{"id":19230,"date":"2022-03-04T16:20:41","date_gmt":"2022-03-04T16:20:41","guid":{"rendered":"https:\/\/zeepedia.com\/?p=19230"},"modified":"2022-11-18T10:33:44","modified_gmt":"2022-11-18T10:33:44","slug":"novofem","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/novofem\/","title":{"rendered":"Novofem Uses, Dose, And Side Effects"},"content":{"rendered":"\n<p><strong>Novofem Film-coated Tablets<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Novofem Is And What Is Novofem Used For<\/h2>\n\n\n\n<p>What is Novofem used for?<\/p>\n\n\n\n<p>This is a sequential combination drug used for\u00a0<a href=\"https:\/\/amzn.to\/3gnsHrP\" rel=\"noopener\">Hormone\u00a0Replacement\u00a0Therapy<\/a>\u00a0(\u00a0HRT\u00a0)\u00a0and is taken daily without interruption.\u00a0<\/p>\n\n\n\n<p>Novofem is used for women whose menstruation has stopped (&nbsp;menopause&nbsp;), at least 6 months after their last natural menstrual period.<\/p>\n\n\n\n<p>It contains two&nbsp;hormones<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li> An&nbsp;estrogen&nbsp;(estradiol).<\/li><li> A&nbsp;progestogen&nbsp;(norethisterone acetate).&nbsp;<\/li><\/ul>\n\n\n\n<p>Estradiol in Novofem is identical to the estradiol produced in a woman&#8217;s ovaries and is considered a natural&nbsp;estrogen.&nbsp;<\/p>\n\n\n\n<p>Norethisterone acetate is a synthetic&nbsp;progestogen, which acts similarly to the corpus luteum hormone (&nbsp;progesterone&nbsp;), another important female sex hormone.<\/p>\n\n\n\n<p><strong>what is novofem used for:<\/strong><\/p>\n\n\n\n<p><strong>Relieve symptoms during and after menopause<\/strong><\/p>\n\n\n\n<p>When menstruation ends (&nbsp;menopause&nbsp;), the woman&#8217;s&nbsp;estrogen&nbsp;decreases.&nbsp;It can cause problems such as sweating and hot flashes.<\/p>\n\n\n\n<p>&nbsp;Novofem relieves these symptoms after&nbsp;menopause.&nbsp;Novofem should only be used if the problems cause problems in daily life.<\/p>\n\n\n\n<p><strong>Prevent osteoporosis<\/strong><\/p>\n\n\n\n<p>After&nbsp;menopause, some women suffer from osteoporosis.&nbsp;Discuss all possible options with your doctor.<\/p>\n\n\n\n<p>If you have an increased risk of&nbsp;fractures&nbsp;(bone fractures) and other medicines that are not suitable for you, you can use Novofem to prevent osteoporosis after&nbsp;menopause.<\/p>\n\n\n\n<p>Experience in the treatment of women older than 65 years is limited.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What You Need To Know Before You Take Novofem<\/h2>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-medium\"><img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"300\" src=\"https:\/\/zeepedia.com\/wp-content\/uploads\/2022\/10\/Novofem-300x300.jpg\" alt=\"novofem hrt\" class=\"wp-image-28317\" srcset=\"https:\/\/zeepedia.com\/medical\/wp-content\/uploads\/2022\/10\/Novofem-300x300.jpg 300w, https:\/\/zeepedia.com\/medical\/wp-content\/uploads\/2022\/10\/Novofem-150x150.jpg 150w, https:\/\/zeepedia.com\/medical\/wp-content\/uploads\/2022\/10\/Novofem.jpg 480w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><figcaption>Novofem HRT<\/figcaption><\/figure><\/div>\n\n\n<h2 class=\"wp-block-heading\">Medical Background And Regular Check-ups<\/h2>\n\n\n\n<p>The use of&nbsp;HRT&nbsp;involves risks that must be taken into account when deciding to start treatment or continue an ongoing treatment.<\/p>\n\n\n\n<p>Experience is limited for the treatment of women whose menstruation has stopped prematurely (when the ovaries have stopped working or the uterus has been removed).&nbsp;If you belong to that group, the risks of&nbsp;HRT&nbsp;may be different.&nbsp;Talk to your doctor.<\/p>\n\n\n\n<p>Before starting treatment (or resuming treatment), your doctor will ask about your own and your family&#8217;s medical background.&nbsp;Your doctor may do a general medical and gynecological examination, which also includes the examination of your breasts.<\/p>\n\n\n\n<p>Once you have started treatment with Novofem, you should go for regular medical check-ups, at least once a year.