{"id":19807,"date":"2022-03-17T11:21:26","date_gmt":"2022-03-17T11:21:26","guid":{"rendered":"https:\/\/zeepedia.com\/?p=19807"},"modified":"2022-03-19T11:00:15","modified_gmt":"2022-03-19T11:00:15","slug":"onivyde-pegylated-liposomal","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/onivyde-pegylated-liposomal\/","title":{"rendered":"Onivyde Pegylated Liposomal &#8211; Irinotecan uses, dose and side effects"},"content":{"rendered":"\n<p>4.3 mg \/ ml&nbsp;concentrate for solution&nbsp;for&nbsp;infusion&nbsp;Irinotecan&nbsp;dispersion<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What ONIVYDE pegylated liposomal is and what it is used for<\/h2>\n\n\n\n<p><strong>What ONIVYDE pegylated liposomal is and how it works<\/strong><\/p>\n\n\n\n<p>ONIVYDE pegylated liposomal is a cancer drug that contains the active substance irinotecan.\u00a0This active substance is found in small fat particles called\u00a0liposomes.<\/p>\n\n\n\n<p>Irinotecan belongs to a group of cancer drugs called topoisomerase inhibitors.\u00a0It blocks an\u00a0enzyme\u00a0called\u00a0topoisomerase\u00a0I, which is\u00a0involved in the division of\u00a0DNA\u00a0molecules.\u00a0This prevents cancer cells from multiplying and growing, and they eventually die.<\/p>\n\n\n\n<p>The liposomes\u00a0are expected to accumulate in the\u00a0tumor\u00a0and slowly release the drug so that it can work for a longer time.<\/p>\n\n\n\n<p><strong>What ONIVYDE pegylated liposomal is used for<\/strong><\/p>\n\n\n\n<p>ONIVYDE pegylated liposomal is used to treat adult patients with metastatic\u00a0pancreatic cancer\u00a0(\u00a0pancreatic cancer\u00a0that has already spread to the body) who have previously undergone cancer treatment with a drug called gemcitabine.\u00a0ONIVYDE pegylated liposomal is used in combination with other anticancer medicines called 5-fluorouracil and leucovorin.<\/p>\n\n\n\n<p>If you have any further questions on the use of ONIVYDE pegylated liposomal or why you have been prescribed it, contact your doctor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using ONIVYDE pegylated liposomal<\/h2>\n\n\n\n<p>Carefully follow all instructions from a doctor.&nbsp;They may differ from the general information in this leaflet.<\/p>\n\n\n\n<p><strong>Do not use ONIVYDE pegylated liposomal:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are severely allergic to irinotecan or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you are breast-feeding<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or nurse before using ONIVYDE pegylated liposomal&nbsp;<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have ever had liver problems or jaundice<\/li><li>if you have ever had a lung disease or have previously been given medicines (colony stimulating factors) to increase your blood count or radiation therapy<\/li><li>if you are taking other medicines (see section Other medicines and ONIVYDE pegylated liposomal)<\/li><li>if you are planning to be vaccinated then multiple vaccinations are inappropriate during&nbsp;chemotherapy<\/li><li>if you have been prescribed a low-sodium diet (low-salt) because this medicine contains&nbsp;sodium&nbsp;.<\/li><\/ul>\n\n\n\n<p>Talk to your doctor or nurse directly during treatment with ONIVYDE pegylated liposomal&nbsp;<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you suddenly have shortness of breath,&nbsp;redness&nbsp;, headache, rash or&nbsp;hives&nbsp;(rapidly itchy itchy rash with swollen red bumps on the skin),&nbsp;itching&nbsp;and swelling around the eyes, pressure over the chest or throat during or shortly after&nbsp;infusion&nbsp;a<\/li><li>if you experience fever, chills or other signs of&nbsp;infection<\/li><li>if you get diarrhea with frequent watery stools and can not control this after 12 to 24 hours of treatment (see below)<\/li><li>if you become short of breath or have a cough<\/li><li>if you get signs or symptoms of a blood clot, such as sudden pain or swelling in a leg or arm, sudden cough, chest pain or difficulty breathing.