{"id":18653,"date":"2022-02-21T15:34:30","date_gmt":"2022-02-21T15:34:30","guid":{"rendered":"https:\/\/zeepedia.com\/?p=18653"},"modified":"2022-02-22T10:08:33","modified_gmt":"2022-02-22T10:08:33","slug":"narop","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/narop\/","title":{"rendered":"Narop &#8211; Ropivacaine hydrochloride uses, dose and side effects"},"content":{"rendered":"\n<p>2 mg \/ ml solution for injection \/ infusion;\u00a05 mg \/ ml, 7.5 mg \/ ml and 10 mg \/ ml solution for injection<br><\/p>\n\n\n\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Narop is and what it is used for<\/h2>\n\n\n\n<p>Narop contains the active substance ropivacaine hydrochloride, which is a topical anesthetic (&nbsp;local anesthetic&nbsp;).<\/p>\n\n\n\n<p>Narop is used in adults to numb certain parts of the body and to relieve pain during various types of surgeries.&nbsp;Narop is also used in children and adolescents for certain types of pain relief and in surgeries.<\/p>\n\n\n\n<p>Narop acts in the surgical area by preventing nerves from sending sensory impulses for pain, heat or cold.&nbsp;Still, you can feel pressure and touch.&nbsp;In this way, the nerves in the operating area are anesthetized and prepared.&nbsp;In many cases, Narop also causes blockage of the motor nerves, ie.&nbsp;temporary muscle weakness and inability to e.g.&nbsp;touch the leg (or lift the arm).<\/p>\n\n\n\n<p>Ropivacaine hydrochloride contained in Narop may also be approved for the treatment of other conditions not mentioned in this leaflet.&nbsp;Ask your doctor, pharmacist or other healthcare professional if you have any further questions and always follow their instructions.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you get Narop<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">You must not be given Narop<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to ropivacaine hydrochloride or any of the other ingredients of this medicine (listed in section 6).<\/li><li>if you are allergic (hypersensitive) to other similar anesthetics ( amide-type&nbsp;local anesthetics&nbsp;).<\/li><li>if you have low blood volume (&nbsp;hypovolemia&nbsp;).&nbsp;This is measured by the health care staff.<\/li><li>as an&nbsp;injection&nbsp;into a blood vessel to numb a certain part of the body.<\/li><li>as an&nbsp;injection&nbsp;in the cervix to relieve labor pains.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Be especially careful to avoid&nbsp;injecting&nbsp;Narop directly into a blood vessel to avoid direct toxic effects.&nbsp;Injection&nbsp;must not be given in inflamed areas.<\/p>\n\n\n\n<p>Talk to a doctor or nurse before receiving Narop:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have poor general condition due to old age or other factors<\/li><li>if you have heart problems (partial or total AV block)<\/li><li>if you have severe liver disease<\/li><li>if you have severe kidney disease<\/li><li>if you have&nbsp;acute&nbsp;porphyria&nbsp;(problems with the production of&nbsp;red blood cells&nbsp;).<\/li><\/ul>\n\n\n\n<p>Tell your doctor if you have any of these conditions, as&nbsp;dose&nbsp;one of Narop may need to be adjusted.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children<\/h2>\n\n\n\n<p>Physicians and healthcare professionals will take special care when treating:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>of newborns, as they are more sensitive to Narop.<\/li><li>of children under 12 years of age, as certain types of&nbsp;injection&nbsp;of Narop have not been established in younger children.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Narop<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines.<\/p>\n\n\n\n<p>Care must be taken if you get<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>other local anesthetics (eg&nbsp;lidocaine&nbsp;) or medicines similar to amide-type local anesthetics, e.g.&nbsp;certain medicines for irregular heartbeat (eg&nbsp;amiodarone&nbsp;)<\/li><li>other anesthetics or&nbsp;opioids&nbsp;(strong painkillers)<\/li><li>certain antidepressants (eg fluvoxamine)<\/li><li>certain&nbsp;antibiotics&nbsp;(eg enoxacin).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.&nbsp;It is not known if Narop affects pregnancy or is excreted in human milk.