&nbsp;During these check-ups, you should discuss with your doctor the <strong>Novofem benefits <\/strong>and risks of continued treatment.<\/p>\n\n\n\n<p>Perform regular examinations of the breasts according to the doctor&#8217;s recommendations.<\/p>\n\n\n\n<p><strong>Do not take Novofem<\/strong><\/p>\n\n\n\n<p>If any of the following apply to you.&nbsp;<strong>If you are not sure, talk to your doctor<\/strong>&nbsp;before taking Novofem.<\/p>\n\n\n\n<p>Do not take:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you have or have had&nbsp;<strong>breast cancer<\/strong>&nbsp;or there is a suspicion that you may have it.<\/li><li>If you have or have had&nbsp;<strong>estrogen-dependent cancer,<\/strong>&nbsp;such as cancer of the uterine lining (endometrium), or if there is a suspicion of such cancer.<\/li><li>If you have&nbsp;unexpected genital bleeding&nbsp;that has not been investigated by a doctor.<\/li><li>If you have&nbsp;severe thickening of the uterine lining&nbsp;(&nbsp;endometrial hyperplasia&nbsp;) and are not treated for it.<\/li><li>If you have or have had a&nbsp;blood clot in a vein&nbsp;(venous&nbsp;thromboembolism&nbsp;) in your legs (deep&nbsp;vein thrombosis&nbsp;) or in your lungs (&nbsp;pulmonary embolism&nbsp;).<\/li><li>If you have a&nbsp;coagulation disorder,&nbsp;a condition with an increased risk of blood clots (lack of&nbsp;protein&nbsp;C,&nbsp;protein&nbsp;S, or antithrombin).<\/li><li>If you have or have had a disease caused by blood clots in the&nbsp;arteries, such as a&nbsp;heart attack,&nbsp;stroke,&nbsp;or&nbsp;angina.<\/li><li>If you have or have had any&nbsp;liver disease&nbsp;and still have abnormal liver values.<\/li><li>If you are&nbsp;allergic&nbsp;(<a href=\"https:\/\/zeepedia.com\/medical\/diseases\/peanut-allergy-and-nut-allergy\/\">hypersensitive<\/a>) to&nbsp;estradiol, norethisterone acetate,&nbsp;or any of the other ingredients of Novofem (listed in section 6 \u201cContents of the pack and other information\u201d).<\/li><li>If you have&nbsp;<strong>porphyria<\/strong><strong>,<\/strong>&nbsp;a&nbsp;<strong>rare<\/strong>&nbsp;inherited&nbsp;<strong>blood disorder.<\/strong><\/li><\/ul>\n\n\n\n<p>If any of the above affects you for the first time when you use Novofem, stop taking Novofem and contact your doctor immediately.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings And Cautions<\/h2>\n\n\n\n<p>Talk to your doctor if you have had any of the following problems before starting treatment.&nbsp;They may recur or worsen during treatment with Novofem.&nbsp;Should this occur, you should have more frequent check-ups with a doctor:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you have any disease affecting the lining of the uterus, as well as muscle knots (&nbsp;fibroids&nbsp;),&nbsp;endometriosis,&nbsp;or have had&nbsp;endometrial hyperplasia&nbsp;(severe thickening of the uterine lining)<\/li><li>If you have an increased risk of getting a blood clot (see below \u201cBlood clots in a vein (venous&nbsp;thromboembolism&nbsp;)\u201d)<\/li><li>If a close relative has had breast cancer or other estrogen-dependent cancer<\/li><li>High&nbsp;blood pressure<\/li><li>Liver disease eg liver adenoma (benign&nbsp;tumor&nbsp;)<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/diabetes-type-1\/\">Diabetes<\/a><\/li><li>Gallstone disease<\/li><li>If you get a&nbsp;migraine&nbsp;or severe headache<\/li><li>If you have <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/sle\/\">systemic lupus erythematosus<\/a> (&nbsp;SLE&nbsp;) &#8211; an&nbsp;autoimmune&nbsp;disease that affects many organs in the body<\/li><li><a href=\"https:\/\/zeepedia.com\/diseases\/brain-and-nerves\/epilepsy\/\">Epilepsy<\/a><\/li><li>Asthma<\/li><li>Otosclerosis (ossification of the middle ear leading to a hearing loss)<\/li><li>Hypertriglyceridemia&nbsp;(elevated blood lipids)<\/li><li>Fluid retention due to heart or kidney disease<\/li><li>Hypothyroidism&nbsp;(the thyroid gland does not produce enough thyroid hormones) and you are treated with thyroid hormone<\/li><li>Hereditary&nbsp;angioedema&nbsp;(recurrent severe swelling), or if you have had occasional swelling of the hands, face, feet, lips, eyes, tongue, throat (blockage of the respiratory tract), or digestive tract<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/lactose-intolerance\/\">Lactose intolerance<\/a>.