{"id":19537,"date":"2022-03-12T17:53:03","date_gmt":"2022-03-12T17:53:03","guid":{"rendered":"https:\/\/zeepedia.com\/?p=19537"},"modified":"2022-03-14T11:22:31","modified_gmt":"2022-03-14T11:22:31","slug":"ofev","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/ofev\/","title":{"rendered":"Ofev &#8211; Nintedanib uses, dose and side effects"},"content":{"rendered":"\n<p>100 mg&nbsp;nintedanib&nbsp;soft capsules<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Ofev is and what it is used for<\/h2>\n\n\n\n<p>Ofev contains the active substance nintedanib, a drug belonging to the group of so-called tyrosine kinase inhibitors, and is used to treat\u00a0idiopathic\u00a0pulmonary fibrosis\u00a0(IPF), other\u00a0chronic\u00a0fibrosing interstitial lung diseases (ILDs) that are exacerbated (with progressive disease progression), and systemic sclerosis-systemic sclerosis. lung disease (SSc-ILD) in adults.<\/p>\n\n\n\n<p><strong>Idiopathic&nbsp;pulmonary fibrosis (IPF)<\/strong><\/p>\n\n\n\n<p>IPF is a disease in which the\u00a0tissue\u00a0in the lungs gradually becomes thickened, stiff, and scarred.\u00a0The scarring leads to a reduced ability to transfer oxygen from the lungs to the blood, and it becomes difficult to take deep breaths.\u00a0Ofev slows down the increasing scarring and stiffness of the lungs.<\/p>\n\n\n\n<p><strong>Other\u00a0chronic\u00a0fibrosing interstitial lung diseases (ILDs) with progressive disease course<\/strong><\/p>\n\n\n\n<p>In addition to IPF, other diseases mean that the\u00a0tissue\u00a0in the lungs over time becomes thickened, stiff, and scarred (\u00a0pulmonary fibrosis\u00a0) and continues to worsen (progressive disease course).\u00a0Examples of these diseases are hypersensitivity pneumonitis, autoimmune ILD diseases (eg ILD in\u00a0rheumatoid arthritis\u00a0),\u00a0idiopathic\u00a0non-specific interstitial\u00a0pneumonia, unclassifiable\u00a0idiopathic\u00a0interstitial\u00a0pneumonia,\u00a0and other ILD diseases.\u00a0Ofev slows down the increasing scarring and stiffness of the lungs.<\/p>\n\n\n\n<p><strong>Systemic sclerosis-associated interstitial lung disease (SSc-ILD)<\/strong><\/p>\n\n\n\n<p>Systemic sclerosis (SSc), also called\u00a0scleroderma, is a rare\u00a0chronic\u00a0autoimmune\u00a0disease that affects the connective tissue in many parts of the body.\u00a0SSc causes\u00a0fibrosis\u00a0(scarring and stiffness) in the skin and other internal organs such as the lungs.\u00a0When the lungs suffer from\u00a0fibrosis, it is called interstitial lung disease (ILD) and thus the disease is called SSc-ILD.\u00a0Fibrosis\u00a0in the lungs reduces the ability to transfer oxygen to the blood and the respiratory capacity decreases.\u00a0Ofev slows down the increasing scarring and stiffness of the lungs.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before taking Ofev<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Ofev<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are pregnant,<\/li><li>if you are allergic to nintedanib, peanuts or soy or any of the other ingredients of this medicine (listed in section 6).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before taking Ofev<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have or have had liver problems,<\/li><li>if you have or have had kidney problems, or if an increased amount of&nbsp;protein&nbsp;has been detected in your urine (&nbsp;proteinuria&nbsp;),<\/li><li>if you have or have had bleeding problems,<\/li><li>if you are taking blood-thinning medicines (eg&nbsp;warfarin&nbsp;, fenprocumon or&nbsp;heparin&nbsp;) to prevent blood clots,<\/li><li>if you are taking pirfenidone as this may increase the risk of diarrhea, nausea, vomiting and liver problems,<\/li><li>if you have or have had heart problems (eg heart attack),<\/li><li>if you have recently had surgery.&nbsp;Nintedanib may affect wound healing.&nbsp;Therefore, a break in the treatment with Ofev is usually made before an operation.