{"id":19160,"date":"2022-03-03T15:15:20","date_gmt":"2022-03-03T15:15:20","guid":{"rendered":"https:\/\/zeepedia.com\/?p=19160"},"modified":"2022-03-04T15:52:32","modified_gmt":"2022-03-04T15:52:32","slug":"noresmea","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/noresmea\/","title":{"rendered":"Noresmea &#8211; Estradiol \/ Norethisterone Acetate uses, dose and side effects"},"content":{"rendered":"\n<p>1 mg \/ 0.5 mg&nbsp;film-coated tablets<br>estradiol \/ norethisterone acetate<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Noresmea is and what it is used for<\/h2>\n\n\n\n<p>Noresmea is a preparation used for\u00a0continuous\u00a0hormonal replacement\u00a0therapy\u00a0(\u00a0Hormone\u00a0Replacement\u00a0Therapy,\u00a0HRT\u00a0).\u00a0It contains two female sex hormones;\u00a0estrogen\u00a0and\u00a0progestogen.\u00a0Noresmea is used for women whose menstruation has stopped (\u00a0menopause\u00a0), at least 1 year after their last natural menstruation.<\/p>\n\n\n\n<p>Noresmea is used to:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Relieve&nbsp;<\/strong><strong>symptoms during and after menopause<\/strong>When menstruation ends (&nbsp;menopause&nbsp;), the woman&#8217;s&nbsp;estrogen&nbsp;decreases .&nbsp;It can cause problems such as sweating and hot flashes.&nbsp;Noresmea relieves these symptoms after&nbsp;menopause&nbsp;.&nbsp;Noresmea should only be used if the problems cause problems in daily life.<\/li><li><strong>Prevent osteoporosis<\/strong>After&nbsp;menopause&nbsp;, some women suffer from osteoporosis.&nbsp;Discuss all possible options with your doctor.If you have an increased risk of&nbsp;fractures&nbsp;(bone fractures) and other medicines that are not suitable for you, you can use Noresmea to prevent osteoporosis after&nbsp;menopause&nbsp;.<\/li><\/ul>\n\n\n\n<p>Noresmea is prescribed for women who have their uterus left and who had their last period more than a year ago.<\/p>\n\n\n\n<p>Experience in the treatment of women older than 65 years with Noresmea is limited.<\/p>\n\n\n\n<p>Estradiol and norethisterone acetate found in Noresmea may also be approved for the treatment of other conditions not mentioned in this product information.\u00a0Ask your doctor, pharmacist, or other healthcare professionals if you have any further questions, and always follow their instructions.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you take Noresmea<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Medical background and regular check-ups<\/h2>\n\n\n\n<p>The use of&nbsp;HRT&nbsp;involves risks that must be taken into account when deciding to start treatment or continue an ongoing treatment.<\/p>\n\n\n\n<p>Experience is limited for the treatment of women whose menstruation has stopped prematurely (when the ovaries have stopped working or the uterus has been removed).&nbsp;If you belong to that group, the risks of&nbsp;HRT&nbsp;may be different.&nbsp;Talk to your doctor.<\/p>\n\n\n\n<p>Before starting treatment (or resuming treatment), your doctor will ask about your own, and your family&#8217;s, medical background.\u00a0Your doctor may do a general medical and gynecological examination, which also includes the examination of your breasts.<\/p>\n\n\n\n<p>Once you have started treatment with Noresmea, you should go for regular medical check-ups, at least once a year.&nbsp;During these check-ups, you should discuss with your doctor the benefits and risks of continued treatment.<\/p>\n\n\n\n<p>Get regular check-ups of your breasts according to your doctor&#8217;s recommendations.<\/p>\n\n\n\n<p><strong>Do not take Noresmea<\/strong><\/p>\n\n\n\n<p>if any of the following apply to you.&nbsp;<strong>If you are not sure, talk to your doctor<\/strong>&nbsp;before taking Noresmea.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you have, have had or suspect you may have&nbsp;<strong>breast cancer<\/strong>&nbsp;.