<\/li><\/ul>\n\n\n\n<p><strong>What to do in case of diarrhea<\/strong><\/p>\n\n\n\n<p>As soon as the first watery stool arrives, start drinking large amounts of fluid against dehydration (eg water, soda, soda, soup) so as not to lose too much fluid and salt from the body.&nbsp;Contact a doctor immediately so that you receive appropriate treatment.&nbsp;Your doctor may give you a medicine that contains loperamide to start treatment at home, but you must not use it for more than 48 hours straight.&nbsp;If the stool is still loose, contact a doctor.<\/p>\n\n\n\n<p><strong>Blood tests and medical examinations<\/strong><\/p>\n\n\n\n<p>Before starting treatment with ONIVYDE pegylated liposomal, your doctor will take blood samples (or do other medical tests) to assess the best starting dose for you.&nbsp;You will need to undergo additional (blood\u2011 or other) tests during treatment so that your doctor can monitor your&nbsp;blood cells&nbsp;and assess how your body responds to treatment.&nbsp;The doctor may need to adjust the&nbsp;dose&nbsp;or discontinue treatment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>ONIVYDE pegylated liposomal is not recommended for use in children and adolescents under 18 years of age.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other drugs and ONIVYDE pegylated liposomal<\/h2>\n\n\n\n<p>Tell your doctor if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>You must tell your doctor if you have previously received irinotecan in any form.<\/p>\n\n\n\n<p>ONIVYDE pegylated liposomal must not be used instead of other medicines containing irinotecan as the substance behaves differently when present inside\u00a0the liposome\u00a0than when given in the free form.<\/p>\n\n\n\n<p>It is also especially important that you tell your doctor if you are also taking the following medicines, as they reduce the availability of irinotecan in your body:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>phenytoin&nbsp;, phenobarbital or carbamazepine (medicines used to treat seizures and&nbsp;epilepsy&nbsp;)<\/li><li>rifampicin and rifabutin (medicines used to treat&nbsp;tuberculosis&nbsp;)<\/li><li>St. John&#8217;s wort&nbsp;(an herbal medicine used to treat mild depression and mild anxiety)<\/li><li>as ONIVYDE pegylated liposomal should not be given to you along with those medicines.<\/li><\/ul>\n\n\n\n<p>It is also especially important that you tell your doctor if you are also taking the following medicines, as they increase the availability of irinotecan in your body:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>ketoconazole&nbsp;, itraconazole or voriconazole (medicines used to treat fungal infections)<\/li><li>clarithromycin (an&nbsp;antibiotic&nbsp;used to treat bacterial infections)<\/li><li>indinavir, lopinavir, nelfinavir, ritonavir, saquinavir, atazanavir (medicines&nbsp;for&nbsp;HIV&nbsp;infection&nbsp;)<\/li><li>regorafenib (a medicine used to treat certain types of cancer)<\/li><li>telaprevir (a medicine used to treat a liver disease called&nbsp;hepatitis&nbsp;C)<\/li><li>nefazodone (a medicine used to treat depression and depression)<\/li><li>gemfibrozil (medicines used to treat high blood fats)<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">ONIVYDE pegylated liposomal with food and drink<\/h2>\n\n\n\n<p>Avoid eating grapefruit and drinking grapefruit juice when receiving ONIVYDE pegylated liposomal as it may increase the availability of the active substance of ONIVYDE pegylated liposomal in your body.