\u201cSection 7. Instructions for Use\u201d<\/strong> in this information before using the pen.<\/p>\n\n\n\nDo not use the pen if the solution is cloudy or colored or contains visible particles.<\/p>\n\n\n\n
The medicine must be mixed before using the pen for the first time.<\/p>\n\n\n\n
After mixing the medicine, the Natpar pen is ready for use and the medicine can be injected under the skin of the thigh. Inject into the other thigh the next day and continue to switch between the two thighs.<\/p>\n\n\n\n
It is strongly recommended that the name and lot of the product on the kit (lot) be noted each time you receive a dose of Natpar to maintain a list of the kits that have been used.<\/p>\n\n\n\n
How long to use Natpar<\/h2>\n\n\n\n
Continue to use Natpar for as long as your doctor prescribes it.<\/p>\n\n\n\n
If you have used too much Natpar<\/h2>\n\n\n\n
If you accidentally inject more than one dose of Natpar a day, contact your doctor or pharmacist immediately.<\/p>\n\n\n\n
If you forget to use Natpar<\/h2>\n\n\n\n
If you forget to use Natpar (or can not inject it at the usual time), inject as soon as you can but do not inject more than one dose on the same day.<\/p>\n\n\n\n
Take the next dose of Natpar at the usual time the next day. You may need to take more calcium supplements if you have signs of low levels of calcium in your blood; see section 4 for symptoms.<\/p>\n\n\n\n
Do not inject a double dose to make up for a forgotten dose.<\/p>\n\n\n\n
If you stop using Natpar<\/h2>\n\n\n\n
Discuss with your doctor if you want to stop using Natpar.<\/p>\n\n\n\n
If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n
Possible side effects<\/h2>\n\n\n\n
Like all medicines, this medicine can cause side effects, although not everybody gets them.<\/p>\n\n\n\n
Serious side effects are<\/strong><\/p>\n\n\n\nThe following potentially serious side effects may occur when using Natpar:<\/p>\n\n\n\n
- Very common: high levels of calcium in the blood, which may occur more often when you start treatment with Natpar.<\/li>
- Very common: low levels of calcium in the blood; this can occur more often if you suddenly stop using Natpar.<\/li><\/ul>\n\n\n\n
Symptoms associated with high or low calcium levels are listed below. If you experience any of these side effects, contact your doctor immediately.<\/p>\n\n\n\n
Other side effects may include:<\/strong><\/p>\n\n\n\nVery common<\/strong> (may affect more than 1 user in 10):<\/p>\n\n\n\n- headache *, \u2020<\/sup><\/li>
- tingling and numbness in the skin \u2020<\/sup><\/li>
- diarrhea *, \u2020<\/sup><\/li>
- nausea and vomiting *<\/sup><\/li>
- joint pain *<\/sup><\/li>
- muscle spasms \u2020<\/sup><\/sup><\/sup><\/li><\/ul>\n\n\n\n
Common<\/strong> (may affect up to 1 in 10 people):<\/p>\n\n\n\n- feeling of nervousness or anxiety \u2020<\/sup><\/sup><\/sup><\/li>
- sleep problems (feeling sleepy during the day or trouble sleeping at night) *<\/sup><\/li>
- fast or irregular heartbeat *, \u2020<\/sup><\/li>
- high blood pressure *<\/sup><\/li>
- cough \u2020<\/sup><\/sup><\/sup><\/li>
- stomach pain *<\/sup><\/li>
- muscle twitching or cramps \u2020<\/sup><\/sup><\/sup><\/li>
- muscle pain \u2020<\/sup><\/sup><\/sup><\/li>
- neck pain \u2020<\/sup><\/sup><\/sup><\/li>
- pain in arms and legs<\/li>
- increased level of calcium in the urine *<\/sup><\/li>
- need to urinate often \u2020<\/sup><\/li>
- fatigue and lack of energy *<\/sup><\/li>
- chest pain<\/li>
- redness and pain at the injection site<\/li>
- thirst *<\/sup><\/li>
- antibodies (produced by your immune system) against Natpar<\/li>
- In blood tests, the doctor may see decreased levels of vitamin D and magnesium \u2020<\/sup><\/sup><\/sup><\/li><\/ul>\n\n\n\n
Has been reported<\/strong> (occurs in an unknown number of users):<\/p>\n\n\n\n- allergic reactions (hypersensitivity), may cause symptoms such as: swelling of the face, lips, mouth or tongue; shortness of breath; itching; rash; hives<\/li>
- seizures due to low levels of calcium in the blood \u2020<\/sup><\/sup><\/sup><\/sup><\/li><\/ul>\n\n\n\n
*<\/sup> These side effects may be related to high levels of calcium in the blood.<\/p>\n\n\n\n\u2020<\/sup> These side effects may be related to low levels of calcium in the blood.<\/p>\n\n\n\nHow to store Natpar<\/h2>\n\n\n\n
Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n
Do not use this medicine after the expiry date which is stated on the cartridge and the carton after EXP. The expiration date is the last day of the specified month.<\/p>\n\n\n\n
Before mixing<\/strong><\/p>\n\n\n\n- Store in a refrigerator (2 \u00b0 C-8 \u00b0 C).<\/li>
