{"id":19428,"date":"2022-03-09T15:43:11","date_gmt":"2022-03-09T15:43:11","guid":{"rendered":"https:\/\/zeepedia.com\/?p=19428"},"modified":"2022-03-11T12:40:30","modified_gmt":"2022-03-11T12:40:30","slug":"nyxoid","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/nyxoid\/","title":{"rendered":"Nyxoid &#8211; Naloxone container uses, dose and side effects"},"content":{"rendered":"\n<p>1.8 mg nasal spray,&nbsp;solution in&nbsp;a single-dose<br>naloxone container<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Nyxoid is and what it is used for<\/h2>\n\n\n\n<p>This medicine contains the active substance naloxone.\u00a0Naloxone temporarily cancels the effects of\u00a0opioids\u00a0such as heroin,\u00a0methadone,\u00a0fentanyl, oxycodone, buprenorphine, and morphine.<\/p>\n\n\n\n<p>Nyxoid is a nasal spray used for the&nbsp;acute&nbsp;treatment of opioid overdose or suspected opioid overdose in adults and adolescents over 14 years of age.&nbsp;Signs of overdose include:<\/p>\n\n\n\n<p>\u2022 breathing problems<\/p>\n\n\n\n<p>\u2022 severe drowsiness<\/p>\n\n\n\n<p>\u2022 no reaction to loud noises or touch.<\/p>\n\n\n\n<p><strong>If you are at risk for an opioid overdose, always carry your Nyxoid with you.\u00a0<\/strong>Nyxoid only works for a short time to eliminate the effects of\u00a0opioids\u00a0while you wait for\u00a0emergency\u00a0medical attention.\u00a0It is not a substitute for\u00a0emergency\u00a0medical care.\u00a0Nyxoid is intended for use by suitably trained persons.<\/p>\n\n\n\n<p>Always tell friends and family that you are taking Nyxoid with you.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you use Nyxoid<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Nyxoid<\/h2>\n\n\n\n<p>If you are allergic to naloxone or any of the other ingredients of this medicine (listed in section 6).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>You will only be given Nyxoid after you or the person giving the medicine have been shown how to use it.<\/p>\n\n\n\n<p>It should be given immediately and does not replace&nbsp;emergency&nbsp;medical care.<\/p>\n\n\n\n<p>\u2022&nbsp;<strong>Call an ambulance in case of suspected opioid overdose.<\/strong><\/p>\n\n\n\n<p>Signs and symptoms of opioid overdose may recur after this nasal spray is given.\u00a0If this happens, an additional\u00a0dose\u00a0may be given to you after 2 to 3 minutes with a new nasal spray.\u00a0The patient should be closely monitored after receiving this medicine until the emergency personnel arrives.<\/p>\n\n\n\n<p><strong>Conditions you should watch out for<\/strong><\/p>\n\n\n\n<p>\u2022 If you are physically addicted to\u00a0opioids\u00a0or if you have been given high\u00a0doses\u00a0of\u00a0opioids\u00a0(eg heroin,\u00a0methadone,\u00a0fentanyl, oxycodone, buprenorphine, or morphine).\u00a0You may experience severe withdrawal symptoms with this medicine (see section 4 below in this leaflet under &#8220;Conditions you should be careful of&#8221;).<\/p>\n\n\n\n<p>\u2022 If you are taking&nbsp;opioids&nbsp;to relieve pain.&nbsp;The pain may increase when you receive Nyxoid.<\/p>\n\n\n\n<p>\u2022 If you are using buprenorphine.&nbsp;Nyxoid may not completely relieve breathing problems.<\/p>\n\n\n\n<p><strong>Tell your doctor<\/strong>&nbsp;if you have nose injuries as this may affect the way Nyxoid works.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Nyxoid must not be used in children and adolescents under 14 years of age.<\/p>\n\n\n\n<p><strong>Getting Nyxoid near a delivery<\/strong><\/p>\n\n\n\n<p><strong>Tell your midwife or doctor<\/strong>\u00a0if you have\u00a0<strong>received Nyxoid<\/strong>\u00a0near or during\u00a0<strong>childbirth<\/strong>.