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>You should not take ONIVYDE pegylated liposomal if you are pregnant as it may harm your baby.\u00a0Tell your doctor if you are pregnant, or if you think you may be pregnant.\u00a0Ask your doctor for advice if you are planning to have a baby.\u00a0If you are receiving ONIVYDE pegylated liposomal, you should not breast-feed until one month after the last\u00a0dose.<\/p>\n\n\n\n<p>During the ONIVYDE pegylated liposomal treatment and one month later, you should choose an effective method of contraception that suits you to prevent pregnancy during this period.\u00a0Men should use condoms during ONIVYDE pegylated liposomal treatment and four months after.<\/p>\n\n\n\n<p>Tell your doctor if you are breast-feeding.&nbsp;You must not take ONIVYDE pegylated liposomal if you are breast-feeding as it may harm your baby.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>ONIVYDE pegylated liposomal may affect your ability to drive and use machines (as you may become drowsy, dizzy, and exhausted when using ONIVYDE pegylated liposomal).\u00a0You should avoid driving, using machines, or performing other tasks that require full attention if you feel sleepy, dizzy, or exhausted.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">ONIVYDE pegylated liposomal contains sodium<\/h2>\n\n\n\n<p>One milliliter of this medicine contains 0.144 mmol (3.31 mg)\u00a0sodium\u00a0&#8211; remember if you have been prescribed a low-sodium (low-salt) diet.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use ONIVYDE pegylated liposomal<\/h2>\n\n\n\n<p>ONIVYDE pegylated liposomal should only be given by healthcare professionals who are trained to administer anti-cancer drugs.<\/p>\n\n\n\n<p>Carefully follow all instructions given to you by your doctor or nurse.<\/p>\n\n\n\n<p>Your doctor will decide what&nbsp;dose&nbsp;you should take.<\/p>\n\n\n\n<p>ONIVYDE pegylated liposomal is given as a drip (&nbsp;infusion fluid&nbsp;) into a vein, which takes at least 90 minutes and should be given as a single dose.<\/p>\n\n\n\n<p>Once you have received ONIVYDE pegylated liposomal, you will be given two other medicines, leucovorin and 5 \u2011 <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/tolak\/\">fluorouracil<\/a>.<\/p>\n\n\n\n<p>The treatment is repeated every two weeks.<\/p>\n\n\n\n<p>In some cases, lower\u00a0doses\u00a0or longer intervals between\u00a0doses\u00a0may be required.<\/p>\n\n\n\n<p>You may be given premedication for nausea and vomiting.\u00a0If you have experienced sweating, abdominal cramps, and salivation along with early frequent and watery bowel movements in previous treatments with ONIVYDE pegylated liposomal, you may be given additional medicines before ONIVYDE pegylated liposomal to prevent or reduce this in future treatment cycles.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause side effects, although not everybody gets them.\u00a0You must be aware of what these\u00a0side effects\u00a0may be.<\/p>\n\n\n\n<p>Your doctor may also prescribe other medicines to help you control your\u00a0side effects.