&nbsp;Your doctor will decide when you can resume treatment with this medicine.<\/li><li>if you have high&nbsp;blood pressure&nbsp;,<\/li><li>if you have abnormally high&nbsp;blood pressure&nbsp;in the blood vessels of the lungs (pulmonary hypertension),<\/li><li>if you have or have had an&nbsp;aneurysm&nbsp;(enlargement and weakening of a vessel wall) or a rupture in a vessel wall.<\/li><\/ul>\n\n\n\n<p>Based on what you have told your doctor, he\/she may take blood samples, for example, to check your liver function.\u00a0The doctor will discuss the results of the tests with you and decide if you can get Ofev.<\/p>\n\n\n\n<p>When taking this medicine, tell your doctor immediately if:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>you get diarrhea.&nbsp;It is important to treat diarrhea as soon as possible (see section 4);<\/li><li>if you vomit or feel unwell;<\/li><li>if have unexplained symptoms such as yellowing of the skin or whites of the eyes (jaundice), dark or brown (tea-colored) urine, right-sided pain in the upper abdomen (abdomen), increased tendency to bleed or bruise or feeling tired.&nbsp;This can be a sign of serious liver problems;<\/li><li>if you experience severe pain in the abdomen, fever, chills, nausea, vomiting, hard abdominal wall or feeling of bloating, as this may be a symptom of a hole in the intestinal wall (&#8220;gastrointestinal perforation&#8221;).&nbsp;Also tell your doctor if you have a history of&nbsp;stomach ulcers&nbsp;or diverticular disease or if you are being treated with anti-inflammatory drugs (&nbsp;NSAIDs&nbsp;commonly used to treat pain and swelling) or&nbsp;corticosteroids&nbsp;(commonly used for&nbsp;inflammation&nbsp;and&nbsp;allergies&nbsp;). ), as this may increase this risk;<\/li><li>if you have a combination of severe pain or cramping in the stomach, red blood in the stool or diarrhea, as these may be symptoms of intestinal inflammation as a result of insufficient blood supply;<\/li><li>if you experience pain, swelling,&nbsp;redness&nbsp;, feeling of heat in an arm or leg, as it may be a symptom of a blood clot in a vein (a type of blood vessel);<\/li><li>if you experience pressure or pain in the chest, especially on the left side, pain in the neck, jaw, shoulder or arm, rapid heartbeat, shortness of breath, nausea, vomiting, as it may be a symptom of a heart attack;<\/li><li>if you experience major bleeding.<\/li><li>if you get bruises, bleeding, fever, feel tired and confused.&nbsp;This may be a sign of an injury to the blood vessels called thrombotic microangiopathy (TMA).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Ofev should not be taken by children and adolescents under 18 years of age.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other drugs and Ofev<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines, including medicines obtained without a prescription and over-the-counter medicines.<\/p>\n\n\n\n<p>Ofev may affect, or be affected by, certain other medicines.&nbsp;The following medicines are examples of medicines that may increase the levels of nintedanib in the blood and thus increase the risk of&nbsp;side effects&nbsp;(see section 4):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>a medicine for fungal infections (&nbsp;ketoconazole&nbsp;)<\/li><li>a drug for bacterial infections (erythromycin)<\/li><li>a drug that affects your immune system (cyclosporine)<\/li><\/ul>\n\n\n\n<p>The following drugs are examples of drugs that can lower the levels of nintedanib in the blood and thus lead to Ofev having a worse effect:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>an&nbsp;antibiotic&nbsp;for&nbsp;tuberculosis&nbsp;(rifampicin)<\/li><li>anticonvulsants (carbamazepine,&nbsp;phenytoin&nbsp;)<\/li><li>a (traditional) herbal remedy for mild depression (&nbsp;St. John&#8217;s wort&nbsp;)<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n<p><strong>Pregnancy<\/strong><\/p>\n\n\n\n<p>Do not use this medicine during pregnancy, as it may harm your unborn baby and cause birth defects.