{"id":19037,"date":"2022-03-01T16:29:30","date_gmt":"2022-03-01T16:29:30","guid":{"rendered":"https:\/\/zeepedia.com\/?p=19037"},"modified":"2022-03-02T14:24:46","modified_gmt":"2022-03-02T14:24:46","slug":"nimvastid","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/nimvastid\/","title":{"rendered":"Nimvastid &#8211; Rivastigmine uses, dose and side effects"},"content":{"rendered":"\n<p>1.5 mg, 3 mg, 4.5 mg, 6 mg&nbsp;hard capsules<br>rivastigmine<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Nimvastid is and what it is used for<\/h2>\n\n\n\n<p>The active substance in Nimvastide is rivastigmine.<\/p>\n\n\n\n<p>Rivastigmine belongs to a group of substances called cholinesterase inhibitors.\u00a0In patients with\u00a0Alzheimer&#8217;s dementia\u00a0or dementia caused by\u00a0Parkinson&#8217;s disease, certain nerve cells in the brain die.\u00a0This leads to low levels of the neurotransmitter\u00a0acetylcholine\u00a0(a substance that allows nerve cells to communicate with each other).\u00a0Rivastigmine works by blocking the\u00a0enzymes\u00a0that break down\u00a0acetylcholine\u00a0(\u00a0acetylcholinesterase\u00a0and butyrylcholinesterase).\u00a0By blocking these\u00a0enzymes, Nimvastid increases acetylcholine levels in the brain, thus helping to reduce the symptoms of\u00a0Alzheimer&#8217;s disease\u00a0and dementia caused by\u00a0Parkinson&#8217;s disease.<\/p>\n\n\n\n<p>Nimvastid is used to treat adult patients with mild to moderate\u00a0Alzheimer&#8217;s dementia, a progressive brain disease that gradually affects memory, intellectual ability, and behavior.\u00a0The capsules and\u00a0orodispersible\u00a0tablets can also be used to treat dementia in adult patients with\u00a0Parkinson&#8217;s disease.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using Nimvastid<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Nimvastid<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to rivastigmine or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you get a skin reaction that spreads beyond the size of the patch, if a more intense local reaction occurs (eg blisters, increasing skin inflammation, swelling) and if it does not improve within 48 hours after removal of the transdermal patch.<\/li><\/ul>\n\n\n\n<p>If this applies to you, talk to your doctor and do not take Nimvastid.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to a doctor before taking Nimvastid:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have, or have ever had, irregular or slow heartbeat.<\/li><li>if you have, or have ever had, an active&nbsp;stomach ulcer&nbsp;.<\/li><li>if you have, or have ever had, difficulty urinating.<\/li><li>if you have, or have ever had, seizures.<\/li><li>if you have, or have ever had,&nbsp;asthma&nbsp;or severe respiratory problems.<\/li><li>if you have, or have ever had, impaired kidney function.<\/li><li>if you have, or have ever had, impaired liver function.<\/li><li>if you suffer from tremors.<\/li><li>if you have low body weight.<\/li><li>if you get reactions from the stomach or intestines such as.&nbsp;nausea, vomiting and diarrhea.&nbsp;You may become dehydrated (lose too much fluid) if vomiting or diarrhea persists for a long time.<\/li><\/ul>\n\n\n\n<p>If any of the above applies to you, your doctor may need to check you more closely when you are being treated with this medicine.<\/p>\n\n\n\n<p>If you have not taken Nimvastid for more than three days, do not take the next&nbsp;dose&nbsp;until you have talked to your doctor.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>There is no relevant use of Nimvastid for a\u00a0pediatric\u00a0population in the treatment of\u00a0Alzheimer&#8217;s disease.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Nimvastid<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>Nimvastid should not be given at the same time as other medicines that have a similar effect to Nimvastid.