<\/p>\n\n\n\n<p><strong>Tell your doctor or nurse straight away if you experience any of the following side effects:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you suddenly have shortness of breath,&nbsp;redness&nbsp;, nausea, headache, skin rash or&nbsp;hives&nbsp;(rapidly itchy itchy rash with swollen red bumps on the skin),&nbsp;itching&nbsp;and swelling around the eyes, pressure over the chest or throat during or shortly after&nbsp;infusion&nbsp;one (because&nbsp;infusion&nbsp;one may need to be stopped and you may need to be treated or admitted for&nbsp;side effects&nbsp;)<\/li><li>if you get a fever, chills and signs of&nbsp;infection&nbsp;(as it may require immediate treatment)<\/li><li>if you have severe persistent diarrhea (watery and frequent stools) &#8211; see section 2<\/li><\/ul>\n\n\n\n<p><strong>The following&nbsp;side effects&nbsp;may occur:<\/strong><\/p>\n\n\n\n<p><strong>Very common<\/strong>&nbsp;(may affect more than 1 in 10 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Low levels of&nbsp;white blood cells&nbsp;(&nbsp;neutropenia&nbsp;and&nbsp;leukopenia&nbsp;), low levels of&nbsp;red blood cells&nbsp;(&nbsp;anemia&nbsp;)<\/li><li>Low&nbsp;platelet count&nbsp;(&nbsp;thrombocytopenia&nbsp;)<\/li><li>Diarrhea (loose or watery and frequent bowel movements)<\/li><li>Nausea and vomiting<\/li><li>Sore stomach or intestinal tract<\/li><li>Cold sores<\/li><li>Weight loss<\/li><li>Reduced appetite<\/li><li>Lost body fluid (dehydration)<\/li><li>Low salt levels (&nbsp;electrolytes&nbsp;) in the body (eg&nbsp;potassium&nbsp;,&nbsp;magnesium&nbsp;)<\/li><li>Abnormal hair loss<\/li><li>Fatigue<\/li><li>Dizziness<\/li><li>Swelling and fluid accumulation in soft tissues (peripheral&nbsp;edema&nbsp;)<\/li><li>Tenderness and swelling of the gastrointestinal tract (mucositis)<\/li><li>Fever<\/li><li>General weakness<\/li><\/ul>\n\n\n\n<p><strong>Common<\/strong>&nbsp;(may affect up to 1 in 10 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Overindulge<\/li><li>Infection&nbsp;is, e.g.&nbsp;fungal infections of the mouth (&nbsp;oral&nbsp;candidiasis), fever with low&nbsp;white blood cell count&nbsp;(febrile&nbsp;neutropenia&nbsp;),&nbsp;infection&nbsp;are related to the&nbsp;administration&nbsp;of the product in a vein<\/li><li>Inflammation&nbsp;of the stomach and intestines (&nbsp;gastroenteritis&nbsp;)<\/li><li>Systemic&nbsp;inflammation&nbsp;, caused by&nbsp;infection&nbsp;(&nbsp;sepsis&nbsp;)<\/li><li>Potential life-threatening complication with whole-body inflammation (&nbsp;septic&nbsp;shock&nbsp;)<\/li><li>Pneumonia&nbsp;_&nbsp;_&nbsp;_<\/li><li>Low levels of a&nbsp;subtype&nbsp;of&nbsp;white blood cells&nbsp;called&nbsp;lymphocytes&nbsp;with an important function of the immune system (lymphopenia)<\/li><li>Reduction of certain salts (&nbsp;electrolytes&nbsp;) in the body (eg&nbsp;phosphate&nbsp;,&nbsp;sodium&nbsp;)<\/li><li>Low blood sugar (&nbsp;hypoglycaemia&nbsp;)<\/li><li>Insomnia<\/li><li>Bad taste in the mouth<\/li><li>A syndrome called cholinergic syndrome with sweating, salivation and abdominal cramps<\/li><li>Low&nbsp;blood pressure&nbsp;(&nbsp;hypotension&nbsp;)<\/li><li>Formation of a blood clot in a deep vein (deep&nbsp;vein thrombosis&nbsp;) or blockage of the main artery of the lungs or any of its branches (&nbsp;pulmonary embolism&nbsp;) or blockage due to a blood clot elsewhere in the bloodstream (embolism)<\/li><li>Voice impairment, hoarse or unusually hissing voice<\/li><li>Shortness of breath<\/li><li>Inflammation&nbsp;of the intestine<\/li><li>Hemorrhoids<\/li><li>Increase in liver enzyme (&nbsp;alanine aminotransferase&nbsp;or&nbsp;aspartate aminotransferase&nbsp;) in laboratory laboratory tests<\/li><li>Increased bilirubin levels (an orange \u2011 yellow pigment, waste product in the normal breakdown of&nbsp;red blood cells&nbsp;) in other laboratory values \u200b\u200brelated to liver function<\/li><li>Increase in other laboratory values \u200b\u200b(increased internationally normalized ratio) related to the function of the blood clotting system<\/li><li>Abnormally low albumin levels in the blood (the main protein in the body)<\/li><li>Sudden problems with kidney function, which can lead to rapid deterioration or loss of kidney function<\/li><li>Abnormal reaction to&nbsp;infusion&nbsp;one that causes symptoms such as shortness of breath,&nbsp;redness&nbsp;, headache, pressure in the chest or throat<\/li><li>Abnormal fluid accumulation in the body that causes swelling in the affected&nbsp;tissues&nbsp;(&nbsp;edema&nbsp;)<\/li><\/ul>\n\n\n\n<p><strong>Uncommon<\/strong>&nbsp;(may affect up to 1 in 100 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Systemic&nbsp;inflammation&nbsp;, caused by&nbsp;infection&nbsp;of the gallbladder and bile ducts (biliary&nbsp;sepsis&nbsp;)<\/li><li>Allergic reaction&nbsp;to ONIVYDE pegylated liposomal (the active substance or excipient)<\/li><li>Reduced availability of oxygen to body tissues<\/li><li>Inflammation&nbsp;of the esophagus (esophagus)<\/li><li>Formation or presence of a blood clot inside a blood vessel, either vein or&nbsp;artery&nbsp;(&nbsp;thrombosis&nbsp;)<\/li><li>Inflammation&nbsp;on the inside of the&nbsp;rectum&nbsp;(end of the colon)<\/li><li>Type of rash characterized by a flat, red area on the skin covered with bumps (maculopapular rash)<\/li><li>Changed color of the nail plates<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store ONIVYDE pegylated liposomal<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton and vial after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Store in a refrigerator (2 \u00b0 C &#8211; 8 \u00b0 C).<\/p>\n\n\n\n<p>Do not freeze.<\/p>\n\n\n\n<p>Keep the vial in the outer carton.&nbsp;Sensitive to light.<\/p>\n\n\n\n<p>Once the concentrate has been diluted into the solution for\u00a0infusion\u00a0with 5% glucose solution for\u00a0injection\u00a0or 9 mg\/ml (0.9%) sodium chloride solution for\u00a0injection, the\u00a0dispersion\u00a0should be used as soon as possible but can be stored at room temperature (15 \u00b0 C to 25 \u00b0 C ).\u00a0) for up to 6 hours.\u00a0The reconstituted\u00a0dispersion\u00a0for\u00a0infusion\u00a0can be stored in a refrigerator (2 \u00b0 C-8 \u00b0 C) for a maximum of 24 hours before use.\u00a0It must be protected from light and it must not be frozen.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the package and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is irinotecan.&nbsp;A 10 ml concentrate vial contains 43 mg irinotecan as an anhydrous base (as sucrose salt in a pegylated liposomal&nbsp;mixture&nbsp;).<\/li><li>The other ingredients are 1.2 \u2011 distearoyl \u2011 sn \u2011 glycero \u2011 3 \u2011 phosphocoline (DSPC),&nbsp;cholesterol&nbsp;, N\u2011 (carbonyl \u2011 methoxypolyethylene glycol \u2011 2000) \u20111,2 \u2011 distearoyl \u2011 sn \u2011 glycero \u2011 3 \u2011 phosphoethanolamine (MPEG MP PEDSPE), sucrose octasulfate;&nbsp;2\u2011 [4\u2011 (2\u2011 hydroxyethyl) piperazine \u2011 1\u2011yl] ethanesulfonic acid (HEPES\u2011&nbsp;buffer&nbsp;), sodium chloride and water for&nbsp;injections&nbsp;.&nbsp;ONIVYDE pegylated liposomal contains&nbsp;sodium&nbsp;&#8211; if you have been prescribed a low-sodium (low-salt) diet, see section 2.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<p>ONIVYDE pegylated liposomal is supplied as a white to slightly yellow&nbsp;opaque&nbsp;isotonic&nbsp;liposomal&nbsp;dispersion&nbsp;in a glass vial.