{"id":18855,"date":"2022-02-24T16:39:12","date_gmt":"2022-02-24T16:39:12","guid":{"rendered":"https:\/\/zeepedia.com\/?p=18855"},"modified":"2022-02-25T12:08:10","modified_gmt":"2022-02-25T12:08:10","slug":"nerlynx","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/nerlynx\/","title":{"rendered":"Nerlynx &#8211; Neratinib uses, dose and side effects"},"content":{"rendered":"\n<p>40 mg&nbsp;film-coated tablets<br>neratinib<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Nerlynx is and what it is used for<\/h2>\n\n\n\n<p><strong>What Nerlynx is<\/strong><\/p>\n\n\n\n<p>Nerlynx contains the active substance neratinib.&nbsp;It belongs to a group of medicines called &#8220;tyrosine kinase inhibitors&#8221; that are used to block cancer cells and treat breast cancer.<\/p>\n\n\n\n<p><strong>What Nerlynx is used for<\/strong><\/p>\n\n\n\n<p>Nerlynx is given to patients with early-stage breast cancer<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>are hormone receptor positive (HR-positive) and&nbsp;human&nbsp;epidermal&nbsp;growth factor receptor 2-positive (&nbsp;HER2&nbsp;&#8211; positive) and<\/li><li>previously treated with another medicine called &#8216;trastuzumab&#8217;.<\/li><\/ul>\n\n\n\n<p>The &#8220;HER2 receptor&#8221; is a\u00a0protein\u00a0found on the surface of cells in the body.\u00a0It helps control the growth of a healthy breast cell.\u00a0In\u00a0HER2\u00a0-positive breast cancer, the cancer cells have large amounts of\u00a0HER2 receptors\u00a0on\u00a0their\u00a0surface.\u00a0This leads to the cancer cells growing and dividing faster.<\/p>\n\n\n\n<p>&#8220;Hormone receptors&#8221; are also\u00a0proteins\u00a0that are expressed inside the cells of certain specific\u00a0issues.\u00a0Estrogen\u00a0and\u00a0progesterone\u00a0bind to these\u00a0proteins\u00a0and regulate cell activity.\u00a0In HR-positive breast cancer, the cell division and growth of the tumor can be enhanced by\u00a0estrogen\u00a0and\/or\u00a0progesterone.<\/p>\n\n\n\n<p>Before using Nerlynx, your cancer must have been tested and found to be HR-positive and&nbsp;HER2&nbsp;&#8211; positive.&nbsp;You must also have previously been treated with <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/trazimera\/\">trastuzumab<\/a>.<\/p>\n\n\n\n<p><strong>How Nerlynx works<\/strong><\/p>\n\n\n\n<p>Nerlynx&nbsp;works by blocking the&nbsp;HER2&nbsp;receptors&nbsp;on the cancer cells.&nbsp;This helps prevent the cells from growing and dividing.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you take Nerlynx<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Nerlynx<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to neratinib or any of the other ingredients of this medicine (listed in section 6),<\/li><li>if you have severe liver problems,<\/li><li>if you are taking rifampicin (a medicine used to&nbsp;treat tuberculosis&nbsp;),<\/li><li>if you are taking carbamazepine or&nbsp;phenytoin&nbsp;(medicines for epileptic seizures),<\/li><li>if you are taking&nbsp;St. John&#8217;s wort&nbsp;(an herbal remedy for depression, mild anxiety).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before taking Nerlynx.<\/p>\n\n\n\n<p><strong>You will need medicine for diarrhea when you start taking Nerlynx<\/strong><\/p>\n\n\n\n<p>Nerlynx can cause diarrhea early in treatment.\u00a0You should take medicine for diarrhea so that your diarrhea does not become severe and to prevent you from becoming dehydrated during treatment with Nerlynx.<\/p>\n\n\n\n<p><strong>Tests and checks of liver problems<\/strong><\/p>\n\n\n\n<p>Nerlynx can cause changes in liver function &#8211; these are shown in blood tests.&nbsp;Your doctor will take blood samples before and during your treatment with Nerlynx.&nbsp;Your doctor will stop your treatment with Nerlynx if your liver tests show serious problems.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Do not use it for children under 18 years.\u00a0The safety and efficacy of Nerlynx have not been studied in this age group.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Nerlynx<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.