<\/li><li>If you have or have had&nbsp;<strong>estrogen-dependent cancer<\/strong>&nbsp;, such as cancer of the uterine lining (endometrium) or if there is a suspicion of such cancer.<\/li><li>If you have&nbsp;<strong>unexpected genital bleeding<\/strong>&nbsp;that has not been investigated by a doctor.<\/li><li>If you have&nbsp;<strong>endometrial hyperplasia<\/strong>&nbsp;(severe thickening of the uterine lining) and are not being treated for it.<\/li><li>If you have or have had a&nbsp;<strong>blood clot in a vein<\/strong>&nbsp;(venous&nbsp;thromboembolism&nbsp;), in your legs (deep&nbsp;vein thrombosis&nbsp;) or in your lungs (&nbsp;pulmonary embolism&nbsp;).<\/li><li>If you have a&nbsp;<strong>coagulation disorder<\/strong>&nbsp;, a condition with an increased risk of blood clots (lack of&nbsp;protein&nbsp;C,&nbsp;protein&nbsp;S or antithrombin).<\/li><li>If you have or have recently had a disease caused by a blood clot in the&nbsp;arteries&nbsp;, such as a&nbsp;<strong>heart attack,&nbsp;stroke<\/strong>&nbsp;or&nbsp;<strong>angina<\/strong>&nbsp;.<\/li><li>If you have or have had any&nbsp;<strong>liver disease<\/strong>&nbsp;and still have abnormal liver values.<\/li><li>If you have&nbsp;<strong>porphyria<\/strong>&nbsp;, a rare inherited blood disorder.<\/li><li>If you are&nbsp;<strong>allergic<\/strong>&nbsp;to estradiol, norethisterone acetate or any of the other ingredients of this medicine (listed in section 6).<\/li><\/ul>\n\n\n\n<p>If any of the above affects you for the first time when you use Noresmea, stop taking Noresmea and contact your doctor immediately.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before taking Noresmea.<\/p>\n\n\n\n<p>Talk to your doctor if you have or have had any of the following problems before starting treatment.&nbsp;They may recur or worsen during treatment with Noresmea.&nbsp;Should these occur, you should have more frequent check-ups with a doctor.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have any disease affecting the lining of the uterus, as well as muscle knots (&nbsp;fibroids&nbsp;),&nbsp;endometriosis&nbsp;or have had&nbsp;endometrial hyperplasia&nbsp;(severe thickening of the uterine lining)<\/li><li>increased risk of getting a blood clot (see below &#8220;Blood clots in a vein (&nbsp;thrombosis&nbsp;)&#8221;)<\/li><li>increased risk of developing estrogen-dependent cancer (eg if you have a mother, sister or grandmother \/ grandmother who has had breast cancer)<\/li><li>high&nbsp;blood pressure<\/li><li>liver disease eg liver adenoma (benign&nbsp;tumor&nbsp;)<\/li><li>diabetes<\/li><li>gallstone disease<\/li><li>migraine&nbsp;or severe headache<\/li><li>systemic lupus erythematosus (&nbsp;SLE&nbsp;) &#8211; an&nbsp;autoimmune&nbsp;disease that affects many organs in the body<\/li><li>epilepsy<\/li><li>asthma<\/li><li>otosclerosis (ossification of the middle ear leading to hearing loss)<\/li><li>hypertriglyceridemia&nbsp;(elevated blood lipids)<\/li><li>fluid retention due to heart or kidney disease<\/li><li>lactose intolerance.<\/li><\/ul>\n\n\n\n<p><strong>You should contact your doctor immediately and discontinue treatment with Noresmea if any of the following occur:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>any of the things mentioned in the section &#8220;Do not take Noresmea&#8221;<\/li><li>if skin or whites of the eyes turn yellow (jaundice);&nbsp;it may be a symptom of liver disease<\/li><li>if your&nbsp;blood pressure&nbsp;rises sharply (symptoms may include headache, fatigue or dizziness)<\/li><li>if you are experiencing migraine-like headaches for the first time<\/li><li>if you become pregnant<\/li><li>if you get symptoms of a blood clot, such as<ul><li>painful swelling and redness of the legs<\/li><li>sudden chest pain<\/li><li>breathing difficulties.