{"id":19168,"date":"2022-03-03T15:22:55","date_gmt":"2022-03-03T15:22:55","guid":{"rendered":"https:\/\/zeepedia.com\/?p=19168"},"modified":"2022-03-04T15:52:11","modified_gmt":"2022-03-04T15:52:11","slug":"normorix-and-normorix-mite","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/normorix-and-normorix-mite\/","title":{"rendered":"Normorix and Normorix mite | Amiloride hydrochloride \/ Hydrochlorothiazide uses, dose and side effects"},"content":{"rendered":"\n<p>5 mg \/ 50 mg 2.5 mg \/ 25 mg&nbsp;tablets<br>amiloride hydrochloride \/ hydrochlorothiazide<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Normorix and Normorix mite are and what they are used for<\/h2>\n\n\n\n<p>Normorix and Normorix\u00a0mite\u00a0are\u00a0diuretics\u00a0and antihypertensives.\u00a0The two active substances complement each other in such a way that\u00a0hydrochlorothiazide\u00a0is\u00a0diuretic\u00a0and lowers blood pressure, while amiloride hydrochloride is potassium-sparing and counteracts the potassium losses that can be caused by\u00a0diuretics.\u00a0Amiloride hydrochloride also has a mild\u00a0diuretic\u00a0and antihypertensive effect, thus enhancing the effect of\u00a0hydrochlorothiazide.<\/p>\n\n\n\n<p>The increased urine excretion begins within 1-2 hours after ingestion is greatest after about 4 hours, and lasts about 12 hours.<\/p>\n\n\n\n<p>Normorix and Normorix\u00a0mite\u00a0are used to treat high\u00a0blood pressure\u00a0or fluid retention in the\u00a0tissues\u00a0(\u00a0edema\u00a0) due to\u00a0heart failure, cirrhosis of the liver with fluid retention in the abdominal cavity.<\/p>\n\n\n\n<p>Amiloride hydrochloride and\u00a0hydrochlorothiazide\u00a0contained in Normorix and Normorix\u00a0mite\u00a0may also be approved for the treatment of other diseases not mentioned in this leaflet.\u00a0Ask your doctor, pharmacist, or other healthcare professionals if you have any further questions, and always follow their instructions.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using Normorix and Normorix mite<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Normorix and Normorix mite<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to&nbsp;hydrochlorothiazide&nbsp;or amiloride hydrochloride or any of the other ingredients of this medicine (listed in section 6).&nbsp;This also applies if you are allergic to substances that are closely related to the active substances, such as so-called&nbsp;thiazides&nbsp;(&nbsp;diuretics&nbsp;) or&nbsp;sulfonamides&nbsp;(eg certain oral diabetes medicines).<\/li><li>if you have severe renal impairment, have high levels of&nbsp;potassium&nbsp;in your blood or if you use other potassium-sparing agents (eg&nbsp;spironolactone&nbsp;) or potassium supplements.<\/li><li>if you have no urine excretion<\/li><li>if you have affected consciousness as a result of cirrhosis.<\/li><li>if you have&nbsp;gout&nbsp;.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse before taking Normorix or Normorix\u00a0mite\u00a0if you:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>have had skin cancer or if you get an unforeseen skin change during treatment.&nbsp;Treatment with&nbsp;hydrochlorothiazide&nbsp;, especially long-term use with high&nbsp;doses&nbsp;, may increase the risk of certain types of skin and lip cancer (non-&nbsp;melanoma&nbsp;skin cancer).&nbsp;Protect your skin from exposure to sunlight and UV rays while taking Normorix or Normorix&nbsp;mite&nbsp;.<\/li><li>have a high age<\/li><li>has impaired renal function<\/li><li>have&nbsp;diabetes<\/li><li>has elevated potassium levels in the blood<\/li><li>has lupus erythematosus (&nbsp;SLE&nbsp;)<\/li><li>have heart-lung disease<\/li><li>have liver problems<\/li><li>have obstruction of the urinary tract<\/li><li>should do a glucose tolerance test<\/li><li>should take a sample to check the level of parathyroid hormone in the blood, as you may need to stop treatment before taking the sample.<\/li><li>have previously had breathing or lung problems (including&nbsp;inflammation&nbsp;or fluid in the lungs) after taking&nbsp;hydrochlorothiazide&nbsp;.