{"id":20061,"date":"2022-03-24T11:13:39","date_gmt":"2022-03-24T11:13:39","guid":{"rendered":"https:\/\/zeepedia.com\/?p=20061"},"modified":"2023-01-28T08:00:09","modified_gmt":"2023-01-28T08:00:09","slug":"ovaleap","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/ovaleap\/","title":{"rendered":"Ovaleap &#8211; Follitropin Alfa Uses, Dose And Side Effects"},"content":{"rendered":"\n<p><strong>Ovaleap 300 IU \/ 0.5 ml and 450 IU \/ 0.75 ml and 900 IU \/ 1.5 ml&nbsp;solution&nbsp;for injection follitropin alfa<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">what Is Ovaleap And What Is Ovaleap Used For<\/h2>\n\n\n\n<p>This medicine contains the active substance follitropin alfa, almost identical to a natural\u00a0hormone\u00a0called &#8216;follicle-stimulating hormone (\u00a0FSH\u00a0).\u00a0FSH\u00a0is a\u00a0gonadotropin, a type of\u00a0hormone\u00a0that plays an important role in\u00a0human\u00a0reproduction and\u00a0fertility.<\/p>\n\n\n\n<p>In women,\u00a0FSH\u00a0is needed for the ovaries (follicles) in the ovaries that contain egg cells to grow and develop.\u00a0In men,\u00a0FSH\u00a0is needed for the production of semen.<\/p>\n\n\n\n<p><strong><span style=\"text-decoration: underline;\">What Ovaleap is used for<\/span><\/strong><\/p>\n\n\n\n<p>In adult women, Ovaleap is used:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>To promote ovulation (\u00a0release\u00a0of a mature egg cell from the follicle) in women who are not ovulating and who have not responded to treatment with a drug called &#8216;clomiphene citrate&#8217;.<\/li><li>To promote the development of\u00a0follicles\u00a0in women undergoing assisted reproduction (measures that can help you conceive) such as &#8221;\u00a0<em>in vitro<\/em>\u00a0fertilization&#8221;, &#8220;gamete transfer to fallopian tubes&#8221; or &#8220;zygote transfer to fallopian tubes&#8221;.<\/li><li>In combination with a drug called &#8220;lutropin alfa&#8221; (a version of another\u00a0gonadotropin\u00a0, &#8220;luteinizing hormone&#8221; or\u00a0LH\u00a0) to promote ovulation in women who do not ovulate because their body produces too little\u00a0FSH\u00a0and\u00a0LH\u00a0.<\/li><\/ul>\n\n\n\n<p>In adult men, Ovaleap injection is used:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>In combination with a drug called &#8216;human chorionic gonadotropin&#8217; (\u00a0hCG\u00a0) to promote sperm production in men who are infertile due to low levels of certain\u00a0hormones\u00a0.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What You Need To Know Before Using Ovaleap<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do Not Use Ovaleap<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>If you are allergic to follitropin alfa, follicle-stimulating\u00a0hormone\u00a0(\u00a0FSH\u00a0) or any of the other ingredients of this medicine (listed in section 6).<\/li><li>If you have a\u00a0tumor\u00a0in your\u00a0hypothalamus\u00a0or\u00a0pituitary gland\u00a0(parts of the brain).<\/li><li>If you are\u00a0<strong><em>a woman<\/em><\/strong>\u00a0with:<ul><li>Large ovaries or fluid-filled blisters in the ovaries (ovarian cysts) of unknown origin<\/li><li>Unexplained\u00a0vaginal\u00a0bleeding<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/getting-a-cancer-message\/\">Cancer<\/a> of the ovaries, uterus or breasts<\/li><li>Any condition that usually makes normal pregnancy impossible, such as ovarian failure (early menopause), fibroid\u00a0tumors\u00a0in the uterus or malformed reproductive organs.<\/li><\/ul><\/li><li>If you are\u00a0<strong><em>a man<\/em><\/strong>\u00a0with:<ul><li>Untreatable testicular failure.<\/li><\/ul><\/li><\/ul>\n\n\n\n<p>Do not use this medicine if any of the above apply to you.&nbsp;If you are not sure, talk to your doctor or pharmacist before taking this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings And Cautions<\/h2>\n\n\n\n<p>Before starting treatment, your and your partner&#8217;s fertility should be evaluated by a doctor who has experience in assessing fertility disorders.