{"id":18463,"date":"2022-02-17T16:31:09","date_gmt":"2022-02-17T16:31:09","guid":{"rendered":"https:\/\/zeepedia.com\/?p=18463"},"modified":"2022-02-18T11:11:20","modified_gmt":"2022-02-18T11:11:20","slug":"mycamine","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/mycamine\/","title":{"rendered":"Mycamine &#8211; Micafungin uses, dose and side effects"},"content":{"rendered":"\n<p>50 mg and 100 mg powder for concentrate for solution for infusion<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Mycamine is and what it is used for<\/h2>\n\n\n\n<p>Mycamine contains the active substance micafungin.\u00a0Mycamine is an antifungal medicine and is used to treat\u00a0infections\u00a0caused by fungal cells.\u00a0Mycamine is used to treat fungal infections caused by fungal or yeast cells called\u00a0<em>Candida<\/em>.\u00a0Mycamine is effective in treating systemic fungal infections (fungal infections inside the body).\u00a0Mycamine interferes with the production of a component in the cell wall of the fungus.\u00a0An intact cell wall is necessary for the fungus to continue to live and grow.\u00a0Mycamine creates\u00a0defects\u00a0in the cell wall of the fungus and thus makes it impossible for the fungus to live and grow.<\/p>\n\n\n\n<p>Your doctor has prescribed Mycamine for any of the following reasons when there is no other suitable antifungal agent available (see section 2):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>To treat adults, adolescents and children including newborns who have a severe fungal infection called&nbsp;invasive&nbsp;candidiasis&nbsp;(fungal infection inside the body).<\/li><li>To treat adults and adolescents \u2265 16 years of age who have a fungal infection of the esophagus (esophagus) where administration of the drug via a vein (&nbsp;intravenous&nbsp;treatment) is appropriate.<\/li><li>To prevent&nbsp;<em>Candida&nbsp;infection&nbsp;<\/em>in&nbsp;patients undergoing bone marrow transplantation or patients who are expected to have&nbsp;neutropenia&nbsp;(low level of&nbsp;neutrophils&nbsp;, a type of white blood cell) for 10 days or more.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using Mycamine<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Mycamine<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to micafungin, other echinocandins (Ecalta or Cancidas) or any of the other ingredients of this medicine (listed in section 6).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p><strong>In rats, long-term treatment with micafungin caused liver damage and subsequent liver tumors.\u00a0The potential risk for humans from developing liver tumors is unknown and your doctor will make a benefit\/risk<\/strong> assessment of the Mycamine treatment before using your medicine.\u00a0Tell your doctor if you have severe liver problems (eg liver failure or\u00a0hepatitis\u00a0) or if you have previously had abnormal liver function tests.\u00a0During treatment, your liver function will be monitored more closely.<\/p>\n\n\n\n<p>Talk to your doctor or pharmacist before using Mycamine<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to any medicine.<\/li><li>if you have&nbsp;hemolytic anemia&nbsp;(&nbsp;anemia&nbsp;due to&nbsp;red blood cell&nbsp;breakdown ) or&nbsp;hemolysis&nbsp;(&nbsp;red blood cell&nbsp;breakdown ).<\/li><li>if you have kidney problems (eg&nbsp;kidney failure&nbsp;and abnormal kidney function values).&nbsp;If this happens, your doctor may monitor your kidney function more closely.<\/li><\/ul>\n\n\n\n<p>Micafungin can also cause severe inflammation\/rash on the skin and mucous membranes (\u00a0Stevens-Johnson syndrome, toxic epidermal\u00a0necrolysis\u00a0).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Mycamine<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>It is especially important to tell your doctor if you are taking amphotericin B deoxycholate or itraconazole (antifungal\u00a0antibiotics\u00a0), sirolimus (an immunosuppressant), or nifedipine (a calcium channel blocker used to treat high\u00a0blood pressure\u00a0).