{"id":19747,"date":"2022-03-16T11:26:47","date_gmt":"2022-03-16T11:26:47","guid":{"rendered":"https:\/\/zeepedia.com\/?p=19747"},"modified":"2022-03-17T10:39:18","modified_gmt":"2022-03-17T10:39:18","slug":"oncovin","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/oncovin\/","title":{"rendered":"Oncovin &#8211; Vincristine sulphate uses, dose and side effects"},"content":{"rendered":"\n<p>1 mg \/ ml&nbsp;solution&nbsp;for injection<br>vincristine sulphate<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Oncovin is and what it is used for<\/h2>\n\n\n\n<p>Oncovin contains the active substance vincristine sulphate.&nbsp;Oncovin is a cancer drug used in combination with other cancer drugs in the treatment of&nbsp;leukemia&nbsp;(blood cancer), malignant&nbsp;lymphoma&nbsp;(lymph node cancer) and&nbsp;small cell lung cancer&nbsp;.&nbsp;It works by&nbsp;inhibiting&nbsp;cell division.<\/p>\n\n\n\n<p>Wine christine sulphate contained in Oncovin may also be approved for the treatment of other conditions not mentioned in this product information.&nbsp;Ask your doctor, pharmacist or other healthcare professional if you have any further questions and always follow their instructions.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you use Oncovin<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Oncovin<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to vincristine sulphate or any of the other ingredients of this medicine (listed in section 6)<\/li><li>if you have Charcot-Marie-Tooth disease (disease that affects nerves or muscles)<\/li><li>if you are being irradiated over an area that includes the liver.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Treatment with Oncovin should be performed by a physician with extensive experience in the treatment of cancer.&nbsp;Oncovin should only be given&nbsp;intravenously&nbsp;(into a vein).&nbsp;Oncovin should never be given intrathecally (in the spinal canal).<\/p>\n\n\n\n<p>Talk to your doctor or nurse before taking Oncovin if you have liver problems<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Oncovin<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.<\/p>\n\n\n\n<p>It is especially important that you tell your doctor if you are taking or have recently taken:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>drugs that inhibit&nbsp;cytochrome P450&nbsp;CYP 3A&nbsp;isoenzymes&nbsp;(eg itraconazole used to treat fungal infections).<\/li><li>aminoglycoside type antibiotics&nbsp;, e.g.&nbsp;gentamicin<\/li><li>other anticancer medicines (eg cisplatin, carboplatin and mitomycin).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n<p><strong>Pregnancy<\/strong><\/p>\n\n\n\n<p>Caution is required when using Oncovin during pregnancy.&nbsp;Vincristine is suspected of causing serious birth defects during pregnancy.&nbsp;During pregnancy, Oncovin should be given only in strict indication and after the mother&#8217;s needs have been weighed against the risks to the fetus.<\/p>\n\n\n\n<p><strong>Breast-feeding<\/strong><\/p>\n\n\n\n<p>There is no information on whether wine christine passes into breast milk.<\/p>\n\n\n\n<p><strong>Fertility<\/strong><\/p>\n\n\n\n<p>Women of&nbsp;childbearing potential&nbsp;should use effective contraception during treatment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Oncovin, especially at the beginning of treatment and when increasing the&nbsp;dose&nbsp;, may, due to&nbsp;side effects&nbsp;, affect the ability to drive and use machines to a lesser or moderate extent.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention.&nbsp;One of the factors that can affect your ability in these respects is the use of drugs due to their effects and \/ or&nbsp;side effects&nbsp;.&nbsp;Descriptions of these effects and&nbsp;side effects&nbsp;can be found in other sections.&nbsp;Read all the information in this leaflet for guidance.&nbsp;If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Oncovin contains methyl parahydroxybenzoate (E218), propyl parahydroxybenzoate (E216) and sodium<\/h2>\n\n\n\n<p>Methyl parahydroxybenzoate and propyl parahydroxybenzoate may cause an&nbsp;allergic reaction&nbsp;(possibly delayed) and exceptionally convulsions in the trachea.<\/p>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg)&nbsp;sodium&nbsp;per ml, ie essentially &#8216;sodium-free&#8217;.&nbsp;is next to &#8220;sodium free&#8221;.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Oncovin<\/h2>\n\n\n\n<p>Oncovin is given only under the supervision of a doctor who has experience in the treatment of cancer.<\/p>\n\n\n\n<p><strong>Dosage<\/strong>&nbsp;: Your doctor will decide what&nbsp;dose&nbsp;you will receive.&nbsp;Talk to your doctor about your&nbsp;dosage&nbsp;.<\/p>\n\n\n\n<p>Oncovin should only be given&nbsp;intravenously&nbsp;(into a vein).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects&nbsp;, although not everybody gets them.<\/p>\n\n\n\n<p>The side effects&nbsp;are generally dose dependent;&nbsp;The higher the&nbsp;dose&nbsp;, the greater the risk of&nbsp;side effects&nbsp;.<\/p>\n\n\n\n<p>The most common&nbsp;side effect&nbsp;is hair loss.<\/p>\n\n\n\n<p><strong>Serious&nbsp;side effects&nbsp;that may occur during treatment with vincristine are:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Intestinal knots (paralytic&nbsp;ileus&nbsp;) can occur in up to 1 in 10 users.