<\/p>\n\n\n\n<p>You must take a pregnancy test to make sure you are not pregnant before starting treatment with Ofev.&nbsp;Talk to your doctor.<\/p>\n\n\n\n<p><strong>Preventive method<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Women who may become pregnant must use a very effective method of contraception to prevent pregnancy when they start taking Ofev, while taking Ofev and for at least 3 months after the end of treatment.<\/li><li>You should consult your doctor about which contraceptive methods are best for you.<\/li><li>Vomiting and \/ or diarrhea or other gastrointestinal disorders may affect the uptake of hormonal contraceptives taken by mouth, e.g.&nbsp;on pills&nbsp;,&nbsp;and may reduce their effect.&nbsp;If you experience this, you should therefore talk to your doctor to discuss an alternative, more appropriate method of contraception.<\/li><li>Tell your doctor or pharmacist immediately if you become pregnant or think you may be pregnant during treatment with Ofev.<\/li><\/ul>\n\n\n\n<p><strong>Breast-feeding<\/strong><\/p>\n\n\n\n<p>You should not breastfeed during treatment with Ofev, as there may be a risk of injury to the breast-fed baby.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Ofev may have a minor effect on the ability to drive and use machines.&nbsp;Do not drive or use machines if you feel sick.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Ofev contains soy lecithin<\/h2>\n\n\n\n<p>If you are allergic to soy or peanuts, do not take this medicine (see section 2).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Ofev<\/h2>\n\n\n\n<p>Always take this medicine exactly as your doctor or pharmacist has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p>The recommended\u00a0dose\u00a0is one capsule of 100 mg twice a day (total 200 mg per day).\u00a0Take the capsules twice daily at about 12-hour intervals, at about the same time each day, for example, one capsule in the morning and one capsule in the evening.\u00a0This way, you are sure to have an even amount of nintedanib in your blood at all times.\u00a0Swallow the capsules whole with water.\u00a0You must not chew them.\u00a0Preferably take the capsules with food, ie during or immediately before or after a meal.\u00a0The capsule must not be opened or crushed (see section 5).<\/p>\n\n\n\n<p>Do not take more than the recommended&nbsp;dose&nbsp;of one of two Ofev 100 mg soft capsules per day.<\/p>\n\n\n\n<p>If you do not take the recommended&nbsp;dose&nbsp;of one of two capsules of Ofev 100 mg per day (see possible&nbsp;side effects&nbsp;in section 4), your doctor may tell you to stop taking the medicine.&nbsp;Do not reduce the&nbsp;dose&nbsp;and do not stop the treatment yourself without first consulting your doctor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you take more Ofev than you should<\/h2>\n\n\n\n<p>Contact a doctor or pharmacist immediately.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Ofev<\/h2>\n\n\n\n<p>Do not take two capsules at the same time if you have forgotten to take your previous\u00a0dose.\u00a0Take the next\u00a0dose of\u00a0100 mg Ofev as planned at the next regular appointment as recommended by your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking Ofev<\/h2>\n\n\n\n<p>Do not stop taking Ofev without first consulting your doctor.\u00a0You must take this medicine every day for as long as your doctor prescribes it.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p>You must pay special attention if you experience the following&nbsp;side effects&nbsp;during treatment with Ofev:<\/p>\n\n\n\n<p><strong>Diarrhea&nbsp;<\/strong><em>(very common, may affect more than 1 user in 10):<\/em><\/p>\n\n\n\n<p>Diarrhea can lead to dehydration: the body loses fluid and important salts (\u00a0electrolytes, such as\u00a0sodium\u00a0or\u00a0potassium\u00a0). At the first sign of diarrhea, drink plenty of fluids and contact your doctor immediately.