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Narop can temporarily affect your reactivity and muscle coordination.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened vigilance.&nbsp;One of the factors that can affect your ability in these respects is the use of drugs due to their effects and \/ or&nbsp;side effects&nbsp;.&nbsp;Descriptions of these effects and&nbsp;side effects&nbsp;can be found in other sections.&nbsp;Read all the information in this leaflet for guidance.&nbsp;If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Narop contains sodium<\/h2>\n\n\n\n<p>This medicine contains no more than 3.7 mg&nbsp;of sodium&nbsp;per milliliter.&nbsp;This should be considered by patients on a low-salt diet.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to get Narop<\/h2>\n\n\n\n<p>Narop is given by a doctor by&nbsp;injection&nbsp;.&nbsp;Your doctor will decide on a&nbsp;dose&nbsp;based on your needs and physical condition.<\/p>\n\n\n\n<p>Healthcare professionals: detailed information on the use of this product can be found at the end of this leaflet.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you take more Narop than you should<\/h2>\n\n\n\n<p>Serious&nbsp;side effects&nbsp;caused by overdose are rare, but require special care.&nbsp;The treating physician is trained in and prepared for these situations.<\/p>\n\n\n\n<p>The first symptoms after narop overdose are usually intoxication, hearing and vision disorders, numbness around the mouth and tongue, speech difficulties, muscle twitching, tremors, low&nbsp;blood pressure&nbsp;, slow or irregular heartbeat.&nbsp;These symptoms may be preceded by cardiac arrest, respiratory arrest and severe seizures.<\/p>\n\n\n\n<p>If you get any of these symptoms, you must tell your doctor or healthcare professional immediately.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause&nbsp;side effects&nbsp;, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Important&nbsp;side effects&nbsp;are to be aware of:<\/strong><\/p>\n\n\n\n<p>Sudden&nbsp;<strong>life-threatening allergic reactions<\/strong>&nbsp;(eg&nbsp;anaphylaxis&nbsp;,&nbsp;angioneurotic edema&nbsp;and&nbsp;urticaria&nbsp;) are rare (may affect up to 1 in 1,000 people).&nbsp;Possible symptoms include:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>sudden onset of rash, itchy or raised rash (hives),<\/li><li>swelling of the face, lips, tongue, throat or other parts of the body,<\/li><li>difficulty swallowing,<\/li><li>shortness of breath, wheezing or difficulty breathing.<\/li><\/ul>\n\n\n\n<p><strong>If you think&nbsp;<\/strong><strong>Narop&nbsp;<\/strong><strong>has given you an&nbsp;allergic reaction&nbsp;, tell your doctor or healthcare professional immediately.<\/strong><\/p>\n\n\n\n<p><strong><em>Other&nbsp;side effects&nbsp;have been reported for Narop<\/em><\/strong><\/p>\n\n\n\n<p><strong>Very common (may affect more than 1 user in 10)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>low&nbsp;blood pressure<\/li><li>nausea.<\/li><\/ul>\n\n\n\n<p><strong>Common (may affect up to 1 in 10 people)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>tingling, dizziness, headache<\/li><li>slow or fast heartbeat<\/li><li>high&nbsp;blood pressure<\/li><li>vomiting<\/li><li>urination problem<\/li><li>fever, chills, back pain.<\/li><\/ul>\n\n\n\n<p><strong>Uncommon (may affect up to 1 in 100 people)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>concern<\/li><li>Some symptoms may occur if&nbsp;injection&nbsp;was accidentally given into a blood vessel or if you received too much Narop.&nbsp;Symptoms include seizures, strokes, intoxication, tingling around the mouth, numbness of the tongue, hearing and vision disorders,&nbsp;tinnitus&nbsp;, speech and articulation difficulties, muscle twitching, tremors, decreased sensitivity of the skin.<\/li><li>fainting<\/li><li>breathing difficulties<\/li><li>low body temperature.<\/li><\/ul>\n\n\n\n<p><strong>Rare (may affect up to 1 in 1,000 people)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>cardiac arrest, cardiac arrhythmias.<\/li><\/ul>\n\n\n\n<p><strong>Has been reported (occurs in an unknown number of users)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>involuntary muscle movements (&nbsp;dyskinesia&nbsp;).