{"id":19108,"date":"2022-03-03T07:37:06","date_gmt":"2022-03-03T07:37:06","guid":{"rendered":"https:\/\/zeepedia.com\/?p=19108"},"modified":"2022-03-03T11:04:14","modified_gmt":"2022-03-03T11:04:14","slug":"nocutil","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/nocutil\/","title":{"rendered":"Nocutil &#8211; Desmopressin acetate uses, dose and side effects"},"content":{"rendered":"\n<p>0.1 mg and 0.2 mg&nbsp;tablets<br>Desmopressin acetate<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Nocutil is and what it is used for<\/h2>\n\n\n\n<p>Nocutil contains desmopressin acetate which is an antidiuretic that makes you produce less urine.<\/p>\n\n\n\n<p><strong>Nocutil is used to treat<\/strong>&nbsp;:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>bedwetting in children over five years after organic causes have been ruled out and other treatments have failed<\/li><li>diabetes insipidus&nbsp;(a disease in which you produce a large amount of urine and become very thirsty, because the brain does not produce enough of the antidiuretic&nbsp;hormone&nbsp;that reduces the amount of water in the urine).&nbsp;Note!&nbsp;Diabetes insipidus&nbsp;is not the same as&nbsp;diabetes mellitus&nbsp;(diabetes)<\/li><li>nocturnal urination in adults.<\/li><\/ul>\n\n\n\n<p>Desmopressin contained in Nocutil may also be approved for the treatment of other conditions not mentioned in this product information.\u00a0Ask your doctor, pharmacist, or other healthcare professionals if you have any further questions and always follow their instructions<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you take Nocutil<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Nocutil<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to desmopressin or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you have any neurological disease or dementia.<\/li><li>if you drink unusually large amounts of water or other liquids (including alcohol) during the day or night.<\/li><li>if you have a heart disease or other condition that requires treatment with diuretics.<\/li><li>if you have low sodium in your blood.<\/li><li>if you have&nbsp;kidney failure&nbsp;.<\/li><li>if you have a syndrome that causes the body to produce the wrong amount of the antidiuretic&nbsp;hormone&nbsp;(SIADH).<\/li><li>if the patient is under five years of age.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>Fluid intake\u00a0<br>Before starting treatment with Nocutil, your doctor will talk to you about fluid intake.\u00a0If you are being treated with Nocutil for bedwetting or nightmares, limit the amount you drink during the period 1 hour before to 8 hours after taking the tablets.<br>Avoid unnecessary fluid intake during treatment with Nocutil and do not swallow water while swimming (especially for children).\u00a0Excessive fluid intake can lead to the\u00a0accumulation\u00a0of water which dilutes the salt in the body (\u00a0electrolytes\u00a0).\u00a0This can happen with or without warning symptoms that include: unusually severe or prolonged headache, nausea or vomiting, unexplained weight gain, and in severe cases seizures, swelling of the brain (cerebral\u00a0edema\u00a0), or\u00a0coma. If you (or your child) have any of these symptoms, stop treatment immediately and contact a doctor.<br>In addition, you should stop taking Nocutil if you have a fever, an\u00a0infection, diarrhea, and\/or vomiting until you get better. This is especially important for very young and older patients.<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p>Before you start taking this medicine, you must tell your doctor if you have:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>cystic fibrosis&nbsp;(a disease in which you are more likely to suffer from lung infections and your body can not absorb fat and other nutrients)<\/li><li>heart disease<\/li><li>high&nbsp;blood pressure<\/li><li>chronic&nbsp;kidney disease or<\/li><li>preeclampsia&nbsp;(high&nbsp;blood pressure&nbsp;caused by pregnancy).<\/li><\/ul>\n\n\n\n<p>You must adhere to a&nbsp;dose&nbsp;that your doctor has prescribed for you and you should not take certain other medicines at the same time (see section \u201cOther medicines and Nocutil\u201d).&nbsp;This way you reduce the risk of seizures.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Nocutil<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.\u00a0<\/p>\n\n\n\n<p>The following drugs may potentiate the effect of desmopressin:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>indomethacin and possibly other non-steroidal anti-inflammatory drugs (&nbsp;NSAIDs&nbsp;)<\/li><li>oxytocin&nbsp;(stimulates pain)<\/li><li>carbamazepine (for&nbsp;epilepsy&nbsp;)<\/li><li>tricyclic antidepressants&nbsp;and selective serotonin reuptake inhibitors (for depression)<\/li><li>chlorpromazine (for&nbsp;psychosis&nbsp;)<\/li><li>loperamide (for diarrhea)<\/li><\/ul>\n\n\n\n<p>Concomitant use of the following drugs may reduce the effect of desmopressin:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>lithium (for depression)<\/li><li>glibenclamide (for&nbsp;diabetes&nbsp;)<\/li><\/ul>\n\n\n\n<p>If you are taking any medicine for heart problems while taking desmopressin, your doctor should check your\u00a0blood pressure,\u00a0plasma\u00a0sodium,\u00a0and urine levels.