\u00a0The reason for this is that Nerlynx may affect the way some other medicines work.\u00a0Some other medicines may also affect the way Nerlynx works.<\/p>\n\n\n\n<p>In particular, tell your doctor or pharmacist if you are taking any of the following medicines:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>rifampicin &#8211; a drug for&nbsp;tuberculosis<\/li><li>carbamazepine, phenobarbital or&nbsp;phenytoin&nbsp;&#8211; medicines for epileptic seizures<\/li><li>St. John&#8217;s wort&nbsp;&#8211; an herbal remedy for depression, mild anxiety<\/li><li>ketoconazole&nbsp;, voriconazole, itraconazole or fluconazole &#8211; antifungal drugs<\/li><li>erythromycin or clarithromycin &#8211; medicines for bacterial infections&nbsp;<\/li><li>protease inhibitors&nbsp;&#8211; antiviral drugs<\/li><li>nefazodone &#8211; a drug used to treat depression<\/li><li>diltiazem&nbsp;or verapamil &#8211; medicines for high&nbsp;blood pressure&nbsp;and chest pain<\/li><li>dabigatran or&nbsp;digoxin&nbsp;&#8211; medicines for heart problems<\/li><li>rosuvastatin &#8211; a drug used to treat high&nbsp;cholesterol<\/li><li>irinotecan &#8211; a drug used in colorectal cancer<\/li><li>sulfasalazine &#8211; an anti-inflammatory drug<\/li><li>medicines for stomach problems such as:<ul><li>lansoprazole, omeprazole or similar medicines called &#8216;proton pump inhibitors&#8217; are not recommended.<\/li><li>ranitidine, cimetidine or similar medicines called &#8216;H&nbsp;<sub>2<\/sub>&nbsp;-receptor antagonists&#8217;.&nbsp;Neratinib should be taken 10 hours after taking the H&nbsp;<sub>2<\/sub>&nbsp;-receptor antagonist and at least 2 hours before the next&nbsp;dose&nbsp;of the H&nbsp;<sub>2<\/sub>&nbsp;-receptor antagonist.<\/li><li>antacids &#8211;&nbsp;dose&nbsp;one of these drugs and Nerlynx should be taken at least 3 hours apart.<\/li><\/ul><\/li><\/ul>\n\n\n\n<p>If any of the above apply to you (or you are not sure), talk to your doctor or pharmacist before taking Nerlynx.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Nerlynx with food and drink<\/h2>\n\n\n\n<p>Avoid grapefruit and pomegranate while taking Nerlynx.\u00a0You should not eat the fruit, drink the juice or take a dietary supplement that may contain grapefruit\/pomegranate.\u00a0The reason for this is that these fruits can interact with Nerlynx and affect the effect of the drug.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, contraception and breastfeeding<\/h2>\n\n\n\n<p><strong>Pregnancy<\/strong><\/p>\n\n\n\n<p>If you are pregnant, your doctor will assess the potential benefit to you and the risk to the fetus before you receive this medicine.&nbsp;If you become pregnant while taking this medicine, your doctor will assess the potential benefit to you and the risk to the fetus of continuing to take this medicine.<\/p>\n\n\n\n<p><strong>Contraceptive<\/strong><\/p>\n\n\n\n<p>Women who may become pregnant must use an effective contraceptive, including a&nbsp;barrier method&nbsp;(such as a condom)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>while taking Nerlynx and<\/li><li>for one month after the end of treatment.<\/li><\/ul>\n\n\n\n<p>Men must use an effective barrier contraceptive such as a condom<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>while taking Nerlynx and<\/li><li>for three months after the end of treatment.<\/li><\/ul>\n\n\n\n<p><strong>Breast-feeding<\/strong><\/p>\n\n\n\n<p>Talk to your doctor before taking Nerlynx if you are breastfeeding or planning to breastfeed, as small amounts of this medicine may pass into breast milk.\u00a0Your doctor will discuss the benefits and risks of taking Nerlynx during this time.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Nerlynx has a minor or moderate effect on the ability to drive and use machines.\u00a0The side effects\u00a0of Nerlynx (for example, dehydration and dizziness due to diarrhea, fatigue, and fainting) may affect the performance of tasks requiring judgment, motor skills, or\u00a0cognitive\u00a0ability.