{"id":19178,"date":"2022-03-03T15:33:37","date_gmt":"2022-03-03T15:33:37","guid":{"rendered":"https:\/\/zeepedia.com\/?p=19178"},"modified":"2022-03-04T15:51:44","modified_gmt":"2022-03-04T15:51:44","slug":"norvir","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/norvir\/","title":{"rendered":"Norvir &#8211; Ritonavir uses, dose and side effects"},"content":{"rendered":"\n<p>100 mg film-coated tablets,<br>ritonavir<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Norvir is and what it is used for<\/h2>\n\n\n\n<p>Norvir contains the active substance ritonavir.\u00a0Norvir is a\u00a0protease inhibitor\u00a0and is used to\u00a0control\u00a0HIV\u00a0infection.\u00a0Norvir is used with other anti &#8211;\u00a0HIV\u00a0medicines (antiretroviral medicines) to control\u00a0your\u00a0HIV\u00a0infection.\u00a0Your doctor will discuss with you which combination of drugs is best for you.<\/p>\n\n\n\n<p>Norvir is used by children 2 years of age and older, adolescents, and adults infected with\u00a0HIV, the\u00a0virus\u00a0that causes\u00a0AIDS.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you or your child take Norvir<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Norvir<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to ritonavir or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you have severe liver disease.<\/li><li>if you are currently taking any of the following medicines:<\/li><\/ul>\n\n\n\n<ul class=\"wp-block-list\"><li>astemizole or terfenadine (commonly used to treat allergy symptoms &#8211; these medicines may be over-the-counter);<\/li><li>amiodarone&nbsp;, bepridil, dronedarone, encainide,&nbsp;flecainide&nbsp;,&nbsp;propafenone&nbsp;,&nbsp;quinidine&nbsp;(used to correct irregular heartbeat);<\/li><li>dihydroergotamine,&nbsp;ergotamine&nbsp;(used to treat&nbsp;migraines&nbsp;);<\/li><li>ergonovine, methylergonovine (used to stop heavy bleeding that may occur after childbirth or an abortion);<\/li><li>chlorazepate,&nbsp;diazepam&nbsp;, estazolam, flurazepam, triazolam or&nbsp;oral&nbsp;(swallowed) midazolam (used to help you sleep and \/ or to relieve anxiety);<\/li><li>clozapine, pimozide (used to treat abnormal thoughts and feelings);<\/li><li>quetiapine (used to treat schizophrenia,&nbsp;bipolar disorder&nbsp;and major depression);<\/li><li>lurasidone (used to treat depression);<\/li><li>ranolazine (used to treat&nbsp;chronic&nbsp;chest pain [angina]);<\/li><li>pethidine, piroxicam, propoxifene (used to relieve pain);<\/li><li>cisapride (used to relieve certain stomach ailments);<\/li><li>rifabutin (used to prevent \/ treat certain&nbsp;infections&nbsp;) *<\/li><li>voriconazole (used to treat fungal infections) *<\/li><li>simvastatin&nbsp;, lovastatin (used to lower blood cholesterol);<\/li><li>neratinib (used to treat breast cancer);<\/li><li>lomitapide (used to lower blood cholesterol);<\/li><li>alfuzosin (used to treat enlarged prostate gland);<\/li><li>fusidic acid (used to treat bacterial infections);<\/li><li>sildenafil if you have a lung disease called&nbsp;pulmonary&nbsp;arterial&nbsp;hypertension&nbsp;which causes difficulty breathing.&nbsp;Patients without this disease may use sildenafil for&nbsp;impotence&nbsp;(&nbsp;erectile dysfunction&nbsp;) under the supervision of a physician (see section&nbsp;<strong>Other medicines&nbsp;<\/strong><strong>and Norvir<\/strong>&nbsp;);<\/li><li>avanafil and vardenafil (used to treat&nbsp;erectile dysfunction&nbsp;)<\/li><li>colchicine (used to treat&nbsp;gout&nbsp;) if you have kidney and \/ or liver problems (see the section on&nbsp;<strong>Other medicines and Norvir<\/strong>&nbsp;);<\/li><li>products containing&nbsp;St. John&nbsp;&#8216;s wort (&nbsp;<em>Hypericum perforatum<\/em>&nbsp;) as these may prevent Norvir from working properly.