<\/li><\/ul>\n\n\n\n<p><strong>You should contact a doctor immediately and discontinue treatment with Novofem if any of the following occur:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Some of what is mentioned in the section &#8220;Do not take Novofem&#8221;.<\/li><li>If the skin or whites of the eyes turn yellow (jaundice);&nbsp;it may be a symptom of liver disease.<\/li><li>If your&nbsp;blood pressure&nbsp;rises sharply (symptoms may include headache, fatigue, and dizziness).<\/li><li>If you are experiencing migraine-like headaches for the first time.<\/li><li>If you become pregnant.<\/li><li>If you get symptoms of a blood clot, such as:<ul><li>Painful swelling and redness of the legs<\/li><li>Sudden chest pain<\/li><li>Breathing difficulties<\/li><\/ul><\/li><\/ul>\n\n\n\n<p>For further information, see below &#8220;Blood clots in a vein (venous&nbsp;thromboembolism&nbsp;)&#8221;.<\/p>\n\n\n\n<p><strong>Does Novofem stop periods?<\/strong><\/p>\n\n\n\n<p><strong>Note:<\/strong>&nbsp;Novofem is not a contraceptive.&nbsp;If it is less than 12 months since your last period, or if you are under 50, you may still need to use contraception to avoid pregnancy.&nbsp;Consult your doctor.<\/p>\n\n\n\n<p><strong>HRT&nbsp;and cancer<\/strong><\/p>\n\n\n\n<p><strong>Severe thickening of the uterine lining (&nbsp;endometrial hyperplasia&nbsp;) and cancer of the uterine lining (endometrial cancer)<\/strong><\/p>\n\n\n\n<p>The use of&nbsp;HRT&nbsp;with&nbsp;estrogen&nbsp;alone increases the risk of severe thickening of the uterine lining and cancer of the uterine lining.<\/p>\n\n\n\n<p>The progestogen&nbsp;in Novofem protects you against this extra risk.<\/p>\n\n\n\n<p><em>Comparison<\/em><\/p>\n\n\n\n<p>For women with the uterus left who do not take&nbsp;HRT, an average of 5 out of 1,000 women aged 50-65 will be diagnosed with endometrial cancer.<\/p>\n\n\n\n<p>For women aged 50\u201365 who have the uterus left and who take&nbsp;HRT&nbsp;with&nbsp;estrogen&nbsp;alone, 10\u201360 women out of 1,000 users will be diagnosed with endometrial cancer (ie between 5\u201355 extra cases) depending on&nbsp;<strong>Novofem dosage <\/strong>one and how long it is taken.<\/p>\n\n\n\n<p><strong>Unexpected bleeding<\/strong><\/p>\n\n\n\n<p>You will have bleeding once a month (so-called dropout bleeding) when you take Novofem.&nbsp;But if you get unexpected bleeding or splashing bleeding in addition to your monthly bleeding, and these:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Lasts longer than 6 months<\/li><li>Starts after taking Novofem for 6 months<\/li><li>Continues after you stop taking Novofem<\/li><\/ul>\n\n\n\n<p><strong>you should see a doctor as soon as possible.<\/strong><\/p>\n\n\n\n<p><strong>Breast cancer<\/strong><\/p>\n\n\n\n<p>Data show that hormone replacement therapy (&nbsp;HRT&nbsp;) with a combination of&nbsp;estrogen-progestogen, or with&nbsp;estrogen&nbsp;alone, increases the risk of breast cancer.&nbsp;The increased risk depends on how long you use&nbsp;Novofem HRT.&nbsp;The increased risk is seen within 3 years.&nbsp;When treatment is stopped, the increased risk decreases over time, but it can persist for 10 years or more if you have used <strong>Novofem&nbsp;HRT<\/strong>&nbsp;for more than 5 years.<\/p>\n\n\n\n<p><em>Comparison<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>For women aged 50 to 54 who do not take&nbsp;HRT, an average of 13 to 17 out of 1,000 will be diagnosed with breast cancer over 5 years.<\/li><li>In women who are 50 years old and start taking&nbsp;HRT&nbsp;with&nbsp;estrogen&nbsp;alone for 5 years, 16-17 cases per 1,000 users (ie 0-3 extra cases) will occur.<\/li><li>In women who are 50 years old and start taking&nbsp;HRT&nbsp;with&nbsp;estrogen-progestogen&nbsp;for 5 years, there will be 21 cases per 1,000 users (ie 4-8 extra cases).