{"id":19297,"date":"2022-03-07T16:47:40","date_gmt":"2022-03-07T16:47:40","guid":{"rendered":"https:\/\/zeepedia.com\/?p=19297"},"modified":"2022-03-08T11:46:29","modified_gmt":"2022-03-08T11:46:29","slug":"nulojix","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/nulojix\/","title":{"rendered":"NULOJIX &#8211; Belatacept uses, dose and side effects"},"content":{"rendered":"\n<p>250 mg&nbsp;powder for concentrate for&nbsp;solution for&nbsp;infusion<br>belatacept<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What NULOJIX is and what it is used for<\/h2>\n\n\n\n<p>NULOJIX contains the active substance belatacept, which belongs to a group of medicines called immunosuppressants.&nbsp;It is a drug that reduces the activity of the immune system, the body&#8217;s natural defenses.<\/p>\n\n\n\n<p>NULOJIX is used in adults to prevent the immune system from attacking the transplanted kidney and causing a rejection reaction.\u00a0It is used in combination with other immunosuppressive drugs, including mycophenolic acid and\u00a0corticosteroids.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using NULOJIX<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use NULOJIX<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>if you are allergic<\/strong>&nbsp;to belatacept or any of the other ingredients of this medicine (listed in section 6).&nbsp;Allergic reactions related to belatacept treatment have been reported in&nbsp;clinical trials&nbsp;.<\/li><li><strong>if you have not been exposed to Epstein-Barr virus<\/strong>&nbsp;(&nbsp;EBV&nbsp;) or are unsure if you have been exposed, do not treat with NULOJIX.&nbsp;EBV&nbsp;causes glandular fever.&nbsp;If you have not been exposed to it, you are at higher risk of developing a type of cancer called post-transplant lymphoproliferative disease (PTLD).&nbsp;Ask your doctor if you are unsure if you have been infected with the&nbsp;virus&nbsp;before.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Lymphoproliferative disease after transplantation:<\/p>\n\n\n\n<p>Treatment with NULOJIX increases the risk of developing a type of cancer called post-transplant lymphoproliferative disease (PTLD).&nbsp;With NULOJIX treatment, this occurs more often in the brain and can lead to death.&nbsp;People are at higher risk of developing PTLD in the following cases:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you have not been exposed to&nbsp;EBV&nbsp;before transplantation<\/li><li>If you are infected with a&nbsp;virus&nbsp;called&nbsp;cytomegalovirus&nbsp;(&nbsp;CMV&nbsp;)<\/li><li>If you have been treated for&nbsp;acute&nbsp;rejection, such as antitymocyte globulin to reduce the number of&nbsp;T cells&nbsp;.&nbsp;T cells&nbsp;are cells that are responsible for your body&#8217;s ability to resist diseases and&nbsp;infections&nbsp;.&nbsp;They can cause rejection of your transplanted kidney.<\/li><li>Ask your doctor if you are unsure about any of these conditions.<\/li><\/ul>\n\n\n\n<p>Serious&nbsp;infection&nbsp;you<\/p>\n\n\n\n<p>Serious&nbsp;infections&nbsp;can occur with NULOJIX treatment and can lead to death.<\/p>\n\n\n\n<p>NULOJIX weakens the body&#8217;s ability to resist\u00a0infection.\u00a0Serious\u00a0infections\u00a0can include:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Tuberculosis<\/li><li>Cytomegalovirus&nbsp;(&nbsp;CMV&nbsp;), a&nbsp;virus&nbsp;that can cause serious tissue and blood infections<\/li><li>Shingles<\/li><li>Other herpes virus infections.<\/li><\/ul>\n\n\n\n<p>There have been reports of a rare type of brain infection called&nbsp;progressive&nbsp;multifocal&nbsp;leukoencephalopathy (PML) in patients receiving NULOJIX.&nbsp;PML often leads to severe disability or death.<\/p>\n\n\n\n<p><strong>Tell your family or carer about your treatment.