&nbsp;St. John&#8217;s wort&nbsp;is often used in herbal remedies that you can buy yourself.<\/li><\/ul>\n\n\n\n<p>* Your doctor may decide that you can take rifabutin and\/or voriconazole with a booster (lower\u00a0dose\u00a0) of Norvir but a full\u00a0dose\u00a0of Norvir should not be taken with these two medicines.<\/p>\n\n\n\n<p>If you are currently taking any of these medicines, ask your doctor if it is possible to switch to another medicine while you are taking Norvir.<\/p>\n\n\n\n<p>Also, read the list of medicines under &#8216;Other medicines and Norvir&#8217; when using certain medicines that require special care.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor before taking Norvir<\/p>\n\n\n\n<p><strong>Important information<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If Norvir is taken in combination with other antiretroviral medicines, it is important that you also carefully read the package leaflet that comes with these medicines.&nbsp;There may be additional information about situations when Norvir should be avoided.&nbsp;If you have any further questions on the use of Norvir (ritonavir) or any of the other medicines, contact your doctor or pharmacist.<\/li><li>Norvir does not&nbsp;cure&nbsp;HIV&nbsp;infection&nbsp;or&nbsp;AIDS&nbsp;.<\/li><li>Those taking Norvir may still develop&nbsp;infection&nbsp;or&nbsp;other conditions associated with&nbsp;HIV&nbsp;infection&nbsp;or&nbsp;AIDS&nbsp;.&nbsp;It is therefore important that your doctor follows you up while you are taking Norvir.<\/li><li>You can still transmit&nbsp;HIV&nbsp;infection when you take this medicine, even though the risk of effective&nbsp;antiviral&nbsp;therapy is reduced.&nbsp;Discuss with your doctor the necessary measures to avoid infecting others.<\/li><\/ul>\n\n\n\n<p><strong>Tell your doctor if you have\/had:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Previous&nbsp;<strong>liver disease.<\/strong><\/li><li><strong>Hepatitis&nbsp;B or C<\/strong>&nbsp;and is treated with a combination of antiretroviral drugs because you then have an increased risk of severe and potentially life-threatening reactions due to the effect on the liver.&nbsp;Regular blood tests may be required to check that the liver is functioning properly.<\/li><li><strong>Hemophilia<\/strong>&nbsp;, as there are reports of increased bleeding&nbsp;in patients with<strong>&nbsp;haemophilia<\/strong>&nbsp;taking this type of medicine (<strong>&nbsp;protease&nbsp;<\/strong>inhibitor&nbsp;).&nbsp;The reason for this is not known.&nbsp;You may need more medication to help the blood clot (&nbsp;factor VIII&nbsp;), to be able to control any bleeding.<\/li><li><strong>Impotence&nbsp;(&nbsp;erectile dysfunction<\/strong>&nbsp;), as drugs used to treat&nbsp;erectile dysfunction&nbsp;can cause low&nbsp;blood pressure&nbsp;and prolonged&nbsp;erection&nbsp;.<\/li><li><strong>Diabetes&nbsp;,<\/strong>&nbsp;as there are reports of worsening or development of&nbsp;diabetes&nbsp;(&nbsp;diabetes mellitus&nbsp;) in some patients taking&nbsp;protease inhibitors&nbsp;.<\/li><li><strong>Kidney disease<\/strong>&nbsp;, as your doctor may need to check the&nbsp;dose&nbsp;of one of your other medicines (such as&nbsp;protease inhibitors&nbsp;).<\/li><\/ul>\n\n\n\n<p><br><strong>Tell your doctor if you experience<\/strong>&nbsp;:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Diarrhea or vomiting<\/strong>&nbsp;that does not improve (lasting), as this may reduce the effect of the medicines you are taking.<\/li><li><strong>Nausea, vomiting<\/strong>&nbsp;or&nbsp;<strong>abdominal pain<\/strong>&nbsp;, as this may be a sign of&nbsp;inflammation&nbsp;of the pancreas (&nbsp;pancreatitis&nbsp;).