\u00a0Your child may suffer from\u00a0sudden opioid withdrawal syndrome\u00a0which can be life-threatening if left untreated.<\/p>\n\n\n\n<p>Look for the following symptoms in your baby for the first&nbsp;<strong>24 hours<\/strong>&nbsp;after the baby is born:<\/p>\n\n\n\n<p>\u2022 seizures (epileptic seizures)<\/p>\n\n\n\n<p>\u2022 cries more than usual<\/p>\n\n\n\n<p>\u2022 increased reflexes.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Nyxoid<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n<p>If you are given Nyxoid while you are pregnant or breastfeeding, your baby should be closely monitored.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Once you have taken this medicine, you must not drive, use machines or engage in any other physically or mentally demanding activity for at least 24 hours, as the effects of&nbsp;opioids&nbsp;may recur.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Nyxoid<\/h2>\n\n\n\n<p>Always use this medicine exactly as your doctor, pharmacist or nurse has told you.\u00a0If you are not sure, talk to your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<p>You will be shown how to use Nyxoid before accessing the medicine.&nbsp;Below is a step-by-step guide.<\/p>\n\n\n\n<p>Instructions for how to give Nyxoid nasal spray:<\/p>\n\n\n\n<p>1.&nbsp;<strong>Check consciousness and breathing.<\/strong><\/p>\n\n\n\n<p>&#8211;&nbsp;<strong>Check if the person can be awakened to see if the person is conscious.<\/strong><\/p>\n\n\n\n<p>You can shout the person&#8217;s name, gently shake your shoulders, speak in a loud voice in your ear, rub the sternum, pinch their ear, or\u00a0nail bed\u00a0one on one finger.<\/p>\n\n\n\n<p>&#8211;\u00a0<strong>Check airway and respiration.\u00a0<\/strong>Make sure your mouth and nose are free of obstructions.\u00a0Check to breathe for 10 seconds &#8211; is your chest moving?\u00a0Can you hear breathing sounds?\u00a0Can you feel the breath on your cheek?<\/p>\n\n\n\n<p>&#8211;\u00a0<strong>Check for signs of overdose<\/strong>, eg: no reaction to touch or sound, slow uneven breathing or no breathing, snoring, wheezing, blue or purple fingernails or lips.<\/p>\n\n\n\n<p>&#8211;&nbsp;<strong>Give Nyxoid if an overdose is suspected.<\/strong><\/p>\n\n\n\n<p>2.&nbsp;<strong>Call for an ambulance.&nbsp;<\/strong>Nyxoid does not replace&nbsp;emergency&nbsp;medical care.<\/p>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20161105000044#\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.fass.se\/imaging\/resources\/e4ef1171-23d0-4c11-96f1-7aff0a221555\" alt=\"Call an ambulance\" title=\"Call an ambulance\"\/><\/a><\/figure>\n\n\n\n<p>3.&nbsp;<strong>Remove<\/strong>&nbsp;the back of the blister pack from the corner to&nbsp;<strong>remove the nasal spray<\/strong>&nbsp;from the container.&nbsp;Place the nasal spray within easy reach.<\/p>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20161105000044#\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.fass.se\/imaging\/resources\/4ea9747b-fc32-45bb-ad0d-9f78946b7820\" alt=\"Pull off the back\" title=\"Pull off the back\"\/><\/a><\/figure>\n\n\n\n<p>4. Place the patient on his back.&nbsp;Support your neck and tilt your head back.&nbsp;Clear everything that blocks the nose.<\/p>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20161105000044#\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.fass.se\/imaging\/resources\/64e65d42-2c98-4d16-8c78-bc419757c972\" alt=\"Support your neck and tilt your head back\" title=\"Support your neck and tilt your head back\"\/><\/a><\/figure>\n\n\n\n<p>5. Hold the nasal spray with your thumb on the underside of the plunger and your index and middle fingers on each side of the nozzle.