10 mg \/ 2 ml (30 IU) solution for injection
somatropin<\/p>\n\n\n\n
NutropinAq is indicated for:<\/strong><\/p>\n\n\n\n NutropinAq contains somatropin which is a\u00a0recombinant\u00a0growth hormone\u00a0that is similar to the human natural\u00a0growth hormone\u00a0that the body produces.\u00a0Recombinant\u00a0is meant that it is made outside the body through a special process.\u00a0Growth hormone\u00a0is a chemical messenger that is produced in a small\u00a0gland\u00a0in the brain called the\u00a0pituitary gland.\u00a0In children, it tells the body to grow, helps the skeleton to develop normally, and later in adulthood, the\u00a0growth hormone\u00a0helps maintain a normal physique and\u00a0metabolism.<\/p>\n\n\n\n In children, NutropinAq is used:<\/em><\/p>\n\n\n\n In adults, NutropinAq is used:<\/em><\/p>\n\n\n\n Benefits of using this drug<\/em><\/p>\n\n\n\n In children, it helps the body to grow and the skeleton to develop normally.<\/p>\n\n\n\n In adults, it helps maintain a normal physique and\u00a0metabolism\u00a0e.g.\u00a0lipid balance and glucose level.<\/p>\n\n\n\n Talk to your doctor or pharmacist before using NutropinAq.<\/p>\n\n\n\n You should stop taking NutropinAq if you are pregnant.<\/p>\n\n\n\n Caution should be exercised when breastfeeding during treatment with NutropinAq.<\/p>\n\n\n\n If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n No effect on the ability to drive or use machines has been observed with NutropinAq.<\/p>\n\n\n\n This medicine contains less than 1 mmol\u00a0sodium\u00a0(23 mg) per\u00a0ampoule, ie essentially ‘sodium-free’.<\/p>\n\n\n\n Always use this medicine exactly as your doctor or pharmacist has told you. Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n NutropinAq treatment should be performed under the regular supervision of a physician experienced in growth hormone deficiency.<\/p>\n\n\n\n The dose of NutropinAq\u00a0to be injected is determined by your doctor.\u00a0Do not change the\u00a0dosage\u00a0without consulting your doctor.\u00a0The recommended\u00a0dose\u00a0is:<\/p>\n\n\n\n In children with growth hormone deficiency:<\/em><\/p>\n\n\n\n 0.025 – 0.035 mg\/kg body weight is injected daily under the skin (\u00a0subcutaneous\u00a0injection\u00a0).<\/p>\n\n\n\n In girls with Turner syndrome:<\/em><\/p>\n\n\n\n Up to 0.05 mg\/kg body weight is injected daily under the skin (\u00a0subcutaneous\u00a0injection\u00a0).<\/p>\n\n\n\n In children with renal impairment:<\/em><\/p>\n\n\n\n Up to 0.05 mg\/kg body weight is injected daily under the skin (\u00a0subcutaneous\u00a0injection\u00a0).<\/p>\n\n\n\n You can continue NutropinAq treatment until you have a kidney transplant.<\/p>\n\n\n\n In adults with growth hormone deficiency:<\/em><\/p>\n\n\n\n Low initial\u00a0doses\u00a0of 0.15 – 0.3 mg are injected daily under the skin (\u00a0subcutaneous\u00a0injection\u00a0).\u00a0Thereafter, your doctor may increase the\u00a0dose\u00a0depending on how you respond to treatment.\u00a0The final\u00a0dose\u00a0rarely exceeds 1.0 mg\/day.\u00a0In general, the lowest\u00a0dose\u00a0one that gives effect should be given to you.<\/p>\n\n\n\n The treatment with NutropinAq is a long-term treatment. Ask your doctor for more information.<\/p>\n\n\n\n The dose of NutropinAq\u00a0to be injected is determined by your doctor.\u00a0You should inject NutropinAq daily under the skin (\u00a0subcutaneous\u00a0injection\u00a0).\u00a0You must change the injection site every day to prevent skin damage.<\/p>\n\n\n\n NutropinAq is provided as a multi-dose solution. If the solution is cloudy when taken from the refrigerator, the contents must not be injected. Spin gently. Do not shake vigorously, as the protein can then be denatured.<\/p>\n\n\n\n You should use the NutropinAq Pen to inject NutropinAq.\u00a0You will need to use a new\u00a0sterile\u00a0injection needle for each\u00a0injection.\u00a0At the beginning of treatment, it is recommended that a doctor or nurse give you an\u00a0injection\u00a0and teach you to use the NutropinAq Pen.