\u00a0Nimvastid can affect other anticholinergic medicines (medicines for stomach cramps or seizures, medicines to treat\u00a0Parkinson&#8217;s disease,\u00a0or medicines to prevent motion sickness).<\/p>\n\n\n\n<p>Nimvastid should not be given concomitantly with metoclopramide (a medicine used to relieve or prevent nausea or vomiting).&nbsp;Taking both medicines at the same time can cause problems such as&nbsp;stiff joints or tremors in the hands.<\/p>\n\n\n\n<p>If you are going to have surgery, tell your doctor that you are taking Nimvastid before you are given anesthesia or anesthesia, as Nimvastid may increase the effects of certain muscle relaxants during anesthesia.<\/p>\n\n\n\n<p>Caution should be exercised when taking Nimvastide concomitantly with beta-blockers\u00a0(medicines such as atenolol for high\u00a0blood pressure, angina, and other heart conditions).\u00a0Taking both medicines at the same time can cause problems such as\u00a0a slower heartbeat (\u00a0bradycardia\u00a0), which can lead to fainting or unconsciousness.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n<p>If you are pregnant, the benefits of using Nimvastid must be weighed against the possible effects on your unborn baby.\u00a0Nimvastid should not be used during pregnancy unless necessary.<\/p>\n\n\n\n<p>You should not breastfeed while you are being treated with Nimvastid.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Your doctor will tell you if you can drive and use machines safely when you have this disease.&nbsp;Nimvastid may cause dizziness and drowsiness, especially at the beginning of treatment or when the&nbsp;dose&nbsp;is increased.&nbsp;If you feel dizzy or sleepy, do not drive, use machines or perform any other tasks that require your attention.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Nimvastid<\/h2>\n\n\n\n<p>Always use this medicine exactly as your doctor has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p><strong>How to start the treatment<\/strong><\/p>\n\n\n\n<p>Your doctor will tell you which&nbsp;dose&nbsp;of Nimvastid to take.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Treatment is usually started with a low&nbsp;dose&nbsp;.<\/li><li>Your doctor will gradually increase the&nbsp;dose&nbsp;depending on the effect you get from the treatment.<\/li><li>The maximum&nbsp;dose&nbsp;is 6.0 mg twice daily.<\/li><\/ul>\n\n\n\n<p>Your doctor will regularly evaluate whether the treatment has the desired effect.&nbsp;Your doctor will also check your weight during treatment with this medicine.<\/p>\n\n\n\n<p>If you have not taken Nimvastid for more than three days, do not take the next&nbsp;dose&nbsp;until you have talked to your doctor.<\/p>\n\n\n\n<p><strong>How to take the medicine<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Tell your healthcare provider that you are taking Nimvastid.<\/li><li>For the medicine to be useful, take it every day.<\/li><li>Take Nimvastid twice a day, once in the morning and once in the evening, with food.<\/li><li>Swallow the capsules whole along with the liquid.<\/li><li>Do not open or crush the capsules.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">If you use more Nimvastid than you should&nbsp;<\/h2>\n\n\n\n<p>If you have accidentally taken more Nimvastid than you should, tell your doctor.\u00a0You may need medical help.\u00a0Some patients who have accidentally taken too much Nimvastid have developed nausea and vomiting, diarrhea, high\u00a0blood pressure,\u00a0and hallucinations.\u00a0Slow heartbeat and fainting may also occur.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to use Nimvastid<\/h2>\n\n\n\n<p>If you forget to take a\u00a0dose\u00a0of Nimvastid, wait until the next dose and then take the next\u00a0dose\u00a0at the usual time.\u00a0Do not take a double\u00a0dose\u00a0to make up for a forgotten\u00a0dose.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p>You will likely experience some\u00a0side effects, especially when you start treatment or when your\u00a0dose\u00a0is increased.