- if you are allergic to insulin aspart or any of the other ingredients of this medicine (listed in section 6, Contents of the pack and other information).<\/li>
- If you feel you are experiencing insulin sensation (symptoms of low blood sugar), see a) Summary of serious and very common side effects in section 4.<\/li>
- in insulin pumps.<\/li>
- if cartridge one or the injection device containing cartridge one has been dropped, damaged or shocked.<\/li>
- if the insulin has not been stored properly or if it has been frozen, see section 5, How to store NovoMix 30.<\/li>
- if the reconstituted insulin is not evenly white, cloudy and watery.<\/li>
- if, after mixing, there are lumps or if solid, white particles adhere to the bottom or wall of the cartridge .<\/li><\/ul>\n\n\n\n
If any of these apply to you, do not use NovoMix 30. Talk to your doctor, nurse, or pharmacist.<\/p>\n\n\n\n
Before using NovoMix 30<\/strong><\/p>\n\n\n\n
- Check on the label that it is the right kind of insulin .<\/li>
- Always check the cartridge one, including the rubber plunger on the bottom of the cartridge one. Do not use it if it has any visible damage or if the rubber plunger has been pulled above the white line on the label at the bottom of the cartridge . This may be due to insulin leakage. If you suspect that the cartridge is damaged, return it to the pharmacist. See the operating instructions for the pen.<\/li>
- Always use a new needle for each injection to prevent contamination.<\/li>
- Injection needles and NovoMix 30 Penfill must not be shared with anyone else.<\/li>
- NovoMix 30 Penfill should only be injected under the skin with a reusable pen. Talk to your doctor if you need to inject your insulin using another method.<\/li><\/ul>\n\n\n\n
Warnings and cautions<\/h2>\n\n\n\n
Certain conditions and activities may affect your need for\u00a0insulin.\u00a0Consult a doctor:<\/p>\n\n\n\n
- If you have problems with your kidneys, liver, adrenal glands, pituitary gland or thyroid gland.<\/li>
- If you exercise more than usual or want to change your diet, as this can affect your blood sugar level.<\/li>
- If you become ill, continue to take your insulin and consult your doctor.<\/li>
- If you are traveling abroad, travel over different time zones can affect your need for insulin and when to take it.<\/li><\/ul>\n\n\n\n
Skin changes at the injection site<\/strong><\/p>\n\n\n\n
To help prevent changes in the adipose tissue under the skin, e.g.\u00a0skin thickening, skin shrinkage, or lumps under the skin, you should always change the injection site.\u00a0Insulin\u00a0may\u00a0not work as well if you inject in an area with nodules or in a thickened or shrunken area (see “How to use NovoMix 30”).\u00a0Contact your doctor if you notice skin changes at the injection site and before changing the injection site if you are currently injecting in an affected area.\u00a0Your doctor may advise you to check your blood sugar more often and to adjust your insulin dose or the\u00a0dose\u00a0of other diabetes medicines.<\/p>\n\n\n\n
Children and young people<\/h2>\n\n\n\n
- NovoMix 30 can be used for adolescents and children 10 years and older.<\/li>
- There is limited experience with NovoMix 30 in children aged 6\u20139 years.<\/li>
- No data are available for NovoMix 30 in children under 6 years of age.<\/li><\/ul>\n\n\n\n
Other medicines and NovoMix 30<\/h2>\n\n\n\n
Tell your doctor, nurse, or pharmacist if you are taking, have recently taken, or might take any other medicines.\u00a0Some medicines affect your blood sugar level and this may mean that your insulin dose needs to be changed.\u00a0Below is a list of the most common medicines that may affect your insulin treatment.<\/p>\n\n\n\n
Your blood sugar level may drop (hypoglycemia) if you take:<\/strong><\/p>\n\n\n\n
- Other medicines to treat diabetes<\/li>
- MAO inhibitors (for the treatment of depression)<\/li>
- Beta-blockers (for the treatment of high blood pressure )<\/li>
- ACE inhibitors (for the treatment of certain heart diseases or high blood pressure )<\/li>
- Salicylates (analgesics and antipyretics)<\/li>
- Anabolic steroids (eg testosterone )<\/li>
- Sulfonamides (for the treatment of infections ).<\/li><\/ul>\n\n\n\n
Your blood sugar level may rise (hyperglycemia) if you take:<\/strong><\/p>\n\n\n\n
- Oral contraceptives ( birth control pills )<\/li>
- Thiazides (for the treatment of high blood pressure or severe fluid retention)<\/li>
- Glucocorticoids (eg cortisone for the treatment of inflammation )<\/li>