\u00a0After this training, you will be able to\u00a0inject\u00a0yourself or get an\u00a0injection\u00a0from a trained relative.<\/p>\n\n\n\n If you have been given more NutropinAq than you should, contact your doctor for advice.<\/p>\n\n\n\n If you inject too much NutropinAq, your blood sugar level may drop and become too low and then increase too much (hyperglycemia).<\/p>\n\n\n\n If you inject too much NutropinAq over a long period (years), you may find that certain parts of your body such as ears, nose, lips, tongue, and jaw grow too much (gigantism and\/or\u00a0acromegaly\u00a0).<\/p>\n\n\n\n Do not take a double\u00a0dose\u00a0to make up for a forgotten\u00a0dose.\u00a0Continue with your usual\u00a0dose\u00a0the next day and tell your doctor at your next visit.<\/p>\n\n\n\n Talk to your doctor before stopping using NutropinAq. If you stop using NutropinAq too soon or use it for too long, the results of the treatment will not be as expected.<\/p>\n\n\n\n If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n Tell your doctor immediately if you notice any change or growth of birthmarks and\/or skin spots (melanocyte nevus).\u00a0If you have a\u00a0tumor\u00a0or regrowth of a previous\u00a0tumor\u00a0(as confirmed by a doctor), treatment with NutropinAq should be stopped immediately.\u00a0This\u00a0side effect\u00a0is less common, it can affect up to 1 in 100 people.<\/p>\n\n\n\n Tell your doctor immediately if you experience vision changes, severe or recurrent headaches, along nausea or vomiting.\u00a0This may be a sign of a temporary increase in pressure in the brain (\u00a0intracranial\u00a0hypertension\u00a0).\u00a0If you have\u00a0intracranial\u00a0hypertension, your doctor may decide to temporarily reduce or stop taking NutropinAq.<\/p>\n\n\n\n Treatment can be started again after the episode is over. This side effect is rare, it can occur in up to 1 in 1000 users.<\/p>\n\n\n\n Other side effects are:<\/strong><\/p>\n\n\n\n Very common (may affect more than 1 user in 10)<\/em><\/p>\n\n\n\n Swelling of the hands and feet due to accumulation of fluid (peripheral edema ), sometimes associated with local muscle pain ( myalgia ) and joint pain ( arthralgia ). These side effects usually occur in adults early in treatment and are short-lived. Edema was reported as a common side effect in children.<\/p>\n\n\n\n Common (may affect up to 1 in 10 people)<\/em><\/p>\n\n\n\n Underactivity of the thyroid gland leads to low levels of thyroid hormone (\u00a0hypothyroidism\u00a0).\u00a0If your\u00a0hypothyroidism\u00a0is not treated, NutropinAq may not work.\u00a0Your doctor should check your thyroid function regularly and\u00a0prescribe\u00a0appropriate treatment if necessary.<\/p>\n\n\n\n Decreased ability to absorb sugar (\u00a0glucose\u00a0) from the blood, leading to high blood sugar (\u00a0hyperglycemia\u00a0).\u00a0Your doctor will monitor you for signs of this during treatment with NutropinAq.\u00a0If you are being treated with\u00a0insulin, your doctor may need to adjust your insulin dose.<\/p>\n\n\n\n A feeling of weakness (\u00a0asthenia\u00a0) and increased muscle tension (increased\u00a0muscle tone\u00a0).<\/p>\n\n\n\n Pain, bleeding, bruising, rash and itching at the injection site. These can be avoided by using the correct injection technique and changing the injection site.<\/p>\n\n\n\n Some patients may develop\u00a0antibodies\u00a0(a type of\u00a0protein\u00a0produced by the body) to somatropin.\u00a0When these\u00a0antibodies\u00a0were found in patients, they did not prevent them from growing.<\/p>\n\n\n\n Uncommon (may affect up to 1 in 100 people)<\/em><\/p>\n\n\n\n Decreased number of\u00a0red blood cells\u00a0in the blood (\u00a0anemia\u00a0), low blood sugar (hypoglycemia), and increase in phosphate levels (\u00a0hyperphosphatemia\u00a0).<\/p>\n\n\n\n Personality changes or deviant behavior.<\/p>\n\n\n\n Persistent stinging, burning sensation, pain, and\/or numbness in the palms of the hands due to a nerve being pinched in the wrist (\u00a0carpal tunnel syndrome\u00a0).