&nbsp;Some patients taking Norvir may develop serious problems with their&nbsp;pancreas&nbsp;.&nbsp;Tell your doctor as soon as possible if this applies to you.<\/li><li><strong>Symptoms of&nbsp;infection<\/strong>&nbsp;&#8211; contact your doctor immediately.&nbsp;Some patients with advanced&nbsp;HIV&nbsp;infection&nbsp;(&nbsp;AIDS&nbsp;) who are starting treatment for&nbsp;HIV&nbsp;may have symptoms from previous&nbsp;infections&nbsp;that they did not know they had.&nbsp;This is probably due to the body&#8217;s improved&nbsp;immune response&nbsp;which enables the body to fight these&nbsp;infections&nbsp;.&nbsp;In addition to the opportunistic infections, autoimmune diseases (a condition that occurs when the immune system attacks healthy body tissue) can also occur after you start taking medicines to treat your&nbsp;HIV&nbsp;infection&nbsp;..&nbsp;Autoimmune diseases can occur several months after starting treatment.&nbsp;If you notice any symptoms of&nbsp;infection&nbsp;or other symptoms such as muscle weakness, weakness that starts in the hands and feet and goes up in the body, palpitations, tremors or hyperactivity, inform your doctor immediately for the necessary treatment.<\/li><li><strong>Stiffness in joints, pain and aches<\/strong>&nbsp;(especially hips, knees and shoulders) and difficulty moving, tell your doctor as this may be a sign of a disease that can destroy bones (&nbsp;osteonecrosis&nbsp;).&nbsp;Some patients receiving combination&nbsp;antiretroviral&nbsp;therapy may develop this disease.<\/li><li><strong>Muscle aches, soreness and weakness<\/strong>&nbsp;, especially in combination with&nbsp;antiretroviral&nbsp;therapy that includes&nbsp;protease inhibitors&nbsp;and&nbsp;nucleoside analogues&nbsp;.&nbsp;On rare occasions, these muscle problems have been severe.&nbsp;(See section 4.&nbsp;<strong>Possible&nbsp;side&nbsp;effects<\/strong>&nbsp;)<\/li><li><strong>Dizziness, fainting or abnormal heartbeat.&nbsp;<\/strong>Some patients taking Norvir may experience&nbsp;electrocardiogram&nbsp;(&nbsp;ECG&nbsp;) changes.&nbsp;Tell your doctor if you have a heart defect or conduction disturbances in the heart.<\/li><li>If you have any other questions concerning your health, discuss these with your doctor as soon as possible.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Norvir is not recommended for use in children under 2 years of age.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Norvir<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines, including medicines obtained without a prescription.\u00a0There are medicines that you can not take with Norvir at all.\u00a0They are listed earlier in section 2, under &#8216;Do not take Norvir&#8217;.\u00a0Other medicines can only be used in special circumstances described below.<\/p>\n\n\n\n<p>The following warnings apply when Norvir is taken as a full\u00a0dose.\u00a0These warnings may also apply when Norvir is used at lower\u00a0doses\u00a0(boosters) with other medicines.<\/p>\n\n\n\n<p><strong>Tell your doctor if you are taking any of the medicines listed below, as special care should be taken.<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Sildenafil or tadalafil<\/strong>&nbsp;for&nbsp;impotence&nbsp;(&nbsp;erectile dysfunction&nbsp;).&nbsp;The dose&nbsp;and \/ or frequency of use of these drugs may need to be reduced to avoid low&nbsp;blood pressure&nbsp;and prolonged&nbsp;erection&nbsp;.&nbsp;You should not take Norvir with sildenafil if you have&nbsp;pulmonary&nbsp;arterial&nbsp;hypertension&nbsp;(see also section 2.&nbsp;<strong>What you need to know before you or your child take Norvir<\/strong>&nbsp;).