<\/p>\n\n\n\n<p>This may also apply to medicines you have taken before.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Nocutil with food and drink<\/h2>\n\n\n\n<p>Do not drink large amounts of water or other liquids.&nbsp;Ask your doctor for advice on your consumption of water and other fluids.&nbsp;Food can reduce your uptake of the drug.&nbsp;Therefore, do not take Nocutil with food.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n<p>Desmopressin can be excreted in human milk in very small amounts.&nbsp;There is no evidence that the child is affected.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Desmopressin is unlikely to affect your ability to drive or use machines.&nbsp;However, some&nbsp;side effects&nbsp;(eg dizziness and headache, see section 4 \u201cPossible side effects\u201d) may affect your ability to concentrate and speed of reaction.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0Descriptions of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Nocutil contains lactose<\/h2>\n\n\n\n<p>If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Nocutil<\/h2>\n\n\n\n<p>Always take this medicine exactly as your doctor has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p>Dose&nbsp;one is determined by the doctor, who adjusts it individually for you.<\/p>\n\n\n\n<p>Desmopressin should always be taken at the same time as food intake, as food reduces\u00a0absorption\u00a0(see &#8220;Taking Nocutil with food and drink&#8221;).<\/p>\n\n\n\n<p>Read the fluid intake information (see &#8220;Warnings and Precautions&#8221;).<\/p>\n\n\n\n<p>The tablets can be divided into two halves to make them easier to swallow.\u00a0Your doctor will decide how long you should take Nocutil.<\/p>\n\n\n\n<p><em>Bedwetting (involuntary nocturnal bladder emptying, nocturnal&nbsp;enuresis&nbsp;) (over 5 years):<\/em><\/p>\n\n\n\n<p>A suitable starting dose is 0.2 mg at bedtime (2 Nocutil tablets of 0.1 mg or 1 Nocutil tablet of 0.2 mg).&nbsp;Your doctor may increase the&nbsp;dose&nbsp;by one up to 0.4 mg (4 Nocutil tablets of 0.1 mg or 2 Nocutil tablets of 0.2 mg) if the lower&nbsp;dose&nbsp;is not effective enough.<\/p>\n\n\n\n<p>The doctor checks the need for continued treatment no later than after three months of treatment by interrupting the treatment for at least one week.<\/p>\n\n\n\n<p><em>Diabetes&nbsp;insipidus:<\/em><\/p>\n\n\n\n<p>The appropriate starting dose for children and adults is 0.1 mg three times daily.&nbsp;Dosage&nbsp;one is then adjusted according to your answer.&nbsp;Clinical experience has shown that the daily dose varies between 0.2 and 1.2 mg.&nbsp;For most patients, the maintenance dose is 0.1\u20130.2 mg three times daily. &nbsp;<\/p>\n\n\n\n<p><em>Frequent bladder discharge during the night (nocturia):<\/em><\/p>\n\n\n\n<p>The recommended starting dose is 0.1 mg at bedtime.&nbsp;If this&nbsp;dose&nbsp;is not effective enough after one week, your doctor may increase it weekly to 0.2 mg and then to 0.4 mg.&nbsp;Limited fluid intake should be observed.<\/p>\n\n\n\n<p>If sufficient clinical effect is not achieved within 4 weeks, with a weekly dose increase, treatment should be discontinued.\u00a0The duration of treatment should not exceed 12 months and the doctor regularly checks the need for further treatment.<\/p>\n\n\n\n<p>The treatment of elderly patients must be monitored frequently due to the higher risk of&nbsp;hyponatremia&nbsp;(low blood sodium).&nbsp;If you belong to this patient group, your&nbsp;serum&nbsp;sodium value should be determined before starting treatment and also after 3 days of treatment and after each dose increase.&nbsp;Serum sodium should also be determined after 2 and 4 months of treatment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you take more Nocutil than you should<\/h2>\n\n\n\n<p>If you happen to take an\u00a0overdose, stop taking the medicine and talk to your doctor immediately.<\/p>\n\n\n\n<p>Overdose can lead to too much water in the body and cause symptoms such as increased\u00a0blood pressure, higher\u00a0heart rate, flushing, headache, nausea, and stomach cramps (see also section 4 \u201cPossible side effects\u201d).<\/p>\n\n\n\n<p>All cases of suspected swelling of the brain (seizures,&nbsp;coma&nbsp;) require immediate intensive care.<\/p>\n\n\n\n<p>If you have ingested too much medicine or if, for example, a child has accidentally ingested the medicine, contact a doctor or hospital for risk assessment and advice.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Nocutil:<\/h2>\n\n\n\n<p>If you miss a\u00a0dose, simply take the next\u00a0dose\u00a0as usual.