<\/li><li>Among women aged 50\u201359 who do not use&nbsp;Novofem HRT, an average of 27 out of 1,000 will be diagnosed with breast cancer over 10 years.<\/li><li>In women who are 50 years old and start taking&nbsp;HRT&nbsp;with&nbsp;estrogen&nbsp;alone for 10 years, 34 cases per 1,000 users (ie 7 extra cases) will occur.<\/li><li>In women who are 50 years old and start taking&nbsp;HRT&nbsp;with&nbsp;estrogen-progestogen&nbsp;for 10 years, 48 \u200b\u200bcases per 1,000 users (ie 21 extra cases) will occur.<\/li><\/ul>\n\n\n\n<p><strong>Check your breasts regularly.&nbsp;Contact a doctor if you notice changes such as:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Indentations or pits<\/li><li>Changes in the nipple<\/li><li>Nodules you can see or feel<\/li><\/ul>\n\n\n\n<p>It is also recommended that you participate in a mammogram when you are called.&nbsp;At the mammogram, you must tell the nurse\/healthcare professional who performs the examination that you are using&nbsp;HRT, as this medicine may increase the density of the breasts.<\/p>\n\n\n\n<p>An increased density in the breasts can make it more difficult to detect lumps on mammography images.<\/p>\n\n\n\n<p><strong>Ovarian cancer (&nbsp;ovarian cancer&nbsp;)<\/strong><\/p>\n\n\n\n<p>Ovarian cancer is rare &#8211; much rare than breast cancer.&nbsp;The use of&nbsp;HRT&nbsp;with&nbsp;estrogen&nbsp;alone or combined&nbsp;estrogen&nbsp;progestogens&nbsp;has been associated with a slightly increased risk of ovarian cancer.<\/p>\n\n\n\n<p>The risk of ovarian cancer varies with age.&nbsp;The diagnosis of ovarian cancer will, for example, be made on about 2 women out of 2000 aged 50 to 54 who do not take&nbsp;HRT&nbsp;for 5 years.&nbsp;For women who have taken&nbsp;HRT&nbsp;for 5 years, there will be about 3 cases per 2000 users (ie about 1 extra case).<\/p>\n\n\n\n<p><strong>How&nbsp;HRT&nbsp;affects the heart and blood circulation<\/strong><\/p>\n\n\n\n<p><strong>Blood clots in a vein (venous&nbsp;thromboembolism&nbsp;)<\/strong><\/p>\n\n\n\n<p>The risk of&nbsp;<strong>blood clots in the veins<\/strong>&nbsp;is 1.3\u20133 times higher for women who take&nbsp;HRT&nbsp;than for those who do not, especially during the first year of treatment.<\/p>\n\n\n\n<p>Blood clots can be serious.&nbsp;If a blood clot ends up in the lungs, it can cause chest pain, shortness of breath, collapse or even lead to death.<\/p>\n\n\n\n<p>You are more likely to get a blood clot in a vein if any of the following apply to you.&nbsp;Tell your doctor if any of the following apply to you:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>You have not been able to walk or stand for a long time due to a major operation, injury or illness (see also section 3, &#8220;If you need surgery&#8221;)<\/li><li>You are severely overweight (&nbsp;BMI&nbsp;over 30 kg \/ m&nbsp;<sup>2<\/sup>&nbsp;)<\/li><li>You have a coagulation disorder that requires long-term treatment with drugs that prevent blood clots<\/li><li>If a close relative has had a blood clot in the bone, lung, or another organ<\/li><li>You have&nbsp;SLE&nbsp;(systemic lupus erythematosus)<\/li><li>You have cancer.<\/li><\/ul>\n\n\n\n<p>The symptoms of blood clots are described in the section &#8220;You should contact a doctor immediately and discontinue treatment with Novofem&#8221;.<\/p>\n\n\n\n<p><em>Comparison<\/em><\/p>\n\n\n\n<p>For women in their 50s who do not take&nbsp;HRT, an average of 4-7 out of 1,000 people are expected to have a blood clot in a vein over 5 years.<\/p>\n\n\n\n<p>For women in their 50s who have taken&nbsp;HRT&nbsp;with&nbsp;estrogen-progestogen&nbsp;for more than 5 years, 9-12 out of 1,000 users are expected to get a blood clot in a vein (ie 5 extra cases).<\/p>\n\n\n\n<p><strong>Heart disease (Heart attack)<\/strong><\/p>\n\n\n\n<p>There is no evidence that&nbsp;HRT&nbsp;prevents heart attacks.&nbsp;For women over 60 who take&nbsp;HRT&nbsp;with&nbsp;estrogen-progestogen, the risk of developing heart disease is slightly higher than for those who do not take&nbsp;HRT.