&nbsp;Tell your doctor if you are taking tadalafil for&nbsp;pulmonary&nbsp;arterial&nbsp;hypertension&nbsp;.<\/li><li><strong>Colchicine<\/strong>&nbsp;(for&nbsp;gout&nbsp;) as Norvir may increase blood levels of this medicine.&nbsp;You must not take Norvir with colchicine if you have kidney and \/ or liver problems (see also&nbsp;<strong>Do not take Norvir<\/strong>&nbsp;above).<\/li><li><strong>Digoxin<\/strong>&nbsp;(heart medicine).&nbsp;Your doctor may need to adjust your digoxin dose and you should check if you are taking&nbsp;digoxin&nbsp;and Norvir to avoid heart problems.<\/li><li><strong>Hormonal contraceptives<\/strong>&nbsp;containing ethinyl estradiol as Norvir may reduce the effect of these drugs.&nbsp;It is recommended that condoms or other non-hormonal contraceptive methods be used instead.&nbsp;You may also experience irregular bleeding if you take this type of hormonal contraceptive with Norvir.<\/li><li><strong>Atorvastatin or rosuvastatin<\/strong>&nbsp;(for high&nbsp;cholesterol&nbsp;) as Norvir may increase the levels of these medicines in the blood.&nbsp;Talk to your doctor before taking any cholesterol-lowering medicines with Norvir (see also&nbsp;<strong>Do not take Norvir<\/strong>&nbsp;above).<\/li><li><strong>Steroids<\/strong>&nbsp;(eg <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/toflacort\/\">dexamethasone<\/a>, fluticasone propionate,&nbsp;prednisolone , triamcinolone) as&nbsp;<strong>Norvir<\/strong>&nbsp;may increase blood levels of these drugs which may lead to Cushing&#8217;s syndrome (development of a round face) and reduce the production of the&nbsp;hormone&nbsp;et&nbsp;cortisol&nbsp;.&nbsp;Your doctor may lower the&nbsp;dose of&nbsp;a&nbsp;steroid&nbsp;and monitor your&nbsp;side effects&nbsp;closely.<\/li><li><strong>Trazodone<\/strong>&nbsp;(antidepressant) as&nbsp;side effects&nbsp;such as nausea, dizziness, low&nbsp;blood pressure&nbsp;and fainting may occur when taking Norvir at the same time.<\/li><li><strong>Rifampicin and saquinavir<\/strong>&nbsp;(used to treat&nbsp;tuberculosis&nbsp;and&nbsp;HIV&nbsp;respectively ) as severe liver damage can occur if you take Norvir at the same time.<\/li><li><strong><a href=\"https:\/\/zeepedia.com\/medical\/medicines\/tracleer\/\">Bosentan<\/a><\/strong><strong>&nbsp;, riociguat<\/strong>&nbsp;(used to&nbsp;treat pulmonary&nbsp;arterial&nbsp;hypertension&nbsp;) as Norvir may increase the blood levels of this medicine.<\/li><\/ul>\n\n\n\n<p>Some medicines may not be taken with Norvir as their effects may increase or decrease when taken together.\u00a0In some cases, your doctor may need to take some tests, change the\u00a0dosage\u00a0or check you regularly.\u00a0Therefore, you should tell your doctor if you are taking other medicines, including those you have bought yourself or herbal medicines, but it is especially important to mention these:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>amphetamine or amphetamine derivative;<\/li><li>antibiotics&nbsp;(eg erythromycin, clarithromycin);<\/li><li>cancer drugs (eg abemaciclib, afatinib, apalutamide, ceritinib, encorafenib, dasatinib, ibrutinib, nilotinib, venetoclax, vincristine, vinblastine);<\/li><li>drugs used to treat&nbsp;platelet&nbsp;deficiency (eg fostamatinib);<\/li><li>anticoagulants&nbsp;(eg rivaroxaban, vorapaxar,&nbsp;warfarin&nbsp;);<\/li><li>antidepressants (eg amitriptyline, desipramine,&nbsp;fluoxetine&nbsp;, imipramine, nefazodone, nortriptyline,&nbsp;paroxetine&nbsp;,&nbsp;sertraline&nbsp;, trazodone);<\/li><li>antifungals (eg&nbsp;ketoconazole&nbsp;, itraconazole);<\/li><li>antihistamines&nbsp;(eg&nbsp;loratadine&nbsp;, fexofenadine);<\/li><li>antiretroviral medicinal products