<\/li><\/ul><\/li><\/ul>\n\n\n\n<p>For more information, see below &#8220;Blood clots in a vein (&nbsp;thrombosis&nbsp;)&#8221;.<\/p>\n\n\n\n<p><strong>Note:<\/strong>&nbsp;Noresmea is not a contraceptive.&nbsp;If it is less than 12 months since your last period, or if you are under 50, you may still need to use contraception to avoid pregnancy.&nbsp;Consult your doctor.<\/p>\n\n\n\n<p><strong>HRT&nbsp;and cancer<\/strong><\/p>\n\n\n\n<p><strong>Severe thickening of the uterine lining (&nbsp;endometrial hyperplasia&nbsp;) and cancer of the uterine lining (endometrial cancer)<\/strong><\/p>\n\n\n\n<p>The use of\u00a0HRT\u00a0with\u00a0estrogen\u00a0alone increases the risk of severe thickening of the uterine lining and cancer of the uterine lining.<\/p>\n\n\n\n<p>The progestogen&nbsp;in Noresmea protects you against this extra risk.<\/p>\n\n\n\n<p><strong>Irregular&nbsp;DNA&nbsp;bleeding<\/strong><\/p>\n\n\n\n<p>Irregular spotting or spotting may occur during the first 3-6 months of taking Noresmea.<\/p>\n\n\n\n<p>But about the bleeding<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>lasts longer than 6 months<\/li><li>begins after taking Noresmea for 6 months<\/li><li>continues after you stop taking Noresmea<strong>you should see a doctor as soon as possible.<\/strong><\/li><\/ul>\n\n\n\n<p><strong>Breast cancer<\/strong><\/p>\n\n\n\n<p>Data show that hormone replacement therapy (\u00a0HRT\u00a0) with a combination of\u00a0estrogen-progestogen\u00a0or with\u00a0estrogen\u00a0alone increases the risk of breast cancer.\u00a0The increased risk depends on how long you use\u00a0HRT.\u00a0The increased risk is seen within 3 years.\u00a0When treatment is stopped, the increased risk decreases over time, but it can persist for 10 years or more if you have used\u00a0HRT\u00a0for more than 5 years.<\/p>\n\n\n\n<p><strong>Comparison<\/strong><\/p>\n\n\n\n<p>Of 1,000 women aged 50 to 54 who do not take\u00a0HRT, an average of 13 to 17 will be diagnosed with breast cancer over 5 years.<\/p>\n\n\n\n<p>In women who are 50 years old and start taking&nbsp;HRT&nbsp;with&nbsp;estrogen&nbsp;alone for 5 years, 16-17 cases per 1,000 users (ie 0-3 extra cases) will occur.<\/p>\n\n\n\n<p>In women who are 50 years old and start taking\u00a0HRT\u00a0with\u00a0estrogen-progestogen\u00a0for 5 years, 21 cases per 1,000 users (ie 4-8 extra cases) will occur.<\/p>\n\n\n\n<p>Among women aged 50\u201359 who do not use\u00a0HRT, an average of 27 out of 1,000 will be diagnosed with breast cancer over 10 years.<\/p>\n\n\n\n<p>In women who are 50 years old and start taking&nbsp;HRT&nbsp;with&nbsp;estrogen&nbsp;alone for 10 years, 34 cases per 1,000 users (ie 7 extra cases) will occur.<\/p>\n\n\n\n<p>In women who are 50 years old and start taking\u00a0HRT\u00a0with\u00a0estrogen-progestogen\u00a0for 10 years, 48 \u200b\u200bcases per 1,000 users (ie 21 extra cases) will occur.<\/p>\n\n\n\n<p><strong>Check your breasts regularly.&nbsp;Contact a doctor if you notice changes such as:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>indentations or pits<\/li><li>changes of the nipple<\/li><li>nodules you can see or feel.<\/li><\/ul>\n\n\n\n<p>It is also recommended that you participate in a mammography examination when you are called to do so.\u00a0At the mammogram, you must tell the nurse\/healthcare professional who performs the examination that you are using\u00a0HRT, as this medicine may increase the density of the breasts.\u00a0An increased density in the breasts can make it more difficult to detect lumps on the mammography images.<\/p>\n\n\n\n<p><strong>Ovarian cancer (&nbsp;ovarian cancer&nbsp;)<\/strong><\/p>\n\n\n\n<p>Ovarian cancer is rare &#8211; much more rare than breast cancer.\u00a0Use of\u00a0HRT\u00a0with\u00a0estrogen\u00a0alone or combined\u00a0estrogen\u00a0&#8211;\u00a0progestogens\u00a0has been associated with a slightly increased risk of ovarian cancer.