\u00a0<\/strong>You may have symptoms that you may not be aware of.\u00a0Your doctor may need to examine your symptoms to rule out PML, PTLD, or other\u00a0infections.\u00a0See section 4, Possible\u00a0side effects, for a list of symptoms.<\/p>\n\n\n\n<p>Skin cancer<\/p>\n\n\n\n<p>Limit your exposure to sunlight and ultraviolet (UV) rays when using NULOJIX.&nbsp;Wear protective clothing and use sunscreen with a high sun protection factor.&nbsp;People who use NULOJIX are at higher risk of getting certain types of cancer, especially skin cancer.<\/p>\n\n\n\n<p>Blood clots in your transplanted kidney<\/p>\n\n\n\n<p>Depending on the type of kidney transplant you have received, you may have a higher risk of getting blood clots in your transplanted kidney.<\/p>\n\n\n\n<p>Use when switching from another type of immunosuppressive maintenance therapy<\/p>\n\n\n\n<p>If healthcare professionals change your maintenance treatment to a NULOJIX-based immunosuppressive treatment, your kidney function may be checked more often for some time after the change.&nbsp;This is done to monitor for signs of rejection.<\/p>\n\n\n\n<p>Use in liver transplants<\/p>\n\n\n\n<p>The use of NULOJIX is not recommended if you have had a liver transplant.<\/p>\n\n\n\n<p>Use with other immunosuppressive drugs<\/p>\n\n\n\n<p>Normally Nulojix is \u200b\u200bgiven with\u00a0steroids.\u00a0Too rapid a reduction in the\u00a0dose\u00a0of one of the\u00a0steroids\u00a0can increase the risk of your body rejecting your transplanted kidney.\u00a0Take exactly the\u00a0dose\u00a0of\u00a0steroid\u00a0you have been prescribed by your doctor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>NULOJIX has not been studied in children and adolescents under the age of 18 and is therefore not recommended for this age group.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and NULOJIX<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking or have recently taken any other medicines.<\/p>\n\n\n\n<p>Ask your doctor or pharmacist for advice before taking any other medicine while you are using NULOJIX.<\/p>\n\n\n\n<p>The use of live vaccines should be avoided during treatment with NULOJIX.&nbsp;Tell your doctor if you need vaccinations.&nbsp;Your doctor will advise you on what to do.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before using this medicine.<\/p>\n\n\n\n<p>Tell your doctor if you become pregnant during NULOJIX treatment.<\/p>\n\n\n\n<p>Do not use NULOJIX if you are pregnant unless your doctor specifically recommends it.\u00a0The effect of NULOJIX in pregnant women is unknown.\u00a0You must not become pregnant during treatment with NULOJIX.\u00a0If you are of\u00a0childbearing potential, you should use effective contraception during treatment with NULOJIX and up to 8 weeks after the last dose of treatment, as the potential risk of developing embryo\/fetus is unknown.\u00a0Your doctor will advise you on reliable contraception.<\/p>\n\n\n\n<p>You must stop breastfeeding if you are being treated with NULOJIX.\u00a0It is not known if the active substance belatacept is excreted in human milk.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Belatacept has a minor influence on the ability to drive and use tools and machines.&nbsp;However, if you get tired or feel unwell after receiving NULOJIX, do not drive or use any tools or machines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Important information about some of the ingredients of NULOJIX<\/h2>\n\n\n\n<p>Tell your doctor if you have been prescribed a low-salt diet (low sodium) before you are treated with NULOJIX.<\/p>\n\n\n\n<p>This medicine contains 0.65 mmol (or 15 mg)\u00a0sodium\u00a0per\u00a0vial, which is equivalent to 1.95 mmol (or 45 mg)\u00a0sodium\u00a0per maximum dose of three vials.