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><span style=\"text-decoration: underline;\"><strong>Porphyry<\/strong><\/span><\/li><\/ul>\n\n\n\n<p>Tell your doctor before starting treatment if you or someone in your family has&nbsp;porphyria.&nbsp;This is a condition that can be transmitted from parents to children and means that you cannot break down porphyrins (organic compounds).<\/p>\n\n\n\n<p>Tell your doctor immediately if:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Your skin becomes brittle and easily gets blisters, especially skin that has often been exposed to sun and\/or<\/li><li>If you get <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/brain-and-nerves\/pain\/\">pain<\/a> in the abdomen, arms or legs.<\/li><\/ul>\n\n\n\n<p>If you experience the above symptoms, your doctor may recommend that you stop treatment.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong><span style=\"text-decoration: underline;\">Ovarian hyperstimulation syndrome (OHSS)<\/span><\/strong><\/li><\/ul>\n\n\n\n<p>If you are a woman, this medicine increases the risk of developing OHSS.&nbsp;This is when your&nbsp;follicles&nbsp;develop too much and become large cysts.<\/p>\n\n\n\n<p>Tell your doctor immediately if:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>You get pain in the lower abdomen (stomach)<\/li><li>You quickly gain weight<\/li><li>You feel sick or vomit<\/li><li>You have difficulty breathing<\/li><\/ul>\n\n\n\n<p>If you experience the above symptoms, your doctor may advise you to stop using this medicine (see also section 4 under \u201cSerious&nbsp;side effects&nbsp;in women\u201d).<\/p>\n\n\n\n<p>If you are not ovulating and if the recommended\u00a0dose\u00a0and the recommended dosing schedule are followed, the occurrence of OHSS is less likely.<\/p>\n\n\n\n<p>Ovaleap treatment rarely causes pronounced OHSS unless the medication used for final follicular maturation (containing\u00a0human chorionic gonadotropin,\u00a0hCG\u00a0) is given.\u00a0If you develop OHSS, your doctor may not give you any\u00a0hCG\u00a0during this treatment cycle.\u00a0You may be told not to have intercourse or to use barrier contraceptives for at least 4 days.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><span style=\"text-decoration: underline;\"><strong>Multiple pregnancies<\/strong><\/span><\/li><\/ul>\n\n\n\n<p>When you use this medicine, there is a greater risk that you will become pregnant with more than one child (ie &#8220;multiple pregnancies&#8221;, usually twins) than if you become pregnant naturally.<\/p>\n\n\n\n<p>Multiple pregnancies can cause medical complications for you and your children.\u00a0You can reduce the risk of multiple pregnancies by using the right\u00a0dose\u00a0of this medicine at the right times.\u00a0<\/p>\n\n\n\n<p>When you undergo assisted reproduction, the risk of multiple pregnancies is related to your age, the quality, and number of fertilized eggs or embryos that are placed with you.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><span style=\"text-decoration: underline;\"><strong>Miscarriage<\/strong><\/span><\/li><\/ul>\n\n\n\n<p>You are at greater risk of miscarriage than the average woman when you undergo assisted reproduction or your ovaries are stimulated to produce eggs.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><span style=\"text-decoration: underline;\"><strong>Excessive pregnancy<\/strong><\/span><\/li><\/ul>\n\n\n\n<p>You are at greater risk of developing an ectopic pregnancy (ectopic pregnancy) than the average woman when you undergo assisted reproduction and if your fallopian tubes are damaged.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong><span style=\"text-decoration: underline;\">Congenital malformations<\/span><\/strong><\/li><\/ul>\n\n\n\n<p>The incidence of congenital malformations after assisted reproduction may be slightly higher than after natural conception.