{"id":19287,"date":"2022-03-07T16:34:44","date_gmt":"2022-03-07T16:34:44","guid":{"rendered":"https:\/\/zeepedia.com\/?p=19287"},"modified":"2022-03-08T11:46:53","modified_gmt":"2022-03-08T11:46:53","slug":"novoseven","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/novoseven\/","title":{"rendered":"NovoSeven &#8211; Eptacog alfa uses, dose and side effects"},"content":{"rendered":"\n<p>1 mg (50 KIU), 2 mg (100 KIU), 5 mg (250 KIU), 8 mg (400 KIU) &#8211;&nbsp;powder and solvent for solution for&nbsp;injection&nbsp;eptacog<br>alfa (activated)&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What NovoSeven\u00ae is and what it is used for<\/h2>\n\n\n\n<p>NovoSeven is a blood clotting factor.\u00a0It works by causing the blood to coagulate at the bleeding site when the body&#8217;s coagulation factor\u00a0is not working.<\/p>\n\n\n\n<p>NovoSeven is used to treat bleeding and to prevent heavy bleeding after surgery or other important treatments.&nbsp;Early treatment with NovoSeven reduces how much you bleed and for how long.&nbsp;It works for all types of bleeding, even for bleeding in joints.&nbsp;This reduces the need for hospital care and the number of days off from work and school.<\/p>\n\n\n\n<p>It is used for certain groups:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you have&nbsp;<em>congenital&nbsp;haemophilia<\/em>&nbsp;and do not normally respond to&nbsp;factor VIII&nbsp;or IX treatment<\/li><li>If you have&nbsp;<em>acquired&nbsp;hemophilia<\/em><\/li><li>If you are&nbsp;<em>deficient in factor VII<\/em><\/li><li>If you have&nbsp;<em>Glanzmann&#8217;s thrombasthenia&nbsp;<\/em>(bleeding disorder) and your condition cannot be effectively treated with&nbsp;platelet&nbsp;transfusion&nbsp;,&nbsp;or&nbsp;platelets&nbsp;are not available.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using NovoSeven\u00ae<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use NovoSeven<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to eptacog alfa (the active substance of NovoSeven) or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you are allergic to&nbsp;protein&nbsp;from mice, hamsters or cattle (such as cow&#8217;s milk).<\/li><\/ul>\n\n\n\n<p><em>If any of these apply to you, do not use NovoSeven.&nbsp;Talk to a doctor.<\/em><\/p>\n\n\n\n<p><strong>Warnings and cautions<\/strong><\/p>\n\n\n\n<p>Before treatment with NovoSeven, make sure your doctor knows:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have recently had surgery<\/li><li>if you have recently suffered a crush or crush injury<\/li><li>if you have narrowing of the&nbsp;arteries&nbsp;due to illness (atherosclerosis)<\/li><li>if you have an increased risk of blood clots (&nbsp;thrombosis&nbsp;)<\/li><li>if you have severe liver disease<\/li><li>if you have blood poisoning<\/li><li>if you have an increased risk of&nbsp;<em>disseminated intravascular&nbsp;coagulation<\/em>&nbsp;(&nbsp;DIC&nbsp;, a condition in which blood clots form throughout the bloodstream), you should be closely monitored.<\/li><\/ul>\n\n\n\n<p><em>If any of these conditions apply to you, talk to your doctor before using the\u00a0injection.<\/em><\/p>\n\n\n\n<p><strong>Other medicines and NovoSeven<\/strong><\/p>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>Do not use NovoSeven at the same time as&nbsp;<em>prothrombin complex<\/em>&nbsp;concentrate or rFXIII.&nbsp;You should talk to your doctor before using NovoSeven if you are also taking&nbsp;factor VIII&nbsp;or IX drugs.<\/p>\n\n\n\n<p>There is limited experience with the use of NovoSeven in combination with&nbsp;<em>antifibrinolytics<\/em>&nbsp;(such as aminocaproic acid or&nbsp;tranexamic acid&nbsp;) which are also used to control bleeding.&nbsp;You should talk to your doctor before using NovoSeven with these medicines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before using NovoSeven.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>There are no studies on the effect of NovoSeven on the ability to drive and use machines.\u00a0However, there is no medical basis to believe that it would affect the ability.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">NovoSeven contains sodium<\/h2>\n\n\n\n<p>This medicine contains less than 1 mmol\u00a0sodium\u00a0(23 mg) per\u00a0injection, ie essentially &#8216;sodium-free&#8217;.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use NovoSeven\u00ae<\/h2>\n\n\n\n<p>The powder for NovoSeven should be dissolved in the diluent and injected into a vein.