{"id":19809,"date":"2022-03-17T11:24:12","date_gmt":"2022-03-17T11:24:12","guid":{"rendered":"https:\/\/zeepedia.com\/?p=19809"},"modified":"2022-03-19T11:00:11","modified_gmt":"2022-03-19T11:00:11","slug":"onpattro","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/onpattro\/","title":{"rendered":"Onpattro &#8211; Patisiran uses, dose and side effects"},"content":{"rendered":"\n<p>2 mg \/ ml&nbsp;concentrate for&nbsp;solution for&nbsp;infusion<br>patisiran<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Onpattro is and what it is used for<\/h2>\n\n\n\n<p>The active substance in Onpattro is patisiran.<\/p>\n\n\n\n<p>Onpattro is a drug that treats a hereditary disease called hereditary transthyretin amyloidosis (hATTR amyloidosis, Skellefte&#8217;s disease).<\/p>\n\n\n\n<p>HATTR amyloidosis is caused by a problem with a\u00a0protein\u00a0in the body called &#8216;transthyretin&#8217; (TTR).<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>This&nbsp;protein&nbsp;is mainly made by the liver and carries around&nbsp;vitamin&nbsp;A and other substances in the body.<\/li><li>In people with this disease, abnormally shaped TTR&nbsp;proteins&nbsp;can clump together and create deposits called &#8220;amyloid&#8221;.<\/li><li>Amyloid can accumulate around nerves, the heart and other places in the body and prevent the organs from functioning properly.&nbsp;This causes the symptoms of the disease.<\/li><\/ul>\n\n\n\n<p>Onpattro works by reducing the amount of TTR&nbsp;protein&nbsp;that the liver produces.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>This means that there is less TTR&nbsp;protein&nbsp;in the blood that can form amyloid.<\/li><li>This can help reduce the effects of this disease.<\/li><\/ul>\n\n\n\n<p>Onpattro is only used for adults.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using Onpattro<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Onpattro<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have ever had a severe&nbsp;allergic reaction&nbsp;to patisiran or any of the other ingredients of this medicine (listed in section 6).&nbsp;If you are not sure, talk to your doctor or nurse before using Onpattro.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p><em>Infusion-related reactions<\/em><\/p>\n\n\n\n<p>Onpattro is given as a drip into a vein (called an &#8220;intravenous infusion&#8221;).\u00a0Reactions to this\u00a0infusion\u00a0may occur during treatment with Onpattro.\u00a0Before each\u00a0infusion, you will be given medicines that help reduce the risk of infusion-related reactions (see &#8220;Medicines given during treatment with Onpattro&#8221; in section 3).<\/p>\n\n\n\n<p>If you get any signs of an infusion-related reaction, tell your doctor or nurse immediately.&nbsp;These characters are listed at the beginning of section 4.<\/p>\n\n\n\n<p>If you get an infusion-related reaction, your doctor or nurse may slow down or stop your\u00a0infusion\u00a0or you may need to take other medicines to keep your symptoms under control.\u00a0When these reactions stop or get better, your doctor or nurse may decide to start the\u00a0infusion\u00a0again.<\/p>\n\n\n\n<p><em>Vitamin&nbsp;A deficiency<\/em><\/p>\n\n\n\n<p>Treatment with Onpattro lowers the amount of&nbsp;vitamin&nbsp;A in your blood.&nbsp;Your doctor will measure your&nbsp;vitamin&nbsp;A levels and if they are too low they should have returned to normal and any symptoms of&nbsp;vitamin&nbsp;A deficiency should have passed before starting treatment with Onpattro.&nbsp;Symptoms of&nbsp;vitamin&nbsp;A deficiency may include:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Impaired night vision, dry eyes, poor eyesight, foggy or cloudy eyesight.<\/li><\/ul>\n\n\n\n<p>If you have vision problems or any other eye problems while using Onpattro, talk to your doctor.&nbsp;Your doctor may refer you to an ophthalmologist for examination if needed.<\/p>\n\n\n\n<p>Your doctor will ask you to take a&nbsp;vitamin&nbsp;A supplement daily during treatment with Onpattro.<\/p>\n\n\n\n<p>Both too high and too low levels of&nbsp;vitamin&nbsp;A can impair the development of unborn children.&nbsp;Therefore, women of childbearing potential should not become pregnant after starting treatment with Onpattro and must use an effective method of contraception (see section \u201cPregnancy, breast-feeding and contraception\u201d below).<\/p>\n\n\n\n<p>Tell your doctor if you are planning to become pregnant.&nbsp;Your doctor may tell you to stop taking Onpattro.&nbsp;Your doctor will check that your&nbsp;vitamin&nbsp;A levels have returned to normal before trying to conceive.<\/p>\n\n\n\n<p>Tell your doctor if you have become unplanned pregnant.\u00a0Your doctor may tell you to stop taking Onpattro.\u00a0During the first three months of pregnancy, your doctor may tell you to stop taking\u00a0vitamin A\u00a0supplements. During the last six months of pregnancy, you should resume the\u00a0vitamin\u00a0A supplement if your\u00a0vitamin\u00a0A levels have not yet returned to normal. due to an increased risk of\u00a0vitamin\u00a0A deficiency during the last three months of pregnancy.