{"id":19874,"date":"2022-03-19T11:25:49","date_gmt":"2022-03-19T11:25:49","guid":{"rendered":"https:\/\/zeepedia.com\/?p=19874"},"modified":"2022-03-21T11:27:47","modified_gmt":"2022-03-21T11:27:47","slug":"optiray","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/optiray\/","title":{"rendered":"Optiray &#8211; Joversol uses, dose and side effects"},"content":{"rendered":"\n<p>240 mg iodine \/ ml,&nbsp;solution for injection&nbsp;or&nbsp;infusion&nbsp;.<br>Active substance: joversol<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Optiray is and what it is used for<\/h2>\n\n\n\n<p>Optiray is used in adults for several different types of X-ray examinations, including:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>imaging of&nbsp;vessels&nbsp;,<\/strong>&nbsp;both&nbsp;arteries&nbsp;and veins<\/li><li><strong>kidneys<\/strong><\/li><li><strong>DT scan<\/strong><\/li><\/ul>\n\n\n\n<p>Optiray is iodine -containing\u00a0X-ray contrast agent.\u00a0Iodine blocks the X-rays and can therefore mark out blood vessels and internal organs that are supplied with blood.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using Optiray<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Optiray<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are&nbsp;<strong>allergic<\/strong>&nbsp;to iodinated&nbsp;<strong>contrast media<\/strong>&nbsp;or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you have an&nbsp;<strong>overactive&nbsp;thyroid gland<\/strong><\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor before using Optiray if you have any<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>asthma&nbsp;or have previously had allergic reactions such as nausea, vomiting, low&nbsp;blood pressure&nbsp;, skin symptoms<\/li><li>heart failure&nbsp;, high&nbsp;blood pressure&nbsp;, circulatory disorders, or have had a&nbsp;stroke&nbsp;or if you are very old<\/li><li>diabetes<\/li><li>kidney or liver disease<\/li><li>brain injury<\/li><li>bone marrow disease, such as certain forms of blood cancer, called paraproteinemia, multiple&nbsp;myeloma<\/li><li>a disorder of the red&nbsp;blood cells&nbsp;called sickle cell disease<\/li><li>adrenal tumor that affects your&nbsp;blood pressure&nbsp;(&nbsp;pheochromocytoma&nbsp;)<\/li><li>increased level of the amino acid&nbsp;homocysteine&nbsp;\u200b\u200bdue to abnormal metabolism<\/li><li>recently conducted gallbladder examination with contrast medium<\/li><li>a planned thyroid examination using an iodine-containing substance.<br>This should be postponed, as Optiray can affect the results for up to 16 days.<\/li><\/ul>\n\n\n\n<p>Severe skin reactions that may be life-threatening and a drug reaction called DRESS have been reported in patients receiving Optiray.\u00a0For signs and symptoms of these\u00a0side effects, see section 4 \u201cPossible side effects\u201d.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children under 18 years<\/h2>\n\n\n\n<p>Optiray 240 is not recommended in this age group.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Optiray<\/h2>\n\n\n\n<p>Tell your doctor or radiologist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>The following&nbsp;<strong>medicines<\/strong>&nbsp;may&nbsp;<strong>affect or be affected by Optiray<\/strong>&nbsp;:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>metformin:<\/strong>&nbsp;for the treatment of&nbsp;diabetes<br>Your doctor measures kidney function before and after using Optiray.&nbsp;Metformin&nbsp;should be discontinued prior to examination.&nbsp;It should not be reinserted for at least 48 hours and not until your kidney function has returned to previous values.<\/li><li><strong>interleukin:<\/strong>&nbsp;for the treatment of&nbsp;certain&nbsp;tumors<\/li><li><strong>Certain medicines that raise&nbsp;blood pressure&nbsp;due<\/strong>&nbsp;to narrowing of the blood vessels<br>To prevent the risk of neurological disorders, Optiray should never be used when taking these medicines.<\/li><li><strong>anesthetics<\/strong><br>A higher frequency of&nbsp;side effects&nbsp;has been reported.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Optiray with food and drink<\/h2>\n\n\n\n<p>Limit your food intake before the examination.&nbsp;Consult your doctor.&nbsp;If you have kidney disease, do not limit your fluid intake, as this may further reduce kidney function.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Pregnancy<\/strong><br>Tell your doctor if you are or think you may be pregnant.&nbsp;Your doctor will only prescribe Optiray during pregnancy&nbsp;<strong>if absolutely necessary,<\/strong>&nbsp;as it may harm the unborn baby.<\/li><li><strong>Breast -feeding Stop breast-feeding<\/strong><br><strong>for one day<\/strong>&nbsp;after&nbsp;injection&nbsp;, as there is not enough safety information.&nbsp;Talk to your doctor or radiologist about this.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Do not drive or use machines\u00a0<strong>for up to 1 hour after\u00a0<\/strong>injection.