&nbsp;This may be related to multiple pregnancies or characteristics of the parents such as the mother&#8217;s age and sperm quality.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong><span style=\"text-decoration: underline;\">Problems with blood clots (thromboembolic events)<\/span><\/strong><\/li><\/ul>\n\n\n\n<p>If you have ever had blood clots in your legs or lungs, a heart attack or&nbsp;stroke,&nbsp;or if your family has had any of these, tell your doctor.&nbsp;You may be at greater risk of having these problems or of getting worse with treatment with Ovaleap.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong><span style=\"text-decoration: underline;\">Men with too much\u00a0FSH\u00a0in their blood<\/span><\/strong><\/li><\/ul>\n\n\n\n<p>If you are a man, too much natural&nbsp;FSH&nbsp;in the blood can be a sign of damaged testicles.&nbsp;This drug is usually not effective in this problem.&nbsp;If your doctor decides that you should try treatment with Ovaleap, he or she can check the effect by asking you to leave semen for analysis 4 to 6 months after the start of treatment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children And Young People<\/h2>\n\n\n\n<p>This medicine is not intended for use in children and adolescents under 18 years of age.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other Drugs And Ovaleap<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you use Ovaleap with other medicines that facilitate ovulation, such as&nbsp;human chorionic gonadotropin&nbsp;(&nbsp;hCG&nbsp;) or clomiphene citrate, these may increase the response of your&nbsp;follicles&nbsp;.<\/li><li>If you are taking Ovaleap at the same time as an&nbsp;agonist&nbsp;or&nbsp;antagonist&nbsp;of &#8216;gonadotropin-releasing hormone&#8217; (&nbsp;GnRH&nbsp;) (these medicines lower sex hormone levels and stop ovulation) you may need a higher&nbsp;dose&nbsp;of Ovaleap to produce&nbsp;follicles&nbsp;.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, Breastfeeding And Fertility<\/h2>\n\n\n\n<p>You should not use this medicine if you are pregnant or breastfeeding.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving And Using Machines<\/h2>\n\n\n\n<p>This medicine does not affect your ability to drive or use machines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Ovaleap Contains Excipients<\/h2>\n\n\n\n<p>This medicine contains less than 1 mmol\u00a0sodium\u00a0(23 mg) per\u00a0dose, ie essentially &#8216;sodium-free&#8217;. This medicine also contains benzalkonium chloride 0.02 mg\/ml and benzyl <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/alcohol-and-drugs-risk-use-harmful-use-and-addiction\/\">alcohol<\/a> 10.0 mg\/ml.\u00a0<\/p>\n\n\n\n<p>If you have liver or kidney problems and are pregnant or breastfeeding, talk to your doctor or pharmacist before taking this medicine.\u00a0Large amounts of benzyl alcohol can be stored in the body and cause\u00a0side effects\u00a0(metabolic\u00a0acidosis\u00a0).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How To Use Ovaleap<\/h2>\n\n\n\n<p>Always use this medicine exactly as your doctor or pharmacist has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p><strong>This medicine is given as an\u00a0injection\u00a0into tissue\u00a0just under the skin (\u00a0subcutaneous\u00a0injection\u00a0).\u00a0<\/strong>Your doctor or nurse will show you how to inject the medicine.\u00a0If you are giving this medicine to yourself, read and follow the instructions for use carefully.<\/p>\n\n\n\n<p><strong>Recommended&nbsp;dose<\/strong><\/p>\n\n\n\n<p>Your doctor will decide how much medicine to take and how often.&nbsp;The&nbsp;doses&nbsp;shown below are given in International Units (IU).<\/p>\n\n\n\n<p>Women<\/p>\n\n\n\n<p>If you are not ovulating and have irregular or no periods<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>This medicine is usually given every day.<\/li><li>If you have irregular periods, start using this medicine within the first 7 days of your menstrual cycle.