&nbsp;If you experience severe shortness of breath or severe breathing problems after taking Normorix or Normorix&nbsp;mite&nbsp;, seek medical attention immediately.<\/li><\/ul>\n\n\n\n<p>Talk to your doctor or nurse if you experience impaired vision or eye pain.\u00a0This may be a symptom of fluid accumulation in the eye (between the choroid and retina) or an increase in pressure in the eye and may occur within a few hours to weeks after taking Normorix or Normorix\u00a0mite.\u00a0This can lead to permanent visual impairment if left untreated.\u00a0If you have previously had a\u00a0penicillin\u00a0or sulfonamide allergy, you may be at a higher risk of developing this.<\/p>\n\n\n\n<p>Normorix \/ Normorix\u00a0mite\u00a0can in rare cases affect the white\u00a0blood cells\u00a0so that the defense against infection deteriorates.\u00a0If you get an\u00a0infection\u00a0with symptoms such as fever with severe general deterioration or fever with local infection symptoms such as sore throat\/throat\/mouth or urination problems, you should see a doctor as soon as possible so that a blood test can rule out a lack of\u00a0white blood cells\u00a0(\u00a0agranulocytosis\u00a0).\u00a0It is important that you then have information about your medication.<\/p>\n\n\n\n<p>Before surgery with anesthesia (also applies to the dentist), the doctor\/dentist should know that you are being treated with Normorix or Normorix\u00a0mite, as there is a risk that the\u00a0blood pressure\u00a0may drop suddenly.<\/p>\n\n\n\n<p>Treatment with&nbsp;thiazides&nbsp;can increase the levels of certain blood fats (&nbsp;cholesterol&nbsp;and&nbsp;triglycerides&nbsp;).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Normorix and Normorix mite<\/h2>\n\n\n\n<p>The effect of the treatment can be affected if Normorix or Normorix\u00a0mite\u00a0is taken at the same time as certain other medicines.\u00a0Tell your doctor or pharmacist if you are taking or have recently taken or might take any other medicines.\u00a0This applies above all to:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>other potassium-sparing agents or potassium supplements<\/li><li>other antihypertensive agents (&nbsp;ACE inhibitors&nbsp;)<\/li><li>insulin&nbsp;and antidiabetic agents<\/li><li>certain lipid-lowering agents (cholestyramine, colestipol)<\/li><li>cardiac medicine (&nbsp;digitalis&nbsp;, sotalol,&nbsp;epinephrine&nbsp;)<\/li><li>cortisone<\/li><li>certain painkillers (eg <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/tiplo-citrus\/\">acetylsalicylic acid<\/a> and&nbsp;ibuprofen&nbsp;)<\/li><li>certain antidepressants (lithium)<\/li><li>certain drugs that lower the immune system (cyclosporine and tacrolimus)<\/li><li>certain agents against disturbed calcium metabolism (calcitriol)<\/li><li>certain antiepileptic&nbsp;drugs&nbsp;(carbamazepine, <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/topiramate-1a-pharma\/\">topiramate<\/a>)<\/li><li>certain anti-cancer drugs (cyclophosphamide)<\/li><li>calcium-containing agents, such as calcium supplements and certain anti-acidic agents (so-called antacids)<\/li><\/ul>\n\n\n\n<p>Some sedatives may increase the blood pressure-lowering effect of Normorix and Normorix\u00a0mite.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Intake of Normorix and Normorix mite with food and drink<\/h2>\n\n\n\n<p>You should avoid consuming large amounts of dairy products or other calcium-containing foods.<\/p>\n\n\n\n<p>Alcohol may increase the blood pressure-lowering effect of Normorix and Normorix\u00a0mite.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n<p><em>Pregnancy<\/em><\/p>\n\n\n\n<p>Contact your doctor if you are pregnant or think you may be pregnant.&nbsp;Your doctor will usually suggest that you take another medicine instead of Normorix \/ Normorix&nbsp;mite&nbsp;as Normorix \/ Normorix&nbsp;mite&nbsp;is not recommended during pregnancy.