&nbsp;See the page below for detailed instructions.<\/p>\n\n\n\n<p><strong>When to treat yourself<\/strong><\/p>\n\n\n\n<p>Start treatment for bleeding as early as possible, preferably within 2 hours.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>In case of mild or moderate bleeding, you should treat yourself as early as possible, preferably at home.<\/li><li>In case of severe bleeding, consult a doctor.&nbsp;Severe bleeding is usually treated in a hospital and you can give yourself the first&nbsp;dose&nbsp;of NovoSeven on the way there.<\/li><\/ul>\n\n\n\n<p>Do not treat yourself for more than 24 hours without consulting your doctor.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Every time you use NovoSeven, tell your doctor or hospital as soon as possible.<\/li><li>If the bleeding is not under control within 24 hours, contact a doctor immediately.&nbsp;Then you usually need hospital care.<\/li><\/ul>\n\n\n\n<p><strong>Dose<\/strong><\/p>\n\n\n\n<p>The first&nbsp;dose&nbsp;should be given as early as possible after the bleeding has started.&nbsp;Talk to your doctor about when to use the&nbsp;injections&nbsp;and how long to use them.<\/p>\n\n\n\n<p>Dose\u00a0one is calculated by your doctor based on your body weight, condition, and blood type.\u00a0For best results, follow the prescribed\u00a0dose\u00a0carefully.\u00a0Your doctor may change the\u00a0dose\u00a0one.<\/p>\n\n\n\n<p><em>If you have hemophilia:<\/em><\/p>\n\n\n\n<p>The usual&nbsp;dose&nbsp;is 90 micrograms for every kilogram you weigh.&nbsp;You can repeat&nbsp;injection&nbsp;one at 2-3 hour intervals until the bleeding is under control.<\/p>\n\n\n\n<p>Your doctor may recommend a single-dose&nbsp;injection&nbsp;of 270 micrograms for every kilogram you weigh.&nbsp;There is no clinical experience in the treatment of patients over 65 years of age with this single dose.<\/p>\n\n\n\n<p><em>If you have a factor VII deficiency:<\/em><\/p>\n\n\n\n<p>The usual dose range, for each\u00a0injection, is 15 to 30 micrograms for each kilogram you weigh.<\/p>\n\n\n\n<p><em>If you have Glanzmann&#8217;s thrombasthenia:<\/em><\/p>\n\n\n\n<p>The usual&nbsp;dose&nbsp;for each&nbsp;injection&nbsp;is 90 micrograms (80 to 120 micrograms) for each kilogram you weigh.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you take more NovoSeven than you should<\/h2>\n\n\n\n<p>If you inject too much NovoSeven, contact your healthcare provider immediately for advice.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take NovoSeven<\/h2>\n\n\n\n<p>If you forget to take an&nbsp;injection&nbsp;or if you want to stop treatment, consult a doctor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Serious&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>Rare&nbsp;<em>(may affect up to 1 in 1,000&nbsp;<\/em><em>people&nbsp;<\/em><em>)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Allergic, hypersensitive or anaphylactic reactions.&nbsp;Symptoms may include rash,&nbsp;itching&nbsp;,&nbsp;redness&nbsp;and hives;&nbsp;wheezing or difficulty breathing;&nbsp;feeling faint or dizzy as well as severe swelling of the lips or throat or at the injection site.<\/li><li>Blood clots in the&nbsp;artery&nbsp;in the heart (which can lead to heart attack or angina), in the brain (which can lead to&nbsp;stroke&nbsp;) or in the intestines or kidneys.&nbsp;Symptoms may include severe chest pain, shortness of breath, confusion, difficulty speaking or moving (paralysis) or abdominal pain.<\/li><\/ul>\n\n\n\n<p>Uncommon&nbsp;<em>(may affect up to 1 in 100&nbsp;<\/em><em>people&nbsp;<\/em><em>)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Blood clots in the veins of the lungs, bones, liver, kidneys or at the injection site.&nbsp;Symptoms may include difficulty breathing, red and painful swelling in the legs and abdominal pain.<\/li><li>Lack of effect or reduced response to treatment.<\/li><\/ul>\n\n\n\n<p><em>If you notice any of these serious\u00a0side effects, contact your healthcare provider immediately.\u00a0Explain that you have used NovoSeven.<\/em><\/p>\n\n\n\n<p>Remind your doctor if you have previously had allergic reactions as you may need to be monitored more closely.&nbsp;In most cases of blood clots, patients had an increased risk of blood clots.<\/p>\n\n\n\n<p><strong>Other rare&nbsp;side effects&nbsp;ar<\/strong><\/p>\n\n\n\n<p><em>(may occur in up to 1 in 1000&nbsp;<\/em><em>treatments&nbsp;<\/em><em>)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Nausea<\/li><li>Headache<\/li><li>Changes in some liver and blood tests.