&nbsp;If you are not menstruating, you can start using the medicine on a day that suits you.<\/li><li>The usual starting dose of this medicine is 75 to 150 IU every day.<\/li><li>The dose&nbsp;of one of these medicines can be increased every 7 or 14 days by 37.5 to 75 IU, until you get the desired answer.<\/li><li>The maximum daily&nbsp;dose&nbsp;of this medicine is usually not higher than 225 IU.<\/li><li>Once you have received the desired answer, you will receive&nbsp;hCG&nbsp;or \u201crecombinant hCG\u201d (r\u2011&nbsp;hCG&nbsp;, a&nbsp;hCG&nbsp;that is produced in the laboratory using a special&nbsp;DNA&nbsp;technique).&nbsp;The single injection will consist of 250 micrograms r\u2011&nbsp;hCG&nbsp;or 5,000 to 10,000 IU&nbsp;hCG&nbsp;24 to 48 hours after your last&nbsp;injection&nbsp;of Ovaleap.&nbsp;The best time to have intercourse is the same day as&nbsp;hCG&nbsp;injection&nbsp;one&nbsp;and the day after.&nbsp;Alternatively, intrauterine insemination can take place by inserting semen into the uterus.<\/li><\/ul>\n\n\n\n<p>If your doctor does not see the desired response after 4 weeks, the Ovaleap treatment cycle should be stopped.&nbsp;In the following treatment cycle, your doctor will give you a higher starting dose of this medicine than before.<\/p>\n\n\n\n<p>If your body responds too strongly, treatment will be stopped and you will not receive any&nbsp;hCG&nbsp;[see section 2 under \u201cOvarian hyperstimulation syndrome (OHSS)\u201d].&nbsp;In the following cycle, your doctor will give you a lower&nbsp;dose&nbsp;of Ovaleap than before.<\/p>\n\n\n\n<p>If you need to develop more eggs for collection before an assisted reproduction<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The usual starting dose of this medicine is 150 to 225 IU every day, from day 2 or 3 of the menstrual cycle.<\/li><li>Dose&nbsp;one can be increased, depending on the response to treatment.&nbsp;The maximum daily&nbsp;dose&nbsp;is 450 IU.<\/li><li>The treatment continues until your eggs have reached the desired development.&nbsp;This usually takes about 10 days, but can take anywhere from 5 to 20 days.&nbsp;Your doctor will use blood samples and \/ or ultrasound equipment to check when this happens.<\/li><li>When your eggs are done, you will get&nbsp;hCG&nbsp;or raw&nbsp;hCG&nbsp;.&nbsp;The single injection will consist of 250 micrograms r\u2011&nbsp;hCG&nbsp;or 5,000 IU to 10,000 IU&nbsp;hCG&nbsp;24 to 48 hours after your last&nbsp;injection&nbsp;of Ovaleap.&nbsp;This will get your eggs ready for collection.<\/li><\/ul>\n\n\n\n<p>Otherwise, your doctor may first stop your ovulation by using a&nbsp;gonadotropin-releasing&nbsp;hormone&nbsp;(GnRH)&nbsp;agonist&nbsp;or&nbsp;antagonist.&nbsp;Thereafter, treatment with Ovaleap is started approximately 2 weeks after the start of agonist treatment.&nbsp;Then both Ovaleap and&nbsp;GnRH&nbsp;agonists are&nbsp;given&nbsp;one until your&nbsp;follicles&nbsp;develop as desired.<\/p>\n\n\n\n<p>If you do not&nbsp;ovulate, have no period, and have a diagnosis of very low levels of&nbsp;FSH&nbsp;and&nbsp;LH&nbsp;hormones<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The usual starting dose of Ovaleap is 75 to 150 IU together with 75 IU lutropin alfa.<\/li><li>You will use these two medicines every day for up to 5 weeks.<\/li><li>Dose&nbsp;one of Ovaleap can be increased every 7 or 14 days by 37.5 to 75 IU, until you get the desired answer.<\/li><li>Once you have the desired answer, you will receive&nbsp;hCG&nbsp;or r\u2011&nbsp;hCG&nbsp;.&nbsp;The single injection will consist of 250 micrograms r\u2011&nbsp;hCG&nbsp;or 5,000 IU to 10,000 IU&nbsp;hCG&nbsp;24 to 48 hours after your last&nbsp;injection&nbsp;of Ovaleap and lutropin alfa.&nbsp;The best time to have intercourse is the same day as&nbsp;hCG&nbsp;injection&nbsp;one&nbsp;and the day after.&nbsp;Alternatively, intrauterine insemination can take place by inserting semen into the uterus.<\/li><\/ul>\n\n\n\n<p>If your doctor cannot see an answer after 5 weeks, the treatment cycle should be stopped.