{"id":18402,"date":"2022-02-16T15:48:04","date_gmt":"2022-02-16T15:48:04","guid":{"rendered":"https:\/\/zeepedia.com\/?p=18402"},"modified":"2022-02-17T15:42:00","modified_gmt":"2022-02-17T15:42:00","slug":"mozobil","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/mozobil\/","title":{"rendered":"Moobil &#8211; Plerixafor uses, dose and side effects"},"content":{"rendered":"\n<p>20 mg \/ ml&nbsp;solution&nbsp;for injection<br>plerixafor<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Mozobil is and what it is used for<\/h2>\n\n\n\n<p>Mozobil contains the active substance plerixafor, which blocks a\u00a0protein\u00a0on the surface of blood stem cells.\u00a0This\u00a0protein\u00a0&#8220;binds&#8221; the blood stem cells to the\u00a0bone marrow.\u00a0Plerixafor improves the release of\u00a0stem cells\u00a0into the bloodstream (mobilization).\u00a0The stem cells\u00a0can then be collected by a machine that separates the blood components (apheresis machine) and frozen and stored until it is time for your transplant.<\/p>\n\n\n\n<p>For patients who have difficulty mobilizing, Mozobil is used to facilitate the collection of blood stem cells from the patient, for collection, storage, and reintroduction (transplantation)<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>For adults with&nbsp;lymphoma&nbsp;(cancer of the&nbsp;white blood cells&nbsp;) or multiple&nbsp;myeloma&nbsp;(cancer affecting plasma cells in the&nbsp;bone marrow&nbsp;).<\/li><li>In children 1 year to younger than 18 years with&nbsp;lymphoma&nbsp;or solid&nbsp;tumor&nbsp;er.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using Mozobil<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Mozobil<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to plerixafor or any of the other ingredients of this medicine (listed in section 6).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor before using Mozobil:<\/p>\n\n\n\n<p>Inform your doctor:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have or have had heart problems.<\/li><li>if you have kidney problems.&nbsp;Your doctor may adjust&nbsp;dose&nbsp;one.<\/li><li>if you have a high number of&nbsp;white blood cells&nbsp;.<\/li><li>if you have low&nbsp;platelet counts&nbsp;.<\/li><li>if you have previously felt weak or dizzy while standing or sitting, or have previously fainted in connection with the&nbsp;injection&nbsp;.<\/li><\/ul>\n\n\n\n<p>Your doctor may take\u00a0<strong>regular blood tests<\/strong>\u00a0to check the number of\u00a0blood cells.<\/p>\n\n\n\n<p>Mozobil should not be used for stem cell mobilization if you have&nbsp;leukemia&nbsp;(cancer of the blood or&nbsp;bone marrow&nbsp;).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Mozobil<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>You should not use Mozobil if you are pregnant, as there is no experience with Mozobil in pregnant women.&nbsp;It is important that you inform your doctor if you are, think you may be or are planning to become pregnant.&nbsp;You should use contraception if you are of&nbsp;childbearing&nbsp;age.<\/p>\n\n\n\n<p>You should not breastfeed if you are using Mozobil, as it is not known if Mozobil is excreted in human milk.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Mozobil can cause dizziness and fatigue.\u00a0You should therefore avoid driving if you feel dizzy, tired, or unwell.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Mozobil contains sodium<\/h2>\n\n\n\n<p>This medicine contains less than 1 mmol\u00a0sodium\u00a0(23 mg) per\u00a0dose, ie essentially &#8216;sodium-free&#8217;.\u00a0is next to &#8220;sodium-free&#8221;.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Mozobil<\/h2>\n\n\n\n<p>The medicine is injected by a doctor or nurse.<\/p>\n\n\n\n<p><strong>You first receive\u00a0G-CSF\u00a0and then Mozobil The<\/strong><br>mobilization starts by first receiving another medicine called\u00a0G-CSF\u00a0(\u00a0granulocyte colony-stimulating factor).\u00a0G-CSF\u00a0helps Mozobil work properly in your body.\u00a0You can find out more about\u00a0G-CSF\u00a0by asking your doctor and reading the accompanying leaflet.<\/p>\n\n\n\n<p><strong>How large a\u00a0dose\u00a0of Mozobil is given?<\/strong><br>The recommended\u00a0dose\u00a0for adults is either 20 mg (fixed-dose\u00a0) or 0.24 mg \/ kg body weight \/ day.\u00a0Your\u00a0dose\u00a0depends on your body weight.\u00a0You will be weighed the week before you receive your first\u00a0dose.\u00a0If you have moderate or severe kidney problems, your doctor will lower\u00a0your dose.<\/p>\n\n\n\n<p>The recommended\u00a0dose\u00a0for children 1 year to younger than 18 years is 0.24 mg\/kg body weight\/day.<\/p>\n\n\n\n<p><strong>How is Mozobil given?<\/strong><br>Mozobil is given by&nbsp;subcutaneous&nbsp;injection&nbsp;(under the skin).<\/p>\n\n\n\n<p><strong>When is Mozobil first given?<\/strong><\/p>\n\n\n\n<p>You will receive your first&nbsp;dose&nbsp;6 to 11 hours before apheresis (collection of blood stem cells).<\/p>\n\n\n\n<p><strong>How long will Mozobil be given?<\/strong><br>The treatment lasts for 2-4 consecutive days (in some cases up to 7 days) until enough\u00a0stem cells\u00a0have been collected for your transplant.\u00a0In some cases, it is not possible to collect enough\u00a0stem cells\u00a0and the collection attempt will then be stopped.