<\/li><\/ul>\n\n\n\n<p><strong>Other less common&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p><em>(may occur in up to 1 in 100&nbsp;<\/em><em>treatment cases)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Allergic skin reactions that include rash,&nbsp;itching&nbsp;and&nbsp;hives<\/li><li>Fever.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store NovoSeven\u00ae<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Keep this medicine out of the sight and reach of children.<\/li><li>Use this medicine before the expiry date which is stated on the carton.&nbsp;The expiration date is the last day of the specified month.<\/li><li>Store powder and&nbsp;diluent&nbsp;at a maximum of 25 \u00b0 C.<\/li><li>Store powder and&nbsp;diluent&nbsp;in light protection.<\/li><li>Do not freeze.<\/li><li>Use NovoSeven immediately after mixing the powder with the diluent to avoid&nbsp;infection&nbsp;.&nbsp;If you can not use the solution immediately after reconstitution, store it in the vial, with the adapter and syringe still in place, in a refrigerator at 2 \u00b0 C-8 \u00b0 C for a maximum of 24 hours.&nbsp;Do not freeze the NovoSeven solution and protect it from light.&nbsp;Do not&nbsp;store injection solution&nbsp;without consulting a doctor or nurse.<\/li><li>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the package and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is&nbsp;recombinant&nbsp;coagulation factor&nbsp;VIIa (activated eptacog alfa).<\/li><li>The other ingredients in the powder are sodium chloride, calcium chloride dihydrate, glycylglycine, polysorbate 80, mannitol, sucrose, methionine,&nbsp;hydrochloric acid&nbsp;, sodium hydroxide.&nbsp;The diluent contains histidine,&nbsp;hydrochloric acid&nbsp;, sodium hydroxide, water for injections.<\/li><\/ul>\n\n\n\n<p>Powder for solution for&nbsp;injection&nbsp;contains:<br>1 mg \/ vial (equivalent to 50 KIU \/ vial), 2 mg \/ vial (equivalent to 100 KIU \/ vial), 5 mg \/ vial (equivalent to 250 KIU \/ vial) or 8 mg \/ vial (equivalent to 400 KIU \/ vial).<\/p>\n\n\n\n<p>After&nbsp;reconstitution&nbsp;, 1 ml solution contains 1 mg eptacog alfa (activated).<\/p>\n\n\n\n<p>1 KIU corresponds to 1,000 IU (international units).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<p>The vial contains a white powder and the pre-filled syringe a clear, colorless solution.&nbsp;The reconstituted solution is colorless.&nbsp;Do not use the reconstituted solution if you see particles in it or if it is discolored.<\/p>\n\n\n\n<p>Each NovoSeven package contains:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>1&nbsp;vial&nbsp;of white powder for&nbsp;solution for&nbsp;injection<\/li><li>1 vial&nbsp;adapter<\/li><li>1 pre-&nbsp;filled&nbsp;syringe&nbsp;with&nbsp;diluent&nbsp;for&nbsp;reconstitution<\/li><li>1 piston rod<\/li><\/ul>\n\n\n\n<p>Pack sizes: 1 mg (50 KIU), 2 mg (100 KIU), 5 mg (250 KIU) and 8 mg (400 KIU).<\/p>\n\n\n\n<p>The current package size is stated on the outer packaging.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p>Novo Nordisk A \/ S<\/p>\n\n\n\n<p>Novo All\u00e9<\/p>\n\n\n\n<p>DK-2880 Bagsv\u00e6rd, Denmark<\/p>\n","protected":false},"excerpt":{"rendered":"<p>NovoSeven is a blood clotting factor. It works by causing the blood to coagulate at the bleeding site, when the body&#8217;s own coagulation factor is not working.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,15581],"tags":[19380,19385,19376,19379,19381,19384,19378,19377,19382,19383],"class_list":["post-19287","post","type-post","status-publish","format-standard","hentry","category-medicines","category-n","tag-benefits-of-eptacog-alfa","tag-benefits-of-novoseven","tag-eptacog-alfa","tag-eptacog-alfa-side-effects","tag-novoseven","tag-novoseven-side-effects","tag-what-eptacog-alfa-is-used-for","tag-what-is-eptacog-alfa","tag-what-is-novoseven","tag-what-novoseven-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/19287","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=19287"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/19287\/revisions"}],"predecessor-version":[{"id":19343,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/19287\/revisions\/19343"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=19287"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=19287"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=19287"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}