<\/p>\n\n\n\n<p>Each pack contains a&nbsp;vial&nbsp;of 10 ml of concentrate.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>Servier Laboratories Servier<\/p>\n\n\n\n<p>50, rue Carnot<\/p>\n\n\n\n<p>92284 Suresnes cedex<\/p>\n\n\n\n<p>France<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>The Laboratory Servier Industrie<\/p>\n\n\n\n<p>905 Route de Saran<\/p>\n\n\n\n<p>45520 Gidy<\/p>\n\n\n\n<p>France<\/p>\n\n\n\n<p>Contact the representative of the marketing authorization holder to find out more about this medicine:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Belgium \/ Belgique \/ Belgien<\/strong>SA Servier Benelux NVTel: +32 (0) 2 529 43 11<\/td><td><strong>Lithuania<\/strong>UAB \u201cSERVIER PHARMA\u201dTel: +370 (5) 2 63 86 28<\/td><\/tr><tr><td><strong>Bulgaria<\/strong>Medical LODG serviceTel: +359 2 921 57 00<\/td><td><strong>Luxembourg \/ Luxemburg<\/strong>SA Servier Benelux NVTel: +32 (0) 2 529 43 11<\/td><\/tr><tr><td><strong>Czech Republic<\/strong>Servier sroTel: +420 222 118 111<\/td><td><strong>Magyarorsz&nbsp;<\/strong><strong>\u00e1&nbsp;<\/strong><strong>g<\/strong>Servier Hungaria Kft.Tel: +36 1 238 7799<\/td><\/tr><tr><td><strong>Denmark<\/strong>Servier Danmark A \/ STel: +45 36 44 22 60<\/td><td><strong>Malta<\/strong>VJ Salomone Pharma LtdTel: + 356 21 22 01 74<\/td><\/tr><tr><td><strong>Germany<\/strong>Servier Deutschland GmbHTel: +49 (0) 89 57095 01<\/td><td><strong>The Netherlands<\/strong>Servier Nederland Farma BVTel: + 31 (0) 71 5246700<\/td><\/tr><tr><td><strong>Eesti<\/strong>Servier Laboratories O\u00dcTel: + 372 664 5040<\/td><td><strong>Norway<\/strong>Servier Danmark A \/ STel: +45 36 44 22 60<\/td><\/tr><tr><td><strong>E&nbsp;<\/strong><strong>\u03bb\u03bb\u03ac\u03b4\u03b1<\/strong>\u0395\u03a0\u0395 \u0395\u039b\u039b\u0391\u03a3 \u03a6\u0391\u03a1\u039c\u0391\u039a\u0395\u03a5\u03a4\u0399\u039a\u0397 \u0395\u03a0\u0395:\u0397\u03bb: + 30 210 939 1000<\/td><td><strong>Austria<\/strong>Servier Austria GmbHTel: +43 (1) 524 39 99<\/td><\/tr><tr><td><strong>Spain<\/strong>Servierios Servier SLTel: + 34 91 748 96 30<\/td><td><strong>Poland<\/strong>Servier Polska Sp.&nbsp;z ooTel: + 48 (0) 22 594 90 00<\/td><\/tr><tr><td><strong>France<\/strong>Servier Laboratories ServierTel: + 33 (0) 1 55 72 60 00<\/td><td><strong>Portugal<\/strong>Servier Portugal, LdaTel: + 351 21 312 20 00<\/td><\/tr><tr><td><strong>Croatia<\/strong>Servier Pharma, dooTel: +385 (0) 1 3016 222<\/td><td><strong>Romania<\/strong>Servier Pharma SRLTel: + 4 021 528 52 80<\/td><\/tr><tr><td><strong>Ireland<\/strong>Servier Laboratories (Ireland) Ltd.Tel: + 353 (0) 1 663 8110<\/td><td><strong>Slovenia<\/strong>Servier Pharma dooTel: + 386 (0) 1 563 48 11<\/td><\/tr><tr><td><strong>Iceland<\/strong>Servier Laboratoriesc \/ o Icepharma hfPhone: + 354 540 8000<\/td><td><strong>Slovak Republic<\/strong>Servier Slovensko spol.&nbsp;s roTel: + 421 2 5920 41 11<\/td><\/tr><tr><td><strong>Italy<\/strong>Servier Italia SpATel: + 39 (06) 669081<\/td><td><strong>Finland \/ Finland<\/strong>Servier Finland OyP. \/ Tel: +358 (0) 9 279 80 80<\/td><\/tr><tr><td><strong>.\u03a0\u03c1\u03bf\u03c2<\/strong>CA Papaellinas Ltd.:\u0397\u03bb: + 357 22 741 741<\/td><td><strong>Sweden<\/strong>Servier Sverige ABTel: +46 (0) 8 522 508 00<\/td><\/tr><tr><td><strong>Latvia<\/strong>SIA Servier LatviaTel: + 371 67502039<\/td><td><strong>United Kingdom<\/strong>Servier Laboratories LtdTel: +44 (0) 1753 666409<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>ONIVYDE pegylated liposomal is a cancer drug that contains the active substance irinotecan. 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