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Tell your doctor immediately<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>shortly after you receive Mozobil you get a rash, swelling around the eyes, shortness of breath or lack of oxygen, feel dizzy when standing or sitting, feel weak or faint<\/li><li>you have pain in the upper left part of the abdomen (stomach) or in the left shoulder.<\/li><\/ul>\n\n\n\n<p><strong>Very common&nbsp;side effects&nbsp;(may affect more than 1 user in 10)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>diarrhea, nausea,&nbsp;flushing&nbsp;or irritation at the injection site<\/li><li>low number of&nbsp;red blood cells&nbsp;from laboratory tests (&nbsp;anemia&nbsp;in children)<\/li><\/ul>\n\n\n\n<p><strong>Common&nbsp;side effects&nbsp;(may affect up to 1 in 10 people)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>headache<\/li><li>dizziness, feeling tired or unwell<\/li><li>sleeping problems<\/li><li>flatulence, constipation, indigestion, vomiting<\/li><li>stomach symptoms such as&nbsp;pain, swelling or discomfort<\/li><li>dry mouth&nbsp;, numbness around the mouth<\/li><li>sweating, general redness of the skin, joint pain, muscle and leg pain.<\/li><\/ul>\n\n\n\n<p><strong>Uncommon&nbsp;side effects&nbsp;(may affect up to 1 in 100 people)<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>allergic reactions such as&nbsp;skin rash, swelling around the eyes, shortness of breath<\/li><li>anaphylactic reactions, including anaphylactic&nbsp;shock<\/li><li>abnormal dreams, nightmares<\/li><\/ul>\n\n\n\n<p>In rare cases,\u00a0side effects\u00a0in the gastrointestinal tract can be serious (diarrhea, vomiting, abdominal pain, and nausea).<\/p>\n\n\n\n<p><strong>Heart attack<\/strong><br>In\u00a0clinical trials, patients with risk factors for heart attack have, in less common cases, suffered a heart attack after receiving Mozobil and\u00a0G-CSF.\u00a0Tell your doctor immediately if you feel any discomfort in your chest.<\/p>\n\n\n\n<p><strong>Ants crawling and numbness<\/strong><br>Ants crawling and numbness are common in patients being treated for cancer.&nbsp;About one in five patients experience these discomforts.&nbsp;But these effects do not seem to occur more often when using Mozobil.<\/p>\n\n\n\n<p>Your blood tests may show that you also have an increase in the number of&nbsp;white blood cells&nbsp;(&nbsp;leukocytosis&nbsp;).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Mozobil<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton and vial.<\/p>\n\n\n\n<p>No special storage instructions.<\/p>\n\n\n\n<p>After opening the vial, use Mozobil immediately.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is plerixafor.&nbsp;Each ml of&nbsp;solution for injection&nbsp;contains 20 mg of plerixafor.&nbsp;Each&nbsp;vial&nbsp;contains 24 mg plerixafor in 1.2 ml solution.<\/li><li>The other ingredients are sodium chloride,&nbsp;hydrochloric acid&nbsp;(concentrated) and sodium hydroxide for&nbsp;pH&nbsp;adjustment and water for injections.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<p>Mozobil is supplied as a clear, colorless, or pale yellow\u00a0solution for injection\u00a0in a glass vial with a latex-free rubber stopper.\u00a0Each\u00a0vial\u00a0contains 1.2 ml of solution.<\/p>\n\n\n\n<p>Each pack contains 1\u00a0vial.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorisation Holder<\/h2>\n\n\n\n<p>Genzyme Europe BV<\/p>\n\n\n\n<p>Paasheuvelweg 25<\/p>\n\n\n\n<p>1105 BP Amsterdam<\/p>\n\n\n\n<p>Netherlands.<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><br>Genzyme Ireland Ltd., IDA Industrial Park, Old Kilmeaden Road, Waterford, Ireland<\/p>\n\n\n\n<p>Contact the representative of the marketing authorization holder if you want to know more about this medicine:<br><br>Sanofi AB<\/p>\n\n\n\n<p>Tel: +46 (0) 8 634 50 00<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Mozobil contains the active substance plerixafor, which blocks a protein on the surface of blood stem cells. This protein &#8220;binds&#8221; the blood stem cells to the bone marrow . Plerixafor improves the release of stem cells into the bloodstream (mobilization). The stem cells can then be collected by a machine that separates the blood components (apheresis machine) and frozen and stored until it is time for your transplant.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,15580],"tags":[18053,18048,18049,18052,18044,18047,18050,18045,18051,18046],"class_list":["post-18402","post","type-post","status-publish","format-standard","hentry","category-medicines","category-m","tag-benefits-of-mozobil","tag-benefits-of-plerixafor","tag-mozobil","tag-mozobil-side-effects","tag-plerixafor","tag-plerixafor-side-effects","tag-what-is-mozobil","tag-what-is-plerixafor","tag-what-mozobil-is-used-for","tag-what-plerixafor-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/18402","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=18402"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/18402\/revisions"}],"predecessor-version":[{"id":18433,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/18402\/revisions\/18433"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=18402"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=18402"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=18402"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}