&nbsp;<strong>Do not test the spray before using it<\/strong>&nbsp;as it contains only one&nbsp;dose&nbsp;of naloxone and cannot be reused.<\/p>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20161105000044#\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.fass.se\/imaging\/resources\/aab46ea0-62ac-45cb-a297-99e7a807b3fa\" alt=\"How to hold the spray\" title=\"How to hold the spray\"\/><\/a><\/figure>\n\n\n\n<p>Carefully insert the device nozzle into one of the patient&#8217;s nostrils.\u00a0Press firmly\u00a0on the plunger\u00a0until it clicks to\u00a0give a\u00a0dose.\u00a0Remove the device nozzle from the nostril after giving one\u00a0dose.<\/p>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20161105000044#\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.fass.se\/imaging\/resources\/1c05fdb1-7aaf-401d-b4a4-55e3be52eda4\" alt=\"How to give the dose\" title=\"How to give the dose\"\/><\/a><\/figure>\n\n\n\n<p>7. Place the patient on his side in a\u00a0<strong>stable side position<\/strong>\u00a0with his mouth open diagonally downwards and stay with the patient until the ambulance arrives.\u00a0Look for an improvement in the patient&#8217;s breathing level, alertness, and response to sound and touch.<\/p>\n\n\n\n<figure class=\"wp-block-image\"><a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20161105000044#\" rel=\"noopener\"><img decoding=\"async\" src=\"https:\/\/www.fass.se\/imaging\/resources\/1424fa74-e471-4900-b5df-e785ebc327c5\" alt=\"Place the patient in a stable lateral position\" title=\"Place the patient in a stable lateral position\"\/><\/a><\/figure>\n\n\n\n<p>8. If the patient does not get better within\u00a0<strong>2-3 minutes<\/strong>, a second\u00a0dose\u00a0may be given.\u00a0Be careful &#8211; even if the patient wakes up, he\/she may lose consciousness again and stop breathing.\u00a0If this happens, a second\u00a0dose\u00a0can be given immediately.\u00a0Repeat steps 3-6 in the other nostril with a new Nyxoid nasal spray.\u00a0This can be done\u00a0<strong>while the patient is in a stable lateral position.<\/strong><\/p>\n\n\n\n<p>9. If the patient does not respond to two\u00a0doses, additional\u00a0doses\u00a0may be given (if available).\u00a0Stay with the patient and look for an improvement until ambulance personnel arrive and can provide further treatment.<\/p>\n\n\n\n<p>In patients who are unconscious and do not breathe normally, additional life-saving treatment should be given if possible.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.\u00a0The following\u00a0side effects\u00a0may occur with this medicine.<\/p>\n\n\n\n<p><strong>Permission to watch out for<\/strong><\/p>\n\n\n\n<p>Nyxoid can cause&nbsp;<strong>acute withdrawal symptoms<\/strong>&nbsp;if the patient is addicted to opioid drugs.&nbsp;Symptoms may include:<\/p>\n\n\n\n<p>\u2022 fast\u00a0heart rate, high\u00a0blood pressure<\/p>\n\n\n\n<p>\u2022 body aches and stomach cramps<\/p>\n\n\n\n<p>\u2022 nausea, vomiting, diarrhea<\/p>\n\n\n\n<p>\u2022 sweating, fever, goosebumps, tremors or tremors<\/p>\n\n\n\n<p>\u2022 changes in behavior, including violent behavior, nervousness, anxiety,\u00a0agitation, restlessness or irritability<\/p>\n\n\n\n<p>\u2022 discomfort or discomfort<\/p>\n\n\n\n<p>\u2022 increase in skin sensitivity<\/p>\n\n\n\n<p>\u2022 hard to sleep.<\/p>\n\n\n\n<p>Acute withdrawal symptoms occur less frequently (may affect up to 1 in 100 people).<\/p>\n\n\n\n<p><strong>Tell your doctor<\/strong>&nbsp;if you experience any of these symptoms.