&nbsp;In the following cycle, your doctor will give you a higher starting dose of this medicine than before.<\/p>\n\n\n\n<p>If your body responds too strongly, treatment with Ovaleap will be stopped and you will not receive any&nbsp;hCG&nbsp;[see section 2 under \u201cOvarian hyperstimulation syndrome (OHSS))\u201d].&nbsp;In the following cycle, your doctor will give you a lower&nbsp;dose&nbsp;of Ovaleap than before.<\/p>\n\n\n\n<p>Men<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The usual&nbsp;dose&nbsp;of this medicine is 150 IU together with&nbsp;hCG&nbsp;.<\/li><li>You use these two medicines three times a week for at least 4 months.<\/li><li>If you have not responded to treatment after 4 months, your doctor may suggest that you continue to use these two medicines for at least 18 months.<\/li><\/ul>\n\n\n\n<p><strong>How are the&nbsp;injections&nbsp;given?<\/strong><\/p>\n\n\n\n<p>This medicine is given as an&nbsp;injection&nbsp;into the&nbsp;tissue&nbsp;just below the skin (&nbsp;subcutaneous&nbsp;injection&nbsp;) with the Ovaleap Pen.&nbsp;Ovaleap Pen is a product (a &#8220;pen&#8221;) that is used to give you&nbsp;injections&nbsp;into the&nbsp;tissue&nbsp;just under the skin.<\/p>\n\n\n\n<p>Your doctor may suggest that you learn how to inject this medicine yourself.&nbsp;The doctor or nurse will inform you on how to do this and you will also find instructions in the separate instructions for use of the pen.&nbsp;Do not try to give yourself the medicine without having been instructed by your doctor or nurse.&nbsp;The very first&nbsp;injection&nbsp;of this medicine should only be given in the presence of a doctor or nurse.<\/p>\n\n\n\n<p>Ovaleap&nbsp;solution for injection&nbsp;in&nbsp;cartridges, cartridges, are intended for use with the Ovaleap Pen.&nbsp;You must follow the separate instructions for use of the Ovaleap Pen carefully.&nbsp;The instructions for use of the pen are included with the Ovaleap Pen.&nbsp;However, the treatment of your condition requires close and continuous cooperation with your doctor.<\/p>\n\n\n\n<p>Dispose of all needles immediately after&nbsp;injection.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If You Use Too Much Ovaleap\u00a0<\/h2>\n\n\n\n<p>The effects of using too much Ovaleap are unknown.&nbsp;Nevertheless, ovarian hyperstimulation syndrome (OHSS) can be expected to occur.&nbsp;This is described in section 4 under &#8220;Serious&nbsp;adverse reactions&nbsp;in women&#8221;.&nbsp;However, OHSS only occurs if&nbsp;hCG&nbsp;has also been administered [see also section 2 under \u201cOvarian hyperstimulation syndrome (OHSS)\u201d]<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If You Forget To Use Ovaleap<\/h2>\n\n\n\n<p>Do not take a double\u00a0dose\u00a0to make up for a forgotten\u00a0dose.\u00a0Talk to your doctor as soon as you realize you have missed a\u00a0dose. If you have any further questions on the use of this product, ask your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible Ovaleap Side Effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Important\u00a0Ovaleap injection side effects\u00a0are<\/strong><\/p>\n\n\n\n<p>Serious&nbsp;side effects&nbsp;are in men and women<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Allergic reactions such as rash, raised, itchy skin areas and severe allergic reactions with weakness, drop in blood pressure, difficulty breathing and swelling of the face have been reported in very rare cases (may affect up to 1 in 10,000 people).&nbsp;If you think you have had such a reaction, you must immediately stop&nbsp;injecting&nbsp;one with Ovaleap and see a doctor.<\/li><\/ul>\n\n\n\n<p>Serious&nbsp;side effects&nbsp;are in women<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Lower abdominal pain along with nausea or <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/stomach-disease-diarrhea-and-vomiting\/\">vomiting<\/a> may be symptoms of ovarian hyperstimulation syndrome (OHSS).