<\/p>\n\n\n\n<p><strong>Stroke&nbsp;<\/strong><\/p>\n\n\n\n<p>The risk of&nbsp;stroke&nbsp;is about 1.5 times higher for those who take&nbsp;HRT&nbsp;compared to those who do not.&nbsp;The risk of&nbsp;stroke&nbsp;is age-dependent, therefore the number of cases of&nbsp;stroke&nbsp;increases due to the use of&nbsp;HRT&nbsp;with increasing age.<\/p>\n\n\n\n<p><em>Comparison<\/em><\/p>\n\n\n\n<p>For women in their 50s who do not take&nbsp;HRT, an average of 8 out of 1,000 are expected to have a&nbsp;stroke&nbsp;over 5 years.<\/p>\n\n\n\n<p>For women in their 50s who take&nbsp;HRT&nbsp;for more than 5 years, 11 out of 1,000 users are expected to have a&nbsp;stroke&nbsp;(ie 3 extra cases).<\/p>\n\n\n\n<p><strong>Other conditions<\/strong><\/p>\n\n\n\n<p>The use of&nbsp;HRT&nbsp;preparations does not prevent memory loss.&nbsp;The risk of memory loss may be slightly higher in women who start using&nbsp;HRT&nbsp;after the age of 65.&nbsp;Consult your doctor.<\/p>\n\n\n\n<p><strong>Other medicines and Novofem<\/strong><\/p>\n\n\n\n<p>Some medicines may affect the way Novofem works, which may lead to irregular bleeding.&nbsp;The following applies:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Medicines for&nbsp;<strong>epilepsy<\/strong>&nbsp;(eg phenobarbital,&nbsp;phenytoin,&nbsp;and carbamazepine).<\/li><li>Medicines for&nbsp;tuberculosis&nbsp;(eg rifampicin and rifabutin).<\/li><li>Medicines for&nbsp;HIV&nbsp;infection&nbsp;(eg nevirapine&nbsp;, efavirenz, ritonavir and nelfinavir).<\/li><li>Medicines for&nbsp;hepatitis&nbsp;C&nbsp;infection&nbsp;(such as telaprevir).<\/li><li>An herbal medicine containing&nbsp;<strong>St. John&#8217;s wort&nbsp;<\/strong>(&nbsp;<em>Hypericum perforatum<\/em>&nbsp;).<\/li><\/ul>\n\n\n\n<p>Other medicines may increase the effect of Novofem:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Medicines containing&nbsp;<strong>ketoconazole<\/strong>&nbsp;(antifungal agent).<\/li><\/ul>\n\n\n\n<p>Novofem may affect ciclosporin when used concomitantly.<\/p>\n\n\n\n<p><strong>Tell your doctor or pharmacist<\/strong>&nbsp;if you are taking or have recently taken any other medicines, including medicines obtained without a prescription and herbal remedies.<\/p>\n\n\n\n<p><strong>Results from blood tests analyze<\/strong><\/p>\n\n\n\n<p>If you need to take a blood sample, tell your doctor or the person taking the blood sample that you are taking Novofem, as this may affect the results of some tests.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Novofem With Food And Drink<\/h2>\n\n\n\n<p>The tablets can be taken with or without food and drink.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy And Breastfeeding<\/h2>\n\n\n\n<p><strong>Novofem and pregnancy<\/strong>:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Novofem is for women whose period has stopped.<\/li><li>If you become pregnant, stop taking Novofem and consult a doctor.<\/li><li><strong>Breastfeeding:<\/strong>&nbsp;You should not use Novofem if you are breastfeeding.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Driving And Using Machines<\/h2>\n\n\n\n<p>Novofem hrt has no known influence on the ability to drive or use machines.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention.&nbsp;One of the possible <strong>side effects of Novofem<\/strong> that can affect your ability in these respects is the use of drugs due to their effects and\/or&nbsp;side effects.&nbsp;<\/p>\n\n\n\n<p>Descriptions of these effects and&nbsp;<strong>side effects of Novofem<\/strong> can be found in other sections.&nbsp;Read all the information in this leaflet for guidance.&nbsp;If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Important Information About A Substance In Novofem<\/h2>\n\n\n\n<p><strong>Novofem hrt<\/strong> contains&nbsp;lactose monohydrates.&nbsp;If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking Novofem.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How To Take Novofem hrt?<\/h2>\n\n\n\n<p><strong>How long does Novofem take to work?<\/strong><\/p>\n\n\n\n<p>Always take this medicine exactly as your doctor has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p>Unless you are switching from another&nbsp;HRT&nbsp;product, you can start treatment with Novofem on any day.