1 mg\u00a0tablets
estriol<\/p>\n\n\n\n
Oestriol Aspen is a drug used\u00a0for\u00a0Hormone\u00a0Replacement\u00a0Therapy\u00a0(\u00a0HRT\u00a0).\u00a0It contains the female sex hormone estriol, a so-called\u00a0estrogen.<\/p>\n\n\n\n
Oestriol Aspen is used to relieving menopausal symptoms such as dryness or irritation.\u00a0The medical term for this is “vaginal atrophy”.\u00a0It is caused by the amount of\u00a0estrogen\u00a0in the body decreasing, which occurs naturally after\u00a0menopause\u00a0(when menstruation ceases).<\/p>\n\n\n\n
Oestriol Aspen works by replacing the\u00a0estrogen\u00a0that is normally produced in a woman’s ovaries.\u00a0It can relieve genital problems and helps keep the genital mucosa elastic and resistant to both mechanical influences and\u00a0infection.<\/p>\n\n\n\n
Oestriol contained in Oestriol Aspen may also be approved for the treatment of other conditions not mentioned in this product information.\u00a0Ask your doctor, pharmacist, or other healthcare professionals if you have any further questions, and always follow their instructions.<\/p>\n\n\n\n
The use of HRT involves risks that must be taken into account when deciding to start treatment or continue an ongoing treatment.<\/p>\n\n\n\n
Experience is limited for the treatment of women whose menstruation has stopped prematurely (when the ovaries have stopped working or the uterus has been removed). If you belong to that group, the risks of HRT may be different. Talk to your doctor.<\/p>\n\n\n\n
Before starting treatment (or resuming treatment), your doctor will ask about your own, and your family’s, medical background.\u00a0Your doctor may do a general medical and gynecological examination, which also includes the examination of your breasts.<\/p>\n\n\n\n
Once you have started treatment, you should go for regular medical check-ups, at least once a year. During these check-ups, you should discuss with your doctor the benefits and risks of continued treatment.<\/p>\n\n\n\n
Perform regular examinations of the breasts according to the doctor’s recommendations.<\/p>\n\n\n\n
Do not take Oestriol Aspen<\/strong><\/p>\n\n\n\n if any of the following apply to you. If you are not sure, talk to your doctor before taking Oestriol Aspen.<\/p>\n\n\n\n Do not take Oestriol Aspen:<\/p>\n\n\n\n If any of the above affects you the first time you use Oestriol Aspen, stop taking Oestriol Aspen and contact your doctor immediately.<\/p>\n\n\n\n Talk to your doctor if you have or have had any of the following problems before starting treatment. They may recur or worsen during treatment with Oestriol Aspen. Should this occur, have more frequent check-ups with a doctor.<\/p>\n\n\n\n Tell your doctor if you have\u00a0hepatitis\u00a0C and are following a combination regimen of the medicines ombitasvir\/paritaprevir\/ritonavir, with or without dasabuvir.\u00a0The use of a combination of these drugs with certain estrogen-containing products may cause elevated liver function tests (increase in liver enzyme ALT);\u00a0The risk of this happening with Oestriol Aspen is currently unknown.<\/p>\n\n\n\n You should contact a doctor immediately and discontinue treatment if any of the following occur:<\/em><\/p>\n\n\n\n Note:<\/strong> Oestriol Aspen is not a contraceptive. If it is less than 12 months since your last period, or if you are under 50, you may still need to use contraception to avoid pregnancy. Consult your doctor.<\/p>\n\n\n\n Hormone therapy <\/strong>and cancer<\/strong><\/p>\n\n\n\n Severe thickening of the uterine lining ( endometrial hyperplasia ) and cancer of the uterine lining (endometrial cancer)<\/strong><\/p>\n\n\n\n The use of\u00a0HRT\u00a0with\u00a0estrogen\u00a0alone increases the risk of severe thickening of the uterine lining and cancer of the uterine lining.