\u00a0Usually, the\u00a0side effects\u00a0gradually disappear when the body gets used to the drug.<\/p>\n\n\n\n<p><strong><em>Very common (may affect more than 1 user in 10)<\/em><\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Dizziness<\/li><li>Decreased appetite<\/li><li>Problems with the stomach such as&nbsp;nausea, vomiting and diarrhea<\/li><\/ul>\n\n\n\n<p><strong><em>Common (may affect up to 1 in 10 people<\/em><\/strong>&nbsp;)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Concern<\/li><li>Sweating<\/li><li>Headache<\/li><li>Heartburn<\/li><li>Weight loss<\/li><li>Magont<\/li><li>Feeling of agitation<\/li><li>Feeling of tiredness or weakness<\/li><li>General malaise<\/li><li>Trembling or feeling of confusion<\/li><li>Decreased appetite<\/li><li>Nightmares<\/li><\/ul>\n\n\n\n<p><strong><em>Uncommon (may affect up to 1 in 100 people)<\/em><\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Depression<\/li><li>Difficulty sleeping<\/li><li>Fainting and falling unintentionally<\/li><li>Elevated liver values<\/li><\/ul>\n\n\n\n<p><strong><em>Rare (may affect up to 1 in 1,000 people)<\/em><\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Pain in the chest<\/li><li>Skin rash,&nbsp;itching<\/li><li>Cramps (seizures)<\/li><li>Stomach or intestinal ulcers<\/li><\/ul>\n\n\n\n<p><strong><em>Very rare (may affect up to 1 in 10,000 people)<\/em><\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>High&nbsp;blood pressure<\/li><li>Urinary tract infection<\/li><li>Seeing things that are not real (hallucinations)<\/li><li>Cardiac arrhythmias (both fast and slow heart rate)<\/li><li>Gastrointestinal bleeding (manifests as blood in the stool or on vomiting)<\/li><li>Inflammation&nbsp;of the pancreas (signs of it include severe pain in the upper abdomen, usually with nausea and vomiting)<\/li><li>Deterioration of the symptoms of&nbsp;Parkinson&#8217;s disease&nbsp;or the onset of similar symptoms &#8211; such as&nbsp;stiffness in the muscles, difficulty moving<\/li><\/ul>\n\n\n\n<p><strong><em>No known frequency (frequency can not be calculated from available data)<\/em><\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Severe vomiting that can lead to ruptures of the esophagus<\/li><li>Dehydration (fluid loss)<\/li><li>Disorders of liver function (yellowing of the skin, yellowing of the whites of the eyes, abnormal dark urine or unexplained nausea, unexplained vomiting, tiredness and loss of appetite)<\/li><li>Aggressiveness, feeling of restlessness<\/li><li>Irregular heartbeat<\/li><\/ul>\n\n\n\n<p><strong>Patients with dementia with&nbsp;Parkinson&#8217;s disease<\/strong><\/p>\n\n\n\n<p>These patients more often experience certain\u00a0side effects.\u00a0They also get some additional side effects:<\/p>\n\n\n\n<p><strong><em>Very common (may affect more than 1 user in 10)<\/em><\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Trembling<\/li><li>Fainting<\/li><li>Stumble unintentionally<\/li><\/ul>\n\n\n\n<p><strong><em>Common (may affect up to 1 in 10 people)<\/em><\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Concern<\/li><li>Restlessness<\/li><li>Slow and fast heartbeat<\/li><li>Difficulty sleeping<\/li><li>Too much saliva and dehydration<\/li><li>Abnormally slow or uncontrolled movements<\/li><li>Deterioration of the symptoms of&nbsp;Parkinson&#8217;s disease&nbsp;or the onset of similar symptoms &#8211; such as&nbsp;muscle stiffness, difficulty moving and muscle weakness<\/li><\/ul>\n\n\n\n<p><strong><em>Uncommon (may affect up to 1 in 100 people)<\/em><\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Irregular heartbeat and poor control of movements<\/li><\/ul>\n\n\n\n<p><strong>Additional&nbsp;side effects&nbsp;that have been seen with rivastigmine transdermal patches and that may occur with the capsules:<\/strong><\/p>\n\n\n\n<p><strong><em>Common (may affect up to 1 in 10 