot in a vein if the following apply to you.&nbsp;Talk to your doctor if any of the following apply to you:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>You have not been able to walk or stand for a long time due to a major operation, injury or illness (see also section 3, \u201cIf you need surgery\u201d)<\/li><li>You are severely overweight (\u00a0BMI\u00a0over 30 kg \/ m\u00a0<sup>2<\/sup>\u00a0)<\/li><li>You have a coagulation disorder that requires long-term treatment with drugs that prevent blood clots.<\/li><li>If a close relative has had a blood clot in the bone, lung, or another organ<\/li><li>You have\u00a0SLE\u00a0(systemic lupus erythematosus)<\/li><li>You have cancer.<\/li><\/ul>\n\n\n\n<p>The symptoms of a blood clot are described in the section &#8220;You should contact a doctor immediately and discontinue treatment if any of the following occur&#8221; above.<\/p>\n\n\n\n<p><em>Compare<\/em><\/p>\n\n\n\n<p>For women in their 50s who do not use&nbsp;HRT, the number of cases of blood clots in a vein over five years is expected to be 4-7 per 1,000.<\/p>\n\n\n\n<p>For women in their 50s who use&nbsp;HRT&nbsp;with&nbsp;estrogen&nbsp;alone for more than 5 years, 5-8 cases per 1,000 users are diagnosed (in other words, a different case).<\/p>\n\n\n\n<p><strong>Heart disease (heart attack)<\/strong><\/p>\n\n\n\n<p>For women who take&nbsp;estrogen&nbsp;alone, there is no increased risk of developing heart disease.<\/p>\n\n\n\n<p><strong>Stroke&nbsp;_<\/strong><\/p>\n\n\n\n<p>The risk of&nbsp;stroke&nbsp;is about 1.5 times higher for those who take&nbsp;HRT&nbsp;than those who do not.&nbsp;The risk of&nbsp;stroke&nbsp;is age-dependent. Therefore, the number of cases of&nbsp;stroke&nbsp;increases due to the use of&nbsp;HRT&nbsp;with increasing age.<\/p>\n\n\n\n<p><em>Comparison<\/em><\/p>\n\n\n\n<p>For women in their 50s who do not take\u00a0HRT, an average of 8 out of 1,000 people are expected to have a\u00a0stroke\u00a0over 5 years.\u00a0For women in their 50s who have taken\u00a0HRT\u00a0for more than 5 years, 11 out of 1,000 users are expected to have a\u00a0stroke\u00a0(i.e., 3 different cases).<\/p>\n\n\n\n<p><strong>Other conditions<\/strong><\/p>\n\n\n\n<p>Using&nbsp;HRT&nbsp;does not prevent memory loss.&nbsp;The risk of memory loss may be slightly higher in women who start using&nbsp;HRT&nbsp;after age 65.&nbsp;Consult your doctor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other Medicines And Ovesterin<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription, herbal medicines, or other natural products.<\/p>\n\n\n\n<p>The estriol dose (&nbsp;estrogen&nbsp;) in Ovesterin vaginal&nbsp;cream&nbsp;is low, and the treatment is local. Therefore, Ovesterin is not expected to affect or be affected by the concomitant use of other medicines.&nbsp;If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<p>Tell your doctor if you have&nbsp;hepatitis&nbsp;C and are following a combination regimen of the medicines ombitasvir\/paritaprevir\/ritonavir, with or without dasabuvir.&nbsp;Using a combination of these drugs with certain estrogen-containing products may cause elevated liver function tests (increase in liver enzyme ALT);&nbsp;The risk of this happening with Ovesterin is currently unknown.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy And Breastfeeding<\/h2>\n\n\n\n<p>Ovesterin is intended for women whose menstruation has stopped.&nbsp;If you become pregnant, stop taking Ovesterin and consult a doctor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving And Using Machines<\/h2>\n\n\n\n<p>No effects on the ability to drive and use machines have been observed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Ovesterin Vaginal Cream Contains Cetyl Alcohol And Stearyl Alcohol<\/h2>\n\n\n\n<p>It may cause local skin reactions (e.g., <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/contact-dermatitis\/\">contact dermatitis<\/a>).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How To Use Ovesterin<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Always use this medicine exactly as your doctor or pharmacist has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/li><li><em>The first 2-3 weeks&nbsp;(maximum 4 weeks&nbsp;):<\/em>&nbsp;One&nbsp;dose&nbsp;per day, preferably at bedtime.