<\/p>\n\n\n\n By taking\u00a0progestogen\u00a0as a supplement to\u00a0estrogen\u00a0for at least 12 days in each 28-day cycle, you are protected against this extra risk.\u00a0The doctor will prescribe the\u00a0progestogen\u00a0if you have your uterus left.\u00a0If your uterus has undergone surgery (\u00a0hysterectomy\u00a0), you should consult your doctor if you can take the medicine without\u00a0a progestogen.<\/p>\n\n\n\n For women with the uterus left who do not take\u00a0HRT, an average of 5 out of 1,000 women aged 50-65 will be diagnosed with endometrial cancer.<\/p>\n\n\n\n For women aged 50-65 who have the uterus left and who take\u00a0HRT\u00a0with\u00a0estrogen\u00a0alone, between 10 and 60 women out of 1,000 users will be diagnosed with endometrial cancer (ie between 5 and 55 extra cases), depending on\u00a0dose\u00a0one and how as long as it is taken.<\/p>\n\n\n\n Unexpected bleeding<\/strong><\/p>\n\n\n\n During long-term treatment, the uterine lining should be checked at least once a year.<\/p>\n\n\n\n Gestagen supplementation may be considered.\u00a0If a\u00a0progestogen\u00a0is added for at least 12-14 days of the cycle, you will have bleeding once a month (so-called dropout bleeding) when you take Oestriol Aspen.<\/p>\n\n\n\n But if you get unexpected bleeding or splashing bleeding in addition to your monthly bleeding, and these:<\/p>\n\n\n\n – lasts longer than 6 months<\/p>\n\n\n\n – starts after taking Oestriol Aspen for 6 months<\/p>\n\n\n\n – continue after you stop taking Oestriol Aspen<\/p>\n\n\n\n you should see a doctor as soon as possible.<\/strong><\/p>\n\n\n\n Breast cancer<\/strong><\/p>\n\n\n\n Data show that hormone replacement therapy (\u00a0HRT\u00a0) with a combination of\u00a0estrogen-progestogen\u00a0or with\u00a0estrogen\u00a0alone increases the risk of breast cancer.\u00a0The increased risk depends on how long you use\u00a0HRT.\u00a0The increased risk is seen within 3 years.\u00a0When treatment is stopped, the increased risk decreases over time, but it can persist for 10 years or more if you have used\u00a0HRT\u00a0for more than 5 years.<\/p>\n\n\n\n Comparison<\/em><\/p>\n\n\n\n Of 1,000 women aged 50 to 54 who do not take\u00a0HRT, an average of 13 to 17 will be diagnosed with breast cancer over 5 years.<\/p>\n\n\n\n In women who are 50 years old and start taking HRT with estrogen alone for 5 years, 16-17 cases per 1,000 users (ie 0-3 extra cases) will occur.<\/p>\n\n\n\n In women who are 50 years old and start taking\u00a0HRT\u00a0with\u00a0estrogen-progestogen\u00a0for 5 years, there will be 21 cases per 1,000 users (ie 4-8 extra cases).<\/p>\n\n\n\n Among women aged 50\u201359 who do not use\u00a0HRT, an average of 27 out of 1,000 will be diagnosed with breast cancer over 10 years.<\/p>\n\n\n\n In women who are 50 years old and start taking HRT with estrogen alone for 10 years, 34 cases per 1,000 users (ie 7 extra cases) will occur.<\/p>\n\n\n\n In women who are 50 years old and start taking\u00a0HRT\u00a0with\u00a0estrogen-progestogen\u00a0for 10 years, 48 \u200b\u200bcases per 1,000 users (ie 21 extra cases) will occur.<\/p>\n\n\n\n Check your breasts regularly. Contact a doctor if you notice changes such as:<\/strong><\/p>\n\n\n\n indentations or pits<\/p>\n\n\n\n – changes in the nipple<\/p>\n\n\n\n nodules you can see or feel.<\/p>\n\n\n\n It is also recommended that you participate in a mammography examination when you are called to do so.\u00a0At the mammogram, you must inform the nurse\/healthcare professional who performs the examination that you are using\u00a0HRT, as this medicine may increase the density of the breasts.\u00a0An increased density in the breasts can make it more difficult to detect lumps on the mammography images.