&nbsp;If you are switching from another&nbsp;HRT&nbsp;product, ask your doctor <strong><span style=\"text-decoration: underline;\">how long does novofem take to work<\/span><\/strong> and when to start treatment with Novofem.<\/p>\n\n\n\n<p><strong>Take one tablet daily at about the same time.<\/strong><\/p>\n\n\n\n<p>Each pack contains 28 tablets.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Day 1\u201316&nbsp;<strong>Take one red<\/strong>&nbsp;tablet every day for 16 days<\/li><li>Day 17\u201328&nbsp;<strong>Take one white<\/strong>&nbsp;tablet every day for 12 days<\/li><\/ul>\n\n\n\n<p>Take the tablets with a glass of water.<\/p>\n\n\n\n<p>Once you have completed a package, start on a new package without interruption.&nbsp;Menstrual-like bleeding usually occurs when you start on a new pack.<\/p>\n\n\n\n<p>For further information on how to use&nbsp;calendar&nbsp;packaging, see INSTRUCTIONS FOR USE at the end of the package leaflet.<\/p>\n\n\n\n<p>Your doctor will strive to give you the lowest&nbsp;<em>Novofem dosage <\/em>which will give you relief of symptoms, and you should use Novofem for the shortest possible time.&nbsp;Talk to your doctor if you do not get any relief from the symptoms, or feel that the&nbsp;<strong>Novofem dosage<\/strong> is too high.<\/p>\n\n\n\n<p>Contact your doctor if you do not get symptom relief after 3 months of treatment.&nbsp;You should only continue treatment as long as the <span style=\"text-decoration: underline;\">Novofem benefits<\/span> outweigh the risks.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If You Take More Novofem Than You Should<\/h2>\n\n\n\n<p>If you have ingested too much medicine or if, for example, a child has accidentally ingested the medicine, contact a doctor or hospital for risk assessment and advice.&nbsp;An&nbsp;estrogen overdose&nbsp;can cause <\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Chest tightness<\/li><li>Nausea<\/li><li>Vomiting<\/li><li>Irregular vaginal bleeding (&nbsp;metrorrhagia&nbsp;)<\/li><\/ul>\n\n\n\n<p><\/p>\n\n\n\n<p>Overdose of&nbsp;progestogens&nbsp;can lead to <\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Depression<\/li><li>Fatigue<\/li><li>Acne<\/li><li>Heavy hair growth on the face and body (&nbsp;hirsutism&nbsp;).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">If You Forget To Take Novofem<\/h2>\n\n\n\n<p>If you forget to take your tablet, you should take it within 12 hours from the usual time.&nbsp;If more than 12 hours have passed, take the next tablet, as usual, the next day.&nbsp;Do not take a double&nbsp;dose&nbsp;to make up for a forgotten tablet.<\/p>\n\n\n\n<p>Missing a&nbsp;dose&nbsp;can increase the likelihood of breakthrough bleeding and splashing bleeding.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If You Stop Taking Novofem<\/h2>\n\n\n\n<p>If you want to stop taking Novofem, first discuss this with your doctor.&nbsp;The doctor will explain what it means to stop taking the tablets and inform about other alternatives.<\/p>\n\n\n\n<p>If you have any further questions about the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<p><strong>If you need surgery<\/strong><\/p>\n\n\n\n<p>If you are going to have surgery, tell your surgeon that you are taking Novofem.&nbsp;You may need to stop taking Novofem for 4 to 6 weeks before surgery to avoid the risk of blood clots (see section 2, \u201cBlood clots in a vein (venous&nbsp;thromboembolism&nbsp;)\u201d).&nbsp;Ask your doctor when it is appropriate to start taking Novofem again.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible Novofem Side Effects<\/h2>\n\n\n\n<p>Side effects of Novofem<\/p>\n\n\n\n<p>Like all medicines, <strong>Novofem side effects <\/strong>cause&nbsp;some problems, although not everybody gets them.