- Thyroid hormones (for the treatment of thyroid diseases)<\/li>
- Sympathomimetics (eg adrenaline , salbutamol or terbutaline for the treatment of asthma )<\/li>
- Growth hormone (for stimulation of skeletal and body growth with a pronounced effect on the body’s metabolism)<\/li>
- Danazol (an agent that affects ovulation).<\/li><\/ul>\n\n\n\n
Octreotide and lanreotide (for the treatment of\u00a0acromegaly, an unusual hormonal disorder with\u00a0pituitary\u00a0overproduction one of\u00a0the growth hormone\u00a0usually in middle-aged adults) can either raise or lower your blood sugar level.<\/p>\n\n\n\n
Beta-blockers\u00a0(for the treatment of high\u00a0blood pressure\u00a0) may weaken or eliminate the first warning signs of low blood sugar.<\/p>\n\n\n\n
Pioglitazone (tablets for the treatment of type 2 diabetes )<\/em><\/p>\n\n\n\n
Some patients who have had type 2\u00a0diabetes\u00a0and heart disease for many years or previous\u00a0strokes\u00a0developed\u00a0heart failure\u00a0during treatment with pioglitazone and\u00a0insulin.\u00a0Tell your doctor as soon as possible if you get signs of\u00a0heart failure\u00a0such as unexpected shortness of breath, rapid weight gain, or local swelling (\u00a0edema\u00a0).<\/p>\n\n\n\n
If you have taken any of these medicines, talk to your doctor, nurse, or pharmacist.<\/p>\n\n\n\n
NovoMix 30 and alcohol<\/h2>\n\n\n\n
If you drink alcohol, your need for insulin may change as your blood sugar level may either rise or fall. Careful blood glucose monitoring is recommended.<\/p>\n\n\n\n
Pregnancy and breastfeeding<\/h2>\n\n\n\n
- If you are pregnant, think you may be pregnant or are planning to have a baby, ask your doctor for advice before taking this medicine. Experience with insulin aspart during pregnancy is limited. The insulin dose may need to be changed during pregnancy and after delivery. Careful monitoring of your diabetes and especially counteracting low blood sugar is important for your baby’s health.<\/li>
- There are no restrictions on treatment with NovoMix 30 during breast-feeding.<\/li><\/ul>\n\n\n\n
Ask your doctor, nurse, or pharmacist for advice before taking any medicine during pregnancy or breastfeeding.<\/p>\n\n\n\n
Driving and using machines<\/h2>\n\n\n\n
Ask your doctor if you can drive or use machines:<\/p>\n\n\n\n
- if you often get low blood sugar levels<\/li>
- if you find it difficult to recognize signs of low blood sugar (insulin detection).<\/li><\/ul>\n\n\n\n
If your blood sugar is low or high, it can affect your ability to concentrate and react and therefore also your ability to drive or use machines. Remember that you can put yourself and others at risk.<\/p>\n\n\n\n
Important information about some of the ingredients of NovoMix 30<\/h2>\n\n\n\n
NovoMix 30 contains less than 1 mmol\u00a0sodium\u00a0(23 mg) per\u00a0dose, ie NovoMix 30 is essential ‘sodium-free’.<\/p>\n\n\n\n
How to use NovoMix 30<\/h2>\n\n\n\n
Dose and when you take your insulin<\/strong><\/p>\n\n\n\n
Always use your\u00a0insulin\u00a0and adjust your\u00a0dose\u00a0exactly as your doctor advised.\u00a0If you are not sure, talk to your doctor, nurse, or pharmacist.<\/p>\n\n\n\n
NovoMix 30 is normally used immediately before a meal. Eat a meal or snack within 10 minutes of injecting one to avoid low blood sugar. When necessary, NovoMix 30 can also be injected shortly after a meal. See How and where to inject below for information.<\/p>\n\n\n\n
Only change your insulin as advised by your doctor.\u00a0If your doctor has switched you from one type of insulin or brand to another, your doctor may need to adjust your\u00a0dose.<\/p>\n\n\n\n
Your doctor may need to adjust your\u00a0dose\u00a0when NovoMix 30 is used in combination with tablets for\u00a0diabetes\u00a0and\/or diabetes medicines for\u00a0injection.<\/p>\n\n\n\n
Use for children and adolescents<\/h2>\n\n\n\n
NovoMix 30 can be used on adolescents and children aged 10 years or older when a mixture of insulin is preferred. There are limited clinical data in children aged 6\u20139 years. No data are available for NovoMix 30 in children under 6 years of age.<\/p>\n\n\n\n
Use for special patient groups<\/strong><\/p>\n\n\n\n
If you have impaired kidney or liver function or if you are over 65, you need to check your blood sugar more regularly and discuss changes in your insulin dose with your doctor.<\/p>\n\n\n\n
How and where to inject<\/strong><\/p>\n\n\n\n