\u00a0<\/p>\n\n\n\n It is not known whether Oestriol Aspen is associated with the same increased risk of breast cancer as other HRT medicines. If you are concerned about the risk of developing breast cancer, you should discuss the pros and cons of treatment with your doctor.<\/p>\n\n\n\n Ovarian cancer ( ovarian cancer )<\/strong><\/p>\n\n\n\n Ovarian cancer is rare – much more rare than breast cancer.\u00a0Use of\u00a0HRT\u00a0with\u00a0estrogen\u00a0alone or combined\u00a0estrogen\u00a0–\u00a0progestogens\u00a0has been associated with a slightly increased risk of ovarian cancer.\u00a0The risk of ovarian cancer varies with age.\u00a0The diagnosis of ovarian cancer will, for example, be made on about 2 women out of 2,000 between the ages of 50 and 54 who do not take\u00a0HRT\u00a0for 5 years.\u00a0For women who have taken\u00a0HRT\u00a0for 5 years, there will be about 3 cases per 2,000 users (ie about 1 extra case).\u00a0It is unclear whether long-term treatment with low-dose estrogens (eg Oestriol Aspen) poses a lower risk than other estrogen products.<\/p>\n\n\n\n How HRT affects the heart and blood circulation<\/strong><\/p>\n\n\n\n Blood clots in a vein ( thrombosis )<\/strong><\/p>\n\n\n\n The risk of blood clots in the veins<\/strong> is 1.3\u20133 times higher for women who take HRT than for those who do not, especially during the first year of treatment.<\/p>\n\n\n\n Blood clots can be serious. If a blood clot ends up in the lungs, it can cause chest pain, shortness of breath, collapse or even lead to death. It is not known whether Oestriol Aspen increases the risk in the same way as other HRT drugs.<\/p>\n\n\n\n You are more likely to get a blood clot in a vein if any of the following apply to you. Tell your doctor if any of the following apply to you:<\/p>\n\n\n\n The symptoms of a blood clot<\/strong> are described in the section “You should contact a doctor immediately and stop the treatment”.<\/p>\n\n\n\n Comparison<\/em><\/p>\n\n\n\n For women in their 50s, who do not take\u00a0HRT, for 5 years, an average of 4-7 out of 1,000 are expected to get a blood clot in a vein.<\/p>\n\n\n\n For women in their 50s who have taken\u00a0HRT\u00a0with\u00a0estrogen-progestogen\u00a0for more than 5 years, 9-12 out of 1,000 users are expected to get a blood clot in a vein (ie 5 extra cases)<\/p>\n\n\n\n For women in their 50s without a uterus who take estrogen alone for more than 5 years, 5-8 out of 1,000 users are expected to have a blood clot in a vein (ie 1 extra case).<\/p>\n\n\n\n Heart disease (heart attack)<\/strong><\/p>\n\n\n\n There is no evidence that HRT prevents heart attacks.<\/p>\n\n\n\n For women over 60 who take\u00a0HRT\u00a0with\u00a0estrogen-progestogen, the risk of developing heart disease is slightly higher than those who do not take\u00a0HRT.<\/p>\n\n\n\n For women without a uterus who take\u00a0estrogen\u00a0alone, there is no increased risk of developing heart disease.<\/p>\n\n\n\n Stroke _<\/strong><\/p>\n\n\n\n The risk of stroke is about 1.5 times higher for those who take HRT compared to those who do not. The risk of stroke is age-dependent, therefore the number of cases of stroke increases due to the use of HRT with increasing age.<\/p>\n\n\n\n Comparison<\/em><\/p>\n\n\n\n For women in their 50s who do not take\u00a0HRT, an average of 8 out of 1,000 people are expected to have a\u00a0stroke\u00a0over 5 years.<\/p>\n\n\n\n For women in their 50s who have taken HRT for more than 5 years, 11 out of 1,000 users are expected to have a stroke (ie 3 extra cases)<\/p>\n\n\n\n Other conditions<\/strong><\/p>\n\n\n\n Using HRT does not prevent memory loss. The risk of memory loss may be slightly higher in women who start using HRT after the age of 65. Consult your doctor.