\u00a0Your doctor may decide to adjust the\u00a0dose\u00a0of one of these medicines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Mycamine with food and drink<\/h2>\n\n\n\n<p>Because Mycamine is given\u00a0intravenously\u00a0(into a vein), no special measures are required about food and drink.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n<p>Mycamine should not be used during pregnancy unless necessary.\u00a0If you are taking Mycamine, you should not breastfeed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Micafungin is unlikely to affect the ability to drive or use machines.\u00a0However, some people may get dizzy when taking this medicine, and should it happen to you, do not drive, use any tools or machines.\u00a0Tell your doctor if you experience any effects that may lead to problems with driving or using machines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Mycamine contains sodium<\/h2>\n\n\n\n<p>This medicine contains less than 1 mmol\u00a0sodium\u00a0(23 mg) per\u00a0dose, ie essentially &#8216;sodium-free&#8217;.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Mycamine<\/h2>\n\n\n\n<p>Mycamine must be prepared and given to you by a doctor or other healthcare professional.\u00a0Mycamine is given once daily by slow\u00a0intravenous\u00a0(into a vein)\u00a0infusion.\u00a0Your doctor will decide how much Mycamine you should receive each day.<\/p>\n\n\n\n<p><strong>Use in adults, adolescents \u2265 16 years and older<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The usual&nbsp;dose&nbsp;for the treatment of&nbsp;invasive&nbsp;<em>Candida<\/em>&nbsp;infection&nbsp;is&nbsp;100 mg per day for patients weighing 40 kg or more and 2 mg \/ kg per day for patients weighing 40 kg or less.<\/li><li>The dose&nbsp;to treat a&nbsp;<em>Candida<\/em>&nbsp;infection&nbsp;in&nbsp;the esophagus is 150 mg for patients weighing more than 40 kg and 3 mg \/ kg per day for patients weighing 40 kg or less.<\/li><li>The usual&nbsp;dose&nbsp;to prevent the development of&nbsp;<em>Candida<\/em>&nbsp;infection&nbsp;is&nbsp;50 mg per day for patients weighing more than 40 kg and 1 mg \/ kg per day for patients weighing 40 kg or less.<em><\/em><\/li><\/ul>\n\n\n\n<p><strong>Use in children&gt; 4 months and adolescents &lt;16 years<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The usual&nbsp;dose&nbsp;for the treatment of&nbsp;invasive&nbsp;Candida&nbsp;infection&nbsp;is&nbsp;100 mg per day for patients weighing 40 kg or more and 2 mg \/ kg per day for patients weighing 40 kg or less.<\/li><li>The usual&nbsp;dose&nbsp;to prevent the development of&nbsp;Candida&nbsp;infection&nbsp;is&nbsp;50 mg per day for patients weighing more than 40 kg and 1 mg \/ kg per day for patients weighing 40 kg or less.<\/li><\/ul>\n\n\n\n<p><strong>Use in children and newborns &lt;4 months<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The usual&nbsp;dose&nbsp;for treating&nbsp;invasive&nbsp;<em>Candida<\/em>&nbsp;infection is&nbsp;4-10&nbsp;mg \/ kg per day<\/li><li>The usual&nbsp;dose&nbsp;to prevent the onset of&nbsp;<em>Candida<\/em>&nbsp;infection&nbsp;is&nbsp;2 mg \/ kg per day.<\/li><\/ul>\n\n\n\n<p><strong>If you use more Mycamine than you should<\/strong><\/p>\n\n\n\n<p>Your doctor will monitor your condition and how you react to the treatment to determine what\u00a0dose\u00a0of Mycamine you need.\u00a0If you are still worried that you may have received too much Mycamine, talk to your doctor or another healthcare professional immediately.<\/p>\n\n\n\n<p><strong>If you forget to use Mycamine<\/strong><\/p>\n\n\n\n<p>Your doctor will monitor your condition and how you react to the treatment to determine which\u00a0dose\u00a0of Mycamine you need.\u00a0If you are still worried that you may have forgotten to take a\u00a0dose\u00a0of Mycamine, talk to your doctor or another healthcare professional immediately.