{"id":19743,"date":"2022-03-16T11:23:39","date_gmt":"2022-03-16T11:23:39","guid":{"rendered":"https:\/\/zeepedia.com\/?p=19743"},"modified":"2022-03-17T10:39:26","modified_gmt":"2022-03-17T10:39:26","slug":"oncaspar","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/oncaspar\/","title":{"rendered":"Oncaspar &#8211; Pegaspar gas uses, dose and side effects"},"content":{"rendered":"\n<p>750 U \/ ml&nbsp;solution for injection \/ infusion<br>pegaspar gas<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Oncaspar is and what it is used for<\/h2>\n\n\n\n<p>Oncaspar contains pegaspar gas, which is an\u00a0enzyme\u00a0(asparaginase) that breaks down asparagine, an important building block of\u00a0protein\u00a0that is necessary for cell survival.\u00a0Normal cells can produce their asparagine while some cancer cells cannot.\u00a0Oncaspar lowers asparagine levels in blood cancer cells and prevents the cancer cells from growing.<\/p>\n\n\n\n<p>Oncaspar is used to treat\u00a0acute\u00a0lymphocytic\u00a0leukemia\u00a0(ALL) in children from birth to 18 years and in adults.\u00a0ALL is a type of cancer in the white\u00a0blood cells, in which certain immature\u00a0white blood cells\u00a0(called\u00a0lymphoblasts\u00a0) begin to grow out of control and thus prevent the production of functioning\u00a0blood cells.\u00a0Oncaspar is used with other medicines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you are given Oncaspar<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Oncaspar<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to pegaspar gas or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you have severe liver disease.<\/li><li>if you have ever had&nbsp;pancreatitis&nbsp;.<\/li><li>if you have ever had heavy bleeding after treatment with asparaginase.<\/li><li>if you have ever had blood clots after treatment with asparaginase.<\/li><\/ul>\n\n\n\n<p>Tell your doctor if any of these apply to you.&nbsp;If you are the parent of a child being treated with Oncaspar, tell your doctor if any of these apply to your child.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor before giving Oncaspar.&nbsp;This medicine may not be suitable for you:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you have had severe allergic reactions to other forms of asparaginase, e.g.&nbsp;itching&nbsp;,&nbsp;redness&nbsp;or swelling of the airways, as severe allergic reactions to Oncaspar may occur.<\/li><li>If you suffer from any bleeding disorder or have had severe blood clots.<\/li><li>If you get a fever.&nbsp;This medicine may make you more susceptible to&nbsp;infection&nbsp;.<\/li><li>If you have had poor liver function or are taking other medicines that can damage your liver.&nbsp;When Oncaspar is used in combination with other cancer treatments, damage to the liver and&nbsp;central nervous system&nbsp;can occur .<\/li><li>If you suffer from abdominal pain.&nbsp;Inflammation&nbsp;of the pancreas, which in some cases has caused death, can occur during treatment with Oncaspar.<\/li><\/ul>\n\n\n\n<p>This medicine may affect the\u00a0coagulation factors\u00a0and increase the risk of bleeding and\/or blood clots.<\/p>\n\n\n\n<p>If you are the parent of a child being treated with Oncaspar, tell your doctor if any of the above conditions apply to your child.<\/p>\n\n\n\n<p><strong>During treatment with Oncaspar<\/strong><\/p>\n\n\n\n<p>During the&nbsp;administration&nbsp;of Oncaspar, you will be closely monitored for one hour after starting treatment for any signs of severe allergic reactions.&nbsp;Medical equipment to treat allergic reactions will be available nearby.<\/p>\n\n\n\n<p><em>Other monitoring tests<\/em><\/p>\n\n\n\n<p>Tests on blood sugar and urine levels, liver and pancreatic function, and other tests will be performed regularly to monitor your health during and after treatment as this medicine may affect your blood and other organs.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Oncaspar<\/h2>\n\n\n\n<p>Tell your doctor if you are taking, have recently taken, or might take any other medicines.\u00a0This is important because Oncaspar can increase the\u00a0side effects\u00a0of other medicines through its effect on the liver.\u00a0The liver plays an important role in getting drugs out of the body.\u00a0It is also especially important to tell your doctor if you are also taking any of the following medicines:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>vaccination with live vaccines within three months of completing your leukemia treatment.