<\/p>\n\n\n\n Some medicines may affect the effect of Oestriol Aspen and, conversely, Oestriol Aspen may also affect the effectiveness of other medicines.\u00a0This can lead to irregular bleeding.\u00a0The following applies:<\/p>\n\n\n\n Tell your doctor if you have\u00a0hepatitis\u00a0C and are following a combination regimen of the medicines ombitasvir\/paritaprevir\/ritonavir, with or without dasabuvir.\u00a0The use of a combination of these drugs with certain estrogen-containing products may cause elevated liver function tests (increase in liver enzyme ALT);\u00a0The risk of this happening with Oestriol Aspen is currently unknown.<\/p>\n\n\n\n Tell your doctor or pharmacist if you are taking or have recently taken any other medicines, including medicines obtained without a prescription and herbal remedies.<\/p>\n\n\n\n Results from blood test analyze<\/strong><\/p>\n\n\n\n If you need to take a blood sample, tell your doctor, or the person taking the blood sample, that you are taking Oestriol Aspen as it may affect the results of some tests.<\/p>\n\n\n\n You can eat and drink as usual while using Oestriol Aspen.<\/p>\n\n\n\n Oestriol Aspen is intended for women whose menstruation has stopped. If you become pregnant, stop taking Oestriol Aspen and consult a doctor.<\/p>\n\n\n\n Oestriol Aspen should not be used if you are pregnant.<\/p>\n\n\n\n Oestriol Aspen should not be used if you are breastfeeding.<\/p>\n\n\n\n No effects on the ability to drive and use machines have been observed.<\/p>\n\n\n\n Oestriol Aspen tablets contain\u00a0lactose monohydrates.\u00a0If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.<\/p>\n\n\n\n Your doctor will strive to give you the lowest\u00a0dose, which will give you symptom relief, and you should use Oestriol Aspen for the shortest possible time.\u00a0Talk to your doctor if you do not get any relief from the symptoms, or feel that the\u00a0dose\u00a0is too high.<\/p>\n\n\n\n Initial treatment: 2-3 mg daily in a single dose for 2-3 weeks.<\/p>\n\n\n\n Maintenance treatment:<\/p>\n\n\n\n The usual dose is 1-2 mg daily (1 to 2 tablets).<\/p>\n\n\n\n Swallow the tablets with water or other beverage.\u00a0You should take the entire daily\u00a0dose\u00a0at about the same time each day.<\/p>\n\n\n\n If you have ingested too much medicine or if, for example, a child has accidentally ingested the medicine, contact a doctor or hospital for risk assessment and advice.<\/p>\n\n\n\n If you forget to take a\u00a0dose, take it as soon as it is discovered unless more than 12 hours have passed since your regular tablet was taken.\u00a0In the latter case, skip the missed\u00a0dose\u00a0one and take the next\u00a0dose\u00a0at the usual time instead.<\/p>\n\n\n\n Do not take a double\u00a0dose\u00a0to make up for\u00a0a forgotten\u00a0dose.<\/p>\n\n\n\n If you are going to have surgery, tell your surgeon that you are taking Oestriol Aspen. You may need to stop taking Oestriol Aspen for 4 to 6 weeks before surgery to avoid the risk of blood clots (see section 2, \u201cBlood clots in a vein ( thrombosis )\u201d). Ask your doctor when it is appropriate to start taking Oestriol Aspen again.<\/p>\n\n\n\n Like all medicines, Oestriol Aspen can cause\u00a0side effects, although not everybody gets them.\u00a0The side effects\u00a0of Oestriol Aspen are usually mild and transient.\u00a0They may also be due to\u00a0a too high\u00a0dose.<\/p>\n\n\n\n The following diseases are more common in women who take HRT than those who do not:<\/p>\n\n\n\n See section 2 for more information on these\u00a0side effects.<\/p>\n\n\n\n Depending on the dose and the patient’s sensitivity, Oestriol Aspen may cause the following side effects (frequency may not be calculated from the available data):<\/p>\n\n\n\n – swelling and feeling of tension in the breasts<\/p>\n\n\n\n – minor bleeding from the abdomen<\/p>\n\n\n\n – nausea<\/p>\n\n\n\n – fluid accumulation in the body, such as swollen ankles or feet.