{"id":18470,"date":"2022-02-17T16:38:08","date_gmt":"2022-02-17T16:38:08","guid":{"rendered":"https:\/\/zeepedia.com\/?p=18470"},"modified":"2022-02-18T11:10:59","modified_gmt":"2022-02-18T11:10:59","slug":"mydrane","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/mydrane\/","title":{"rendered":"Mydrane &#8211; Tropicamide \/ phenylephrine hydrochloride \/ lidocaine hydrochloride | uses, dose and side effects"},"content":{"rendered":"\n<p>0.2 mg \/ ml + 3.1 mg \/ ml + 10 mg \/ ml&nbsp;solution&nbsp;for injection<br>tropicamide \/ phenylephrine hydrochloride \/ <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/triolif\/\">lidocaine hydrochloride<\/a><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Mydrane is and what it is used for<\/h2>\n\n\n\n<p><strong>What Mydrane is<\/strong><\/p>\n\n\n\n<p>This medicine is a solution that is injected into the eye.<\/p>\n\n\n\n<p>It contains three active substances:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>tropicamide, which belongs to a group of medicines that block the impulse transmission via certain nerves (called anticholinergics)<\/li><li>phenylephrine&nbsp;(as phenylephrine hydrochloride) which belongs to a group of medicines that mimic the effects of impulses transmitted through certain nerves (called alpha-sympathomimetics)<\/li><li>lidocaine&nbsp;(as lidocaine hydrochloride) which belongs to a group of medicines called amide-type local anesthetics.<\/li><\/ul>\n\n\n\n<p><strong>What it is used for<\/strong><\/p>\n\n\n\n<p>This medicine is for adults only.<\/p>\n\n\n\n<p>Your eye surgeon will give this medicine as an&nbsp;injection&nbsp;into the eye at the beginning of cataract surgery (clouding of the lens) to dilate the&nbsp;pupil&nbsp;(&nbsp;mydriasis&nbsp;) and to numb the eye during the operation.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you get Mydrane<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">You should not be given Mydrane:<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to tropicamide, phenylephrine hydrochloride and \/ or lidocaine hydrochloride or any of the other ingredients of this medicine (listed in section 6)<\/li><li>if you are allergic to amide-type anesthetics (articles, bupivacaine, mepivacaine, prilocaine, ropivacaine)<\/li><li>if you are allergic to atropine-like medicines.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Mydrane is not recommended:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if cataract surgery is performed in combination with a certain other eye surgery (vitrectomy)<\/li><li>if the front part (front chamber) of your eye is shallow<\/li><li>if you have previously had a sudden increase in eye pressure (&nbsp;acute&nbsp;narrow-angle glaucoma&nbsp;).<\/li><\/ul>\n\n\n\n<p>Talk to a doctor especially if you have:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>high&nbsp;blood pressure&nbsp;(&nbsp;hypertension&nbsp;)<\/li><li>thickening of the artery wall (atherosclerosis)<\/li><li>any heart disease and especially if it affects the heart rate<\/li><li>any obstacle (&nbsp;contraindication&nbsp;) to the use of antihypertensive drugs (amine-type antihypertensive drugs:&nbsp;adrenaline&nbsp;,&nbsp;noradrenaline&nbsp;,&nbsp;dopamine&nbsp;,&nbsp;dobutamine&nbsp;)<\/li><li>overactive&nbsp;thyroid gland&nbsp;(&nbsp;hyperthyroidism&nbsp;)<\/li><li>disorder of the prostate<\/li><li>seizures (&nbsp;epilepsy&nbsp;)<\/li><li>any liver disease or kidney problem<\/li><li>breathing problems<\/li><li>loss of muscle function and weakness (&nbsp;myasthenia gravis&nbsp;).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Mydrane<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding and fertility<\/h2>\n\n\n\n<p>This medicine should not be used:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>during pregnancy<\/li><li>during breastfeeding.<\/li><\/ul>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking any medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Mydrane has a moderate effect on the ability to drive and use machines.&nbsp;Therefore, do not drive or use machines until your vision has returned to normal.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0Descriptions of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Mydrane contains sodium<\/h2>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg)\u00a0sodium\u00a0per\u00a0dose, ie essentially &#8216;sodium-free&#8217;.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How Mydrane should be given<\/h2>\n\n\n\n<p>You should only receive this medicine if you have received sufficient\u00a0pupil\u00a0dilation during the examination before the operation, through treatment with pupil dilating (mydriatic)\u00a0eye drops.<\/p>\n\n\n\n<p><strong>Dosage&nbsp;and route of administration<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The eye surgeon will inject Mydrane under&nbsp;local anesthesia&nbsp;at the beginning of the cataract surgery.<\/li><li>The recommended&nbsp;dose&nbsp;is 0.2 ml solution as a single&nbsp;injection&nbsp;.&nbsp;No additional&nbsp;dose&nbsp;should be injected as no additional effect has been demonstrated and as increased loss of endothelial cells (cells covering the back of the cornea) has been observed.<\/li><li>The same&nbsp;dose&nbsp;is used for both adults and the elderly.