<\/p>\n\n\n\n<p>The risk of ovarian cancer varies with age.\u00a0The diagnosis of ovarian cancer will, for example, be made on about 2 women out of 2,000 aged 50 to 54 who do not take\u00a0HRT\u00a0for 5 years.\u00a0For women who have taken\u00a0HRT\u00a0for 5 years, there will be about 3 cases per 2,000 users (ie about 1 extra case).<\/p>\n\n\n\n<p><strong>How&nbsp;HRT&nbsp;affects the heart and blood circulation<\/strong><\/p>\n\n\n\n<p><strong>Blood clots in a vein (&nbsp;thrombosis&nbsp;)<\/strong><\/p>\n\n\n\n<p>The risk of blood clots in the veins is 1.3\u20133 times higher for women who take&nbsp;HRT&nbsp;than for those who do not, especially during the first year of treatment.<\/p>\n\n\n\n<p>Blood clots can be serious.&nbsp;If a blood clot ends up in the lungs, it can cause chest pain, shortness of breath, collapse or even lead to death.<\/p>\n\n\n\n<p>You are more likely to get a blood clot in a vein if any of the following apply to you.&nbsp;Tell your doctor if any of the following apply to you:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>you have not been able to walk or stand for a long time due to a major operation, injury or illness (see also section 3, \u201cIf you need surgery\u201d)<\/li><li>you are severely overweight (&nbsp;BMI&nbsp;over 30 kg \/ m&nbsp;<sup>2<\/sup>&nbsp;)<\/li><li>you have a coagulation disorder that requires long-term treatment with drugs that prevent blood clots<\/li><li>if a close relative has had a blood clot in the bone, lung or other organ<\/li><li>you have&nbsp;SLE&nbsp;(systemic lupus erythematosus)<\/li><li>you have cancer.<\/li><\/ul>\n\n\n\n<p>The symptoms of a blood clot are described in the section &#8220;You should contact a doctor immediately and discontinue treatment with Noresmea if any of the following occur&#8221;.<\/p>\n\n\n\n<p><strong>Comparison<\/strong><\/p>\n\n\n\n<p>For women in their 50s who do not take\u00a0HRT, an average of 4\u20137 out of 1,000 are expected to have a blood clot in a vein over 5 years.<\/p>\n\n\n\n<p>For women in their 50s who have taken\u00a0HRT\u00a0with\u00a0estrogen-progestogen\u00a0for more than 5 years, 9-12 out of 1,000 users are expected to get a blood clot in a vein (ie 5 extra cases).<\/p>\n\n\n\n<p><strong>Heart disease (heart attack)<\/strong><\/p>\n\n\n\n<p>There is no evidence that&nbsp;HRT&nbsp;prevents heart attacks.<\/p>\n\n\n\n<p>For women over 60 who take\u00a0HRT\u00a0with\u00a0estrogen-progestin, the risk of developing heart disease is slightly higher than for those who do not take\u00a0HRT.<\/p>\n\n\n\n<p><strong>Stroke&nbsp;_<\/strong><\/p>\n\n\n\n<p>The risk of&nbsp;stroke&nbsp;is about 1.5 times higher for those who take&nbsp;HRT&nbsp;compared to those who do not.&nbsp;The risk of&nbsp;stroke&nbsp;is age-dependent, therefore the number of cases of&nbsp;stroke&nbsp;increases due to the use of&nbsp;HRT&nbsp;with increasing age.<\/p>\n\n\n\n<p><strong>Comparison<\/strong><\/p>\n\n\n\n<p>For women in their 50s who do not take\u00a0HRT, an average of 8 out of 1,000 people are expected to have a\u00a0stroke\u00a0over 5 years.\u00a0For women in their 50s who take\u00a0HRT, 11 out of 1,000 users are expected to have a\u00a0stroke\u00a0(ie 3 extra cases) over 5 years.<\/p>\n\n\n\n<p><strong>Other conditions<\/strong><\/p>\n\n\n\n<p>Using&nbsp;HRT&nbsp;does not prevent memory loss.&nbsp;The risk of memory loss may be slightly higher in women who start using&nbsp;HRT&nbsp;after the age of 65.&nbsp;Consult your doctor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Noresmea<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>Some medicines may affect the way Noresmea works, which may lead to irregular bleeding.