&nbsp;Insert a pre-filled syringe deep into the vagina.<\/li><li><span style=\"background-color: rgba(0, 0, 0, 0.2);\"><i>Afte<\/i><\/span><em>r that<\/em>: After 2-3 weeks of treatment, the symptoms should have subsided, and then the dose is reduced&nbsp;to&nbsp;one&nbsp;dose&nbsp;twice a week.<\/li><li>Other doses&nbsp;according to doctor&#8217;s prescription.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\"><em>How should a&nbsp;cream&nbsp;be used?<\/em><\/h2>\n\n\n\n<p>Use the dosing syringe to insert&nbsp;cream&nbsp;into the vagina.<\/p>\n\n\n\n<p>1. Remove the cap on the cream tube and use the tip of the cap to open the tube.<\/p>\n\n\n\n<p>2. Screw the nozzle of the dosing syringe onto the tube.<\/p>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=19830805000022#\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.fass.se\/res\/RootMedia\/Organon\/Media\/Ovesterin\/Bild1.jpg\" alt=\"Figure 1\" title=\"Figure 1\"\/><\/a><\/figure>\n\n\n\n<p>3. Squeeze as much&nbsp;cream&nbsp;into the dosing syringe to fill to the mark (to stop the flask, see the arrows in the figure).<a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=19830805000022#\" rel=\"noopener\"><\/a><\/p>\n\n\n\n<p>4. Unscrew the dosing syringe and screw the cap onto the tube.<\/p>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=19830805000022#\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.fass.se\/res\/RootMedia\/Organon\/Media\/Ovesterin\/Bild2.jpg\" alt=\"Figure 3\" title=\"Figure 3\"\/><\/a><\/figure>\n\n\n\n<p>5. Lie on your back when using&nbsp;the cream.&nbsp;Insert the dosing syringe deep into the vagina and slowly push in the plunger.<\/p>\n\n\n\n<p>After use, the dosing syringe should be cleaned in warm soapy water.\u00a0When disassembling the dosing syringe, you must take a little closer to loosen the plunger.\u00a0After cleaning, push the plunger back.\u00a0Rinse thoroughly afterward.\u00a0Detergents must not be used nor boiling water.<\/p>\n\n\n\n<p>Seek medical attention if symptoms worsen or do not improve within 3-4 weeks.<\/p>\n\n\n\n<p>You should use panty liners after applying Ovesterin vaginal&nbsp;cream as some excess may leak out.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If You Use More Ovesterin Than You Should<\/h2>\n\n\n\n<p>The estriol dose (&nbsp;estrogen&nbsp;) in Ovesterin vaginal&nbsp;cream&nbsp;is low, and the treatment is local; therefore, no overdose is expected.<\/p>\n\n\n\n<p>If you have ingested too much medicine or if, for example, a child has accidentally ingested the medicine, contact a doctor or hospital for risk assessment and advice.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If You Forget To Use Ovesterin<\/h2>\n\n\n\n<p>Do not take a double&nbsp;dose&nbsp;to make up for a&nbsp;forgotten&nbsp;dose. If you forget to apply a&nbsp;dose&nbsp;one day, apply a&nbsp;dose&nbsp;as soon as you remember.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If You Need Surgery<\/h2>\n\n\n\n<p>If you are going to have surgery, tell your doctor that you are taking Ovesterin.&nbsp;You may need to stop taking Ovesterin for 4 to 6 weeks before surgery to avoid the risk of blood clots (see section 2, \u201cBlood clots in a vein (&nbsp;thrombosis&nbsp;)\u201d).&nbsp;Ask your doctor when it is appropriate to start taking Ovesterin again.<\/p>\n\n\n\n<p>If you have any further questions about the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible Ovesterin Side Effects<\/h2>\n\n\n\n<p>This medicine can cause side effects like all medicines, although not everybody gets them.<\/p>\n\n\n\n<p>The side effects&nbsp;wofOvesterin are usually mild and transient.&nbsp;They may also be due to&nbsp;a too-high&nbsp;dose. <\/p>\n\n\n\n<p>Contact your doctor if you experience bleeding from the abdomen. See also &#8220;Do not use Ovesterin.&#8221;<\/p>\n\n\n\n<p>The following diseases are reported more often in women who use hormone replacement therapy circulating in the blood than in non-users.