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">If you get more or less Mydrane<\/h2>\n\n\n\n<p>This medicine will be given by an eye surgeon.&nbsp;It is unlikely that you will get an overdose.&nbsp;Too much can increase the loss of corneal endothelial cells (cells that cover the back of the cornea).<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>The most serious well-known complications during or after cataract surgery:<\/strong><\/p>\n\n\n\n<p><strong>Uncommon: may affect up to 1 in 100 people<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>damage to the lens of the eye (&nbsp;rupture&nbsp;of the posterior capsule)<\/li><li>swelling of the retina (cystic macular edema).<\/li><\/ul>\n\n\n\n<p>In these cases, you should seek medical attention immediately.<\/p>\n\n\n\n<p><strong>Other side effects:<\/strong><\/p>\n\n\n\n<p><strong>Uncommon: may affect up to 1 in 100 people<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>headache<\/li><li>corneal swelling (&nbsp;keratitis&nbsp;), increased eye pressure,&nbsp;redness&nbsp;of the eye (&nbsp;ocular&nbsp;hyperemia&nbsp;)<\/li><li>high&nbsp;blood pressure&nbsp;(&nbsp;hypertension&nbsp;).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Mydrane<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton, blister, and\u00a0ampoule.\u00a0The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>No special storage instructions.<\/p>\n\n\n\n<p>For single use in one eye.\u00a0This medicine should be used immediately after opening the\u00a0ampoule.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substances are 0.04 mg tropicamide, 0.62 mg phenylephrine hydrochloride and 2 mg lidocaine hydrochloride per 0.2 ml&nbsp;dose&nbsp;, corresponding to 0.2 mg tropicamide, 3.1 mg phenylephrine hydrochloride and 10 mg lidocaine hydrochloride per 1 ml.<\/li><li>The other ingredients are sodium chloride, disodium phosphate dodecahydrate, disodium phosphate dihydrate disodium edetate and water for injections.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<p>Mydrane is a clear, slightly brownish-yellow\u00a0solution for injection\u00a0that is practically free of visible particles.\u00a0It comes in a 1 ml brown\u00a0glass ampoule.\u00a0Each\u00a0sterile\u00a0ampoule\u00a0contains 0.6 ml of\u00a0injection\u00a0liquid and is packaged separately or together with a 5-micrometer filter needle in a paper \/ PVC blister.<\/p>\n\n\n\n<p>One carton contains 1, 20, or 100 sterile\u00a0ampoules\u00a0and the same number of sterile needles with 5-micrometer filters packaged either separately or together in a blister pack.\u00a0The cannula with a 5-micrometer filter is intended only for drawing up the contents of\u00a0the ampoule\u00a0one.\u00a0All equipment is for single use only.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>The Laboratories<\/p>\n\n\n\n<p>12, Rue Louis Bleriot<\/p>\n\n\n\n<p>63017 Clermont-Ferrand Cedex 2<\/p>\n\n\n\n<p>France<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Delpharm Tours<\/p>\n\n\n\n<p>Rue Paul Langevin<\/p>\n\n\n\n<p>37170 Chambray Les Tours<\/p>\n\n\n\n<p>France<\/p>\n\n\n\n<p>or<\/p>\n\n\n\n<p>The Laboratories<\/p>\n\n\n\n<p>12, Rue Louis Bleriot<\/p>\n\n\n\n<p>63017 Clermont-Ferrand Cedex 2<\/p>\n\n\n\n<p>France<\/p>\n\n\n\n<p><strong>This medicinal product is authorized under the European Economic Area under the names:<\/strong><\/p>\n\n\n\n<p>Belgium, Bulgaria, Cyprus, Denmark, Finland, France, Greece, Iceland, Italy, Croatia, Luxembourg, Netherlands, Poland, Portugal, Romania, Slovakia, Slovenia, Sweden, United Kingdom, Czech Republic, Germany, Austria: Mydrane<\/p>\n\n\n\n<p>Ireland, Spain: Fydrane<\/p>\n\n\n\n<p>Norway: Mydane<\/p>\n","protected":false},"excerpt":{"rendered":"<p>0.2 mg \/ ml + 3.1 mg \/ ml + 10 mg \/ ml&nbsp;solution&nbsp;for injectiontropicamide \/ phenylephrine hydrochloride \/ lidocaine hydrochloride What Mydrane is and what it is used for What Mydrane is This medicine is a solution that is injected into the eye. It contains three active substances: tropicamide, which belongs to a group [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,15580],"tags":[5305,5307,18141,18143,18130,18133,18126,18129,5306,18140,18131,18127,12666,18142,18132,18128],"class_list":["post-18470","post","type-post","status-publish","format-standard","hentry","category-medicines","category-m","tag-lidocaine-hydrochloride","tag-lidocaine-hydrochloride-side-effects","tag-mydrane","tag-mydrane-side-effects","tag-phenylephrine-hydrochloride","tag-phenylephrine-hydrochloride-side-effects","tag-tropicamide","tag-tropicamide-side-effects","tag-what-is-lidocaine-hydrochloride","tag-what-is-mydrane","tag-what-is-phenylephrine-hydrochloride","tag-what-is-tropicamide","tag-what-lidocaine-hydrochloride-is-used-for","tag-what-mydrane-is-used-for","tag-what-phenylephrine-hydrochloride-is-used-for","tag-what-tropicamide-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/18470","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=18470"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/18470\/revisions"}],"predecessor-version":[{"id":18502,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/18470\/revisions\/18502"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=18470"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=18470"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=18470"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}