NovoMix 30 is\u00a0for\u00a0subcutaneous\u00a0injection.\u00a0You should never inject\u00a0insulin\u00a0directly into a blood vessel (\u00a0intravenously\u00a0) or a muscle (\u00a0intramuscularly\u00a0).\u00a0NovoMix 30\u00a0Penfill\u00a0should only be injected under the skin with a reusable pen.\u00a0Talk to your doctor if you need to inject your\u00a0insulin\u00a0using another method.<\/p>\n\n\n\n
At each\u00a0injection, change the injection site within the same specific skin area.\u00a0This may reduce the risk of developing lumps or pits in the skin (see section 4, Possible\u00a0side effects\u00a0).\u00a0The best area to\u00a0inject\u00a0one is the front of the waist (abdomen);\u00a0the buttocks;\u00a0the front of the thighs or upper arm.\u00a0Insulin\u00a0works faster if you inject it around the waist.\u00a0Always check your blood sugar regularly.<\/p>\n\n\n\n
- Do not refill cartridge one .<\/li>
- NovoMix 30 Penfill cartridges are designed to be used with insulin injection devices from Novo Nordisk and NovoFine or NovoTwist injection needles.<\/li>
- If you are taking NovoMix 30 Penfill and another insulin in a Penfill cartridge , use two different injection aids, one for each type of insulin.<\/li>
- Always carry an extra Penfill cartridge with you in case of loss or damage.<\/li><\/ul>\n\n\n\n
Mixing NovoMix 30<\/strong><\/p>\n\n\n\n
Always check that there is enough\u00a0insulin\u00a0left (at least 12 units) in\u00a0cartridge\u00a0one.\u00a0This gives an even\u00a0mixture.\u00a0If there is not enough\u00a0insulin\u00a0left, use a new\u00a0cartridge.\u00a0See also the instructions for use for the pen.<\/p>\n\n\n\n
Each time you use a new NovoMix 30 <\/strong>Penfill (<\/strong> before inserting a cartridge into the injection aid).<\/p>\n\n\n\n
- Allow insulin to reach room temperature before using. This makes it easier to remix.<\/li>
- Roll the cartridge one between the palms 10 times – it is important that the cartridge is held horizontally (horizontally) (see picture A<\/strong> ).<\/li>
- Then turn the cartridge one upside down between positions a and b (see picture B<\/strong> ) 10 times so that the glass ball moves from one end of the cartridge one to the other.<\/li>
- Repeat this rolling and turning procedure (see pictures A<\/strong> and B<\/strong> ) until the injection liquid is evenly white, cloudy and watery. Do not use cartridge if the reconstituted insulin is not evenly white, cloudy and watery.<\/li>
- Complete other injection steps without delay.<\/li><\/ul>\n\n\n\n
Before each subsequent injection<\/strong><\/p>\n\n\n\n
- Turn the injection device with a cartridge one up and down between positions a and b (see picture B<\/strong> ) at least 10 times with a cartridge one i, until the solution for injection is evenly white, cloudy and watery. Do not use cartridge if the reconstituted insulin is not evenly white, cloudy and watery.<\/li>
- Complete other injection steps without delay.<\/li><\/ul>\n\n\n\n
<\/a><\/figure>\n\n\n\n
<\/a><\/figure>\n\n\n\n
How to inject NovoMix 30<\/strong><\/p>\n\n\n\n
- Inject insulin under your skin. Use the injection technique shown to you by your doctor or nurse and described in the instructions for use of the pen.<\/li>
- Hold the injection needle under the skin for at least 6 seconds. Hold down the push-button completely until the injection needle has been pulled out of the skin. This ensures proper administration and limits the possibility of blood entering the injection needle or insulin container.<\/li>
- After each injection , it is important to remove and discard the injection needle and store NovoMix 30 without the needle attached. Liquid may otherwise leak and cause incorrect dosing .<\/li><\/ul>\n\n\n\n
If you take more insulin than you should<\/h2>\n\n\n\n
If you take too much\u00a0insulin, your blood sugar may become too low (hypoglycemia).\u00a0See a) Summary of serious and very common\u00a0side effects\u00a0in section 4.<\/p>\n\n\n\n
If you forget to take your insulin<\/h2>\n\n\n\n
If you forget to take your\u00a0insulin, your blood sugar may become too high (hyperglycemia).\u00a0See c)\u00a0Diabetes Disorders\u00a0in Section 4.<\/p>\n\n\n\n
If you stop taking your insulin<\/h2>\n\n\n\n
Do not stop taking insulin without talking to your doctor, who will tell you what to do.\u00a0This can lead to very high blood sugar (severe\u00a0hyperglycemia) and\u00a0ketoacidosis.\u00a0See c)\u00a0Diabetes Disorders\u00a0in Section 4.<\/p>\n\n\n\n
If you have any further questions on the use of this product, ask your doctor, nurse, or pharmacist.<\/p>\n\n\n\n
How to store NovoMix 30<\/h2>\n\n\n\n
Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n
Do not use this medicine before the expiry date which is stated on the label and carton of the cartridges after “EXP”. The expiration date is the last day of the specified month.<\/p>\n\n\n\n
To protect insulin from light, always keep the cartridge in the outer carton when not in use. NovoMix 30 must be protected from strong heat and light.<\/p>\n\n\n\n
Unopened packaging:<\/strong> NovoMix 30 Penfill that is not being used should be stored in a refrigerator at 2 \u00b0 C-8 \u00b0 C, not near the cooling element. Do not freeze.<\/p>\n\n\n\n
Before using the NovoMix 30\u00a0Penfill, remove it from the refrigerator.\u00a0You should mix the\u00a0insulin\u00a0according to the instructions each time you use a new NovoMix 30\u00a0Penfill.\u00a0See section 3, How to use NovoMix 30.<\/p>\n\n\n\n
During use or as a spare:<\/strong> NovoMix 30 Penfill that is currently being used or taken as a spare should not be stored in the refrigerator. You can take it with you and store it at room temperature (maximum 30 \u00b0 C) for up to 4 weeks.<\/p>\n\n\n\n
Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.<\/p>\n\n\n\n
Contents of the pack and other information<\/h2>\n\n\n\n
Content declaration<\/h2>\n\n\n\n
- The active substance is insulin aspart. NovoMix 30 is a mixture containing 30% soluble insulin aspart and 70% insulin aspart crystallized with protamine. 1 ml contains 100 units of insulin aspart. Each cartridge contains 300 units of insulin aspart in 3 ml suspension for injection .<\/li>
- The other ingredients are glycerol , phenol, metacresol, zinc chloride, disodium phosphate dihydrate, sodium chloride, protamine sulphate, hydrochloric acid , sodium hydroxide and water for injections.<\/li><\/ul>\n\n\n\n
What the medicine looks like and contents of the pack<\/h2>\n\n\n\n
NovoMix 30 is in the form of a\u00a0suspension\u00a0for\u00a0injection.\u00a0The cartridge\u00a0contains a glass ball to facilitate mixing.\u00a0After mixing, the liquid should be evenly white, cloudy, and watery.\u00a0Do not use\u00a0insulin\u00a0unless it is uniformly white, cloudy, and watery after mixing.<\/p>\n\n\n\n
Pack sizes: 5 and 10 cartridges of 3 ml. Not all pack sizes may be marketed.<\/p>\n\n\n\n
The suspension is cloudy, white, and watery.<\/p>\n\n\n\n
Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n
Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n
Novo Nordisk A \/ S<\/p>\n\n\n\n
Novo All\u00e9<\/p>\n\n\n\n
DK-2880 Bagsv\u00e6rd, Denmark<\/p>\n\n\n\n
Manufacturer<\/strong><\/p>\n\n\n\n
The manufacturer can be identified by the batch number printed on the tab on the carton and the label:<\/p>\n\n\n\n
- If the second and third characters are S6, P5, K7, R7, VG, FG or ZF, the manufacturer is Novo Nordisk A \/ S, Novo All\u00e9, DK-2880 Bagsv\u00e6rd, Denmark<\/li>
- If the second and third characters are H7 or T6, the manufacturer is Novo Nordisk Production SAS, 45 Avenue d’Orl\u00e9ans, F-28000 Chartres, France.<\/li><\/ul>\n","protected":false},"excerpt":{"rendered":"
NovoMix 30 is a modern insulin (insulin analogue) with both fast-acting and medium-acting effects in the ratio 30\/70. Modern insulin preparations are improved versions of human insulin .<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,15581],"tags":[19241,19236,19242,19240,19239,19243,19237,19238],"class_list":["post-19234","post","type-post","status-publish","format-standard","hentry","category-medicines","category-n","tag-benefits-of-novomix-30-penfill","tag-novomix-30-penfill","tag-novomix-30-penfill-dosage","tag-novomix-30-penfill-insulin","tag-novomix-30-penfill-side-effects","tag-novomix-30-penfill-usage","tag-what-is-novomix-30-penfill","tag-what-novomix-30-penfill-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/19234","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=19234"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/19234\/revisions"}],"predecessor-version":[{"id":19276,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/19234\/revisions\/19276"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=19234"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=19234"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=19234"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
- Complete other injection steps without delay.<\/li><\/ul>\n\n\n\n
- Then turn the cartridge one upside down between positions a and b (see picture B<\/strong> ) 10 times so that the glass ball moves from one end of the cartridge one to the other.<\/li>