<\/p>\n\n\n\n<p>Symptoms such as dizziness, drowsiness, lethargy, and visual disturbances have been reported.\u00a0If you are affected in any of these ways, do not try to perform any activities that require concentration and good reactivity.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened vigilance.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0Descriptions of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Optiray contains excipients<\/h2>\n\n\n\n<p><strong>Optiray contains\u00a0sodium.<\/strong><\/p>\n\n\n\n<p>This medicine contains less than 1 mmol&nbsp;sodium&nbsp;(23 mg) per 100 ml, ie essentially &#8216;sodium-free&#8217;.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Optiray<\/h2>\n\n\n\n<p>Optiray examinations are\u00a0<strong>only performed by a doctor or X-ray specialist,<\/strong>\u00a0who also determines the\u00a0dose.<br>Optiray is\u00a0injected into a blood vessel\u00a0and the circulatory system distributes it throughout the body.\u00a0It is warmed to body temperature before use and is then injected one or more times during the X-ray examination.<br>Dose\u00a0one depends on the specific examination you are going to undergo as well as other factors, such as your health and age.<br>The lowest possible\u00a0dose\u00a0to produce adequate X-rays will be used.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you have used more Optiray than you should<\/h2>\n\n\n\n<p>Overdose is potentially dangerous and can affect breathing, heart, and circulatory system.\u00a0Tell your doctor or radiologist immediately if you experience any of these symptoms after receiving Optiray.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or X-ray specialist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.\u00a0The side effects\u00a0associated with Optiray are generally not dependent on the\u00a0dose\u00a0used.\u00a0In most cases, the\u00a0side effects\u00a0are mild or moderate and in very rare cases severe or life-threatening.<\/p>\n\n\n\n<p><strong>Tell your doctor immediately<\/strong>&nbsp;if you develop any of the following&nbsp;<strong>signs of serious side effects:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>heart attack or inability to breathe<\/li><li>severe chest pain, which may indicate angina pectoris or blood clots<\/li><li>stroke&nbsp;, blue lips, fainting<\/li><li>memory loss<\/li><li>speech disorders<\/li><li>sudden movements,<\/li><li>temporary blindness<\/li><li>acute&nbsp;renal failure<\/li><li>skin rash,&nbsp;redness&nbsp;or blisters, which can develop into life-threatening skin reactions with extensive skin flaking (toxic&nbsp;epidermal&nbsp;necrolysis&nbsp;) or a drug reaction that causes rash, fever,&nbsp;inflammation&nbsp;of internal organs, blood clots and systemic disease (DRESS)<\/li><li>signs of allergic reactions, e.g.<ul><li>allergic&nbsp;shock<\/li><li>narrow airways<\/li><li>swelling of the larynx \/ throat \/ tongue<\/li><li>breathing difficulties<\/li><li>cough, sneezing<\/li><li>redness&nbsp;or swelling of the face and eyes<\/li><li>itching&nbsp;,&nbsp;hives&nbsp;and other rashes<\/li><\/ul><\/li><\/ul>\n\n\n\n<p><strong>Side effects&nbsp;can occur with the following frequencies:<\/strong><br><strong>very common,<\/strong>&nbsp;affecting more than 1 user in 10<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>feeling of warmth<\/li><\/ul>\n\n\n\n<p><strong>common,<\/strong>&nbsp;1 to 10 per 100 users affected:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>pain<\/li><\/ul>\n\n\n\n<p><strong>uncommon,<\/strong>&nbsp;1 to 10 per 1,000 users affected:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>nausea<\/li><li>hives<\/li><\/ul>\n\n\n\n<p><strong>rare,<\/strong>&nbsp;1 to 10 per 10,000 users affected:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>fainting<\/li><li>uncontrollable tremors<\/li><li>dizziness, instability<\/li><li>headache<\/li><li>deviant sensation, e.g.&nbsp;knitting<\/li><li>taste disorders<\/li><li>dimsyn<\/li><li>fast&nbsp;pulse<\/li><li>low&nbsp;blood pressure<\/li><li>hemorrhage<\/li><li>cramp in the larynx<\/li><li>swollen and narrow airways, including feeling of tightness in the throat, wheezing and wheezing<\/li><li>breathing difficulties<\/li><li>inflammation&nbsp;of the nose leading to sneezing and nasal congestion<\/li><li>cough, throat irritation<\/li><li>vomiting<\/li><li>dry mouth<\/li><li>redness,&nbsp;itching&nbsp;, rash<\/li><li>urinary incontinence<\/li><li>swelling of the face and eyes<\/li><li>chills, feeling cold<\/li><\/ul>\n\n\n\n<p><strong>very rare,<\/strong>&nbsp;less than 1 in 10,000 users affected:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>severe&nbsp;allergic reaction<\/li><li>confusion, anxiety, restlessness<\/li><li>unconsciousness, numbness<\/li><li>paralysis<\/li><li>somnolence<\/li><li>speech disorders<\/li><li>impaired sense of touch and sensation<\/li><li>allergic eye inflammation that leads to red, watery and itchy eyes<\/li><li>ringing or hissing in the ears<\/li><li>irregular heartbeat, slow&nbsp;pulse<\/li><li>chest pain<\/li><li>changes in cardiac activity measured by&nbsp;ECG<\/li><li>disease that disrupts blood flow to the brain<\/li><li>high&nbsp;blood pressure<\/li><li>venous inflammation, dilation of blood vessels<\/li><li>fluid accumulation in the lungs<\/li><li>sore throat<\/li><li>low oxygen content in the blood<\/li><li>abdominal pain<\/li><li>salivary gland inflammation, swelling of the tongue<\/li><li>difficulty swallowing, increased salivation<\/li><li>often painful, severe swelling of deep layers of skin, mainly on the face.