\u00a0This corresponds to 2.25% of the maximum recommended daily\u00a0sodium\u00a0intake for adults.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use NULOJIX<\/h2>\n\n\n\n<p>Treatment with NULOJIX is prescribed and monitored by a kidney transplant specialist.&nbsp;NULOJIX will be given to you by healthcare professionals.<\/p>\n\n\n\n<p>It will be given to you by\u00a0infusion\u00a0(as a drip) into one of your veins over 30 minutes.<\/p>\n\n\n\n<p>The recommended\u00a0dose\u00a0is based on your body weight (in kg) and is calculated by healthcare professionals.\u00a0Dosage\u00a0one and the frequency of treatment can be seen below.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>Initial treatment<\/td><td>Dose<\/td><\/tr><tr><td>Transplant day, before&nbsp;implantation&nbsp;(day 1)<\/td><td>10 mg \/ kg<\/td><\/tr><tr><td>Day 5, day 14, and day 28<\/td><\/tr><tr><td>End of week 8 and week 12 after transplantation<\/td><\/tr><tr><td>Maintenance treatment<\/td><td>Dose<\/td><\/tr><tr><td>Every 4 weeks (\u00b1 3 days) starting at the end of week 16 after transplantation<\/td><td>5 mg \/ kg<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>In connection with your kidney transplant, you can receive NULOJIX in combination with other types of immunosuppressive drugs, to prevent your immune system from attacking your transplanted kidney.<\/p>\n\n\n\n<p>Your doctor may decide to change your immunosuppressive treatment to treatment with NULOJIX during the maintenance phase after your kidney transplant.<\/p>\n\n\n\n<p>Information for healthcare professionals on dose calculation,\u00a0preparation,\u00a0and\u00a0administration\u00a0of NULOJIX is provided at the end of this leaflet.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you use more NULOJIX than you should&nbsp;<\/h2>\n\n\n\n<p>Should this occur you will be monitored by a doctor for any signs or symptoms of&nbsp;side effects&nbsp;and if necessary these symptoms will be treated.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use NULOJIX<\/h2>\n\n\n\n<p>You must appear at all times booked for the\u00a0administration\u00a0of NULOJIX.\u00a0If you miss an opportunity, ask your doctor when you should receive the next\u00a0dose.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop using NULOJIX<\/h2>\n\n\n\n<p>Your body may reject the transplanted kidney if you stop using NULOJIX.\u00a0The decision to stop using NULOJIX should be discussed with your doctor and usually, other treatments will be started.<\/p>\n\n\n\n<p>If you stop using NULOJIX for a long period, do not take any other medicines to prevent your body from rejecting your transplanted kidney, and then start treatment with NULOJIX again, it is unknown if belatacept has the same effect as before.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p>However, NUJOJIX can cause serious&nbsp;side effects&nbsp;that may require treatment.<\/p>\n\n\n\n<p>Tell your family or carer about your treatment, as you may have symptoms that you may not be aware of.<\/p>\n\n\n\n<p>Tell your doctor immediately if you or your family notice any of the symptoms listed below:<\/p>\n\n\n\n<p>Symptoms from the central and&nbsp;peripheral nervous system&nbsp;may include memory problems;&nbsp;language and communication difficulties;&nbsp;change in your mood or behavior;&nbsp;confusion or inability to control your muscles;&nbsp;weakness in one side of the body;&nbsp;visual changes;&nbsp;headache.<\/p>\n\n\n\n<p>Infectious symptoms\u00a0may include fever;\u00a0unexplained weight loss;\u00a0swollen glands;\u00a0cold symptoms such as the runny nose or sore throat;\u00a0cough with mucus or blood-mixed mucus;\u00a0earache;\u00a0cuts or abrasions that are red, hot, and with warts.