&nbsp;The following applies:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>antiepileptic&nbsp;<strong>drugs<\/strong>&nbsp;(eg phenobarbital,&nbsp;phenytoin&nbsp;and carbamazepine)<\/li><li>drugs against&nbsp;<strong>tuberculosis<\/strong>&nbsp;(eg rifampicin and rifabutin)<\/li><li>medicines for&nbsp;<strong>HIV infection<\/strong>&nbsp;(eg nevirapine, efavirenz, ritonavir and nelfinavir)<\/li><li>herbal medicine containing&nbsp;<strong>St. John&#8217;s wort<\/strong>&nbsp;(&nbsp;<em>Hypericum perforatum<\/em>&nbsp;)<\/li><li>medicines for&nbsp;<strong>hepatitis&nbsp;C infections<\/strong>&nbsp;(eg telaprevir).<\/li><\/ul>\n\n\n\n<p>Other medicines may increase the effect of Noresmea:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>medicines containing&nbsp;<strong>ketoconazole&nbsp;<\/strong>(antifungal agents).<\/li><\/ul>\n\n\n\n<p>Noresmea may affect cyclosporine when used concomitantly.<\/p>\n\n\n\n<p><strong>Results from blood test analyze<\/strong><\/p>\n\n\n\n<p>If you need to take a blood sample, tell your doctor, or the person taking the blood sample, that you are taking Noresmea as it may affect the results of some tests.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Noresmea with food and drink<\/h2>\n\n\n\n<p>The tablets can be taken with or without food and drink.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Pregnancy<\/strong>Noresmea is for women whose menstruation has stopped.&nbsp;If you become pregnant, stop taking Noresmea and contact your doctor.<\/li><li><strong>Breast-feeding<\/strong>You should not use Noresmea if you are breast-feeding.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Noresmea has no known influence on the ability to drive or use machines.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0Descriptions of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Noresmea contains lactose<\/h2>\n\n\n\n<p>If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Noresmea<\/h2>\n\n\n\n<p>Always take this medicine exactly as your doctor has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p><strong>Take one tablet daily at about the same time&nbsp;<\/strong><strong>without pausing between tablets<\/strong>&nbsp;<\/p>\n\n\n\n<p>When you start taking Noresmea, take the first tablet where the day of the week is indicated on the tablet map.&nbsp;Then follow the direction of the arrows from the first tablet and take one tablet every day, until the tablet map is finished.&nbsp;When you have taken all 28 tablets in&nbsp;calendar pack&nbsp;one, you continue immediately without interruption with the next pack.<\/p>\n\n\n\n<p><strong>You can start treatment with Noresmea<\/strong>&nbsp;on any day.&nbsp;However, if you switch from an&nbsp;HRT&nbsp;preparation when you have your monthly bleeding, you should start treatment immediately after the bleeding has stopped.<\/p>\n\n\n\n<p>Your doctor should strive for you to take the lowest&nbsp;dose&nbsp;that gives you symptom relief and that you should use Noresmea for the shortest possible time.&nbsp;Talk to your doctor if you do not get any relief from the symptoms, or feel that the&nbsp;dose&nbsp;is too high.<\/p>\n\n\n\n<p><strong>If you need surgery<\/strong><\/p>\n\n\n\n<p>If you are having surgery, tell your surgeon that you are taking Noresmea.&nbsp;You may need to stop taking Noresmea for 4 to 6 weeks before surgery to avoid the risk of blood clots (see section 2, \u201cBlood clots in a vein (&nbsp;thrombosis&nbsp;)&nbsp;<strong>\u201d<\/strong>&nbsp;).&nbsp;Ask your doctor when it is appropriate to start taking Noresmea again.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you take more Noresmea than you should<\/h2>\n\n\n\n<p>If you have ingested too much medicine or if, for example, a child has accidentally ingested the medicine, contact a doctor or hospital for risk assessment and advice.\u00a0Overdose of Noresmea may cause nausea and vomiting.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Noresmea<\/h2>\n\n\n\n<p>If you forget to take your tablet, you should take it within 12 hours from the usual time.