<\/p>\n\n\n\n Rapid involuntary eye movements (\u00a0nystagmus\u00a0), swelling of the\u00a0optic nerve\u00a0in the eye (papilloedema), double vision (\u00a0diplopia\u00a0), headache, drowsiness, and dizziness (\u00a0vertigo\u00a0).<\/p>\n\n\n\n Increased heart rate ( tachycardia ) and high blood pressure ( hypertension ).<\/p>\n\n\n\n Vomiting, abdominal pain, gas in the stomach (\u00a0flatulence\u00a0), and nausea.<\/p>\n\n\n\n Sensitive and dry skin (exfoliative\u00a0dermatitis\u00a0), the altered thickness of the skin, heavy hair growth on the face and body (\u00a0hirsutism\u00a0),\u00a0hives\u00a0(\u00a0urticaria\u00a0).<\/p>\n\n\n\n Lateral curvature of the spine (scoliosis). If you have scoliosis, you need to be examined often to see if the curvature increases.<\/p>\n\n\n\n A bone disease where the upper part of the bone (femur) slides apart from the hip (displacement in the upper femoral epiphysis).\u00a0This usually occurs in rapidly growing patients.\u00a0Patients with diseases of the hormonal system are more likely to develop displacement in the upper femoral epiphysis.<\/p>\n\n\n\n Decreased muscle size (muscle atrophy), joint pain (\u00a0arthralgia\u00a0), and skeletal pain.<\/p>\n\n\n\n Involuntary urine leakage (urinary incontinence), increased urination frequency (\u00a0pollakiuria\u00a0), and increased urine output (\u00a0polyuria\u00a0).<\/p>\n\n\n\n Uterine bleeding (uterine bleeding), genital discharge, and breast enlargement (\u00a0gynecomastia\u00a0).<\/p>\n\n\n\n Local loss\/increase of fat in the skin (lipodystrophy, atrophy\/hypertrophy at the injection site).<\/p>\n\n\n\n Enlarged lymphatic tissue in the upper part of the pharynx (adenoid) with symptoms similar to those of enlarged tonsils (see Rare).<\/p>\n\n\n\n Rare (may affect up to 1 in 1,000 people)<\/em><\/p>\n\n\n\n Elevated blood sugar (hyperglycemia,\u00a0diabetes mellitus\u00a0).\u00a0Diabetes mellitus\u00a0can lead to increased urination, thirst, and hunger.\u00a0If you experience any of these symptoms, tell your doctor.<\/p>\n\n\n\n Enlarged\u00a0tonsils\u00a0lead to snoring, difficulty breathing or swallowing, short-term pauses in sleep (\u00a0sleep apnea\u00a0), or fluid in the ear and ear infections.\u00a0If this proves to be particularly troublesome, you should discuss this with your doctor.<\/p>\n\n\n\n An abnormal sensation of tingling or numbness (\u00a0paresthesia\u00a0), abnormal skeletal development, a disease affecting skeletal growth (osteochondrosis), and muscle weakness.<\/p>\n\n\n\n Other rare\u00a0side effects\u00a0observed with NutropinAq include\u00a0itching\u00a0all over the body, rash, blurred vision, weight gain, dizziness, diarrhea, swelling of the face, fatigue, pain, fever, depression, and difficulty sleeping (insomnia).<\/p>\n\n\n\n Indication-specific adverse reactions noted during clinical trials<\/em><\/p>\n\n\n\n In children with a growth hormone deficiency,\u00a0tumors\u00a0in the brain (\u00a0central nervous system\u00a0) were reported as common\u00a0side effects.\u00a0Of the 236 patients included in the clinical trials, three patients had a\u00a0tumor\u00a0of the\u00a0central nervous system.\u00a0Of the three patients with a\u00a0central nervous system\u00a0tumor,\u00a0two patients suffered from a recurrence of a\u00a0tumor\u00a0in the cerebellum (medulloblastoma) and one patient with a\u00a0tumor\u00a0containing histiocytes (histiocytoma).\u00a0See also section “warnings and precautions”.<\/p>\n\n\n\n Girls with\u00a0Turner syndrome\u00a0reported abnormally heavy menstrual bleeding as a common\u00a0side effect.<\/p>\n\n\n\n Children with renal impairment reported\u00a0peritonitis, bone\u00a0rot,\u00a0and increased levels of blood creatinine as common\u00a0side effects.\u00a0They are at greater risk of developing increased pressure in the brain (\u00a0intracranial\u00a0hypertension\u00a0), with the greatest risk at the beginning of treatment, although children with organic growth hormone deficiency and\u00a0Turner syndrome\u00a0also have an increased risk.