<\/p>\n\n\n\n –\u00a0flu-like symptoms.<\/p>\n\n\n\n In most patients, these side effects disappear after the first weeks of treatment. Contact your doctor if vaginal bleeding occurs or if any side effects get worse or persist.<\/p>\n\n\n\n The following side effects have been reported with other HRTs:<\/p>\n\n\n\n Keep out of sight and reach of children.<\/p>\n\n\n\n No special storage instructions.<\/p>\n\n\n\n Do not use this medicine after the expiry date which is stated on the carton after EXP. The expiration date is the last day of the specified month.<\/p>\n\n\n\n The medicine should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.<\/p>\n\n\n\n The active substance in Oestriol Aspen tablets is estriol.<\/p>\n\n\n\n The other ingredients are amylopectin, magnesium stearate, potato starch, and\u00a0lactose monohydrate\u00a0(86 mg).<\/p>\n\n\n\n The tablets are white, round, flat, with break marks and beveled edges.\u00a0The tablets are marked with the code “DG” above the notch and “7” below.<\/p>\n\n\n\n Oestriol Aspen 1 mg is available in packs of 90 tablets (pressure pack).<\/p>\n\n\n\n Marketing Authorisation Holder:<\/em><\/p>\n\n\n\n Aspen Pharma Trading Limited, 3016 Lake Drive, Citywest Business Campus, Dublin 24, Ireland. Tel: +46 856 642 572<\/p>\n\n\n\n Manufacturer:<\/em><\/p>\n\n\n\n Cyndea Pharma, Pol\u00edgono Industrial Emiliano Revilla Sanz, Avendia de \u00c1greda, 31 42110 \u00d3lvega (Soria), Spain<\/p>\n","protected":false},"excerpt":{"rendered":" Oestriol Aspen is a drug used for Hormone Replacement Therapy ( HRT ) . It contains the female sex hormone estriol, a so-called estrogen .<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,18526],"tags":[19754,19761,3550,3553,19755,19756,19760,19759,8633,8632,19757,19758],"class_list":["post-19533","post","type-post","status-publish","format-standard","hentry","category-medicines","category-o","tag-benefits-of-estriol","tag-benefits-of-oestriol-aspen","tag-estriol","tag-estriol-side-effects","tag-estriol-tablet","tag-oestriol-aspen","tag-oestriol-aspen-side-effects","tag-oestriol-aspen-tabelt","tag-what-estriol-is-used-for","tag-what-is-estriol","tag-what-is-oestriol-aspen","tag-what-oestriol-aspen-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/19533","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=19533"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/19533\/revisions"}],"predecessor-version":[{"id":19600,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/19533\/revisions\/19600"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=19533"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=19533"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=19533"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}Warnings and cautions<\/h2>\n\n\n\n
For further information, see below \u201cBlood clots in a vein ( thrombosis )\u201d.<\/li><\/ul><\/li><\/ul>\n\n\n\nOther medicines and Oestriol Aspen<\/h2>\n\n\n\n
Use of Oestriol Aspen with food and drink<\/h2>\n\n\n\n
Pregnancy and breastfeeding<\/h2>\n\n\n\n
Driving and using machines<\/h2>\n\n\n\n
Important information about some of the ingredients of Oestriol Aspen<\/h2>\n\n\n\n
How to use Oestriol Aspen<\/h2>\n\n\n\n
If you use more Oestriol Aspen than you should<\/h2>\n\n\n\n
If you forget to take Oestriol Aspen<\/h2>\n\n\n\n
If you need surgery<\/h2>\n\n\n\n
Possible side effects<\/h2>\n\n\n\n
How to store Oestriol Aspen<\/h2>\n\n\n\n
Other information<\/h2>\n\n\n\n
Content declaration<\/h2>\n\n\n\n
What the medicine looks like and contents of the pack<\/h2>\n\n\n\n
Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n