\u00a0Initiate appropriate treatment for diarrhea, e.g.\u00a0with loperamide, as soon as possible.<\/p>\n\n\n\n<p><strong>The following other&nbsp;side effects&nbsp;were observed during treatment with this drug.<\/strong><\/p>\n\n\n\n<p>If you get\u00a0any side effects, talk to your doctor.<\/p>\n\n\n\n<p><strong>Idiopathic&nbsp;pulmonary fibrosis&nbsp;(IPF)<\/strong><\/p>\n\n\n\n<p><em>Very common&nbsp;side effects&nbsp;(may affect&nbsp;<\/em><em>more than 1 user in 10&nbsp;<\/em><em>)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Nausea<\/li><li>Abdominal pain<\/li><li>Abnormal liver samples<\/li><\/ul>\n\n\n\n<p><em>Common&nbsp;side effects&nbsp;(may affect up to&nbsp;<\/em><em>1 in 10 people&nbsp;<\/em><em>)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Vomiting<\/li><li>Loss of appetite<\/li><li>Weight loss<\/li><li>Bleeding<\/li><li>Rash<\/li><li>Headache<\/li><\/ul>\n\n\n\n<p><em>Uncommon&nbsp;side effects&nbsp;(may affect up to 1 in 100 people)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Pancreatitis<\/li><li>Inflammation&nbsp;of the colon<\/li><li>Serious liver problems<\/li><li>Low&nbsp;platelet count&nbsp;(&nbsp;thrombocytopenia&nbsp;)<\/li><li>High&nbsp;blood pressure&nbsp;(&nbsp;hypertension&nbsp;)<\/li><li>Jaundice, ie yellowing of the skin and whites of the eyes due to high levels of&nbsp;bilirubin<\/li><li>Itching<\/li><li>Myocardial infarction<\/li><li>Hair loss (&nbsp;alopecia&nbsp;)<\/li><li>Increased amount of&nbsp;protein&nbsp;in your urine (&nbsp;proteinuria&nbsp;)<\/li><\/ul>\n\n\n\n<p><em>Has been reported (occurs in an unknown number of users)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Kidney failure<\/li><li>An enlargement and weakening of a vessel wall or a rupture in a vessel wall (&nbsp;aneurysms&nbsp;and arterial dissections).<\/li><\/ul>\n\n\n\n<p><strong>Other\u00a0chronic\u00a0fibrosing interstitial lung diseases (ILDs) with a\u00a0progressive\u00a0phenotype<\/strong><\/p>\n\n\n\n<p><em>Very common&nbsp;side effects&nbsp;(may affect more than 1 user in 10)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Nausea<\/li><li>Vomiting<\/li><li>Loss of appetite<\/li><li>Abdominal pain<\/li><li>Abnormal liver samples<\/li><\/ul>\n\n\n\n<p><em>Common&nbsp;side effects&nbsp;(may affect up to 1 in 10 people)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Weight loss<\/li><li>High&nbsp;blood pressure&nbsp;(&nbsp;hypertension&nbsp;)<\/li><li>Bleeding<\/li><li>Serious liver problems<\/li><li>Rash<\/li><li>Headache<\/li><\/ul>\n\n\n\n<p><em>Uncommon&nbsp;side effects&nbsp;(may affect up to 1 in 100 people)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Pancreatitis<\/li><li>Inflammation&nbsp;of the colon<\/li><li>Low&nbsp;platelet count&nbsp;(&nbsp;thrombocytopenia&nbsp;)<\/li><li>Jaundice, ie yellowing of the skin and whites of the eyes due to high levels of&nbsp;bilirubin<\/li><li>Itching<\/li><li>Myocardial infarction<\/li><li>Hair loss (&nbsp;alopecia&nbsp;)<\/li><li>Increased amount of&nbsp;protein&nbsp;in your urine (&nbsp;proteinuria&nbsp;)<\/li><\/ul>\n\n\n\n<p><em>Has been reported (occurs in an unknown number of users)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Kidney failure<\/li><li>An enlargement and weakening of a vessel wall or a rupture in a vessel wall (&nbsp;aneurysms&nbsp;and arterial dissections).<\/li><\/ul>\n\n\n\n<p><strong>Systemic sclerosis-associated interstitial lung disease (SSc \u2011 ILD)<\/strong><\/p>\n\n\n\n<p><em>Very common&nbsp;side effects&nbsp;(may affect&nbsp;<\/em><em>more than 1 user in 10&nbsp;<\/em><em>)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Nausea<\/li><li>Vomiting<\/li><li>Abdominal pain<\/li><li>Abnormal liver samples<\/li><\/ul>\n\n\n\n<p><em>Common&nbsp;side effects&nbsp;(may affect up to 1 in 10 people)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Bleeding<\/li><li>High&nbsp;blood pressure&nbsp;(&nbsp;hypertension&nbsp;)<\/li><li>Loss of appetite<\/li><li>Weight