\u00a0If more than 12 hours have passed, skip this\u00a0dose\u00a0and take the next tablet, as usual, the next day.\u00a0Do not take a double\u00a0dose\u00a0to make up for a forgotten tablet.<br><br>Missing a\u00a0dose\u00a0can increase the likelihood of breakthrough bleeding and spotting if you still have your uterus.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking Noresmea<\/h2>\n\n\n\n<p>If you want to stop taking Noresmea, you should first discuss this with your doctor.&nbsp;The doctor will explain what it means to stop taking the tablets and inform about other alternatives.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Hypersensitivity\/allergy<\/strong>\u00a0(uncommon: may affect up to 1 in 100 people)<\/p>\n\n\n\n<p>Although less common, hypersensitivity\/allergy may occur and include one or more of the following symptoms:\u00a0hives,\u00a0itching, swelling, difficulty breathing, low\u00a0blood pressure\u00a0(pale cold skin, palpitations), dizziness, sweating.\u00a0These may be signs of a so-called anaphylactic reaction\/shock.\u00a0If you get any of the listed symptoms,\u00a0<strong>stop taking Noresmea immediately and seek medical advice immediately.<\/strong><\/p>\n\n\n\n<p>See section 2, \u201cWhat you need to know before you take Noresmea\u201d, for more information on these\u00a0side effects.<\/p>\n\n\n\n<p>The following diseases are more common in women who take&nbsp;HRT&nbsp;than in those who do not:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>breast cancer<\/li><li>severe thickening of the uterine lining (&nbsp;endometrial hyperplasia&nbsp;) or cancer of the uterine lining (endometrial cancer)<\/li><li>ovarian cancer (&nbsp;ovarian cancer&nbsp;)<\/li><li>blood clots in veins in bones or lungs (venous&nbsp;thromboembolism&nbsp;)<\/li><li>heart disease<\/li><li>stroke&nbsp;_<\/li><li>probable memory loss, if treatment with&nbsp;HRT&nbsp;is started after the age of 65.See section 2 for more information on these&nbsp;side effects&nbsp;.<\/li><\/ul>\n\n\n\n<p>The following&nbsp;side effects&nbsp;have been observed during treatment with the active substances in Noresmea:<\/p>\n\n\n\n<p><strong>Very common:<\/strong>&nbsp;may affect more than 1 user in 10<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>chest pain or tenderness in the breasts<\/li><li>vaginal bleeding.<\/li><\/ul>\n\n\n\n<p><strong>Common:<\/strong>&nbsp;may affect up to 1 in 10 users<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>fungal infection of the vagina<\/li><li>inflammation&nbsp;of the vagina<\/li><li>weight gain due to accumulation of fluid in the body<\/li><li>depression or worsening of current depression<\/li><li>headache<\/li><li>migraine&nbsp;or worsening of current&nbsp;migraine<\/li><li>nausea<\/li><li>back pain<\/li><li>breast enlargement or tightness in the breasts (breast edema)<\/li><li>uterine fibroid (benign&nbsp;tumor&nbsp;), worsening or recurrence of&nbsp;tumor<\/li><li>swollen arms and legs (peripheral&nbsp;edema&nbsp;)<\/li><li>weight gain.<\/li><\/ul>\n\n\n\n<p><strong>Uncommon:<\/strong>&nbsp;may affect up to 1 in 100 people<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>allergic reaction<\/li><li>nervousness<\/li><li>superficial venous inflammation (superficial&nbsp;thrombophlebitis&nbsp;)<\/li><li>abdominal pain, tension or discomfort in the stomach, flatulence<\/li><li>hair loss, increased hair growth on body and face, acne<\/li><li>itching<\/li><li>hives (&nbsp;urticaria&nbsp;)<\/li><li>no effect<\/li><li>leg cramps.<\/li><\/ul>\n\n\n\n<p><strong>Rare:<\/strong>&nbsp;may affect up to 1 in 1,000 users<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>blood clots in the blood vessels of the legs or lungs (deep&nbsp;vein thrombosis&nbsp;,&nbsp;pulmonary embolism&nbsp;).