<\/li><li>Severe&nbsp;allergic reaction&nbsp;(&nbsp;hypersensitivity reaction&nbsp;with fever, rash, swelling and sometimes drop in blood pressure), may occur in up to 1 in 100 users.<\/li><li>Convulsions followed by&nbsp;coma&nbsp;in children can occur in up to 1 in 1,000 users.<\/li><li>Myocardial infarction has been reported in patients treated with vincristine in combination with other anticancer medicines when treatment is started after radiation over the space between the lungs (&nbsp;mediastinum&nbsp;).<\/li><\/ul>\n\n\n\n<p>If any of these conditions occur, immediate contact with healthcare is required.<\/p>\n\n\n\n<p>The following&nbsp;side effects&nbsp;may occur.<\/p>\n\n\n\n<p><strong>Common<\/strong>&nbsp;(may affect up to 1 in 10 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>low&nbsp;white blood cell count&nbsp;(&nbsp;leukopenia&nbsp;)<\/li><li>platelet&nbsp;deficiency&nbsp;(&nbsp;thrombocytopenia&nbsp;)<\/li><li>high \/ low&nbsp;blood pressure&nbsp;(hypertension \/&nbsp;hypotension&nbsp;).<\/li><li>loss of deep tendon reflexes<\/li><li>numbness and tingling in fingers and toes<\/li><li>difficulty coordinating body movements (&nbsp;ataxia&nbsp;)<\/li><li>effects on cerebral nerves<\/li><li>trailing foot (drip foot)<\/li><li>disorder of nerve function<\/li><li>paralysis<\/li><li>paralysis of the eye (&nbsp;ocular&nbsp;paresis)<\/li><li>constipation<\/li><li>suspended intestinal function<\/li><li>abdominal pain<\/li><li>vocal cord paralysis (vocal cord paralysis)<\/li><li>hair loss (&nbsp;Alopecia&nbsp;)<\/li><li>leg pain<\/li><li>jaw pain<\/li><li>sore throat<\/li><li>local reactions at the injection site<\/li><\/ul>\n\n\n\n<p><strong>Uncommon<\/strong>&nbsp;(may affect up to 1 in 100 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>seizures (especially in children)<\/li><li>nausea<\/li><li>vomiting<\/li><li>inflammation&nbsp;of the oral mucosa (&nbsp;stomatitis&nbsp;)<\/li><li>diarrhea<\/li><li>impaired ability to empty the bladder (bladder atony)<\/li><li>burning, discomfort or pain when urinating (&nbsp;dysuria&nbsp;)<\/li><li>fever<\/li><li>loss of appetite<\/li><li>headache<\/li><\/ul>\n\n\n\n<p><strong>Rare<\/strong>&nbsp;(may affect up to 1 in 1,000 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>low sodium levels in the blood due to decreased fluid secretion (SIADH)<\/li><li>transient and permanent blindness<\/li><li>rash<\/li><li>cellulite<\/li><li>partial or total deafness.<\/li><\/ul>\n\n\n\n<p><strong>Other&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>Difficulty breathing has been reported in patients treated with Oncovin concomitantly with mitomycin.<\/p>\n\n\n\n<p>Azoospermia&nbsp;(lack of semen) and&nbsp;amenorrhea&nbsp;(absence of menstruation) can occur in adolescents treated with several cancer drugs at the same time.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Oncovin<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the label after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Store in a refrigerator (2&nbsp;<sup>\u00b0<\/sup>&nbsp;C &#8211; 8&nbsp;<sup>\u00b0<\/sup>&nbsp;C).<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is vincristine sulphate.&nbsp;1 ml Oncovin contains 1 mg vincristine sulphate.<\/li><li>The other ingredients are methyl parahydroxybenzoate (E218), propyl parahydroxybenzoate (E216), mannitol and water for injections.&nbsp;Acetic acid and sodium acetate trihydrate may have been added to adjust the acidity.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<p>Oncovin is a clear, colorless solution.<\/p>\n\n\n\n<p>Glass vial&nbsp;containing 1 ml or 2 ml Oncovin.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p>STADA Nordic ApS<\/p>\n\n\n\n<p>Marielundvej 46 A<\/p>\n\n\n\n<p>2730 Herlev<\/p>\n\n\n\n<p>Denmark<\/p>\n\n\n\n<p><strong>Manufacturer:<\/strong><\/p>\n\n\n\n<p>STADApharm GmbH<\/p>\n\n\n\n<p>Stadastrasse 2-18<\/p>\n\n\n\n<p>61118 Bad Vilbel<\/p>\n\n\n\n<p>Germany<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Oncovin contains the active substance vincristine sulphate. Oncovin is a cancer drug used in combination with other cancer drugs in the treatment of leukemia (blood cancer), malignant lymphoma (lymph node cancer) and small cell lung cancer . It works by inhibiting cell division.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18526],"tags":[19947,19942,19943,19946,19938,19941,19944,19939,19945,19940],"class_list":["post-19747","post","type-post","status-publish","format-standard","hentry","category-medicines","category-o","tag-benefits-of-oncovin","tag-benefits-of-vincristine-sulphate","tag-oncovin","tag-oncovin-side-effects","tag-vincristine-sulphate","tag-vincristine-sulphate-side-effects","tag-what-is-oncovin","tag-what-is-vincristine-sulphate","tag-what-oncovin-is-used-for","tag-what-vincristine-sulphate-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/19747","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=19747"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/19747\/revisions"}],"predecessor-version":[{"id":19782,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/19747\/revisions\/19782"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=19747"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=19747"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=19747"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}