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Onpattro is not recommended for children and adolescents under 18 years of age.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Onpattro<\/h2>\n\n\n\n<p>Tell your doctor or nurse if you are taking, have recently taken, or might take any other medicines.\u00a0You must tell your doctor or nurse if you are taking any of the following medicines, as your doctor may need to change the dose:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Bupropion, a drug used to treat depression or to help quit smoking<\/li><li>Efavirenz, a medicine used to&nbsp;treat&nbsp;HIV&nbsp;infection&nbsp;and&nbsp;AIDS&nbsp;.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breast-feeding, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before using this medicine.<\/p>\n\n\n\n<p><em>Women of&nbsp;childbearing&nbsp;potential<\/em><\/p>\n\n\n\n<p>Onpattro will lower the level of&nbsp;vitamin&nbsp;A in the blood.&nbsp;Vitamin&nbsp;A is important for the normal development of your unborn baby. If you are a&nbsp;fertile&nbsp;woman, you should use an effective method of contraception during treatment with Onpattro.&nbsp;Talk to your doctor or nurse about appropriate contraceptive methods.&nbsp;Pregnancy should be ruled out before starting treatment with Onpattro.<\/p>\n\n\n\n<p><em>Pregnancy<\/em><\/p>\n\n\n\n<p>You should not use Onpattro if you are pregnant unless your doctor advises you to do so.&nbsp;If you are&nbsp;fertile&nbsp;and intend to use Onpattro, use an effective method of contraception.<\/p>\n\n\n\n<p><em>Breast-feeding<\/em><\/p>\n\n\n\n<p>The ingredients in Onpattro can be transferred to breast milk.&nbsp;Talk to your doctor about stopping breast-feeding or stopping treatment with Onpattro.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Onpattro is considered to have no or negligible effect on the ability to drive and use machines.&nbsp;Your doctor will tell you if your condition allows you to drive vehicles and use machines safely.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Onpattro contains excipients<\/h2>\n\n\n\n<p>This medicine contains 3.99 milligrams (mg)\u00a0sodium\u00a0(the main ingredient in table salt\/table salt) per milliliter (ml).\u00a0This corresponds to 0.2% of the maximum recommended daily intake of\u00a0sodium\u00a0for adults.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Onpattro<\/h2>\n\n\n\n<p><strong>How much Onpattro is given<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Your doctor will calculate how much Onpattro should be given to you &#8211; this depends on your body weight.<\/li><li>The usual&nbsp;dose&nbsp;of Onpattro is 300 micrograms per kilogram (kg) body weight and is given once every three weeks.<\/li><\/ul>\n\n\n\n<p><strong>How Onpattro is given<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Onpattro will be given to you by a doctor or nurse.<\/li><li>It is given as a drip into a vein (&#8220;intravenous infusion&#8221;), usually for about 80 minutes.<\/li><\/ul>\n\n\n\n<p>If you have no problems with your&nbsp;infusions&nbsp;at the clinic, your doctor can discuss with you that healthcare professionals give you your&nbsp;infusions&nbsp;at home.<\/p>\n\n\n\n<p><strong>Medicines are given during treatment with Onpattro<\/strong><\/p>\n\n\n\n<p>Before each\u00a0infusion\u00a0of Onpattro, you will be given medicines that will help reduce the risk of infusion-related reactions.\u00a0These include\u00a0antihistamines, a\u00a0corticosteroid\u00a0(an anti-inflammatory\u00a0drug ), and a painkiller.<\/p>\n\n\n\n<p><strong>How long to use Onpattro<\/strong><\/p>\n\n\n\n<p>Your doctor will tell you how long you need to use Onpattro.&nbsp;Do not stop taking Onpattro unless your doctor tells you to.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you take more Onpattro than you should<\/h2>\n\n\n\n<p>This medicine is given to you by a doctor or nurse.\u00a0In the unlikely event that you are given too much (an overdose), your doctor or nurse will monitor you for\u00a0side effects.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you miss your dose of Onpattro<\/h2>\n\n\n\n<p>If you miss an appointment to receive Onpattro, ask your doctor or nurse when to book your next treatment.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Infusion-related reactions<\/strong><\/p>\n\n\n\n<p>Infusion-related reactions are very common (may affect more than 1 in 10 people).<\/p>\n\n\n\n<p>Tell your doctor or nurse immediately if you get any of the following signs of an infusion-related reaction during treatment.&nbsp;Infusion&nbsp;one may need to be slowed down or discontinued and you may need to take other medicines to manage the reaction.