<\/p>\n\n\n\n<p>Do not take a double\u00a0dose\u00a0to make up for a forgotten\u00a0dose.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p>Side effects&nbsp;are listed in the following categories:<\/p>\n\n\n\n<p>Very common: occurs in more than one in 10 patients taking the medicine.<\/p>\n\n\n\n<p>Common: occurs in more than one in 100 patients (but in less than one in 10).<\/p>\n\n\n\n<p>Uncommon: occurs in more than one in 1,000 patients (but in less than one in 100).<\/p>\n\n\n\n<p>Rare: occurs in less than one in 1,000 patients.<\/p>\n\n\n\n<p>Very rare: affects less than one in 10,000 patients.<\/p>\n\n\n\n<p>If you notice any of the following&nbsp;<strong>very rare<\/strong>&nbsp;reactions, contact your doctor immediately before taking another&nbsp;dose&nbsp;:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Signs of water poisoning or low sodium in the blood (severe headache, nausea, severe seizures and&nbsp;coma&nbsp;).&nbsp;This&nbsp;side effect&nbsp;is&nbsp;<strong>more common<\/strong>&nbsp;at the beginning of nocturia treatment and during dose adjustment.<\/li><li>Common allergic reactions including skin rash (red spots,&nbsp;hives&nbsp;,&nbsp;itching&nbsp;), feeling of tightness in the chest, swelling of the eyelids, face or lips (sometimes with difficulty breathing or swallowing).<\/li><\/ul>\n\n\n\n<p>Other possible&nbsp;side effects&nbsp;are:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>Common:<\/strong>&nbsp;Stomach pain, nausea, vomiting<\/li><li><strong>Common:<\/strong>&nbsp;Headache (very common after dose adjustment during treatment for nocturia)<\/li><li><strong>Very rare:<\/strong>&nbsp;Emotional disorders in children<\/li><\/ul>\n\n\n\n<p>When treating nocturia also:<\/p>\n\n\n\n<p><strong>Common<\/strong>: Swelling of the arms and legs, nausea, weight gain,\u00a0dry mouth, increased frequency of urination.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Nocutil<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not store above 25 \u00b0 C.<\/p>\n\n\n\n<p>Store in the original package.<\/p>\n\n\n\n<p>Close the package tightly.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton and plastic container after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is desmopressin acetate.&nbsp;Each tablet contains 0.1 mg or 0.2 mg desmopressin acetate corresponding to 0.089 mg and 0.1780 mg desmopressin respectively.<br><\/li><li>The other ingredients are 60 mg&nbsp;lactose monohydrate&nbsp;, potato starch, povidone, magnesium stearate and anhydrous&nbsp;colloidal&nbsp;silica.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack:<\/h2>\n\n\n\n<p>Nocutil is uncoated, white, round, and convex.\u00a0Using a notch on one side, the tablet can be divided into two parts that are easier to swallow.<\/p>\n\n\n\n<p>Each jar contains 15, 28, 30, 60, 90 or 100 tablets.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p>Gebro Pharma GmbH<\/p>\n\n\n\n<p>6391 Fieberbrunn<\/p>\n\n\n\n<p>Austria<\/p>\n\n\n\n<p><strong>Information provided by:<\/strong><\/p>\n\n\n\n<p>medac<\/p>\n\n\n\n<p>Box 120<\/p>\n\n\n\n<p>432 23 Varberg<\/p>\n\n\n\n<p>Tel: 0340-645470<\/p>\n\n\n\n<p>Fax: 0340-645479<\/p>\n\n\n\n<p><strong>This medicinal product is authorized under the European Economic Area under the names:<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td>Austria:<\/td><td>Nocutil 0.1 mg &#8211; The tabletsNocutil 0.2 mg &#8211; The tablets<\/td><\/tr><tr><td>Denmark:<\/td><td>Nocutil 0.1 mg tabletsNocutil 0.2 mg tablets<\/td><\/tr><tr><td>Sweden:<\/td><td>Nocutil 0.1 mg tabletsNocutil 0.2 mg tablets<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Nocutil contains desmopressin acetate which is an antidiuretic that makes you produce less urine.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,15581],"tags":[19065,13703,19055,19059,19058,19060,19064,19063,19057,19056,19061,19062],"class_list":["post-19108","post","type-post","status-publish","format-standard","hentry","category-medicines","category-n","tag-benefits-of-nocutil","tag-benefits-of-v","tag-desmopressin-acetate","tag-desmopressin-acetate-side-effects","tag-desmopressin-acetate-tablet","tag-nocutil","tag-nocutil-side-effects","tag-nocutil-tablet","tag-what-desmopressin-acetate-is-used-for","tag-what-is-desmopressin-acetate","tag-what-is-nocutil","tag-what-nocutil-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/19108","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=19108"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/19108\/revisions"}],"predecessor-version":[{"id":19154,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/19108\/revisions\/19154"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=19108"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=19108"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=19108"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}