{"id":19803,"date":"2022-03-17T11:17:30","date_gmt":"2022-03-17T11:17:30","guid":{"rendered":"https:\/\/zeepedia.com\/?p=19803"},"modified":"2022-03-19T11:00:24","modified_gmt":"2022-03-19T11:00:24","slug":"ondexxya","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/ondexxya\/","title":{"rendered":"Ondexxya &#8211; Andexane alfa uses, dose and side effects"},"content":{"rendered":"\n<p>200 mg&nbsp;powder for solution for&nbsp;infusion&nbsp;andexane<br>alfa<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Ondexxya is and what it is used for<\/h2>\n\n\n\n<p>Ondexxya contains the active substance andexane alfa.&nbsp;It eliminates the effects of certain blood-thinning (&nbsp;anticoagulant&nbsp;) medicines called factor Xa inhibitors (apixaban or rivaroxaban).&nbsp;Factor Xa inhibitors are given to prevent blood clots in the blood vessels.&nbsp;Your doctor may decide to give you Ondexxya to quickly eliminate the effects of the blood-thinning medicine in a life-threatening or uncontrolled bleeding situation.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you get Ondexxya<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Ondexxya&nbsp;<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to andexane alfa or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you are allergic to hamster proteins.<\/li><li>if you are receiving&nbsp;heparin&nbsp;.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Undoing the effect of a factor Xa inhibitor with Ondexxya may increase the risk of blood clots.&nbsp;After treatment with Ondexxya, your doctor will decide when to start treatment with blood thinners again.<\/p>\n\n\n\n<p>An independent procoagulant effect of andexane alfa may pose an additional risk of developing blood clots.<\/p>\n\n\n\n<p>If you get\u00a0any side effects\u00a0while taking Ondexxya as an\u00a0infusion\u00a0(drip), your doctor may decide to\u00a0slow\u00a0down or pause the treatment.\u00a0Your doctor may prescribe you medicine with\u00a0antihistamines\u00a0to help with\u00a0side effects\u00a0(see section 4).<\/p>\n\n\n\n<p>If surgery requiring&nbsp;heparin&nbsp;as a blood thinner is planned, Ondexxya should be avoided.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>There is no information on the use of Ondexxya in children and adolescents.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Ondexxya&nbsp;<\/h2>\n\n\n\n<p>Tell your doctor if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>This medicine is only intended to abolish the effects of factor Xa inhibitors.\u00a0It is unlikely that Ondexxya will affect the effectiveness of other medicines or that other medicines will affect Ondexxya.<\/p>\n\n\n\n<p>Treatment with Ondexxya should be avoided if treatment with&nbsp;heparin&nbsp;as a blood thinner may become necessary.&nbsp;Ondexxya leads to treatment with&nbsp;heparin&nbsp;not working.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>Tell your doctor if you are pregnant or breast-feeding, think you may be pregnant, or are planning to have a baby.<\/p>\n\n\n\n<p>Ondexxya is not recommended during pregnancy or if you may become pregnant and do not use contraception.<\/p>\n\n\n\n<p>You should not breast-feed your baby while taking this medicine.&nbsp;It is unknown whether andexane alfa passes into breast milk.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>This medicine is unlikely to affect your ability to drive or use machines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Ondexxya<\/h2>\n\n\n\n<p>This medicine is for hospital use only.<\/p>\n\n\n\n<p>Your doctor or nurse will give you this medicine as an&nbsp;injection&nbsp;or&nbsp;infusion&nbsp;into a vein.<\/p>\n\n\n\n<p>Your doctor and nurse will calculate the&nbsp;dose&nbsp;you need for this medicine.&nbsp;Dose&nbsp;one is based on the blood-thinning medicine you are taking and its&nbsp;dose&nbsp;and the time that has elapsed since your last&nbsp;dose&nbsp;of the blood-thinning medicine.<\/p>\n\n\n\n<p>After receiving Ondexxya, your doctor will decide when you can start treatment with blood thinners again.<\/p>\n\n\n\n<p>Detailed instructions for the doctor or nurse on how to take Ondexxya can be found at the end of this information (see &#8220;Handling instructions&#8221;).<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p>The most common\u00a0adverse reactions\u00a0observed with Ondexxya in\u00a0clinical trials\u00a0in healthy subjects were infusion-related reactions, usually with mild symptoms such as\u00a0redness, feeling hot (a very common\u00a0side effect\u00a0that may affect more than 1 user in 10).\u00a0Headache, cough, or shortness of breath (common\u00a0side effects\u00a0that may affect up to 1 in 10 people), occurred within minutes to a few hours after\u00a0infusion.