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p>If you have an allergic attack or a severe skin reaction (eg blisters and scaling of the skin), you must inform your doctor or nurse immediately.<\/p>\n\n\n\n<p>Mycamine can cause the following other side effects:<\/p>\n\n\n\n<p>Common (may affect up to 1 in 10 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>abnormal blood counts (decreased number of&nbsp;white blood cells&nbsp;[leukopenia;&nbsp;neutropenia&nbsp;]), decreased number of&nbsp;red blood cells&nbsp;(&nbsp;anemia&nbsp;)<\/li><li>decreased blood potassium (&nbsp;hypokalaemia&nbsp;), decreased magnesium content in the blood (&nbsp;hypomagnesaemia&nbsp;), decreased blood calcium (&nbsp;hypocalcaemia&nbsp;)<\/li><li>headache<\/li><li>inflammation&nbsp;of the vessel wall of the veins (at the injection site)<\/li><li>nausea, vomiting, diarrhea, abdominal pain<\/li><li>abnormal liver function tests (increased number of alkaline phosphatases, elevated&nbsp;AST&nbsp;, elevated&nbsp;ALT&nbsp;)<\/li><li>increase in bile pigments in the blood (hyperbilirubinemia)<\/li><li>rash<\/li><li>fever<\/li><li>stiffness (with chills)<\/li><\/ul>\n\n\n\n<p>Uncommon (may affect up to 1 in 100 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>abnormal blood counts (decreased number of&nbsp;blood cells&nbsp;[pancytopenia]), decreased number of&nbsp;platelets&nbsp;(&nbsp;thrombocytopenia&nbsp;), increase in certain types of&nbsp;white blood cells&nbsp;called&nbsp;eosinophils&nbsp;, decreased albumin content in the blood (hypoalbuminemia)<\/li><li>hypersensitivity<\/li><li>increased sweating<\/li><li>decreased sodium levels in the blood (&nbsp;hyponatremia&nbsp;), increased potassium levels in the blood (&nbsp;hyperkalaemia&nbsp;), decreased levels of phosphatases in the blood (&nbsp;hypophosphatemia&nbsp;),&nbsp;anorexia&nbsp;(eating disorders)<\/li><li>insomnia (difficulty sleeping), anxiety, confusion<\/li><li>drowsiness (&nbsp;somnolence&nbsp;), tremors, dizziness, taste disturbances<\/li><li>increased&nbsp;heart rate&nbsp;, stronger heartbeat, irregular heartbeat<\/li><li>high or low&nbsp;blood pressure&nbsp;, reddening of the skin<\/li><li>respiratory distress<\/li><li>indigestion, constipation<\/li><li>liver failure, elevated liver enzymes (gamma-glutamyltransferase), jaundice (yellowing of the skin or whites of the eyes due to liver or blood problems), decreased bile in the intestines (cholestasis), enlarged liver, hepatitis<\/li><li>itchy rash (&nbsp;urticaria&nbsp;),&nbsp;itching&nbsp;, redness of the skin (&nbsp;erythema&nbsp;)<\/li><li>abnormal renal function values \u200b\u200b(increased blood creatinine, increased&nbsp;urea&nbsp;level in the blood), worsening&nbsp;renal failure<\/li><li>increased levels of an&nbsp;enzyme&nbsp;called&nbsp;lactate dehydrogenase<\/li><li>blood clotting in the veins at the injection site,&nbsp;inflammation&nbsp;at the injection site, pain at the injection site, fluid accumulation in the body<\/li><\/ul>\n\n\n\n<p>Rare (may affect up to 1 in 1,000 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>anemia&nbsp;(&nbsp;anemia&nbsp;) due to&nbsp;red blood cell&nbsp;breakdown (&nbsp;hemolytic anemia&nbsp;),&nbsp;red blood cell&nbsp;breakdown (&nbsp;hemolysis&nbsp;)<\/li><\/ul>\n\n\n\n<p>Has been reported (occurs in an unknown number of users)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>disturbance in the blood&#8217;s ability to coagulate<\/li><li>(allergic)&nbsp;shock<\/li><li>liver cell damage including death<\/li><li>kidney problems,&nbsp;acute&nbsp;renal failure<\/li><\/ul>\n\n\n\n<p><strong>Additional&nbsp;side effects&nbsp;are in children and adolescents<\/strong><\/p>\n\n\n\n<p>The following reactions have been reported more frequently in children than in adults:<\/p>\n\n\n\n<p>Common (may affect up to 1 in 10 people)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>decreased&nbsp;platelet count&nbsp;(&nbsp;thrombocytopenia&nbsp;)<\/li><li>increased&nbsp;heart rate&nbsp;(&nbsp;tachycardia&nbsp;)<\/li><li>high or low&nbsp;blood pressure<\/li><li>elevated bile pigment levels in the blood (hyperbilirubinemia), enlarged liver<\/li><li>acute&nbsp;renal failure&nbsp;, elevated&nbsp;urea&nbsp;in the blood<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Mycamine<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the vial and the carton.