<\/p>\n\n\n\n<p>Kidney and urinary tract symptoms&nbsp;may include tenderness at the transplant site;&nbsp;difficulty urinating;&nbsp;changes in the amount of urine you produce (urine production);&nbsp;blood in the urine;&nbsp;pain or burning when urinating (urination).<\/p>\n\n\n\n<p>Symptoms of the gastrointestinal tract\u00a0may include pain when swallowing;\u00a0painful cold sores;\u00a0white spots in the mouth or throat;\u00a0stomach upset;\u00a0abdominal pain;\u00a0vomiting;\u00a0diarrhea.<\/p>\n\n\n\n<p>Skin changes&nbsp;may include an increased tendency for bruising or bleeding;&nbsp;brown or black skin changes with uneven edges or that one part of the change does not look like the other;&nbsp;a change in the size and color of a birthmark;&nbsp;a new skin change or lump.<\/p>\n\n\n\n<p>Allergic reactions\u00a0may include, but are not limited to;\u00a0rash;\u00a0reddening of the skin;\u00a0hives;\u00a0itching;\u00a0swelling of the lips, tongue, or face;\u00a0swelling all over the body;\u00a0chest pain;\u00a0shortness of breath;\u00a0rustling\/wheezing or dizziness.<\/p>\n\n\n\n<p><strong>Very common&nbsp;side effects&nbsp;(<\/strong>&nbsp;may affect more than 1 user in 10) are:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Bladder or kidney infection, upper respiratory tract infection,&nbsp;CMV&nbsp;infection&nbsp;(&nbsp;may cause severe blood and tissue infections), fever, cough,&nbsp;bronchitis<\/li><li>Shortness of breath<\/li><li>Constipation, diarrhea, nausea, vomiting, abdominal pain<\/li><li>High or low&nbsp;blood pressure<\/li><li>Headache, difficulty sleeping, nervousness or anxiety, swelling of hands and feet<\/li><li>Joint pain, back pain, pain in&nbsp;the&nbsp;extremities<\/li><li>Pain when urinating (urination), blood in the urine<\/li><\/ul>\n\n\n\n<p>Samples may show:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Decreased number of&nbsp;blood cells&nbsp;or&nbsp;anemia&nbsp;, decreased number of&nbsp;white blood cells<\/li><li>Increased amount of&nbsp;creatinine&nbsp;in your blood (a blood test used to measure kidney function), increased amount of&nbsp;protein&nbsp;in urine<\/li><li>Changes in salt and electrolyte levels in the blood<\/li><li>Increased&nbsp;cholesterol&nbsp;and&nbsp;triglycerides&nbsp;(blood fats)<\/li><li>High blood sugar<\/li><\/ul>\n\n\n\n<p><strong>Common&nbsp;side effects&nbsp;(<\/strong>&nbsp;may affect up to 1 in 10 people) are:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Cancer or non-cancerous growth of the skin<\/li><li>Dangerous reduction in&nbsp;blood pressure&nbsp;, which can lead to collapse,&nbsp;coma&nbsp;and death if left untreated<\/li><li>Stroke<\/li><li>Tissue death due to blocked blood flow<\/li><li>Hepatitis (cytolytic&nbsp;hepatitis&nbsp;)<\/li><li>Kidney damage<\/li><li>Fluid in the lungs and wheezing, wheezing when breathing, chest pain or angina, enlarged heart muscle (lower part of the heart)<\/li><li>Infection&nbsp;of blood or&nbsp;tissue&nbsp;,&nbsp;infection&nbsp;of the respiratory tract,&nbsp;pneumonia&nbsp;,&nbsp;influenza&nbsp;, sinusitis, runny nose, sore throat, pain in the mouth and throat region, herpes virus infection,&nbsp;shingles&nbsp;and other viral infections, cold sores, cold sores, kidney infection, fungal and other fungal infections of the skin, nail fungus , skin infection,&nbsp;soft&nbsp;tissue infection, wound infection,&nbsp;infection&nbsp;limited to a specific area, slow healing, bloody bruising, accumulation of lymph fluid around the transplanted kidney<\/li><li>High and low heart rate, abnormal and irregular heartbeat, weak heart<\/li><li>Diabetes<\/li><li>Dehydration<\/li><li>Inflammation&nbsp;of the stomach and intestines, often caused by&nbsp;viruses<\/li><li>Stomach upset<\/li><li>Unusual feeling of tingling, numbness or weakness in arms and legs<\/li><li>Rash,&nbsp;itching<\/li><li>Muscle