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Stomach pain<\/li><li>Nausea<\/li><li>Pain or pain in the body, including the back, neck or joints<\/li><li>Headache<\/li><li>Fatigue (exhaustion)<\/li><li>Overindulge<\/li><li>Dizziness<\/li><li>Cough, shortness of breath or other breathing problems<\/li><li>Redness&nbsp;of the face or body (hot flashes), feeling of warmth in the skin or rash<\/li><li>Chest discomfort or chest pain<\/li><li>Fast heartbeat<\/li><li>Low or high&nbsp;blood pressure&nbsp;;&nbsp;Some patients have fainted during&nbsp;infusion&nbsp;one due to low&nbsp;blood pressure<\/li><li>Pain,&nbsp;redness&nbsp;, burning or swelling at or near the infusion site<\/li><li>Swelling of the face<\/li><\/ul>\n\n\n\n<p><strong>Other&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>Tell your doctor or nurse if you notice any of the following side effects:<\/p>\n\n\n\n<p><strong>Very common:<\/strong>&nbsp;may affect more than 1 in 10 people<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Swelling of the arms or legs (peripheral&nbsp;edema&nbsp;)<\/li><\/ul>\n\n\n\n<p><strong>Common:<\/strong>&nbsp;may affect up to 1 in 10 people<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Joint pain (&nbsp;arthralgia&nbsp;)<\/li><li>Muscle spasms<\/li><li>Indigestion (&nbsp;dyspepsia&nbsp;)<\/li><li>Shortness of breath (&nbsp;dyspnoea&nbsp;)<\/li><li>Redness&nbsp;of the skin (&nbsp;erythema&nbsp;)<\/li><li>Feeling dizzy or fainting (dizziness)<\/li><li>Clogged or runny nose (&nbsp;rhinitis&nbsp;)<\/li><li>Irritation or&nbsp;infection&nbsp;of the respiratory tract (sinusitis,&nbsp;bronchitis&nbsp;)<\/li><\/ul>\n\n\n\n<p><strong>Uncommon:<\/strong>&nbsp;may occur in up to&nbsp;1 in 100&nbsp;infusions<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Leakage of the drug into the surrounding&nbsp;tissue&nbsp;at the infusion site which may cause swelling and&nbsp;redness<\/li><\/ul>\n\n\n\n<p>Tell your doctor or nurse if you notice any of the&nbsp;side effects&nbsp;listed above.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Onpattro<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton after \u201cEXP\u201d.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Store in a refrigerator (2 \u00b0 C &#8211; 8 \u00b0 C).&nbsp;Do not freeze.<\/p>\n\n\n\n<p>If refrigerator storage is not available, Onpattro can be stored at room temperature (maximum 25 \u00b0 C) for up to 14 days.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the package and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is patisiran.<\/li><li>Each ml contains patisiran sodium equivalent to 2 mg patisiran.<\/li><li>Each 5 ml&nbsp;vial&nbsp;contains patisiran sodium equivalent to 10 mg patisiran.<\/li><li>The other ingredients are Dlin \u2011 MC3 \u2011 DMA ((6Z, 9Z, 28Z, 31Z) \u2011heptatria account \u2011 6,9,28,31 \u2011 tetraene \u2011 19 \u2011 yl \u2011 4\u2011 (dimethylamino) \u2011butanoate), PEG&nbsp;<sub>2000<\/sub>&nbsp;\u2011C \u2011 DMG (\u03b1- (3 &#8216;- {[1,2-di (myristyloxy) propanoxy] carbonylamino} propyl) methoxy, polyoxyethylene), DSPC (1,2-distearoyl-&nbsp;<em>sn<\/em>&nbsp;-glycero-3-phosphocholine),&nbsp;cholesterol&nbsp;, disodium hydrogen phosphate heptahydrate, anhydrous potassium dihydrogen phosphate, sodium chloride and water for injections (see \u201cOnpattro contains sodium\u201d in section 2).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Onpattro is a white to off-white, opalescent, homogeneous concentrate for solution for&nbsp;infusion&nbsp;.<\/li><li>Onpattro is delivered in cartons, each containing a&nbsp;vial&nbsp;.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p>Alnylam Netherlands BV<\/p>\n\n\n\n<p>Antonio Vivaldi Street 150<\/p>\n\n\n\n<p>1083 HP Amsterdam<\/p>\n\n\n\n<p>Netherlands<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Onpattro is a drug that treats a hereditary disease called hereditary transthyretin amyloidosis (hATTR amyloidosis, Skellefte&#8217;s disease).<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18526],"tags":[20042,20037,20038,20041,20033,20036,20039,20034,20040,20035],"class_list":["post-19809","post","type-post","status-publish","format-standard","hentry","category-medicines","category-o","tag-benefits-of-onpattro","tag-benefits-of-patisiran","tag-onpattro","tag-onpattro-side-effects","tag-patisiran","tag-patisiran-side-effects","tag-what-is-onpattro","tag-what-is-patisiran","tag-what-onpattro-is-used-for","tag-what-patisiran-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/19809","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=19809"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/19809\/revisions"}],"predecessor-version":[{"id":19841,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/19809\/revisions\/19841"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=19809"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=19809"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=19809"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}