&nbsp;This is because Normorix \/ Normorix&nbsp;mite&nbsp;passes to the fetus and can cause harm to the fetus and the newborn baby if used during the last 6 months of pregnancy.<\/p>\n\n\n\n<p><em><br>Breast-feeding<\/em><\/p>\n\n\n\n<p>Tell your doctor if you are breastfeeding or planning to start breastfeeding.\u00a0Normorix \/ Normorix\u00a0mite\u00a0is not recommended for breastfeeding.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Side effects\u00a0such as dizziness and fatigue may occur.\u00a0Under these conditions, the ability to react and the ability to judge can decrease and this should be observed, for example, when driving a car and precision work.\u00a0You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0Descriptions of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Normorix and Normorix mite contain lactose<\/h2>\n\n\n\n<p>If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Normorix and Normorix mite<\/h2>\n\n\n\n<p>Always use this medicine exactly as your doctor has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.&nbsp;Dose&nbsp;one is determined by the doctor, who adjusts it individually for you.<\/p>\n\n\n\n<p>The usual\u00a0dose\u00a0is 1 tablet daily.\u00a0Do not change the\u00a0dosage\u00a0without consulting your doctor.<\/p>\n\n\n\n<p><strong><em>Normorix<\/em><\/strong><\/p>\n\n\n\n<p>The tablet can be divided into two equal\u00a0doses.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you use too much Normorix or Normorix mite<\/h2>\n\n\n\n<p>If you have ingested too much medicine or if, for example, a child has accidentally ingested the medicine, contact a doctor or hospital for risk assessment and advice.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use Normorix or Normorix mite<\/h2>\n\n\n\n<p>Do not take a double&nbsp;dose&nbsp;to make up for a forgotten tablet.&nbsp;Return to the regular schedule the next day.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><em>Common (may affect up to 1 in 10 people):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Fatigue, weakness<\/li><li>Headache and dizziness<\/li><li>Nausea, diarrhea and indigestion<\/li><li>Skin rash,&nbsp;itching<\/li><li>Pain in legs and arms<\/li><li>Shortness of breath, cough<\/li><li>Irregular heartbeat<\/li><li>Loss of appetite.&nbsp;Elevated blood sugar levels, elevated or decreased (with long-term use) potassium levels in the blood.&nbsp;Decreased magnesium levels in the blood.&nbsp;Increased amount of&nbsp;uric acid&nbsp;in the blood.<\/li><\/ul>\n\n\n\n<p><em>Uncommon (may affect up to 1 in 100 people):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Vomiting, constipation, flatulence, hiccups,&nbsp;dry mouth<\/li><li>Thirst<\/li><li>Insomnia, nervousness, depression and confusion<\/li><li>Dizziness due to drop in blood pressure when getting up quickly, dizziness, fast&nbsp;pulse<\/li><li>Angina pectoris<\/li><li>Ant crawls, numbness, decreased alertness<\/li><li>Muscle cramps, joint pain, chest and back pain<\/li><li>Urinary incontinence and&nbsp;incontinence<\/li><li>Impotence<\/li><li>Visual disturbances<\/li><\/ul>\n\n\n\n<p><em>Rare (may affect up to 1 in 1,000 people):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Hypersensitivity reaction&nbsp;with fever, rash, swelling and sometimes a drop in blood pressure.&nbsp;Vascular wall inflammation<\/li><li>Skin reaction in connection with sun exposure<\/li><li>Fainting<\/li><li>Impaired renal function<\/li><li>Gastrointestinal bleeding,&nbsp;inflammation&nbsp;of the pancreas<\/li><li>Jaundice<\/li><li>Decreased sodium levels in the blood<\/li><li>Anemia&nbsp;and other changes in the blood picture, eg lack of&nbsp;white blood cells&nbsp;, so-called&nbsp;agranulocytosis&nbsp;, see also Warnings and caution<\/li><\/ul>\n\n\n\n<p><em>Very rare (may affect up to 1 in 10,000 people):<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Fluid in the lungs<\/li><li>Acute&nbsp;shortness of breath syndrome (signs of this are severe shortness of breath, fever, weakness and confusion).