including&nbsp;HIV&nbsp;protease inhibitors&nbsp;( amprenavir&nbsp;, atazanavir, darunavir, fosamprenavir, indinavir, nelfinavir, saquinavir, tipranavir), non-nucleoside reverse transcriptase inhibitors (NNRTIs) (delavirdine, ravapine, efavirenz, maravapine, );<\/li><li>drugs against&nbsp;tuberculosis&nbsp;(bedacillin and delamanide);<\/li><li>antiviral drugs used to treat&nbsp;chronic&nbsp;hepatitis&nbsp;C (&nbsp;HCV&nbsp;)&nbsp;infection&nbsp;in adults (eg glekaprevir \/ pibrentasvir and simeprevir);<\/li><li>antianxiety drugs, buspirone;<\/li><li>asthma medication, theophylline, salmeterol;<\/li><li>atovaquone, a drug used to treat a specific type of&nbsp;pneumonia&nbsp;and malaria;<\/li><li>buprenorphine, a drug used in the treatment of&nbsp;chronic&nbsp;pain;<\/li><li>bupropion, a drug used for smoking cessation;<\/li><li>epilepsy drugs (eg carbamazepine, divalproex, lamotrigine,&nbsp;phenytoin&nbsp;);<\/li><li>cardiac drugs (eg&nbsp;disopyramide&nbsp;, mexiletine and calcium channel antagonists such as amlodipine,&nbsp;diltiazem&nbsp;and nifedipine);<\/li><li>immune system (eg cyclosporine, tacrolimus, everolimus);<\/li><li>levothyroxine (used to treat thyroid problems);<\/li><li>morphine and morphine-like drugs used in the treatment of severe pain (eg&nbsp;methadone&nbsp;,&nbsp;fentanyl&nbsp;);<\/li><li>hypnotics (eg alprazolam, zolpidem) and also midazolam given as an injection;<\/li><li>sedatives (eg&nbsp;haloperidol&nbsp;,&nbsp;risperidone&nbsp;, thioridazine)<\/li><li>colchicine, a treatment for gout;<\/li><\/ul>\n\n\n\n<p>There are certain medicines that you can not take with Norvir at all.&nbsp;These are listed earlier in section 2. under &#8216;Do not take Norvir&#8217;.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Norvir with food and drink<\/h2>\n\n\n\n<p>Norvir tablets should be taken with food.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p><strong>If you are pregnant or breastfeeding<\/strong>, think you may be pregnant, or are planning to have a baby, you must consult<strong> your doctor before taking this medicine.<\/strong><\/p>\n\n\n\n<p>There is a lot of information about the use of ritonavir (the active substance in Norvir) during pregnancy.\u00a0After the first three months, in most cases, pregnant women received ritonavir at lower\u00a0doses\u00a0(booster) with other\u00a0protease inhibitors.\u00a0Norvir does not appear to increase the risk of malformations compared with the rest of the population.<\/p>\n\n\n\n<p>Norvir can pass into breast milk.\u00a0To avoid transmitting the infection, women with\u00a0HIV\u00a0infection\u00a0should not breastfeed their children.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Norvir may cause dizziness.&nbsp;If you are affected, do not drive or use machines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Norvir<\/h2>\n\n\n\n<p><strong>Norvir tablets<\/strong><\/p>\n\n\n\n<p>Always take this medicine exactly as your doctor or pharmacist has told you.\u00a0Ask your doctor or pharmacist if you are unsure.\u00a0Take this medicine once or twice a day with food. <a href=\"https:\/\/www.fass.se\/LIF\/product?userType=2&amp;nplId=20090114000014#\" rel=\"noopener\">Show larger<\/a><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>It is important that Norvir tablets are swallowed whole and not chewed, divided, or crushed.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>Recommended&nbsp;doses&nbsp;of Norvir are:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If Norvir is used to enhance the effect of certain other anti &#8211;&nbsp;HIV&nbsp;medicines, the most common&nbsp;dose&nbsp;is one to 1 to 2 tablets for adults once or twice daily.