<\/p>\n\n\n\n<p>The following diseases are more common in women who take&nbsp;HRT&nbsp;than those who do not:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Breast cancer<\/li><li>Severe thickening of the uterine lining (&nbsp;endometrial hyperplasia&nbsp;) or cancer of the uterine lining (endometrial cancer)<\/li><li>Ovarian cancer (&nbsp;ovarian cancer&nbsp;)<\/li><li>Blood clots in veins in bones or lungs (venous&nbsp;thromboembolism&nbsp;)<\/li><li>Heart disease<\/li><li>Stroke&nbsp;<\/li><li>Probable memory loss, if treatment with&nbsp;HRT&nbsp;is started after the age of 65.<\/li><\/ul>\n\n\n\n<p>See section 2 \u201cWhat you need to know before you take Novofem\u201d for more information on these&nbsp; Novofem side effects.<\/p>\n\n\n\n<p>(uncommon&nbsp;<em>side effects of Novofem<\/em>&nbsp;&#8211; may affect up to 1 in 100 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Hypersensitivity\/allergy<\/strong>&nbsp;<\/li><\/ul>\n\n\n\n<p>Although a less common&nbsp;<span style=\"text-decoration: underline;\">side effect of Novofem<\/span>, hypersensitivity\/allergy may occur.&nbsp;<\/p>\n\n\n\n<p>Signs of hypersensitivity\/allergy may include one or more of the following symptoms:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Hives<\/li><li>Itching <\/li><li>Swelling <\/li><li>Difficulty breathing<\/li><li>Low&nbsp;blood pressure&nbsp;(pale, cold skin, palpitations)<\/li><li>Dizziness <\/li><li>Sweating&nbsp;<\/li><\/ul>\n\n\n\n<p>These may be signs of a so-called anaphylactic reaction\/shock.&nbsp;If you get any of the listed symptoms,&nbsp;<strong>stop taking Novofem immediately and contact a doctor immediately.<\/strong><\/p>\n\n\n\n<p><strong>Very common&nbsp;Novofem side effects&nbsp;(may affect more than 1 user in 10)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Headache<\/li><li>Tenderness in the breasts.<\/li><\/ul>\n\n\n\n<p><strong>Common&nbsp;Novofem side effects&nbsp;(may affect up to 1 in 10 people)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Increased&nbsp;blood pressure, worsening of high&nbsp;blood pressure<\/li><li>Fungal infection of the abdomen<\/li><li>Dizziness, insomnia, depression<\/li><li>Indigestion, abdominal pain, gas in the stomach<\/li><li>Nausea<\/li><li>Skin rash,&nbsp;itching<\/li><li>Vaginal&nbsp;bleeding (see section 2, subheading \u201cIrregular bleeding\u201d)<\/li><li>Deterioration of uterine fibroid (benign genital&nbsp;tumor&nbsp;)<\/li><li>Edema&nbsp;(swollen hands, ankles, and feet)<\/li><li>Weight gain.<\/li><\/ul>\n\n\n\n<p><strong>Uncommon&nbsp;<\/strong><em><strong>Novofem side effects<\/strong> <\/em><strong>(may affect up to 1 in 100 people)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Migraine<\/li><li>Altered sexual desire (&nbsp;libido&nbsp;)<\/li><li>Blood clot (&nbsp;peripheral&nbsp;embolism,&nbsp;thrombosis&nbsp;)<\/li><li>Vomiting<\/li><li>Gallbladder disease,&nbsp;gallstones<\/li><li>Hair loss<\/li><li>Muscle cramps.<\/li><\/ul>\n\n\n\n<p><strong>Rare&nbsp;Novofem side effects&nbsp;(may affect up to 1 in 1,000 people)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Allergic reaction<\/li><li>Nervousness<\/li><li>Dizziness<\/li><li>Diarrhea<\/li><li>Driving up<\/li><li>Acne<\/li><li>Uterine fibroid (benign&nbsp;tumor&nbsp;of the abdomen).<\/li><\/ul>\n\n\n\n<p><strong>Has been reported (occurs in an unknown number of users):<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Severe thickening of the uterine lining (&nbsp;endometrial hyperplasia&nbsp;)<\/li><li>Increased hair growth on the body and face<\/li><li>Anxiety<\/li><li>Visual disturbances<\/li><li>Seborrhea&nbsp;(increased sebum formation in the skin&#8217;s sebaceous glands, which gives the skin an oily appearance)<\/li><li>Itching&nbsp;in the abdomen.<\/li><\/ul>\n\n\n\n<p><strong>Other&nbsp;side effects&nbsp;are&nbsp;HRT&nbsp;combination products<\/strong><\/p>\n\n\n\n<p>The following&nbsp;<strong>Novofem side effects<\/strong>&nbsp;have been reported with other HRTs:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Various skin diseases:<ul><li>Dark skin spots, especially on the face and neck, so-called &#8220;pregnancy spots&#8221; (chloasma)<\/li><li>Painful reddish-purple bumps on the skin (erythema nodosum)<\/li><li>Annular redness or sore rash (erythema multiforme)<\/li><li>Red or purple discolorations on the skin and\/or mucous membranes (&nbsp;vascular&nbsp;purpura)<\/li><\/ul><\/li><li>Dry eyes<\/li><li>Changes in the tear film composition.