<\/li><li>Abdominal pain<\/li><li>Skin and mucosal changes (sometimes severe)<\/li><\/ul>\n\n\n\n<p><em>Has been reported (occurs in an unknown number of users<\/em>&nbsp;):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Skin and lip cancer (non-&nbsp;melanoma&nbsp;skin cancer)<\/li><li>Decreased vision or pain in the eyes due to high pressure (possible signs of fluid accumulation in the eye (between the choroid and retina) or&nbsp;acute&nbsp;narrow-angle glaucoma&nbsp;)<\/li><li>Gout&nbsp;, dehydration<\/li><li>Nasal congestion<\/li><li>Impaired bile flow<\/li><li>Nocturnal urination<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Normorix and Normorix mite<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>No special storage instructions.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the label after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substances are amiloride chloride and&nbsp;hydrochlorothiazide&nbsp;.<\/li><li>Normorix 5 mg \/ 50 mg contains 5 mg of amiloride hydrochloride in the form of amiloride hydrochloride dihydrate and 50 mg of&nbsp;hydrochlorothiazide&nbsp;.<\/li><li>Normorix&nbsp;mite&nbsp;2.5 mg \/ 25 mg contains 2.5 mg amiloride hydrochloride in the form of amiloride hydrochloride dihydrate and 25 mg&nbsp;hydrochlorothiazide&nbsp;.<\/li><li>The other ingredients are&nbsp;lactose monohydrate&nbsp;60 mg (Normorix) and 30 mg (Normorix&nbsp;mite&nbsp;), magnesium stearate, povidone, microcrystalline cellulose, talc and rice starch.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<p>Normorix 5 mg \/ 50 mg is a white to yellowish, round tablet with a diameter of 8 mm.&nbsp;The tablet has a breaking notch and is embossed with AB 71.<\/p>\n\n\n\n<p>Normorix&nbsp;mite&nbsp;2.5 mg \/ 25 mg is a white to yellowish, round tablet with a diameter of 6 mm.&nbsp;The tablet is slightly concave and is embossed with AB 73.<\/p>\n\n\n\n<p><em>Pack sizes:<\/em><\/p>\n\n\n\n<p>30 and 100 tablets in a plastic jar, respectively.<\/p>\n\n\n\n<p>98 x 1 tablets (single dose) in the blister pack.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Orifarm Healthcare A \/ S<\/p>\n\n\n\n<p>Energizer 15<\/p>\n\n\n\n<p>5260 Odense S<\/p>\n\n\n\n<p>Denmark<\/p>\n\n\n\n<p>info@orifarm.com<\/p>\n\n\n\n<p><strong>Local representative<\/strong><\/p>\n\n\n\n<p>Orifarm Healthcare<\/p>\n\n\n\n<p>Box 56048<\/p>\n\n\n\n<p>102 17 Stockholm<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Orifarm Manufacturing Poland Sp.&nbsp;z oo<\/p>\n\n\n\n<p>Ul.&nbsp;Ksi\u0119stwa \u0141owickiego 12<\/p>\n\n\n\n<p>99-420 \u0141yszkowice<\/p>\n\n\n\n<p>Poland<\/p>\n","protected":false},"excerpt":{"rendered":"<p>5 mg \/ 50 mg 2.5 mg \/ 25 mg tablets<br \/>\namiloride hydrochloride \/ hydrochlorothiazide<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,15581],"tags":[10656,10659,3664,4301,19149,19153,19156,19157,19152,10658,7947,10657,4300,19150,19154,19151,19155],"class_list":["post-19168","post","type-post","status-publish","format-standard","hentry","category-medicines","category-n","tag-amiloride-hydrochloride","tag-amiloride-hydrochloride-tablet","tag-hydrochlorothiazide","tag-hydrochlorothiazide-tablet","tag-normorix","tag-normorix-mite","tag-normorix-mite-side-effects","tag-normorix-mite-tablet","tag-normorix-tabelt","tag-what-amiloride-hydrochloride-is-used-for","tag-what-hydrochlorothiazide-is-used-for","tag-what-is-amiloride-hydrochloride","tag-what-is-hydrochlorothiazide","tag-what-is-normorix","tag-what-is-normorix-mite","tag-what-normorix-is-used-for","tag-what-normorix-mite-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/19168","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=19168"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/19168\/revisions"}],"predecessor-version":[{"id":19215,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/19168\/revisions\/19215"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=19168"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=19168"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=19168"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}