loss<\/li><li>Headache<\/li><\/ul>\n\n\n\n<p><em>Uncommon&nbsp;side effects&nbsp;(may affect up to 1 in 100 people)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Inflammation&nbsp;of the colon<\/li><li>Serious liver problems<\/li><li>Kidney failure<\/li><li>Low&nbsp;platelet count&nbsp;(&nbsp;thrombocytopenia&nbsp;)<\/li><li>Rash<\/li><li>Itching<\/li><\/ul>\n\n\n\n<p><em>Has been reported (occurs in an unknown number of users)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Myocardial infarction<\/li><li>Pancreatitis<\/li><li>Jaundice, ie yellowing of the skin and whites of the eyes due to high levels of&nbsp;bilirubin<\/li><li>An enlargement and weakening of a vessel wall or a rupture in a vessel wall (&nbsp;aneurysms&nbsp;and arterial dissections)<\/li><li>Hair loss (&nbsp;alopecia&nbsp;)<\/li><li>Increased amount of&nbsp;protein&nbsp;in your urine (&nbsp;proteinuria&nbsp;)<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Ofev<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton and blister.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Do not store above 25 \u00b0 C.<\/p>\n\n\n\n<p>Store in the original package.&nbsp;Moisture sensitive.<\/p>\n\n\n\n<p>Do not use this medicine if you notice that the blister containing the capsules is open or a capsule is broken.<\/p>\n\n\n\n<p>If you come into contact with the contents of the capsule, wash your hands immediately with plenty of water (see section 3).<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the package and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is nintedanib.&nbsp;Each capsule contains 100 mg of nintedanib (as esilate).<\/li><li>Other ingredients are:<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li>Capsule content: Medium&nbsp;chain triglycerides&nbsp;, hard fat, soy lecithin (E322) (see section 2)<\/li><li>Capsule shell: Gelatin,&nbsp;glycerol&nbsp;(85%), titanium dioxide (E171), red iron oxide (E172), yellow iron oxide (E172)<\/li><li>Ink: Shellac glaze, black iron oxide (E172), propylene glycol (E1520)<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<p>Ofev 100 mg capsules are peach-colored, opaque, elongated soft gelatin capsules with the Boehringer Ingelheim company symbol and \u201c100\u201d printed in black on one side.<\/p>\n\n\n\n<p>There are two different pack sizes of Ofev 100 mg:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>30 x 1 soft capsules in perforated single-dose aluminum \/ aluminum blisters<\/li><li>60 x 1 soft capsules in perforated single-dose blisters of aluminum \/ aluminum<\/li><\/ul>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Boehringer Ingelheim International GmbH<\/p>\n\n\n\n<p>Binger Strasse 173<\/p>\n\n\n\n<p>55216 Ingelheim am Rhein<\/p>\n\n\n\n<p>Germany<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Boehringer Ingelheim Pharma GmbH &amp; Co.&nbsp;KG<\/p>\n\n\n\n<p>Binger Strasse 173<\/p>\n\n\n\n<p>55216 Ingelheim am Rhein<\/p>\n\n\n\n<p>Germany<\/p>\n\n\n\n<p>Boehringer Ingelheim France<\/p>\n\n\n\n<p>100-104 Avenue de France<\/p>\n\n\n\n<p>75013 Paris<\/p>\n\n\n\n<p>France<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Belgium \/ Belgique \/ Belgien<\/strong>SCS.&nbsp;Boehringer Ingelheim Comm.VTel: +32 2 773 33 11<\/td><td><strong>Lithuania<\/strong>Boehringer Ingelheim RCV GmbH &amp; Co KGLithuanian branchesTel: +370 5 2595942<\/td><\/tr><tr><td><strong>Bulgaria<\/strong>Boringer Inglehaim RIV Gemba and Co.&nbsp;K\u0413 &#8211; clone of BulgariaTel: +359 2 958 79 98<\/td><td><strong>Luxembourg \/ Luxemburg<\/strong>SCS.&nbsp;Boehringer Ingelheim Comm.VTel: +32 2 773 33 11<\/td><\/tr><tr><td><strong>Czech Republic<\/strong>Boehringer Ingelheim spol.&nbsp;s roTel: +420 234 655 111<\/td><td><strong>Hungary<\/strong>Boehringer Ingelheim RCV GmbH &amp; Co KG Magyarorsz\u00e1gi Fi\u00f3ktelepeTel: +36 1 299 8900<\/td><\/tr><tr><td><strong>Denmark<\/strong>Boehringer Ingelheim Danmark A \/ STel: +45 39 15 88 88<\/td><td><strong>Malta<\/strong>Boehringer Ingelheim Ireland Ltd.Tel: +353 1 295 9620<\/td><\/tr><tr><td><strong>Germany<\/strong>Boehringer Ingelheim Pharma GmbH &amp; Co.