&nbsp;This may indicate that the ovaries are overreacting to the treatment and that large ovarian cysts have developed [see also section 2 under \u201cOvarian hyperstimulation syndrome (OHSS)\u201d].&nbsp;This&nbsp;side effect&nbsp;is common (may affect up to 1 in 10 people).<\/li><li>OHSS can be pronounced with clearly enlarged ovaries, decreased urine production, weight gain, difficulty breathing and \/ or possible fluid accumulation in the abdominal cavity or chest.&nbsp;This&nbsp;side effect&nbsp;is less common (may affect up to 1 in 100 people).<\/li><li>Complications of OHSS, such as ovarian torsion or blood clots, can occur in rare cases (may affect up to 1 in 1,000 people).<\/li><li>Severe thrombotic complications (thromboembolic events), sometimes independent of OHSS, can occur in very rare cases (may affect up to 1 in 10,000 people).&nbsp;This can cause chest pain, shortness of breath,&nbsp;stroke&nbsp;or heart attack (see also section 2 under \u201cThromboembolic events\u201d).<\/li><\/ul>\n\n\n\n<p>If you notice any of the side effects listed above,&nbsp;contact your doctor immediately who may ask you to stop using Ovaleap.<\/p>\n\n\n\n<p><strong>Other\u00a0Ovaleap injection side effects\u00a0are in women<\/strong><\/p>\n\n\n\n<p>Very common&nbsp;(may affect more than 1 user in 10)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Local reactions at the injection site, such as pain,&nbsp;redness&nbsp;, bruising, swelling and \/ or irritation)<\/li><li>Headache<\/li><li>Fluid-filled blisters in the ovaries (ovarian cysts)<\/li><\/ul>\n\n\n\n<p>Common&nbsp;(may affect up to 1 in 10 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Magont<\/li><li>Weather voltage<\/li><li>Abdominal cramps<\/li><li>Nausea<\/li><li>Vomiting<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/diarrhea-in-children\/\">Diarrhea<\/a><\/li><\/ul>\n\n\n\n<p>Very rare&nbsp;(may affect up to 1 in 10,000 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Your&nbsp;asthma&nbsp;can get worse.<\/li><\/ul>\n\n\n\n<p><strong>Other&nbsp;side effects&nbsp;are in men<\/strong><\/p>\n\n\n\n<p>Very common&nbsp;(may affect more than 1 user in 10)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Local reactions at the injection site, such as pain,&nbsp;redness&nbsp;, bruising, swelling and \/ or irritation)<\/li><\/ul>\n\n\n\n<p>Common&nbsp;(may affect up to 1 in 10 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Swollen veins above and behind the testicles (varicocele)<\/li><li>Breast development<\/li><li>Acne<\/li><li>Weight gain<\/li><\/ul>\n\n\n\n<p>Very rare&nbsp;(may affect up to 1 in 10,000 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Your&nbsp;asthma&nbsp;can get worse.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How To Store Ovaleap<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Keep this medicine out of the sight and reach of children.<\/li><li>Do not use this medicine after the expiry date which is stated on the label after EXP or on the outer carton after EXP.\u00a0The expiration date is the last day of the specified month.<\/li><li>Store in a refrigerator (2 \u00b0 C \u2011 8 \u00b0 C).<\/li><li>Do not freeze.<\/li><li>The cartridge, cassette, is stored in the outer carton.\u00a0Sensitive to light.<\/li><li>Before opening the package and within the shelf life, you can remove this medicine from the refrigerator and store it for up to 3 months without putting it in the refrigerator again.\u00a0Do not store above 25 \u00b0 C.\u00a0You must discard the medicine if it has not been used within 3 months.<\/li><li>After opening,\u00a0the cartridge, the cartridge, during use in the pen can be stored for a maximum of 28 days.\u00a0Do not store above 25 \u00b0 C.\u00a0Make a note of the first use date in the patient diary that comes with the Ovaleap Pen.<\/li><li>Replace the cap on the Ovaleap Pen after each\u00a0injection\u00a0to protect\u00a0the cartridge, the cartridge, from light.<\/li><li>Do not use this medicine if you notice that it is cloudy or contains particles.