&nbsp;For more detailed dosing recommendations, including those for children, read the package leaflet for the other anti-&nbsp;HIV&nbsp;medicines that Norvir is given with.<\/li><li>If your doctor prescribes a full&nbsp;dose&nbsp;, adults can start with 3 tablets in the morning and 3 tablets 12 hours later, gradually increasing the&nbsp;dose&nbsp;one over a 14-day period to achieve the full&nbsp;dose&nbsp;of 6 tablets twice daily (total 1200 mg per day) .&nbsp;Children (2 &#8211; 12 years) start with a smaller&nbsp;dose&nbsp;and continue up to the&nbsp;dose&nbsp;that is maximum allowed for their size.<\/li><\/ul>\n\n\n\n<p>Your doctor will tell you which&nbsp;dose&nbsp;to use.<\/p>\n\n\n\n<p>Norvir should be taken daily to help keep your&nbsp;HIV&nbsp;infection under&nbsp;control&nbsp;no matter how much better you feel.&nbsp;If a side effect prevents you from taking Norvir as prescribed, you must tell your doctor immediately.&nbsp;During periods of diarrhea, your doctor may decide that extra checks are needed.<\/p>\n\n\n\n<p>Always have enough Norvir on hand so that it does not run out.&nbsp;When you travel or need to be hospitalized, make sure you have enough Norvir so that you have enough until you can get more.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you take more Norvir than you should<\/h2>\n\n\n\n<p>Numbness, tingling, or ant crawling can occur if you take too much Norvir.\u00a0If you find that you have taken more Norvir than you should, contact your doctor immediately or go to the emergency department at the nearest hospital.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Norvir<\/h2>\n\n\n\n<p>If you miss a\u00a0dose, take the missed\u00a0dose\u00a0as soon as possible.\u00a0If it is soon time for your next\u00a0dose, just take it.\u00a0Do not take a double\u00a0dose\u00a0to make up for a forgotten\u00a0dose.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking Norvir<\/h2>\n\n\n\n<p>Even if you feel better, do not stop taking Norvir without talking to your doctor.\u00a0Using Norvir as prescribed, should give you the best opportunity to delay the development of\u00a0resistance\u00a0to the drug.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>During&nbsp;HIV&nbsp;treatment, weight gain and increased levels of&nbsp;lipids&nbsp;and&nbsp;glucose&nbsp;in the blood may occur.&nbsp;This is partly related to restored health and lifestyle, but when it comes to blood lipids, there can sometimes be a connection with&nbsp;HIV&nbsp;drugs.&nbsp;The doctor will perform tests to find such changes.<\/p>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.\u00a0When Norvir is used with other antiretroviral medicines, the\u00a0side effects\u00a0are dependent on the other medicines.\u00a0Therefore, it is important that you carefully read the side effects section of the package leaflet that comes with these medicines.<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><thead><tr><th scope=\"col\"><strong>Very common:&nbsp;<\/strong><strong>may affect more than 1 user in 10<\/strong><\/th><\/tr><\/thead><tbody><tr><td>\u2022 pain in the upper or lower abdomen\u2022 vomiting\u2022 diarrhea (may be severe)\u2022nausea\u2022 reddening of the skin, feeling hot\u2022headache\u2022dizziness\u2022sore throat\u2022cough\u2022 indigestion or indigestion<\/td><td>Tingling or numbness in the hands, feet, or around the lips and mouth\u2022 feeling of weakness \/ tiredness\u2022 bad taste in the mouth\u2022 nerve damage that can cause weakness or pain\u2022itching\u2022rash\u2022 joint and back pain<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<figure class=\"wp-block-table\"><table><thead><tr><th scope=\"col\"><strong>Common: may<\/strong>&nbsp;affect