&nbsp;This increases the risk of serious&nbsp;infection&nbsp;.<\/li><li>vincristine, another cancer drug.&nbsp;If used at the same time as Oncaspar, there is an increased risk of&nbsp;side effects&nbsp;or allergic reactions.<\/li><li>drugs that impair the blood&#8217;s ability to coagulate, such as&nbsp;anticoagulants&nbsp;(eg coumarin \/ warfarin and&nbsp;heparin&nbsp;), dipyridamole,&nbsp;acetylsalicylic acid&nbsp;and non-steroidal anti-inflammatory drugs (eg&nbsp;ibuprofen&nbsp;or&nbsp;naproxen&nbsp;).&nbsp;If used at the same time as Oncaspar, there is a greater risk of bleeding problems.<\/li><li>drugs that require cell division to be effective, e.g.&nbsp;methotrexate (a medicine used to treat cancer and&nbsp;arthritis&nbsp;) which may have a reduced effect.<\/li><li>prednisone, a steroid drug.&nbsp;If used at the same time as Oncaspar, the effects on the blood&#8217;s&nbsp;coagulation&nbsp;capacity will increase .<\/li><li>cytarabine, a drug that can be used in cancer treatment and that can interfere with the effects of Oncaspar.<\/li><\/ul>\n\n\n\n<p>Oncaspar can also cause changes in liver function, which may affect the way other medicines work.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breast-feeding, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before using this medicine.<\/p>\n\n\n\n<p>You should not use Oncaspar if you are pregnant, as its effects during pregnancy have not been studied.&nbsp;Your doctor will decide if your illness requires treatment.&nbsp;Women who may become pregnant must use reliable contraception during treatment and for at least 6 months after stopping treatment with Oncaspar.&nbsp;Oral contraceptives are not an effective contraceptive during treatment with Oncaspar.&nbsp;Consult your doctor about which contraceptive is best for you to use.&nbsp;Men must also use effective contraception while they or their partners are being treated with Oncaspar.<\/p>\n\n\n\n<p>It is unknown whether pegaspar gas is excreted in human milk.&nbsp;As a precautionary measure, breast-feeding should be discontinued during treatment with Oncaspar and not resumed until after stopping treatment with Oncaspar.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Avoid driving or using machines while taking this medicine, as it may make you drowsy, tired, or confused.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Oncaspar contains sodium<\/h2>\n\n\n\n<p>This medicine contains less than 1 mmol\u00a0sodium\u00a0per\u00a0dose, ie essentially &#8216;sodium-free&#8217;.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to get Oncaspar<\/h2>\n\n\n\n<p>Treatment with Oncaspar has been prescribed by a doctor who has experience in medicines used to treat cancer.&nbsp;Your doctor will decide which&nbsp;dose&nbsp;of the medicine is needed and how often, based on your age and body surface area calculated by your height and weight.<\/p>\n\n\n\n<p>This drug is given as a solution by&nbsp;injection&nbsp;into a muscle, or into a vein if this is more appropriate.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you take more Oncaspar than you should<\/h2>\n\n\n\n<p>Because doctors will&nbsp;administer&nbsp;the drug, it is very unlikely that you will get more than you need.<\/p>\n\n\n\n<p>In the unlikely event of an accidental overdose, you will be closely monitored by medical personnel and given appropriate treatment.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Serious&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>Tell your doctor&nbsp;<strong>immediately<\/strong>&nbsp;if you get any of the following side effects:<\/p>\n\n\n\n<p><strong>Very common (may affect more than 1 in 10 people)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Inflammation&nbsp;or other disorders of the pancreas (&nbsp;pancreatitis&nbsp;) that cause severe abdominal pain that can spread to the back, vomiting, increased blood sugar levels&nbsp;<\/li><li>Severe allergic reactions with symptoms such as skin rash,&nbsp;itching&nbsp;, swelling,&nbsp;hives&nbsp;, shortness of breath, rapid heartbeat and drop in blood pressure<\/li><li>Blood clots<\/li><li>Fever with low&nbsp;white blood cell count&nbsp;.<\/li><\/ul>\n\n\n\n<p><strong>Common (may affect up to 1 in 10 people)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Heavy bleeding or bruising<\/li><li>Severe tremors (seizures) and unconsciousness<\/li><li>Severe&nbsp;infection&nbsp;with very high fever<\/li><li>Liver problems (eg discoloration of the skin or urine or faeces and laboratory results indicating elevated levels of liver enzymes or&nbsp;bilirubin&nbsp;).