<\/p>\n\n\n\n<p>Very common: may affect more than 1 in 10 people<\/p>\n\n\n\n<p>\u2022 Nausea<\/p>\n\n\n\n<p>Common: may affect up to 1 in 10 people<\/p>\n\n\n\n<p>\u2022 Dizziness, headache<\/p>\n\n\n\n<p>\u2022 Fast&nbsp;pulse<\/p>\n\n\n\n<p>\u2022 High\u00a0blood pressure, low\u00a0blood pressure<\/p>\n\n\n\n<p>\u2022 Nausea (vomiting)<\/p>\n\n\n\n<p>Uncommon: may affect up to 1 in 100 people<\/p>\n\n\n\n<p>\u2022 Shaking<\/p>\n\n\n\n<p>\u2022 Slow&nbsp;pulse<\/p>\n\n\n\n<p>\u2022 Sweating<\/p>\n\n\n\n<p>\u2022 Irregular heartbeat<\/p>\n\n\n\n<p>\u2022 Diarrhea<\/p>\n\n\n\n<p>\u2022&nbsp;Dry mouth<\/p>\n\n\n\n<p>\u2022 Rapid breathing<\/p>\n\n\n\n<p>Very rare: may affect up to 1 in 10,000 people<\/p>\n\n\n\n<p>\u2022 Allergic reactions such as swelling of the face, mouth, lips, or throat, allergic\u00a0shock<\/p>\n\n\n\n<p>Life-threatening irregular heartbeat, heart attack<\/p>\n\n\n\n<p>Accumulation of fluid in the lungs<\/p>\n\n\n\n<p>\u2022 Skin problems such as\u00a0itching, rash,\u00a0redness, swelling, severe flaky or scaly skin<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Nyxoid<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton, blister, and label after \u201cEXP\u201d.\u00a0The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Do not freeze.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<p>&#8211; The active substance is naloxone.&nbsp;Each nasal spray contains 1.8 mg of naloxone (as<\/p>\n\n\n\n<p>hydrochloride dihydrate).<\/p>\n\n\n\n<p>The other ingredients are trisodium citrate dihydrate, sodium chloride,\u00a0hydrochloric acid, sodium hydroxide, and purified water.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<p>This medicine contains 0.1 ml of naloxone in a clear, colorless to pale yellow solution in a pre-filled nasal spray, solution in\u00a0single-dose containers.<\/p>\n\n\n\n<p>Nyxoid is packaged in a carton containing 2 nasal sprays, individually packaged in blisters.&nbsp;Each nasal spray contains a single&nbsp;dose of&nbsp;naloxone.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder:<\/strong><\/p>\n\n\n\n<p>Mundipharma Corporation (Ireland) Limited<\/p>\n\n\n\n<p>Millbank House<\/p>\n\n\n\n<p>Arkle Road<\/p>\n\n\n\n<p>Sandyford Industrial Estate<\/p>\n\n\n\n<p>Dublin 18<\/p>\n\n\n\n<p>Ireland<\/p>\n\n\n\n<p><strong>Manufacturer:<\/strong><\/p>\n\n\n\n<p>Mundipharma DC BV<\/p>\n\n\n\n<p>Listening 16<\/p>\n\n\n\n<p>3832 RC Leusden<\/p>\n\n\n\n<p>Netherlands<\/p>\n\n\n\n<p>Contact the representative of the marketing authorization holder to find out more about this medicine:<\/p>\n\n\n\n<p>Mundipharma AB<\/p>\n\n\n\n<p>Tel: + 46 (0) 31 773 75 30<\/p>\n\n\n\n<p>info@mundipharma.se<\/p>\n","protected":false},"excerpt":{"rendered":"<p>This medicine contains the active substance naloxone. Naloxone temporarily cancels the effects of opioids such as heroin, methadone , fentanyl , oxycodone, buprenorphine and morphine.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,15581],"tags":[19509,19505,19508,19510,19506,19511,19507],"class_list":["post-19428","post","type-post","status-publish","format-standard","hentry","category-medicines","category-n","tag-benefits-of-naloxone-container","tag-naloxone-container","tag-naloxone-container-side-effects","tag-nyxoid","tag-what-is-naloxone-container","tag-what-is-nyxoid","tag-what-naloxone-container-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/19428","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=19428"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/19428\/revisions"}],"predecessor-version":[{"id":19460,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/19428\/revisions\/19460"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=19428"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=19428"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=19428"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}