up to 1 in 10 users<\/th><\/tr><\/thead><tbody><tr><td>\u2022 allergic reactions including rash (maybe red, increased, itchy), severe swelling of the skin and\u00a0other\u00a0tissues\u2022 difficulty sleeping\u2022concern\u2022 increased\u00a0cholesterol levels\u2022 increased levels\u00a0of\u00a0triglycerides\u2022gout\u2022gastric haemorrhage\u2022 hepatitis and yellowish color of the skin and whites of the eyes\u2022 denser water discharge\u2022 impaired renal function\u2022 cramps\u2022 reduced\u00a0platelet count\u2022 thirst (dehydration)\u2022 Abnormally abundant menstruation<\/td><td>\u2022inflated stomach\u2022 loss of appetite could sores\u2022 muscle pain, tenderness or weakness\u2022fever\u2022weight loss\u2022 laboratory tests: changes in results from blood tests (eg composition of substances in the blood and number of blood cells)\u2022confusion\u2022 difficulty retaining attention\u2022 fainting\u2022 dimsyn\u2022 swelling of the hands and feet\u2022 high\u00a0blood pressure\u2022 low\u00a0blood pressure\u00a0and fainting when getting up\u2022 cold hands and feet\u2022 acne<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<figure class=\"wp-block-table\"><table><thead><tr><th scope=\"col\"><strong>Uncommon: may affect up to 1 in 100 people<\/strong><\/th><\/tr><\/thead><tbody><tr><td>\u2022 heart attack\u2022diabetes<\/td><td><br>kidney failure<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<figure class=\"wp-block-table\"><table><thead><tr><th scope=\"col\"><strong>Rare: may affect up to 1 in 1000 people<\/strong><\/th><\/tr><\/thead><tbody><tr><td>\u2022 severe or life-threatening skin reaction including blisters (Stevens-Johnson syndrome,\u00a0toxic epidermal necrolysis\u00a0)<\/td><td>\u2022 severe allergic reactions\u2022 elevated blood sugar levels<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>No known frequency<\/strong>: can not be calculated from the available data<\/td><\/tr><tr><td>\u2022&nbsp;kidney stones&nbsp;ar<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>Tell your doctor if you feel nauseous, vomit or have abdominal pain as these may be signs of an inflamed\u00a0pancreas.\u00a0Also tell your doctor if you have joint stiffness, aches, and pains (especially in the hip, knee, and shoulder) and difficulty moving, as this may be a sign of\u00a0osteonecrosis.\u00a0See also section 2.\u00a0What you need to know before you or your child takes<strong> Norvir.<\/strong><\/p>\n\n\n\n<p>In patients with\u00a0hemophilia\u00a0type A and B, there have been reports of an increased tendency to bleed when taking this or another\u00a0protease inhibitor.\u00a0If this happens to you, talk to your doctor straight away.<\/p>\n\n\n\n<p>There are reports of abnormal liver values,\u00a0hepatitis\u00a0(\u00a0inflammation\u00a0of the liver), and, in rare cases, jaundice in patients taking Norvir.\u00a0Some people had other illnesses or were on other medications.\u00a0People who already have liver disease or\u00a0hepatitis\u00a0may get worse.<\/p>\n\n\n\n<p>There are reports of muscle pain, soreness, or weakness in the muscles, especially with concomitant use of cholesterol-lowering drugs in combination\u00a0with antiretroviral\u00a0therapy including\u00a0protease inhibitors\u00a0and\u00a0nucleoside analogs.\u00a0In rare cases, these muscle problems have been severe (\u00a0rhabdomyolysis\u00a0).\u00a0In case of unexplained or persistent muscle pain, soreness, weakness, or cramps, stop taking the medicine, contact your doctor as soon as possible or go to the\u00a0emergency room\u00a0at the nearest hospital.<\/p>\n\n\n\n<p>Tell your doctor immediately if you get any symptoms that indicate an\u00a0allergic reaction\u00a0after taking Norvir, such as\u00a0itching, rash, or difficulty breathing.