<\/p>\n\n\n\n Adults with growth hormone deficiency reported abnormal tingling or numbness (\u00a0paresthesia\u00a0), abnormally high blood sugar levels, excess fat in the blood, insomnia, joint problems,\u00a0osteoarthritis\u00a0(degrading joint disease), muscle weakness, back pain, chest pain, and breast enlargement (\u00a0habitual\u00a0breast\u00a0enlargement ).<\/p>\n\n\n\n Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n Do not use this medicine after the expiry date which is stated on the label and carton after EXP. The expiration date is the last day of the specified month.<\/p>\n\n\n\n Store in a refrigerator (2\u00baC-8\u00baC).<\/p>\n\n\n\n Do not freeze.<\/p>\n\n\n\n Store blisters in the outer carton.<\/p>\n\n\n\n After the first use, the\u00a0cartridge\u00a0can be stored for up to 28 days at 2 \u00b0 C – 8 \u00b0 C.\u00a0Do not remove the\u00a0ampoule\u00a0used from the NutropinAq Pen between\u00a0injections.<\/p>\n\n\n\n Do not use NutropinAq if you notice that the solution is cloudy.<\/p>\n\n\n\n Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.<\/p>\n\n\n\n The active substance in NutropinAq is somatropin *.<\/p>\n\n\n\n * Somatropin is a human growth hormone produced in Escherichia coli<\/em> cells by recombinant DNA technology.<\/p>\n\n\n\n The other ingredients are sodium chloride, liquid phenol, polysorbate 20, sodium citrate, anhydrous citric acid, and water for injections.<\/p>\n\n\n\n NutropinAq is a solution for injection (in a cartridge (10mg \/ 2ml) – pack sizes 1, 3 and 6). The solution for multi-dose use is clear and colorless.<\/p>\n\n\n\n Not all pack sizes may be marketed.<\/p>\n\n\n\n Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n Ipsen Pharma, 65 quai Georges Gorse, 92100 Boulogne-Billancourt, France<\/p>\n\n\n\n Manufacturer<\/strong><\/p>\n\n\n\n IPSEN PHARMA BIOTECH SAS, Signes Plateau Activity Park, CD no 402, 83870 Signes, France<\/p>\n","protected":false},"excerpt":{"rendered":" NutropinAq contains somatropin which is a recombinant growth hormone that is similar to the human natural growth hormone that the body produces. By recombinant is meant that it is made outside the body through a special process. Growth hormone is a chemical messenger that is produced in a small gland in the brain called the pituitary gland . In children, it tells the body to grow, helps the skeleton to develop normally and later in adulthood, the growth hormone helps maintain a normal physique and metabolism .<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,15581],"tags":[19581,13646,19577,19580,13643,13647,19578,13644,19579,13645],"class_list":["post-19410","post","type-post","status-publish","format-standard","hentry","category-medicines","category-n","tag-benefits-of-nutropinaq","tag-benefits-of-somatropin","tag-nutropinaq","tag-nutropinaq-side-effects","tag-somatropin","tag-somatropin-side-effects","tag-what-is-nutropinaq","tag-what-is-somatropin","tag-what-nutropinaq-is-used-for","tag-what-somatropin-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/19410","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=19410"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/19410\/revisions"}],"predecessor-version":[{"id":19469,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/19410\/revisions\/19469"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=19410"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=19410"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=19410"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}BEFORE YOU USE NUTROPINAQ<\/h2>\n\n\n\n
Do not use NutropinAq<\/h2>\n\n\n\n
Take special care with NutropinAq<\/h2>\n\n\n\n
Pregnancy and breastfeeding<\/h2>\n\n\n\n
Driving and using machines<\/h2>\n\n\n\n
NutropinAq is almost “sodium free”<\/h2>\n\n\n\n
HOW TO USE NUTROPINAQ<\/h2>\n\n\n\n
If you use more NutropinAq than you should <\/h2>\n\n\n\n
If you forget to take NutropinAq<\/h2>\n\n\n\n
If you stop using NutropinAq<\/h2>\n\n\n\n
POSSIBLE SIDE EFFECTS<\/h2>\n\n\n\n
HOW TO STORE NUTROPINAQ<\/h2>\n\n\n\n
FURTHER INFORMATION<\/h2>\n\n\n\n
Content declaration<\/h2>\n\n\n\n
What the medicine looks like and contents of the pack<\/h2>\n\n\n\n
Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n