Swallow the Nexavar tablets with a glass of water<\/strong>, either without food or with a low-fat meal.\u00a0Do not take this medicine with a high-fat meal as it may reduce the effect of Nexavar.\u00a0If you plan to eat a high-fat meal, take the tablets at least 1 hour before or 2 hours after the meal.<\/p>\n\n\n\nAlways take this medicine exactly as your doctor has told you. Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n
It is important to take this medicine at about the same time each day so that there is the same amount of medicine in your blood at all times.<\/p>\n\n\n\n
You will usually be treated with this medicine as long as you benefit from the treatment and do not suffer from unacceptable\u00a0side effects.<\/p>\n\n\n\n
If you take more Nexavar than you should<\/h2>\n\n\n\n
Talk to your doctor immediately<\/strong>\u00a0if you (or anyone else) have taken more than the prescribed\u00a0dose.\u00a0Taking too much Nexavar causes a greater risk of\u00a0side effects\u00a0or more pronounced\u00a0side effects, especially diarrhea and skin reactions.\u00a0Your doctor may advise you to stop taking this medicine.<\/p>\n\n\n\nIf you forget to take Nexavar<\/h2>\n\n\n\n
If you forget to take a\u00a0dose, take it as soon as you remember.\u00a0If it is near the time of the next\u00a0dose, ignore the missed\u00a0dose\u00a0and continue as previously prescribed.
Do not take a double\u00a0dose\u00a0to make up for a single forgotten\u00a0dose.<\/p>\n\n\n\n
Possible side effects<\/h2>\n\n\n\n
Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.\u00a0This medicine may also affect the results of certain blood tests.<\/p>\n\n\n\n
Very common:<\/strong> may affect more than 1 user in 10<\/p>\n\n\n\n- diarrhea<\/li>
- nausea<\/li>
- feeling of abnormal weakness or fatigue (fatigue)<\/em><\/li>
- pain (including pain in the mouth, abdominal pain, headache, pain in the bones and bones, tumor pain)<\/li>
- hair loss ( alopecia )<\/em><\/li>
- redness or pain in hands or soles of the feet (hand-foot-skin reaction)<\/li>
- itching or rash<\/li>
- vomiting<\/li>
- bleeding (including bleeding in the brain, intestines and airways)<\/li>
- high blood pressure or increase in blood pressure ( hypertension )<\/em><\/li>
- infection is<\/li>
- loss of appetite ( anorexia )<\/li>
- constipation<\/li>
- joint pain ( arthralgia )<\/li>
- fever<\/li>
- weight loss<\/li>
- dry skin<\/li><\/ul>\n\n\n\n
Common:<\/strong> may affect up to 1 in 10 users<\/p>\n\n\n\n- flu-like illness<\/li>
- indigestion ( dyspepsia )<\/em><\/li>
- difficulty swallowing ( dysphagia )<\/em><\/li>
- inflamed or dry mouth, pain in the tongue ( stomatitis and mucositis)<\/em><\/li>
- low levels of calcium in the blood ( hypocalcaemia )<\/em><\/li>
- low levels of potassium in the blood ( hypokalaemia<\/em> )<\/li>
- low blood sugar levels ( hypoglycaemia )<\/em><\/li>
- muscle pain ( myalgia )<\/em><\/li>
- altered sensation in fingers and toes, including tingling and numbness ( peripheral sensory neuropathy )<\/em><\/li>
- Depression<\/li>
- erection problem ( impotence )<\/em><\/li>
- voice change ( dysphonia )<\/em><\/li>
- acne<\/li>
- inflamed, dry or scaly skin ( dermatitis , skin desquamation)<\/em><\/li>
- heart failure<\/li>
- heart attack (heart attack)<\/em> or chest pain<\/li>
- tinnitus (ringing sound in the ears)<\/em><\/li>
- kidney failure<\/li>
- abnormally high levels of protein in the urine ( proteinuria<\/em> )<\/li>
- pronounced weakness or weakness ( asthenia )<\/em><\/li>
- decreased white blood cell count ( leukopenia and neutropenia )<\/em><\/li>
- decreased number of red blood cells ( anemia )<\/em><\/li>
- decreased platelet count ( thrombocytopenia )<\/em><\/li>
- inflammation of hair follicles ( folliculitis )<\/em><\/li>
- hypothyroidism _<\/em><\/li>
- low level of sodium in the blood ( hyponatremia )<\/em><\/li>
- taste changes ( dysgeusia )<\/em><\/li>
- redness of the face and often other skin areas (swelling)<\/em><\/li>
- runny nose ( rhinorrhea )<\/em><\/li>
- heartburn ( gastroesophageal reflux )<\/em><\/li>
- skin cancer (keratoacanthoma or squamous cell carcinoma of the skin)<\/em><\/li>
- thickening of the outer layer of skin ( hyperkeratosis )<\/em><\/li>
- sudden, involuntary muscle contractions (muscle spasms)<\/em><\/li><\/ul>\n\n\n\n
Uncommon:<\/strong> may affect up to 1 in 100 people<\/p>\n\n\n\n- inflamed gastric mucosa ( gastritis )<\/em><\/li>
- abdominal pain caused by inflammation of the pancreas, inflammation of the gallbladder and \/ or bile ducts<\/li>
- yellow skin or yellow whites of the eyes (jaundice)<\/em> caused by elevated levels of bile pigment (hyperbilirubinemia)<\/em><\/li>
- allergy-like reactions (including skin reaction and hives)<\/li>
- dehydration<\/li>
- enlarged breasts ( gynecomastia )<\/em><\/li>
- breathing difficulties ( lung disease<\/em> )<\/li>