<\/li><\/ul>\n\n\n\n<p>Medicines should not be disposed of via wastewater.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents Of The Package And Other Information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content Declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is follitropin alfa.<ul><li>Ovaleap 300 IU \/ 0.5 ml: Each\u00a0cartridge\u00a0, cassette, contains 300 IU (equivalent to 22 micrograms) follitropin alfa in 0.5 ml solution.<\/li><li>Ovaleap 450 IU \/ 0.75 ml: Each\u00a0cartridge\u00a0, cassette, contains 450 IU (equivalent to 33 micrograms) follitropin alfa in 0.75 ml solution.<\/li><li>Ovaleap 900 IU \/ 1.5 ml: Each\u00a0cartridge\u00a0, cassette, contains 900 IU (equivalent to 66 micrograms) follitropin alfa in 1.5 ml solution.<\/li><li>Each ml of solution contains 600 IU (equivalent to 44 micrograms) follitropin alfa.<\/li><\/ul><\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li>The other ingredients are disodium hydrogen phosphate dihydrate, sodium hydroxide (2 M) (for&nbsp;pH&nbsp;adjustment), mannitol, methionine, polysorbate 20, benzyl alcohol, benzalkonium chloride and water for injections.<\/li><\/ul>\n\n\n\n<p>All strengths listed above contain other ingredients.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What The Medicine Looks Like And Contents Of The Pack<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Ovaleap is a\u00a0solution for injection\u00a0(\u00a0injection\u00a0).\u00a0Ovaleap is a clear and colorless solution.<\/li><li>Ovaleap 300 IU \/ 0.5 ml is available in packs containing 1\u00a0cartridge, cartridge, and 10 injection needles.<\/li><li>Ovaleap 450 IU \/ 0.75 ml is available in packs containing 1\u00a0cartridge, cartridge, and 10 injection needles.<\/li><li>Ovaleap 900 IU \/ 1.5 ml is available in packs containing 1\u00a0cartridge, cartridge, and 20 injection needles.<\/li><li>Not all pack sizes may be marketed.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder And Manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>Thermax Ireland Limited<\/p>\n\n\n\n<p>3&nbsp;<sup>rd<\/sup>&nbsp;Floor, Kilmore House,<\/p>\n\n\n\n<p>Spencer Dock Park Lane,<\/p>\n\n\n\n<p>Dublin 1<\/p>\n\n\n\n<p>D01 YE64<\/p>\n\n\n\n<p>Ireland<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Teva Biotech GmbH<\/p>\n\n\n\n<p>Dornierstra\u00dfe 10<\/p>\n\n\n\n<p>89079 Ulm<\/p>\n\n\n\n<p>Germany<\/p>\n\n\n\n<p>Teva Pharmaceuticals Europe BV<\/p>\n\n\n\n<p>Swensen 5<\/p>\n\n\n\n<p>2031 GA Haarlem<\/p>\n\n\n\n<p>Netherlands<\/p>\n\n\n\n<p>Merckle GmbH<\/p>\n\n\n\n<p>Graf-Arco-Stra\u00dfe 3<\/p>\n\n\n\n<p>89079 Ulm,<\/p>\n\n\n\n<p>Germany<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ovaleap is used to stimulate the ovaries to develop more than one egg at a time in women who have significant luteinising hormone (LH) and follicle stimulating hormone (FSH) deficit (extremely low levels) (FSH).<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18526],"tags":[20462,20467,20458,20461,20463,20466,20460,20459,20464,20465],"class_list":["post-20061","post","type-post","status-publish","format-standard","hentry","category-medicines","category-o","tag-benefits-of-follitropin-alfa","tag-benefits-of-ovaleap","tag-follitropin-alfa","tag-follitropin-alfa-side-effects","tag-ovaleap","tag-ovaleap-side-effects","tag-what-follitropin-alfa-is-used-for","tag-what-is-follitropin-alfa","tag-what-is-ovaleap","tag-what-ovaleap-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20061","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=20061"}],"version-history":[{"count":49,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20061\/revisions"}],"predecessor-version":[{"id":46978,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/20061\/revisions\/46978"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=20061"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=20061"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=20061"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}