\u00a0In\u00a0clinical trials\u00a0in patients with life-threatening bleeding, fever and\u00a0stroke\u00a0have been observed in up to 1 in 10 users;\u00a0transient\u00a0ischemic attack (\u00a0TIA)- one type of\u00a0stroke\u00a0), heart attack, and blood clots in the bones or lungs can occur in up to 1 in 100 users (less common\u00a0side effects\u00a0).<\/p>\n\n\n\n<p><strong>List of possible&nbsp;side&nbsp;effects<\/strong><\/p>\n\n\n\n<p><strong>Very common<\/strong>&nbsp;(may affect more than 1 user in 10)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>redness&nbsp;or feeling of heat<\/li><li>effects on markers of blood coagulation (clotting of the blood): some markers affecting blood coagulation were elevated for a short period and then returned to normal.&nbsp;No blood clots were seen in these healthy individuals<\/li><\/ul>\n\n\n\n<p><strong>Common<\/strong>&nbsp;(may affect up to 1 in 10 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>hives<\/li><li>dizziness<\/li><li>fast or irregular heartbeat<\/li><li>pain or discomfort in the stomach<\/li><li>dry mouth<\/li><li>taste disorders<\/li><li>nausea<\/li><li>chest discomfort<\/li><li>feel frozen<\/li><li>heavy sweating<\/li><li>itching<\/li><li>back pain<\/li><li>muscle twitching<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Ondexxya<\/h2>\n\n\n\n<p>This medicine is stored in the hospital and these instructions are for hospital staff only.<\/p>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the vial and carton after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Store in a refrigerator (2 \u00b0 C &#8211; 8 \u00b0 C).<\/p>\n\n\n\n<p>Do not freeze.<\/p>\n\n\n\n<p>After reconstitution,&nbsp;Ondexxya&nbsp;should be used immediately.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the package and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is andexane alfa.<\/li><li>The other ingredients are <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/tribonate\/\">trometamol<\/a>, trometamol hydrochloride, L \u2011 arginine hydrochloride, sucrose, mannitol and polysorbate 80.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<p>Ondexxya is supplied in glass vials as a white to off-white powder for solution for\u00a0infusion\u00a0and is prepared (dissolved) before use.\u00a0The reconstituted solution is a clear, colorless, or slightly yellowish solution.<\/p>\n\n\n\n<p>Each pack contains four vials.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p>Marketing Authorisation Holder:<\/p>\n\n\n\n<p>Alexion Europe SAS<\/p>\n\n\n\n<p>103-105 rue Anatole France<\/p>\n\n\n\n<p>92300 Levallois-Perret<\/p>\n\n\n\n<p>France<\/p>\n\n\n\n<p>Manufacturer:<\/p>\n\n\n\n<p>Alexion Pharma International Operations Unlimited Company<\/p>\n\n\n\n<p>Alexion Dublin Manufacturing Facility<\/p>\n\n\n\n<p>College Business and Technology Park<\/p>\n\n\n\n<p>Blanchardstown Rd North<\/p>\n\n\n\n<p>Dublin D15 R925<\/p>\n\n\n\n<p>Ireland<\/p>\n\n\n\n<p><br>This medicine has been given a &#8220;conditional authorization&#8221;.&nbsp;This means that there will be more information about the medicine.&nbsp;The European Medicines Agency reviews new information on this medicine at least every year and updates this summary of product characteristics as needed.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Ondexxya contains the active substance andexane alfa. It eliminates the effects of certain blood-thinning ( anticoagulant ) medicines called factor Xa inhibitors (apixaban or rivaroxaban). Factor Xa inhibitors are given to prevent blood clots in the blood vessels. Your doctor may decide to give you Ondexxya to quickly eliminate the effects of the blood-thinning medicine in a life-threatening or uncontrolled bleeding situation.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18526],"tags":[20056,20059,20060,20065,20061,20064,20058,20057,20062,20063],"class_list":["post-19803","post","type-post","status-publish","format-standard","hentry","category-medicines","category-o","tag-andexane-alfa","tag-andexane-alfa-side-effects","tag-benefits-of-andexane-alfa","tag-benefits-of-ondexxya","tag-ondexxya","tag-ondexxya-side-effects","tag-what-andexane-alfa-is-used-for","tag-what-is-andexane-alfa","tag-what-is-ondexxya","tag-what-ondexxya-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/19803","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=19803"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/19803\/revisions"}],"predecessor-version":[{"id":19844,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/19803\/revisions\/19844"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=19803"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=19803"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=19803"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}