- Do not freeze.<\/li>
- Store cartridge one in the cartridge holder in the outer carton. Sensitive to light.<\/li><\/ul>\n\n\n\n
After mixing<\/strong><\/p>\n\n\n\n- Store in a refrigerator (2 \u00b0 C-8 \u00b0 C).<\/li>
- Do not freeze.<\/li>
- Keep the pen containing a mixed cartridge tightly closed. Sensitive to light.<\/li>
- Do not use this medicine for more than 14 days after mixing it.<\/li>
- Do not use this medicine if it has not been stored properly.<\/li>
- Before attaching a new needle to the Natpar pen, check that the solution is clear and colorless. It is normal for small bubbles to appear. Do not use this medicine if the solution is cloudy, colored or contains visible particles.<\/li><\/ul>\n\n\n\n
Medicines should not be disposed of via household waste. Ask your pharmacist how to dispose of medicines no longer required. These measures will help to protect the environment.<\/p>\n\n\n\n
Contents of the pack and other information<\/h2>\n\n\n\nContent declaration<\/h2>\n\n\n\n
The active substance is parathyroid hormone (rDNA).<\/p>\n\n\n\n
The medicine is available in 4 different strengths in cartridges (one cartridge contains 14 doses):<\/p>\n\n\n\n
Natpar 25 micrograms<\/strong><\/p>\n\n\n\nOne dose contains 25 micrograms of parathyroid hormone in 71.4 microliters of solution after reconstitution.<\/p>\n\n\n\n
Natpar 50 micrograms<\/strong><\/p>\n\n\n\nOne dose contains 50 micrograms of parathyroid hormone in 71.4 microliters of solution after reconstitution.<\/p>\n\n\n\n
Natpar 75 micrograms<\/strong><\/p>\n\n\n\nOne dose contains 75 micrograms of parathyroid hormone in 71.4 microliters of solution after reconstitution.<\/p>\n\n\n\n
Natpar 100 micrograms<\/strong><\/p>\n\n\n\nOne dose contains 100 micrograms of parathyroid hormone in 71.4 microliters of solution after reconstitution.<\/p>\n\n\n\n
The other ingredients in cartridge one (for all strengths) are:<\/p>\n\n\n\n
In the powder:<\/strong><\/p>\n\n\n\n- sodium chloride<\/li>
- mannitol<\/li>
- citric acid monohydrate<\/li>
- sodium hydroxide (for pH adjustment)<\/li><\/ul>\n\n\n\n
In the liquid:<\/strong><\/p>\n\n\n\n- metacresol<\/li>
- water for injection solution ar<\/li><\/ul>\n\n\n\n
What the medicine looks like and contents of the pack<\/h2>\n\n\n\n
A cartridge Natpar contains medicines in the form of a powder together with a liquid to make a solution for injection. Cylinder cartridge one is made of glass with a rubber seal at the top. The cartridge is enclosed in a plastic container.<\/p>\n\n\n\n
Natpar is available in packs of 2 cartridges in a holder.<\/p>\n\n\n\n
The color of the carton\/cartridge shows the strength of Natpar:<\/p>\n\n\n\n
Natpar 25 micrograms \/ dose<\/strong><\/p>\n\n\n\nPurple cartridge<\/p>\n\n\n\n
Natpar 50 micrograms \/ dose<\/strong><\/p>\n\n\n\nRed cartridge<\/p>\n\n\n\n
Natpar 75 micrograms \/ dose<\/strong><\/p>\n\n\n\nGray cartridge<\/p>\n\n\n\n
Natpar 100 micrograms \/ dose<\/strong><\/p>\n\n\n\nBlue cartridge<\/p>\n\n\n\n
Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n
Takeda Pharmaceuticals International AG Ireland Branch<\/p>\n\n\n\n
Block 3 Miesian Plaza<\/p>\n\n\n\n
50-58 Baggot Street Lower<\/p>\n\n\n\n
Dublin 2<\/p>\n\n\n\n
Ireland<\/p>\n\n\n\n
Tel: +800 66838470<\/p>\n\n\n\n
Email: medinfoEMEA@takeda.com<\/p>\n","protected":false},"excerpt":{"rendered":"
Natpar is a hormone replacement for adults with impaired parathyroid function, a condition called “hypoparathyroidism”.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,15581],"tags":[18450,18445,18446,18449,18441,18444,18447,18442,18448,18443],"class_list":["post-18663","post","type-post","status-publish","format-standard","hentry","category-medicines","category-n","tag-benefits-of-natpar","tag-benefits-of-parathyroid-hormone","tag-natpar","tag-natpar-side-effects","tag-parathyroid-hormone","tag-parathyroid-hormone-side-effects","tag-what-is-natpar","tag-what-is-parathyroid-hormone","tag-what-natpar-is-used-for","tag-what-parathyroid-hormone-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/18663","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=18663"}],"version-history":[{"count":5,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/18663\/revisions"}],"predecessor-version":[{"id":18692,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/18663\/revisions\/18692"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=18663"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=18663"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=18663"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}