- eczema<\/li>
- increased thyroid function (hyperthyroidism)<\/em><\/li>
- skin rash with blisters (erythema multiforme)<\/em><\/li>
- abnormally high blood pressure<\/li>
- hole in the intestinal wall ( gastrointestinal perforation )<\/em><\/li>
- temporary swelling of the back of the brain which can cause headaches, altered consciousness, seizures and changes in vision including vision loss ( reversible posterior leukoencephalopathy)<\/em><\/li>
- sudden, severe allergic reaction ( anaphylactic reaction )<\/em><\/li><\/ul>\n\n\n\n
Rare:<\/strong><\/p>\n\n\n\ncan occur in up to 1 in 1,000 users<\/p>\n\n\n\n
- allergic reaction with swelling of the skin (eg on the face, on the tongue) which may lead to difficulty breathing or swallowing ( angioedema )<\/em><\/li>
- abnormal heart rhythm ( QT prolongation)<\/em><\/li>
- inflammation of the liver that can lead to nausea, vomiting, abdominal pain and jaundice (drug-induced hepatitis )<\/em><\/li>
- sunburn-like rash that can occur on skin that has previously been exposed to radiation therapy and that can become serious (“radiation recall” – dermatitis )<\/em><\/li>
- severe reactions in the skin and \/ or mucous membranes that can cause painful blisters and fever, as well as skin that loosens ( Stevens-Johnson syndrome and toxic epidermal necrolysis )<\/em><\/li>
- abnormal muscle breakdown that can lead to kidney problems ( rhabdomyolysis )<\/em><\/li>
- damage to the kidneys that leads to the leakage of large amounts of protein ( nephrotic syndrome )<\/em><\/li>
- inflammation of the blood vessels in the skin that can result in rash (leukocytoclastic vasculitis )<\/em> .<\/li><\/ul>\n\n\n\n
No known frequency<\/strong>: can not be calculated from the available data<\/p>\n\n\n\n- Impairment of brain function that can be linked to e.g. drowsiness, behavioral changes or confusion ( encephalopathy )<\/em><\/li>
- An enlargement and weakening of a vessel wall or a rupture in a vessel wall ( aneurysms and arterial dissections)<\/em> .<\/li><\/ul>\n\n\n\n
How to store Nexavar<\/h2>\n\n\n\n
Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n
Do not use this medicine after the expiry date<\/strong>\u00a0which is stated on the carton and each blister after EXP.\u00a0The expiration date is the last day of the specified month.<\/p>\n\n\n\nThis medicine should not be stored above 25 \u00b0 C.<\/p>\n\n\n\n
Medicines should not be disposed of via wastewater or household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.<\/p>\n\n\n\n
Contents of the pack and other information<\/h2>\n\n\n\nContent declaration<\/h2>\n\n\n\n- The active substance is sorafenib. Each film-coated tablet contains 200 mg sorafenib (as tosylate).<\/li>
- Other ingredients are:Tablet core:<\/strong> Croscarmellose sodium, microcrystalline cellulose, hypromellose, sodium lauryl sulphate, magnesium stearate.Tablet cover:<\/strong> Hypromellose, macrogol, titanium dioxide (E 171), red iron oxide (E 172).<\/li><\/ul>\n\n\n\n
What the medicine looks like and contents of the pack<\/h2>\n\n\n\n
Nexavar 200 mg film-coated tablets are red and round, marked with the Bavarian cross on one side and \u201c200\u201d on the other side. They are available in calendar packs of 112 tablets: four transparent blister packs with 28 tablets in each.<\/p>\n\n\n\n
Marketing Authorisation Holder<\/h2>\n\n\n\n
Bayer AG
51368 Leverkusen
Germany<\/p>\n\n\n\n
Manufacturer<\/strong><\/p>\n\n\n\nBayer AG
Kaiser-Wilhelm-Allee<\/p>\n\n\n\n
51368 Leverkusen<\/p>\n\n\n\n
Germany<\/p>\n\n\n\n
Bayer HealthCare Manufacturing Srl.<\/p>\n\n\n\n
Via Delle Groaned, 126<\/p>\n\n\n\n
20024 Garbagnate Milanese<\/p>\n\n\n\n
Italy<\/p>\n","protected":false},"excerpt":{"rendered":"
Nexavar is used to treat liver cancer (hepatocellular carcinoma) .<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,15581],"tags":[18838,18833,18834,18837,18829,18832,18835,18830,18836,18831],"class_list":["post-18913","post","type-post","status-publish","format-standard","hentry","category-medicines","category-n","tag-benefits-of-nexavar","tag-benefits-of-sorafenib","tag-nexavar","tag-nexavar-side-effects","tag-sorafenib","tag-sorafenib-side-effects","tag-what-is-nexavar","tag-what-is-sorafenib","tag-what-nexavar-is-used-for","tag-what-sorafenib-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/18913","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=18913"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/18913\/revisions"}],"predecessor-version":[{"id":18970,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/18913\/revisions\/18970"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=18913"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=18913"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=18913"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}