&nbsp;These risks apply to a lesser extent to vaginally use estrogen treatments:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Ovarian cancer (&nbsp;ovarian cancer&nbsp;)<\/li><li>Blood clots in veins in bones or lungs (venous&nbsp;thromboembolism&nbsp;)<\/li><li>Stroke&nbsp;<\/li><li>Probable memory loss, if treatment with&nbsp;HRT&nbsp;is started after the age of 65<\/li><\/ul>\n\n\n\n<p>See section 2 for more information on these&nbsp;side effects&nbsp;<\/p>\n\n\n\n<p>The following\u00a0Ovesterin side effects have been reported with Ovesterin (affects unknown users):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>A feeling of tension and tenderness in the breasts<\/li><li>Bleeding from the genitals<\/li><li>Nausea<\/li><li>Fluid accumulation in the body, such as swollen ankles or feet<\/li><li>Local irritation of the abdomen.<\/li><li>Flu-like symptoms<\/li><\/ul>\n\n\n\n<p>The following&nbsp;side effects&nbsp;have been reported with other HRTs:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Diseases of the gallbladder<\/li><li>Various skin diseases:<ul><li>Dark skin spots, especially on the face and neck, so-called &#8220;pregnancy spots&#8221; (chloasma)<\/li><li>Painful reddish-purple bumps on the skin (erythema nodosum)<\/li><li>Annular redness or sore rash (erythema multiforme).<\/li><\/ul><\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How To Store Ovesterin<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Keep this medicine out of sight and reach of children.<\/li><li>Do not store above 25 \u00b0 C.&nbsp;Do not freeze.<\/li><li>Do not use this medicine after the expiry date stated on the carton after EXP.&nbsp;The expiration date is the last day of the specified month.<\/li><\/ul>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines that are no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents Of The Package And Other Information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content Declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is estriol 1 mg \/ g, corresponding to 0.5 mg per&nbsp;dose.<\/li><li>The other ingredients are octyl dodecanol, cetyl palmitate,&nbsp;glycerol, cetyl alcohol, stearyl alcohol, polysorbate 60, sorbitan stearate,&nbsp;lactic acid, chlorhexidine dihydrochloride, sodium hydroxide, water.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What The Medicine Looks Like And The Contents Of The Pack<\/h2>\n\n\n\n<p>Vaginal cream\u00a0is provided in an aluminum tube of 15 g. The tube is packed in an outer carton together with an\u00a0applicator\u00a0<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder And Manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p><strong>Aspen Pharma Trading Limited, 3016 Lake Drive, Citywest Business Campus, Dublin 24, Ireland<\/strong><\/p>\n\n\n\n<p>Tel: +46 856 642 572<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Aspen Bad Oldesloe GmbH, Industriestrasse 32-36, D-23843 Bad Oldesloe, Germany<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ovesterin is a treatment of vaginal estrogen deficiency symptoms: Treatment of symptoms of vaginal atrophy due to estrogen deficiency in postmenopausal women.  Ovestin cream is an estrogen-only product for intravaginal use.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18526],"tags":[19754,20457,3550,20451,3553,20452,20455,20456,8633,8632,20453,20454],"class_list":["post-20063","post","type-post","status-publish","format-standard","hentry","category-medicines","category-o","tag-benefits-of-estriol","tag-benefits-of-ovesterin","tag-estriol","tag-estriol-cream","tag-estriol-side-effects","tag-ovesterin","tag-ovesterin-cream","tag-ovesterin-side-effects","tag-what-estriol-is-used-for","tag-what-is-estriol","tag-what-is-ovesterin","tag-what-ovesterin-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20063","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=20063"}],"version-history":[{"count":57,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20063\/revisions"}],"predecessor-version":[{"id":41406,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20063\/revisions\/41406"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=20063"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=20063"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=20063"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}