aches, muscle weakness, pain in bone tissue, swollen joints, abnormal&nbsp;cartilage&nbsp;between the vertebrae of the spine, sudden inability to bend joints, muscle spasms, joint inflammation<\/li><li>Blockage in the blood vessels in the kidney, enlarged kidney due to blockage in the urine flow from the kidney, backflow of urine from the bladder to the&nbsp;ureter&nbsp;, inability to hold urine, incomplete emptying of the bladder, nocturnal urination, blood in the urine<\/li><li>Weight gain, weight loss<\/li><li>Cataracts, blood clots in the eye, blurred vision<\/li><li>Shaking or trembling, dizziness, fainting or loss of consciousness, earache, wheezing, ringing or other persistent sound in the ears<\/li><li>Acne, hair loss, abnormal skin changes, heavy sweating, night sweats<\/li><li>Weakness or loosening of the abdominal muscles and bulging of the skin at the healed scar,&nbsp;hernia&nbsp;of the stomach wall<\/li><li>Depression, fatigue, tiredness, drowsiness, lack of energy, general malaise, difficulty lying down, nosebleeds<\/li><li>Typical appearance for a person who has high cortisone levels such as moon face, humpback, obesity on the upper body<\/li><li>Abnormal fluid retention<\/li><\/ul>\n\n\n\n<p>Samples may show:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Low&nbsp;platelet count&nbsp;, too many&nbsp;white blood cells&nbsp;, too many&nbsp;red blood cells<\/li><li>Changes in the level of carbon dioxide in the blood, retaining fluid, low amount of protein in the blood<\/li><li>Abnormal liver function tests, elevated blood parathyroid hormone<\/li><li>Increased protein (C-reactive&nbsp;protein&nbsp;) in the blood which indicates&nbsp;inflammation<\/li><li>Decreased number of&nbsp;antibodies&nbsp;(&nbsp;proteins&nbsp;that fight&nbsp;infections&nbsp;) in the blood<\/li><\/ul>\n\n\n\n<p><strong>Uncommon&nbsp;side effects&nbsp;(<\/strong>&nbsp;may affect up to 1 in 100 people) are:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Lung cancer, rectal cancer, breast cancer, cancer of bone tissue, muscle or fat tissue,&nbsp;tumor&nbsp;of the skin or intestines caused by a herpes virus and seen in patients with a weakened immune system, prostate cancer, cervical cancer, throat cancer,&nbsp;lymph node&nbsp;cancer, bone marrow cancer, kidney cancer ,&nbsp;ureter&nbsp;or bladder.<\/li><li>Fungal infection of the brain, encephalitis, severe brain infection called PML (&nbsp;progressive&nbsp;multifocal&nbsp;leukoencephalopathy)<\/li><li>Abnormal swelling of the brain, increased pressure in the skull and brain, cramps, weakness that causes loss of movement in one half of the body, loss of&nbsp;tissue&nbsp;surrounding nerves, inability to move the facial muscles<\/li><li>Brain disease that causes headache, fever, hallucinations, confusion, abnormal speech or abnormal body movements<\/li><li>Weak blood flow to the heart, extra beats, changes in the aortic valve, abnormally high heart rate<\/li><li>Sudden problems with breathing that cause damage to the lungs, increased&nbsp;blood pressure&nbsp;in the lungs,&nbsp;pneumonia&nbsp;, coughing up blood, changes in the ability to transport air in the lungs and airways, fluid around the alveoli, respiratory arrest during sleep, changes in the voice<\/li><li>Genital herpes<\/li><li>Inflammation&nbsp;of the colon caused by&nbsp;cytomegalovirus&nbsp;, pancreatitis,&nbsp;gastric ulcer&nbsp;, ulcer of the small or large intestine, blockage of the small intestine, black tar-like stool, bleeding in the rectum, abnormal color of the stool<\/li><li>Bacterial&nbsp;infection&nbsp;,&nbsp;inflammation&nbsp;or&nbsp;infection&nbsp;of the inner part of the heart,&nbsp;tuberculosis&nbsp;,&nbsp;infection&nbsp;of bone tissue,&nbsp;inflammation&nbsp;of