<\/li><\/ul>\n\n\n\n<p><strong>Rare (may affect up to 1 in 1,000 patients)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Liver failure<\/li><li>Jaundice<\/li><li>Blocked bile flow from the liver (cholestasis)<\/li><li>Degradation of liver cells (liver cell necrosis)<\/li><\/ul>\n\n\n\n<p><strong>No known frequency (can not be calculated from the available data)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Severe skin reaction called&nbsp;toxic epidermal necrolysis<\/li><li>Loss of kidney function (eg change in urine production, swollen feet and ankles)<\/li><li>Stroke<\/li><li>Severe&nbsp;allergic reaction&nbsp;that may cause unconsciousness and be life-threatening (anaphylactic&nbsp;shock&nbsp;).<\/li><\/ul>\n\n\n\n<p><strong>Other&nbsp;side effects&nbsp;ar<\/strong><\/p>\n\n\n\n<p>Tell your doctor if you get any of the following:<\/p>\n\n\n\n<p><strong>Very common (may affect more than 1 user in 10)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Altered function of the pancreas<\/li><li>Weight loss<\/li><li>Pain in the legs (may be a symptom of&nbsp;thrombosis&nbsp;), chest pain or shortness of breath (may be a symptom of a blood clot in the lungs, called&nbsp;pulmonary embolism&nbsp;)<\/li><li>Decreased appetite, general weakness, vomiting, diarrhea, nausea<\/li><li>Elevated blood sugar levels<\/li><\/ul>\n\n\n\n<p><strong>Common (may affect up to 1 in 10 people)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Reduced number of&nbsp;red blood cells<\/li><li>Accumulation of fluid in the abdominal cavity (&nbsp;ascites&nbsp;)<\/li><li>Fever and flu-like symptoms<\/li><li>Cold sores<\/li><li>Pain in the back, joints or abdomen<\/li><li>High levels of fat and&nbsp;cholesterol&nbsp;in the blood, low levels of&nbsp;potassium&nbsp;in the blood.<\/li><\/ul>\n\n\n\n<p><strong>Rare (may affect up to 1 in 1,000 people)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Reversible posterior leukoencephalopathy syndrome (RPLS), a syndrome characterized by headache, confusion, seizures and vision loss that passes after a while.<\/li><\/ul>\n\n\n\n<p><strong>No known frequency (can not be calculated from the available data)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Decreased number of&nbsp;white blood cells&nbsp;and&nbsp;platelets<\/li><li>Fast heartbeat<\/li><li>Fever<\/li><li>Cysts in the pancreas, swelling of the salivary glands.<\/li><li>High levels of&nbsp;urea&nbsp;in the blood,&nbsp;antibodies&nbsp;to Oncaspar, high levels of ammonia in the blood, decreased blood sugar levels<\/li><li>Drowsiness, confusion, slight twitching of the fingers.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Oncaspar<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the label and carton after EXP.\u00a0date.\u00a0The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Store in a refrigerator (2 \u00b0 C &#8211; 8 \u00b0 C).<\/p>\n\n\n\n<p>Do not freeze.<\/p>\n\n\n\n<p>After dilution, the solution should be used immediately.&nbsp;If immediate use is not possible, the diluted solution can be stored at 2 \u00b0 C-8 \u00b0 C for up to 48 hours.<\/p>\n\n\n\n<p>Do not use this medicine if you notice that the solution is cloudy or has visible particles.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<p>The active substance is pegaspar gas.&nbsp;One ml of solution contains 750 units of pegaspar gas.&nbsp;One&nbsp;vial&nbsp;of 5 ml solution contains 3,750 units of pegaspar gas.<\/p>\n\n\n\n<p>The other ingredients are sodium dihydrogen phosphate monohydrate, disodium phosphate heptahydrate, sodium chloride, and water for injections (see section 2 &#8220;Oncaspar contains sodium&#8221;).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<p>Oncaspar is a clear, colorless\u00a0solution for injection\u00a0in a glass bottle.\u00a0Each pack contains 1\u00a0vial.