<\/li><\/ul>\n\n\n\n<p><strong>Very rare:<\/strong>&nbsp;may affect up to 1 in 10,000 people<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>cancer of the uterine lining (endometrial cancer), severe thickening of the uterine lining (&nbsp;endometrial hyperplasia&nbsp;)<\/li><li>insomnia<\/li><li>anxiety<\/li><li>altered sex drive<\/li><li>dizziness<\/li><li>visual disturbances<\/li><li>increased&nbsp;blood pressure&nbsp;or worsening of high&nbsp;blood pressure<\/li><li>heart attack and&nbsp;stroke<\/li><li>heartburn<\/li><li>vomiting<\/li><li>gallbladder disease<\/li><li>gallstones&nbsp;, deterioration or new occurrence of&nbsp;gallstones<\/li><li>strong secretion of sebum<\/li><li>rash<\/li><li>acute&nbsp;or recurrent&nbsp;edema&nbsp;(&nbsp;angioneurotic edema&nbsp;)<\/li><li>itching&nbsp;in the abdomen<\/li><li>weight loss.<\/li><\/ul>\n\n\n\n<p>The following\u00a0side effects\u00a0have been reported for other\u00a0HRT\u00a0with\u00a0estrogen-progestogen:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>gallbladder disease<\/li><li>various skin diseases:<ul><li>dark skin spots, especially on the face and neck, so-called &#8220;pregnancy spots&#8221; (chloasma)<\/li><li>painful reddish-purple bumps on the skin (erythema nodosum)<\/li><li>annular redness or sore rash (erythema multiforme)<\/li><li>red or purple discolorations on the skin and \/ or mucous membranes (&nbsp;vascular&nbsp;purpura).<\/li><\/ul><\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Noresmea<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the blister and carton after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Do not store above 25 \u00b0 C.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substances are: estradiol 1 mg (as estradiol hemihydrate) and norethisterone acetate 0.5 mg.<\/li><li>The other ingredients are:&nbsp;lactose monohydrate&nbsp;, corn starch, copovidone, talc and magnesium stearate.<\/li><li>The film coating contains: hypromellose, hydroxypropylcellulose, talc, hydrogenated cottonseed oil and titanium dioxide.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<p>Noresmea film-coated tablets are white, round, and biconvex with a diameter of 6 mm.<\/p>\n\n\n\n<p>The tablets are packaged in transparent blister packs of PVC \/ aluminum.<\/p>\n\n\n\n<p>Pack sizes:<\/p>\n\n\n\n<p>1&#215;28 and 3&#215;28 (84) film-coated tablets in\u00a0calendar pack.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>Sandoz A \/ S, Edvard Thomsens Vej 14, 2300 Copenhagen S, Denmark<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Salutas Pharma GmbH, Otto-von-Guericke-Allee 1, 39179 Barleben, German<\/p>\n","protected":false},"excerpt":{"rendered":"<p>1 mg \/ 0.5 mg film-coated tablets<br \/>\nestradiol \/ norethisterone acetate<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,15581],"tags":[3093,3096,10344,19187,19191,19190,3576,19194,5414,19188,19192,19189],"class_list":["post-19160","post","type-post","status-publish","format-standard","hentry","category-medicines","category-n","tag-estradiol","tag-estradiol-side-effects","tag-estradiol-tablet","tag-noresmea","tag-noresmea-side-effects","tag-noresmea-tablet","tag-norethisterone-acetate","tag-norethisterone-acetate-tablet","tag-what-is-estradiol","tag-what-is-noresmea","tag-what-is-norethisterone-acetate","tag-what-noresmea-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/19160","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=19160"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/19160\/revisions"}],"predecessor-version":[{"id":19219,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/19160\/revisions\/19219"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=19160"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=19160"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=19160"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}