<\/li><li>increased sweating<\/li><li>muscle cramps<\/li><li>acute&nbsp;renal failure&nbsp;or abnormal renal function<\/li><li>urinary incontinence, blood in the urine, small amount of urine<\/li><li>tissue swelling due to excess fluid<\/li><li>injection site reactions including pain,&nbsp;redness&nbsp;, bleeding or degradation of cells<\/li><li>malaise or abnormal fatigue, inertia<\/li><\/ul>\n\n\n\n<p><strong>No known frequency<\/strong>&nbsp;(can not be calculated from the available data)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>severe allergic&nbsp;shock<\/li><li>temporarily underactive&nbsp;thyroid gland&nbsp;in newborns<\/li><li>attack<\/li><li>movement disorders<\/li><li>memory loss<\/li><li>temporary blindness<\/li><li>cardiac arrest, life-threatening irregular heartbeat<\/li><li>extra heartbeat<\/li><li>heart artery spasm, throbbing heart<\/li><li>blue skin due to low oxygen content in the blood<\/li><li>shock<\/li><li>blood clot or&nbsp;spasm&nbsp;in a blood vessel<\/li><li>inability to breathe,&nbsp;asthma&nbsp;, narrow airways<\/li><li>impaired ability to create sound with the vocal cords<\/li><li>diarrhea<\/li><li>pallor<\/li><li>inability to urinate or painful \/ difficult to urinate<\/li><li>fever<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Optiray<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the label.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Store the bottle in the outer carton.&nbsp;Sensitive to light.&nbsp;Must be protected from X-rays.&nbsp;Do not store above 30 \u00b0 C.&nbsp;Optiray 240 can be stored for one month at 37 \u00b0 C in a contrast medium heater with circulating air.<\/p>\n\n\n\n<p>Do not use this medicine if the solution is discolored or contains particles.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is&nbsp;<strong>joversol.<\/strong><br>One milliliter of Optiray contains 509 mg of joversol, equivalent to 240 mg of organically bound iodine.<\/li><li>The other ingredients are: sodium calcium edetate (stabilizer), <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/tribonate\/\">trometamol<\/a> and trometamol hydrochloride (&nbsp;buffer&nbsp;) and water for injections.<br>Sodium hydroxide or&nbsp;hydrochloric acid&nbsp;can be used to adjust the&nbsp;pH&nbsp;from 6.0 to 7.4.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<p>Optiray is packaged in colorless bottles.&nbsp;The bottles are equipped with 32 mm closures of bromobutyl rubber and aluminum caps.<\/p>\n\n\n\n<p>50 ml (carton with 1 or 10 and 25 bottles)<\/p>\n\n\n\n<p>100 ml (carton with 1 or 10 and 12 bottles)<\/p>\n\n\n\n<p>Optiray is also available in pre-filled handheld syringes and auto-injector syringes made of polypropylene.\u00a0The syringe tip and piston are made of natural rubber.<\/p>\n\n\n\n<p>Pre-filled hand-held syringes: 50 ml (carton with 1 or 10 and 20 syringes)<\/p>\n\n\n\n<p>Syringes for auto-injector: 75, 125 ml (carton with 1 or 10 auto-injector syringes)<\/p>\n\n\n\n<p>Not all pack sizes and carton sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Marketing Authorization Holder<\/strong><br>Guerbet, BP 57400, 95943 Roissy CdG Cedex, France<\/li><li><strong>Manufacturer<\/strong><br>Guerbet Ireland ULC, Damastown, Mulhuddart, Dublin 15, Ireland<br>Or<br>Guerbet BP 57400 95943 Roissy CdG Cedex France, located at 16-24 rue Jean Chaptal, 93600 Aulnay sous Bois, France<\/li><\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Optiray is used in adults for several different types of X-ray examinations, including:<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18526],"tags":[20121,20126,20117,20120,20122,20125,20123,20118,20119,20124],"class_list":["post-19874","post","type-post","status-publish","format-standard","hentry","category-medicines","category-o","tag-benefits-of-joversol","tag-benefits-of-optiray","tag-joversol","tag-joversol-side-effects","tag-optiray","tag-optiray-side-effects","tag-what-iiiiiiiiiiiiiiiiiiiii","tag-what-is-joversol","tag-what-joversol-is-used-for","tag-what-optiray-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/19874","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=19874"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/19874\/revisions"}],"predecessor-version":[{"id":19908,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/19874\/revisions\/19908"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=19874"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=19874"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=19874"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}