\u00a0The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>An unopened&nbsp;vial&nbsp;does not require any special storage instructions.<\/p>\n\n\n\n<p>The reconstituted concentrate and diluted infusion solution should be used immediately, as it does not contain any&nbsp;preservatives&nbsp;that prevent bacterial contamination.&nbsp;Only trained healthcare professionals who have read the entire instructions for use properly can prepare this medicine before use.<\/p>\n\n\n\n<p>Do not use the diluted infusion solution if it is cloudy or if there is a\u00a0precipitate.<\/p>\n\n\n\n<p>To protect the infusion bottle\/bag containing the diluted infusion fluid from light, it should be tucked into a sealable opaque bag.<\/p>\n\n\n\n<p>The vials are for single use only.&nbsp;Therefore, dispose of unused, dissolved concentrate immediately.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is micafungin sodium.1&nbsp;vial&nbsp;contains 50 mg or 100 mg micafungin (as sodium salt).<\/li><li>The other ingredients are&nbsp;lactose monohydrate&nbsp;, anhydrous citric acid and sodium hydroxide.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<p>Mycamine 50 mg or 100 mg powder for concentrate for solution for\u00a0infusion\u00a0is a white, compact, lyophilized powder.<\/p>\n\n\n\n<p>Mycamine is supplied in cartons containing 1\u00a0vial.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Astellas Pharma Europe BV<\/p>\n\n\n\n<p>Sylviusweg 62<\/p>\n\n\n\n<p>2333 BE Leiden<\/p>\n\n\n\n<p>Netherlands<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Astellas Ireland Co., Ltd.<\/p>\n\n\n\n<p>Killorglin, County Kerry<\/p>\n\n\n\n<p>Ireland<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Mycamine contains the active substance micafungin. Mycamine is an antifungal medicine and is used to treat infections caused by fungal cells. Mycamine is used to treat fungal infections caused by fungal or yeast cells called Candida . Mycamine is effective in treating systemic fungal infections (fungal infections inside the body). Mycamine interferes with the production of a component in the cell wall of the fungus. An intact cell wall is necessary for the fungus to continue to live and grow. Mycamine creates defects in the cell wall of the fungus and thus makes it impossible for the fungus to live and grow.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,15580],"tags":[18166,18173,18162,18168,18165,18167,18169,18172,18163,18170,18164,18171],"class_list":["post-18463","post","type-post","status-publish","format-standard","hentry","category-medicines","category-m","tag-benefits-of-micafungin","tag-benefits-of-mycamine","tag-micafungin","tag-micafungin-dosage","tag-micafungin-side-effects","tag-micafungin-uses","tag-mycamine","tag-mycamine-side-effects","tag-what-is-micafungin","tag-what-is-mycamine","tag-what-micafungin-is-used-for","tag-what-mycamine-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/18463","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=18463"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/18463\/revisions"}],"predecessor-version":[{"id":18505,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/18463\/revisions\/18505"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=18463"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=18463"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=18463"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}