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Nerlynx<\/h2>\n\n\n\n<p>Always take this medicine exactly as your doctor has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p><strong>How much Nerlynx to take<\/strong><\/p>\n\n\n\n<p>The recommended&nbsp;dose&nbsp;of Nerlynx is 6 tablets once daily (240 mg total).<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The tablets must be taken with food.&nbsp;They must not be crushed or dissolved.&nbsp;Do not swallow the desiccant.<\/li><li>Take all tablets with water, at about the same time each day, preferably in the morning.<\/li><\/ul>\n\n\n\n<p>The treatment lasts for one year.<\/p>\n\n\n\n<p><strong>You will need medicine for diarrhea when you start taking Nerlynx<\/strong><\/p>\n\n\n\n<p>Nerlynx can cause diarrhea early in treatment if you are not taking medicines to prevent or reduce diarrhea.\u00a0Diarrhea usually occurs early in treatment with Nerlynx.\u00a0It can be difficult and cause you to become dehydrated.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Start taking diarrhea medication with the first&nbsp;dose&nbsp;of Nerlynx.<\/li><li>Your doctor will tell you how to take the medicine for diarrhea.<\/li><li>Continue taking medicines for diarrhea during the first one to two months of treatment with Nerlynx.&nbsp;After this time, your doctor will tell you if you need to continue taking any medicines to control your diarrhea.<\/li><li>Your doctor will tell you if you need to change the&nbsp;dose&nbsp;of Nerlynx due to diarrhea.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">If you take more Nerlynx than you should<\/h2>\n\n\n\n<p>Contact a doctor or hospital immediately.&nbsp;Take the medicine pack with you.<\/p>\n\n\n\n<p>Some\u00a0side effects\u00a0associated with taking too much Nerlynx are the following: diarrhea, nausea, vomiting, and\u00a0dehydration.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Nerlynx<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>If you miss a&nbsp;dose&nbsp;, wait until the next day before taking your next&nbsp;dose&nbsp;.<\/li><li>Do not take a double&nbsp;dose&nbsp;to make up for a forgotten&nbsp;dose&nbsp;.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">If you stop taking Nerlynx<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Do not stop taking Nerlynx without talking to your doctor first.<\/li><\/ul>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.\u00a0The following\u00a0side effects\u00a0may occur with this medicine:<\/p>\n\n\n\n<p><strong>Diarrhea<\/strong><\/p>\n\n\n\n<p>Nerlynx can cause diarrhea early in treatment if you are not taking medicines to prevent or reduce diarrhea.\u00a0Diarrhea can be severe, and you may become dehydrated.\u00a0See section 3 for more information on the medicines for diarrhea you need to take with Nerlynx.<\/p>\n\n\n\n<p><strong>Talk to your doctor about<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>your diarrhea does not go away &#8211; they can give you advice on how to control the diarrhea,<\/li><li>you feel dizzy or weak from diarrhea &#8211; alternatively go to the hospital immediately.<\/li><\/ul>\n\n\n\n<p><strong>Liver problem<\/strong><\/p>\n\n\n\n<p>Nerlynx can cause changes in liver function &#8211; these are shown in blood tests.\u00a0You may, but need not, have signs or symptoms of liver problems (eg yellow skin and\/or yellow eyes, dark urine, or light stools).\u00a0Your doctor will take blood samples before and during your treatment with Nerlynx.\u00a0Your doctor will stop your treatment with Nerlynx if your liver tests show serious problems.