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>Servier Laborierires Servier<\/p>\n\n\n\n<p>50, rue Carnot<\/p>\n\n\n\n<p>92284 Suresnes cedex<\/p>\n\n\n\n<p>France<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>The Laboratories Servier Industrie<\/p>\n\n\n\n<p>905 Route de Saran<\/p>\n\n\n\n<p>45520 Gidy<\/p>\n\n\n\n<p>France<\/p>\n\n\n\n<p>Contact the representative of the marketing authorization holder to find out more about this medicine:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Belgium \/ Belgique \/ Belgien<\/strong>SA Servier Benelux NVTel: +32 (0) 2 529 43 11<\/td><td><strong>Lithuania<\/strong>UAB \u201cSERVIER PHARMA\u201dTel: +370 (5) 2 63 86 28<\/td><\/tr><tr><td><strong>Bulgaria<\/strong>Medical LODG serviceTel: +359 2 921 57 00<\/td><td><strong>Luxembourg \/ Luxemburg<\/strong>SA Servier Benelux NVTel: +32 (0) 2 529 43 11<\/td><\/tr><tr><td><strong>Czech&nbsp;<\/strong><strong>Republic&nbsp;<\/strong><strong>_&nbsp;<\/strong><strong>_<\/strong>Servier sroTel: +420 222 118 111<\/td><td><strong>Magyarorsz&nbsp;<\/strong><strong>\u00e1&nbsp;<\/strong><strong>g<\/strong>Servier Hungaria Kft.Tel: +36 1 238 7799<\/td><\/tr><tr><td><strong>Denmark<\/strong>Servier Danmark A \/ STel: +45 36 44 22 60<\/td><td><strong>Malta<\/strong>VJ Salomone Pharma Ltd&nbsp;Tel: + 356 21 22 01 74<\/td><\/tr><tr><td><strong>Germany<\/strong>Servier Deutschland GmbHTel: +49 (0) 89 57095 01<\/td><td><strong>The Netherlands<\/strong>Servier Nederland Farma BVTel: +31 (0) 71 5246700<\/td><\/tr><tr><td><strong>Eesti<\/strong>Servier Laboratories O\u00dcTel: + 372 664 5040<\/td><td><strong>Norway<\/strong>Servier Danmark A \/ STel.&nbsp;+45 36 44 22 60<\/td><\/tr><tr><td><strong>E&nbsp;<\/strong><strong>\u03bb\u03bb\u03ac\u03b4\u03b1<\/strong>\u0395\u03a0\u0395 \u0395\u039b\u039b\u0391\u03a3 \u03a6\u0391\u03a1\u039c\u0391\u039a\u0395\u03a5\u03a4\u0399\u039a\u0397 \u0395\u03a0\u0395:\u0397\u03bb: +30 210 939 1000<\/td><td><strong>Austria<\/strong>Servier Austria GmbHTel: +43 (1) 524 39 99<\/td><\/tr><tr><td><strong>Spain<\/strong>Servierios Servier SLTel: +34 91 748 96 30<\/td><td><strong>Poland<\/strong>Servier Polska Sp.&nbsp;z ooTel: +48 (0) 22 594 90 00<\/td><\/tr><tr><td><strong>France<\/strong>Servier Laborierires ServierTel: +33 (0) 1 55 72 60 00<\/td><td><strong>Portugal<\/strong>Servier Portugal, LdaTel .: +351 21 312 20 00<\/td><\/tr><tr><td><strong>Croatia<\/strong>Servier Pharma, dooTel .: +385 (0) 1 3016 222<\/td><td><strong>Romania<\/strong>Servier Pharma SRLTel: +4 021 528 52 80<\/td><\/tr><tr><td><strong>Ireland<\/strong>Servier Laboratories (Ireland) Ltd.Tel: +353 (0) 1 663 8110<\/td><td><strong>Slovenia<\/strong>Servier Pharma dooTel .: +386 (0) 1 563 48 11<\/td><\/tr><tr><td><strong>Iceland<\/strong>Servier Laboratoriesc \/ o Icepharma hfPhone: +354 540 8000<\/td><td><strong>Slovak Republic<\/strong>Servier Slovensko spol.&nbsp;s roTel: +421 (0) 2 5920 41 11<\/td><\/tr><tr><td><strong>Italy<\/strong>Servier Italia SpATel: +39 06 669081<\/td><td><strong>Finland \/ Finland<\/strong>Servier Finland OyP. \/ Tel: +358 (0) 9 279 80 80<\/td><\/tr><tr><td><strong>.\u03a0\u03c1\u03bf\u03c2<\/strong>CA Papaellinas Ltd.:\u0397\u03bb: +357 22741741<\/td><td><strong>Sweden<\/strong>Servier Sverige ABTel: +46 (0) 8 522 508 00<\/td><\/tr><tr><td><strong>Latvia<\/strong>SIA Servier LatviaTel: +371 67502039<\/td><td><strong>United Kingdom<\/strong>Servier Laboratories LtdTel: +44 (0) 1753 666409<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Oncaspar contains pegaspar gas, which is an enzyme (asparaginase) that breaks down asparagine, an important building block of protein that is necessary for cell survival. Normal cells can produce their own asparagine while some cancer cells cannot. Oncaspar lowers asparagine levels in blood cancer cells and prevents the cancer cells from growing.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18526],"tags":[19967,19962,19963,19966,19958,19961,19964,19959,19965,19960],"class_list":["post-19743","post","type-post","status-publish","format-standard","hentry","category-medicines","category-o","tag-benefits-of-oncaspar","tag-benefits-of-pegaspar-gas","tag-oncaspar","tag-oncaspar-side-effects","tag-pegaspar-gas","tag-pegaspar-gas-side-effects","tag-what-is-oncaspar","tag-what-is-pegaspar-gas","tag-what-oncaspar-is-used-for","tag-what-pegaspar-gas-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/19743","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=19743"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/19743\/revisions"}],"predecessor-version":[{"id":19784,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/19743\/revisions\/19784"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=19743"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=19743"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=19743"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}