the&nbsp;lymph&nbsp;nodes,&nbsp;chronic&nbsp;dilation of the airways in the lungs with frequent lung infections<\/li><li>Infection&nbsp;is with strongyloidasis mask, diarrhea infection with giardia parasite<\/li><li>Kidney disease caused by&nbsp;virus&nbsp;(polyomavirus-associated&nbsp;nephropathy&nbsp;), kidney inflammation, scar tissue in the kidney, shrinkage of the small kidney tubes,&nbsp;inflammation&nbsp;of the bladder with bleeding<\/li><li>Blood clots in the renal artery<\/li><li>Guillain-Barr\u00e9 syndrome&nbsp;(a condition that causes muscle weakness or paralysis)<\/li><li>EBV&nbsp;(&nbsp;Epstein-Barr&nbsp;virus&nbsp;) lymphoproliferative disease<\/li><li>Blood clots in veins, inflamed veins, regular cramps in the legs<\/li><li>Altered&nbsp;arteries&nbsp;, scarring of the&nbsp;arteries&nbsp;, blood clots in the&nbsp;arteries&nbsp;, narrowing of the&nbsp;arteries&nbsp;, temporary flushing \/ swollen face<\/li><li>Gallstones&nbsp;, fluid-filled pockets in the liver,&nbsp;fatty liver<\/li><li>Skin disease with red spots of thickened skin, often scaly, abnormal hair growth, brittle hair, brittle nails, ulcers on the penis<\/li><li>Abnormal balance of minerals in the body leading to bone problems, bone inflammation, abnormal weakening of bones leading to bone problems,&nbsp;inflammation&nbsp;of joints, unusual diseases of bone tissue<\/li><li>Testicular inflammation, abnormally prolonged penis erection, abnormal cervical cells, changes in the breasts, testicular pain, wounds in female genitals, weakened vaginal wall,&nbsp;infertility&nbsp;or inability to conceive, swelling of the scrotum<\/li><li>Seasonal asthma<\/li><li>Poor appetite, lost sense of taste, impaired hearing<\/li><li>Abnormal dreams, mood swings, abnormal inability to focus and sit still, difficulty understanding or thinking, poor memory,&nbsp;migraine&nbsp;, irritability<\/li><li>Numbness or weakness due to poorly controlled&nbsp;diabetes&nbsp;, changes in the foot due to&nbsp;diabetes&nbsp;, difficulty in keeping the legs still<\/li><li>Swelling of the back of the eye which leads to changes in vision, eye inflammation, troublesome \/ increased sensitivity to light, swollen eyelids<\/li><li>Cracked mouth pores, swollen gums, pain in salivary glands<\/li><li>Increased sex drive<\/li><li>Burning sensation<\/li><li>Infusion reaction wound tissue,&nbsp;inflammation&nbsp;, recurrence of disease, feeling hot, wounds<\/li><li>Decreased urine production<\/li><li>Insufficient function of the transplanted kidney, problems during or after a&nbsp;transfusion&nbsp;, separation of wound edges, broken bones, total&nbsp;rupture&nbsp;or separation of tendons, low and \/ or high&nbsp;blood pressure&nbsp;during or after a procedure, bruising \/ accumulation of blood in soft parts after a procedure , pain and \/ or headache related to a procedure, bruising in soft tissues<\/li><\/ul>\n\n\n\n<p>Samples may show:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Dangerously low&nbsp;red blood cell count&nbsp;, dangerously low&nbsp;white blood cell count ,&nbsp;red blood cell&nbsp;degradation&nbsp;, blood clotting problems, acidity in the blood due to&nbsp;diabetes&nbsp;, lack of acid in the blood<\/li><li>Altered production of&nbsp;hormones&nbsp;in the adrenal gland<\/li><li>Low&nbsp;vitamin D&nbsp;levels<\/li><li>Increased levels of pancreatic enzymes in the blood, increased troponin levels in the blood, increased amount of prostate&nbsp;-specific antigen&nbsp;(PSA), high levels of&nbsp;uric acid&nbsp;in the blood, decreased number of CD4&nbsp;lymphocytes&nbsp;, low blood sugar<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store NULOJIX<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the vial and carton after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>This medicine is stored in a healthcare facility where it is administered.