&nbsp;KGTel: +49 (0) 800 77 90 900<\/td><td><strong>The Netherlands<\/strong>Boehringer Ingelheim bvTel: +31 (0) 800 22 55 889<\/td><\/tr><tr><td><strong>Eesti<\/strong>Boehringer Ingelheim RCV GmbH &amp; Co KGEesti subsidiaryTel: +372 612 8000<\/td><td><strong>Norway<\/strong>Boehringer Ingelheim Norway KSTel: +47 66 76 13 00<\/td><\/tr><tr><td><strong>Greece<\/strong>Boehringer Ingelheim \u0395\u03bb\u03bb\u03ac\u03c2 \u039c\u03bf\u03bd\u03bf\u03c0\u03c1\u03cc\u03c3\u03c9\u03c0\u03b7 AET\u03b7\u03bb: +30 2 10 89 06 300<\/td><td><strong>Austria<\/strong>Boehringer Ingelheim RCV GmbH &amp; Co KGTel: +43 1 80 105-7870<\/td><\/tr><tr><td><strong>Spain<\/strong>Boehringer Ingelheim Espa\u00f1a SATel: +34 93 404 51 00<\/td><td><strong>Poland<\/strong>Boehringer Ingelheim Sp.z ooTel: +48 22 699 0 699<\/td><\/tr><tr><td><strong>France<\/strong>Boehringer Ingelheim France SASTel: +33 3 26 50 45 33<\/td><td><strong>Portugal<\/strong>Boehringer Ingelheim Portugal, Lda.Tel: +351 21 313 53 00<\/td><\/tr><tr><td><strong>Croatia<\/strong>Boehringer Ingelheim Zagreb dooTel: +385 1 2444 600<\/td><td><strong>Romania<\/strong>Boehringer Ingelheim RCV GmbH &amp; Co KG Viena &#8211; Sucursala BucurestiTel: +40 21 302 28 00<\/td><\/tr><tr><td><strong>Ireland<\/strong>Boehringer Ingelheim Ireland Ltd.Tel: +353 1 295 9620<\/td><td><strong>Slovenia<\/strong>Boehringer Ingelheim RCV GmbH &amp; Co KG, Podru\u017enica LjubljanaTel: +386 1 586 40 00<\/td><\/tr><tr><td><strong>Iceland<\/strong>Vistor hf.Phone: +354 535 7000<\/td><td><strong>Slovak Republic<\/strong>Boehringer Ingelheim RCV GmbH &amp; Co KG,organizing serviceTel: +421 2 5810 1211<\/td><\/tr><tr><td><strong>Italy<\/strong>Boehringer Ingelheim Italia SpATel: +39 02 5355 1<\/td><td><strong>Finland \/ Finland<\/strong>Boehringer Ingelheim Finland KyPuh \/ Tel: +358 10 3102 800<\/td><\/tr><tr><td><strong>.\u03a0\u03c1\u03bf\u03c2<\/strong>Boehringer Ingelheim \u0395\u03bb\u03bb\u03ac\u03c2 \u039c\u03bf\u03bd\u03bf\u03c0\u03c1\u03cc\u03c3\u03c9\u03c0\u03b7 AET\u03b7\u03bb: +30 2 10 89 06 300<\/td><td><strong>Sweden<\/strong>Boehringer Ingelheim ABTel: +46 8 721 21 00<\/td><\/tr><tr><td><strong>Latvia<\/strong>Boehringer Ingelheim RCV GmbH &amp; Co.&nbsp;KGLatvian branchTel: +371 67 240 011<\/td><td><strong>United Kingdom (Northern Ireland)<\/strong>Boehringer Ingelheim Ireland Ltd.Tel: +353 1 295 9620<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Ofev contains the active substance nintedanib, a drug belonging to the group of so-called tyrosine kinase inhibitors, and is used to treat idiopathic pulmonary fibrosis (IPF), other chronic fibrotizing interstitial lung diseases (ILDs) that are exacerbated (with progressive disease progression) and systemic sclerosis-systemic sclerosis. lung disease (SSc-ILD) in adults.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18526],"tags":[19748,19753,19743,19747,19746,19749,19752,19744,19750,19745,19751],"class_list":["post-19537","post","type-post","status-publish","format-standard","hentry","category-medicines","category-o","tag-benefits-of-nintedanib","tag-benefits-of-ofev","tag-nintedanib","tag-nintedanib-capsule","tag-nintedanib-side-effects","tag-ofev","tag-ofev-side-effects","tag-what-is-nintedanib","tag-what-is-ofev","tag-what-nintedanib-is-used-for","tag-what-ofev-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/19537","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=19537"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/19537\/revisions"}],"predecessor-version":[{"id":19599,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/19537\/revisions\/19599"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=19537"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=19537"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=19537"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}