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Novofem<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Keep this medicine out of the sight and reach of children.<\/li><li>Do not use this medicine after the expiry date which is stated on the label and the carton after \u201cEXP\u201d.&nbsp;The expiration date is the last day of the specified month.<\/li><li>Do not store above 25 \u00b0 C.&nbsp;Store in a cold place.<\/li><li>Store the container in the outer carton.&nbsp;Sensitive to light.<\/li><li>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Contents Of The Pack And Other Information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content Declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li> The active substances are estradiol and norethisterone acetate.<\/li><li>The red film-coated tablets contain estradiol 1 mg (as estradiol hemihydrate).<\/li><li>The white film-coated tablets contain estradiol 1 mg (as estradiol hemihydrate) and norethisterone acetate 1 mg.<\/li><li>The other ingredients are&nbsp;<ul><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/lactose-intolerance\/\">Lactose<\/a> monohydrate<\/li><li>Corn starch<\/li><li>Hydroxypropyl cellulose <\/li><li>Talc<\/li><li>Magnesium stearate<\/li><\/ul><\/li><li>Film coating:<ul><li> (Red tablet) contains hypromellose<\/li><li>Talc, titanium dioxide (E171)<\/li><li>Propylene glycol<\/li><li>Red iron oxide (E172)<\/li><\/ul><\/li><li>Film coating (white tablet) contains <ul><li>Hypromellose, <\/li><li>Triacetate, <\/li><li>Talc<\/li><\/ul><\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What The Medicine Looks Like And Contents Of The Pack<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The film-coated tablets are round with a diameter of 6 mm.&nbsp;The red tablets are labeled NOVO 282. The white tablets are labeled NOVO 283.<\/li><li>Each pack of 28 tablets contains 16 red tablets and 12 white tablets.<\/li><li>Pack sizes:<ul><li>1 x 28 film-coated tablets<\/li><li>3 x 28 film-coated tablets<\/li><\/ul><\/li><li>Not all pack sizes may be marketed.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder And Manufacturer<\/h2>\n\n\n\n<p>Novo Nordisk A \/ S<\/p>\n\n\n\n<p>Novo All\u00e9<\/p>\n\n\n\n<p>DK-2880 Bagsv\u00e6rd<\/p>\n\n\n\n<p>Denmark<\/p>\n\n\n\n<p><strong>This medicinal product is authorized under the European Economic Area under the names:<\/strong><\/p>\n\n\n\n<p>All countries (excerpt below): Novofem<\/p>\n\n\n\n<p>France: Novofemme<\/p>\n\n\n\n<p>Spain: Duofemme.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Novofem\u00ae is a combined Hormone Replacement Therapy (HRT). Novofem\u00ae is used in post-maturity women with at least 6 months as their last natural period).<\/p>\n","protected":false},"author":2,"featured_media":28317,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"yes","footnotes":""},"categories":[2200,15581],"tags":[19259,19254,19261,19258,19257,19260,19262,19255,19256],"class_list":["post-19230","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-medicines","category-n","tag-benefits-of-novofem","tag-novofem","tag-novofem-dosage","tag-novofem-side-effects","tag-novofem-tablet","tag-novofem-usage","tag-sequential-combination-drug","tag-what-is-novofem","tag-what-novofem-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/19230","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=19230"}],"version-history":[{"count":85,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/19230\/revisions"}],"predecessor-version":[{"id":34261,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/19230\/revisions\/34261"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media\/28317"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=19230"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=19230"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=19230"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}