<\/p>\n\n\n\n<p>Store in a refrigerator (2&nbsp;<sup>\u00b0<\/sup>&nbsp;C &#8211; 8&nbsp;<sup>\u00b0<\/sup>&nbsp;C).<\/p>\n\n\n\n<p>Store in the original package.&nbsp;Sensitive to light.<\/p>\n\n\n\n<p>After\u00a0reconstitution, the solution should be transferred immediately from the vial to the infusion bag or vial.<\/p>\n\n\n\n<p>After dilution and from a&nbsp;microbiological&nbsp;point of view, the drug should be used immediately.&nbsp;If not used immediately, the infusion solution can be stored in a refrigerator (2&nbsp;<sup>\u00b0<\/sup>&nbsp;C &#8211; 8&nbsp;<sup>\u00b0<\/sup>&nbsp;C) for up to 24 hours.&nbsp;The infusion solution can be stored below 25&nbsp;<sup>o<\/sup>&nbsp;C for a maximum of 4 hours out of a total of 24 hours.&nbsp;Do not freeze.<\/p>\n\n\n\n<p>Infusion&nbsp;one of NULOJIX ends within 24 hours after&nbsp;reconstitution&nbsp;of the powder.<\/p>\n\n\n\n<p>Do not use NULOJIX if you notice any particles or discoloration in the reconstituted or diluted solution.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the package and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<p><strong>What NULOJIX contains<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is belatacept.&nbsp;Each&nbsp;vial&nbsp;contains 250 mg belatacept.&nbsp;After&nbsp;reconstitution&nbsp;, each ml of concentrate contains 25 mg of belatacept.<\/li><li>The other ingredients are sodium chloride, sodium dihydrogen phosphate monohydrate, sucrose, sodium hydroxide (for&nbsp;pH&nbsp;control) and&nbsp;hydrochloric acid&nbsp;(for&nbsp;pH&nbsp;control).&nbsp;(See section 2.)<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<p>NULOJIX powder for concentrate for solution for\u00a0infusion\u00a0(powder for concentrate) is a white to off-white powder that appears in the form of a cake or is broken up into pieces.<\/p>\n\n\n\n<p>Each&nbsp;vial&nbsp;contains 250 mg belatacept.<\/p>\n\n\n\n<p>Packs of either 1&nbsp;vial&nbsp;and 1&nbsp;syringe&nbsp;or 2 vials and 2 syringes.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p>Marketing Authorisation Holder:<\/p>\n\n\n\n<p>Bristol-Myers Squibb Pharma EEIG<\/p>\n\n\n\n<p>Plaza 254<br>Blanchardstown Corporate Park 2<br>Dublin 15, D15 T867<br>Ireland<\/p>\n\n\n\n<p>Manufacturer:<\/p>\n\n\n\n<p>Swords Laboratories T \/ A Bristol-Myers Squibb Cruiserath Biologics<br>Cruiserath Road, Mulhuddart<br>Dublin 15, D15 H6EF<br>Ireland<\/p>\n","protected":false},"excerpt":{"rendered":"<p>NULOJIX contains the active substance belatacept, which belongs to a group of medicines called immunosuppressants. It is a drug that reduces the activity of the immune system, the body&#8217;s natural defenses.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,15581],"tags":[19324,19327,19328,19333,19329,19332,19326,19325,19330,19331],"class_list":["post-19297","post","type-post","status-publish","format-standard","hentry","category-medicines","category-n","tag-belatacept","tag-belatacept-side-effects","tag-benefits-of-belatacept","tag-benefits-of-nulojix","tag-nulojix","tag-nulojix-side-effects","tag-what-belatacept-is-used-for","tag-what-is-belatacept","tag-what-is-nulojix","tag-what-nulojix-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/19297","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=19297"}],"version-history":[{"count":3,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/19297\/revisions"}],"predecessor-version":[{"id":19338,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/19297\/revisions\/19338"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=19297"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=19297"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=19297"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}