people)<\/em><\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Fever<\/li><li>Severe confusion<\/li><li>Urinary incontinence (inability to retain urine)<\/li><\/ul>\n\n\n\n<p><strong><em>Uncommon (may affect up to 1 in 100 people)<\/em><\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Hyperactivity (high activity, restlessness)<\/li><\/ul>\n\n\n\n<p><strong><em>No known frequency (frequency can not be calculated from available data)<\/em><\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Allergic reaction&nbsp;where the patch has been applied, such as&nbsp;blisters or inflammation of the skin<\/li><\/ul>\n\n\n\n<p>If you get any of these\u00a0side effects, talk to your doctor as you may need medical attention.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Nimvastid<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>No special warning instructions.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the package and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is rivastigmine hydrogen tartrate salt.Each Nimvastide capsule contains rivastigmine hydrogen tartrate&nbsp;equivalent&nbsp;to 1.5 mg, 3 mg, 4.5 mg or 6 mg rivastigmine.<\/li><li>The other ingredients of Nimvastide 1.5 mg are: Capsule content: microcrystalline cellulose, hypromellose,&nbsp;colloidal&nbsp;silica , anhydrous, magnesium stearate.&nbsp;Capsule shell: titanium dioxide (E171), yellow iron oxide (E172) and gelatin.<\/li><li>The other ingredients of Nimvastide 3 mg, 4.5 mg and 6 mg are: Capsule content: microcrystalline cellulose, hypromellose,&nbsp;colloidal&nbsp;silica , anhydrous, magnesium stearate.&nbsp;Capsule shell: titanium dioxide (E171), yellow iron oxide (E172), red iron oxide (E172) and gelatin.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<p>Nimvastid 1.5 mg hard capsules contain white to off-white powder in a capsule with a yellow upper and lower part.<\/p>\n\n\n\n<p>Nimvastid 3 mg hard capsules contain white to off-white powder in a capsule with an orange top and bottom.<\/p>\n\n\n\n<p>Nimvastid 4.5 mg hard capsules contain white to off-white powder in a capsule with a brownish-red top and bottom.<\/p>\n\n\n\n<p>Nimvastid 6 mg hard capsules contain white to off-white powder in a capsule with a brownish-red top and orange bottom.<\/p>\n\n\n\n<p>Blister pack (PVC \/ PVDC \/ Al foil): pack of 14 (1.5 mg only), 28, 30, 56, 60, or 112 hard capsules are available.<\/p>\n\n\n\n<p>HDPE can: pack of 200 or 250 hard capsules available.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p>KRKA, dd, Novo mesto, \u0160marje\u0161ka cesta 6, 8501 Novo mesto, Slovenia<\/p>\n\n\n\n<p><strong>Contact the representative of the marketing authorization holder to find out more about this medicine:<\/strong><\/p>\n\n\n\n<p>KRKA Sverige AB<\/p>\n\n\n\n<p>Tel: + 46 (0) 8 643 67 66 (SE)<\/p>\n","protected":false},"excerpt":{"rendered":"<p>1.5 mg, 3 mg, 4.5 mg, 6 mg hard capsules<br \/>\nrivastigmine<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,15581],"tags":[19012,19007,19008,19011,3354,3357,19004,19009,19010,19006],"class_list":["post-19037","post","type-post","status-publish","format-standard","hentry","category-medicines","category-n","tag-benefits-of-nimvastid","tag-benefits-of-rivastigmine","tag-nimvastid","tag-nimvastid-side-effects","tag-rivastigmine","tag-rivastigmine-side-effects","tag-wat-is-rivastigmine","tag-what-is-nimvastid","tag-what-nimvastid-is-used-for","tag-what-rivastigmine-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/19037","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=19037"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/19037\/revisions"}],"predecessor-version":[{"id":19096,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/19037\/revisions\/19096"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=19037"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=19037"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=19037"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}