<\/p>\n\n\n\n<p><strong>Other&nbsp;side effects&nbsp;are<\/strong><\/p>\n\n\n\n<p>Tell your doctor or pharmacist immediately if any of the following&nbsp;side effects&nbsp;occur:<\/p>\n\n\n\n<p><strong>Very common<\/strong>: may affect more than 1 user in 10<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>diarrhea<\/li><li>stomach pain, nausea, vomiting, poor appetite<\/li><li>dry or inflamed mouth, including blisters or cold sores<\/li><li>rash<\/li><li>muscle cramps<\/li><li>severe fatigue<\/li><\/ul>\n\n\n\n<p><strong>Common:<\/strong>&nbsp;may affect up to 1 in 10 users<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>burning sensation during urination and frequent and sudden need to urinate (may be a symptom of a urinary tract infection)<\/li><li>dehydration<\/li><li>nosebleeds<\/li><li>mild stomach upset<\/li><li>dry mouth<\/li><li>changes in blood tests for liver function<\/li><li>nail problems such as cracked nails or nails that change color<\/li><li>dry skin including cracked skin<\/li><li>changes in kidney function tests<\/li><li>weight loss<\/li><\/ul>\n\n\n\n<p><strong>Uncommon<\/strong>&nbsp;: affects 1 in 1,000 people<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>kidney failure<\/li><li>changes in blood tests for liver function (ie increased&nbsp;bilirubin&nbsp;in the blood)<\/li><\/ul>\n\n\n\n<p>Tell your doctor or pharmacist if any of the above&nbsp;side effects&nbsp;occur.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Nerlynx<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the can and carton after \u201cEXP\u201d.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Close the jar tightly.&nbsp;Moisture sensitive.<\/p>\n\n\n\n<p>No special temperature instructions.<\/p>\n\n\n\n<p>Do not use Nerlynx if you notice that the packaging is damaged or if there are any signs of tampering (eg broken inner seal).<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the package and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is neratinib.&nbsp;Each film-coated tablet contains neratinib maleate equivalent to 40 mg neratinib.<\/li><li>Other ingredients:<ul><li>Tablet core: mannitol (E421), microcrystalline cellulose, crospovidone, povidone,&nbsp;colloidal&nbsp;anhydrous silica, magnesium stearate.<\/li><li>Tablet coating: polyvinyl alcohol, titanium dioxide (E171), macrogol, talc, red iron oxide (E172).<\/li><\/ul><\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<p>The film-coated tablets are red, oval-shaped, and embossed with \u201cW104\u201d on one side and smooth on the other.<\/p>\n\n\n\n<p>Nerlynx film-coated tablets are packaged in a white round jar of high-density polyethylene (HDPE) with a child-resistant polypropylene closure, as well as an internal security seal of foil.\u00a0Each jar contains 180 film-coated tablets.<\/p>\n\n\n\n<p>A container of HDPE desiccant with 1 g of silica gel is included in the tablets in each jar.&nbsp;Do not swallow the desiccant.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>PIERRE FABRE MEDICAMENT<\/p>\n\n\n\n<p>Les Cauquillous<\/p>\n\n\n\n<p>81500 Lavaur<\/p>\n\n\n\n<p>France<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>AndersonBrecon (UK) Limited<\/p>\n\n\n\n<p>Pharos House, Wye Valley Business Park<\/p>\n\n\n\n<p>Brecon Road, Hay-on-Wye<\/p>\n\n\n\n<p>Hereford HR3 5PG<\/p>\n\n\n\n<p>UK<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Nerlynx contains the active substance neratinib. It belongs to a group of medicines called &#8220;tyrosine kinase inhibitors&#8221; that are used to block cancer cells and treat breast cancer.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,15581],"tags":[18720,18726,18716,18719,18721,18722,18725,18717,18723,18718,18724],"class_list":["post-18855","post","type-post","status-publish","format-standard","hentry","category-medicines","category-n","tag-benefits-of-neratinib","tag-benefits-of-nerlynx","tag-neratinib","tag-neratinib-side-effects","tag-neratinib-tablet","tag-nerlynx","tag-nerlynx-side-effects","tag-what-is-neratinib","tag-what-is-nerlynx","tag-what-neratinib-is-used-for","tag-what-nerlynx-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/18855","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=18855"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/18855\/revisions"}],"predecessor-version":[{"id":18903,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/18855\/revisions\/18903"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=18855"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=18855"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=18855"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}