<\/p>\n\n\n\n<p><strong>If any of the\u00a0side effects\u00a0gets serious, or if you notice any\u00a0side effects\u00a0not listed in this leaflet, please tell your doctor or pharmacist, emergency department or if you have\u00a0an emergency, seek medical advice immediately.<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Norvir<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>No special temperature instructions.&nbsp;Store in the original jar.&nbsp;Moisture sensitive.<\/p>\n\n\n\n<p>Do not use this medicine if you notice any discoloration.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is ritonavir.&nbsp;Each film-coated tablet contains 100 mg ritonavir.<\/li><li>The other ingredients of the tablet are copovidone, sorbitan laurate, anhydrous calcium hydrogen phosphate, anhydrous&nbsp;colloidal&nbsp;silica, sodium stearyl fumarate.<\/li><li>The coating of the tablet consists of: hypromellose, titanium dioxide, macrogol, hydroxypropylcellulose, talc, colloidal anhydrous silica, polysorbate 80.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<p>Norvir&nbsp;<strong>film-coated tablets<\/strong>&nbsp;are white and imprinted with [Abbott logo] and the code \u201cNK\u201d.<\/p>\n\n\n\n<p>Three packs are available for Norvir tablets:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>1 jar with 30 tablets<\/li><li>1 jar with 60 tablets<\/li><li>Multipack containing 3 jars, each containing 30 film-coated tablets (90 tablets)<\/li><\/ul>\n\n\n\n<p>Not all packaging may be marketed.<\/p>\n\n\n\n<p>Norvir is also available as a powder for\u00a0an oral\u00a0suspension\u00a0containing 100 mg ritonavir.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>AbbVie Deutschland GmbH &amp; Co.&nbsp;KG<\/p>\n\n\n\n<p>Knollstrasse<\/p>\n\n\n\n<p>67061 Ludwigshafen<\/p>\n\n\n\n<p>Germany<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>AbbVie Deutschland GmbH &amp; Co.&nbsp;KG<\/p>\n\n\n\n<p>Knollstrasse<\/p>\n\n\n\n<p>67061 Ludwigshafen<\/p>\n\n\n\n<p>Germany<\/p>\n\n\n\n<p><strong>Information provided by:<\/strong><\/p>\n\n\n\n<p>AbbVie AB<\/p>\n\n\n\n<p>Box 1523<\/p>\n\n\n\n<p>171 29 Solna<\/p>\n\n\n\n<p>Tel: 08-684 44600<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Norvir contains the active substance ritonavir. Norvir is a protease inhibitor and is used to control HIV infection . Norvir is used with other anti &#8211; HIV medicines (antiretroviral medicines) to control your HIV infection . Your doctor will discuss with you which combination of drugs is best for you.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,15581],"tags":[19113,16399,19108,19112,19111,16394,16398,16397,19109,16395,19110,16396],"class_list":["post-19178","post","type-post","status-publish","format-standard","hentry","category-medicines","category-n","tag-benefits-of-norvir","tag-benefits-of-ritonavir","tag-norvir","tag-norvir-side-effects","tag-norvir-tablet","tag-ritonavir","tag-ritonavir-side-effects","tag-ritonavir-tablet","tag-what-is-norvir","tag-what-is-ritonavir","tag-what-norvir-is-used-for","tag-what-ritonavir-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/19178","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=19178"}],"version-history":[{"count":3,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/19178\/revisions"}],"predecessor-version":[{"id":19210,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/19178\/revisions\/19210"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=19178"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=19178"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=19178"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}