<\/li><\/ul>\n\n\n\n<p>Side effects&nbsp;such as headache, slow heartbeat, vomiting, difficulty urinating, decreased sensitivity or sensation in the skin, fainting, difficulty breathing and low body temperature are more common when&nbsp;injection&nbsp;takes place in the lower back (&nbsp;intrathecal&nbsp;administration&nbsp;).&nbsp;In addition to the above&nbsp;side effects&nbsp;, stiffness can also occur in up to 1 in 10 users with this type of use.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Additional side effects in children<\/h2>\n\n\n\n<p>Children experience the same&nbsp;side effects&nbsp;as adults, except that low&nbsp;blood pressure&nbsp;is less common in children (may occur in more than 1 in 100 users) and that vomiting occurs more often (may occur in more than 1 in 10 users).<\/p>\n\n\n\n<p>Tell your doctor as soon as possible if you do not feel well during the&nbsp;administration&nbsp;of Narop.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Narop<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Do not store above 30 \u00b0 C.&nbsp;Do not freeze.<\/p>\n\n\n\n<p>For information on shelf life after opening or adding other medicines, see section \u201cThe following information is intended for healthcare professionals only\u201d at the end of this leaflet.<\/p>\n\n\n\n<p>Doctors or hospitals usually store Narop products.&nbsp;The staff is trained in storing, dosing and disposing of Narop injection and&nbsp;infusion fluid&nbsp;.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is ropivacaine hydrochloride.<\/li><li>The other ingredients are sodium chloride, sodium hydroxide and \/ or&nbsp;hydrochloric acid&nbsp;, water for injections.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<p>Narop solution for injection \/ infusion is a&nbsp;sterile&nbsp;,&nbsp;isotonic&nbsp;, isobaric, clear&nbsp;aqueous solution&nbsp;with a&nbsp;pH value&nbsp;adjusted with sodium hydroxide and \/ or&nbsp;hydrochloric acid&nbsp;to 4.0\u20116.0.&nbsp;Narop contains no&nbsp;preservatives&nbsp;and is for single use only.<\/p>\n\n\n\n<p>Narop&nbsp;solution for injection&nbsp;is supplied in polypropylene plastic ampoules (&nbsp;Polyamp&nbsp;).<\/p>\n\n\n\n<p>Narop 2 mg \/ ml is available in pack sizes of 5 x 10 ml and 5 x 20 ml.<\/p>\n\n\n\n<p>Narop 5 mg \/ ml is available in the pack size: 5 x 10 ml.<\/p>\n\n\n\n<p>Narop 7.5 mg \/ ml is available in the pack size: 5 x 20 ml.<\/p>\n\n\n\n<p>Narop 10 mg \/ ml is available in pack sizes of 5 x 10 ml and 5 x 20 ml.<\/p>\n\n\n\n<p>Narop 2 mg \/ ml&nbsp;infusion solution&nbsp;is supplied in polypropylene plastic bags (Polybag&nbsp;<sup>\u00ae<\/sup>&nbsp;) and is available in pack sizes of 5 x 100 ml and 5 x 200 ml.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>Aspen Pharma Trading Limited<\/p>\n\n\n\n<p>3016 Lake Drive, Citywest Business Campus<\/p>\n\n\n\n<p>Dublin 24, Ireland<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>AstraZeneca AB<\/p>\n\n\n\n<p>S\u00f6dert\u00e4lje<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Narop contains the active substance ropivacaine hydrochloride, which is a topical anesthetic ( local anesthetic ).<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,15581],"tags":[18440,18435,18436,18439,18431,18434,18437,18432,18438,18433],"class_list":["post-18653","post","type-post","status-publish","format-standard","hentry","category-medicines","category-n","tag-benefits-of-narop","tag-benefits-of-ropivacaine-hydrochloride","tag-narop","tag-narop-side-effects","tag-ropivacaine-hydrochloride","tag-ropivacaine-hydrochloride-side-effects","tag-what-is-narop","tag-what-is-ropivacaine-hydrochloride","tag-what-narop-is-used-for","tag-what-ropivacaine-hydrochloride-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/18653","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=18653"}],"version-history":[{"count":3,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/18653\/revisions"}],"predecessor-version":[{"id":18697,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/18653\/revisions\/18697"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=18653"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=18653"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=18653"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}