{"id":18256,"date":"2022-02-14T15:45:34","date_gmt":"2022-02-14T15:45:34","guid":{"rendered":"https:\/\/zeepedia.com\/?p=18256"},"modified":"2022-02-15T15:06:40","modified_gmt":"2022-02-15T15:06:40","slug":"monoket-od","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/monoket-od\/","title":{"rendered":"Monoket OD &#8211; Isosorbide mononitrate uses, dose and side effects"},"content":{"rendered":"\n<p>25mg \/ 50mg \/ 100 mg&nbsp;hard<br>prolonged-release capsules isosorbide mononitrate<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Monoket OD is and what it is used for<\/h2>\n\n\n\n<p>Monoket OD is used as a preventive treatment for angina in the heart (&nbsp;angina pectoris&nbsp;).<\/p>\n\n\n\n<p>This drug works by dilating the blood vessels and thereby reducing the work of the heart.<\/p>\n\n\n\n<p>Isosorbide mononitrate contained\u00a0in Monoket OD may also be approved for the treatment of other conditions not mentioned in this leaflet.\u00a0Ask your doctor, pharmacist, or other healthcare professional if you have any further questions, and always follow their instructions.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before using Monoket OD<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not use Monoket OD<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic to&nbsp;isosorbide mononitrate&nbsp;, other nitrates or any of the other ingredients of this medicine (listed in section 6)<\/li><li>if your heart has severely impaired pump function (&nbsp;cardiogenic&nbsp;shock&nbsp;), so that your&nbsp;blood pressure&nbsp;does not become high enough<\/li><li>if you have a heart muscle disease that leads to thickening of the heart wall (obstructive&nbsp;hypertrophic&nbsp;cardiomyopathy&nbsp;)<\/li><li>if you have&nbsp;inflammation&nbsp;of the pericardium (constrictive pericarditis)<\/li><li>if you have accumulation of fluid between the heart and the pericardium (&nbsp;cardiac tamponade&nbsp;)<\/li><li>if you have&nbsp;acute&nbsp;circulatory failure&nbsp;(&nbsp;shock&nbsp;or circulatory collapse)<\/li><li>if you have very low&nbsp;blood pressure&nbsp;(systolic&nbsp;blood pressure&nbsp;below 90 mmHg)<\/li><li>if you have a sharp decrease in blood volume (severe&nbsp;hypovolemia&nbsp;)<\/li><li>if you are taking riociguat, a medicine for certain types of high&nbsp;blood pressure&nbsp;(so-called&nbsp;pulmonary&nbsp;hypertension&nbsp;)<\/li><li>if you have severe&nbsp;anemia&nbsp;(&nbsp;anemia&nbsp;).<\/li><\/ul>\n\n\n\n<p>When using Monoket, do not use phosphodiesterase inhibitors (\u00a0PDE\u00a05 inhibitors), such as sildenafil, tadalafil, or vardenafil, which are used for\u00a0impotence\u00a0as concomitant use with this medicine may lead to a severe drop in\u00a0blood pressure\u00a0which may damage the heart or brain (see also section Other medicines and Monoket).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before using Monoket OD.<\/p>\n\n\n\n<p>Take special care with this medicine<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have heart problems (such as&nbsp;acute&nbsp;heart attack or left ventricular dysfunction), low&nbsp;blood pressure&nbsp;, narrowing of large blood vessels or heart valve<\/li><li>if you have problems with low&nbsp;blood pressure&nbsp;e.g.&nbsp;when getting up from sitting<\/li><li>if you have increased pressure in the skull,&nbsp;anemia&nbsp;, too little oxygen in the blood or impaired thyroid function.<\/li><li>if you have overactive or irritated bowel because this medicine may pass through the gastrointestinal tract too quickly, before complete&nbsp;release&nbsp;of the active substance.<\/li><\/ul>\n\n\n\n<p>Those who have these diseases should consult a doctor before starting treatment with this drug.<\/p>\n\n\n\n<p>This medicine should not be used to treat an&nbsp;acute&nbsp;angina attack, as it does not have a fast enough effect to alleviate this condition.<\/p>\n\n\n\n<p>Monoket OD and similar drugs have been shown to stop working or become less effective after being continuously taken in high\u00a0doses.\u00a0It is important to follow the dosing instructions to avoid this.<\/p>\n\n\n\n<p>This medicine should not be used concomitantly with\u00a0PDE\u00a05 inhibitors (eg sildenafil, tadalafil, or vardenafil).\u00a0Your treatment with this medicine should not be stopped for the use of medicines containing\u00a0PDE\u00a0-5 inhibitors.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children<\/h2>\n\n\n\n<p>Safety and efficacy in children have not yet been established.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Monoket OD<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>This medicine should not be used concomitantly with certain\u00a0impotence\u00a0medicines (\u00a0PDE\u00a0-5 inhibitors, which contain eg sildenafil, vardenafil, or tadalafil) as this may result in a severe drop in blood pressure which may cause permanent damage to the heart and brain.<\/p>\n\n\n\n<p>Concomitant treatment with antihypertensive drugs (beta-blockers, calcium channel blockers, vasodilators, riociguat) and\/or alcohol may potentiate the antihypertensive effect of Monoket OD.\u00a0The same can happen with drugs for mental illness (\u00a0neuroleptics\u00a0) and depression (tricyclic antidepressants and\u00a0MAO inhibitors\u00a0).<\/p>\n\n\n\n<p>Concomitant treatment with migraine medication (dihydroergotamine) may affect raising blood pressure.<\/p>\n\n\n\n<p>Ask your doctor if you are taking medicines containing sapropterin (also known as tetrahydrobiopterin or BH4) for certain metabolic diseases.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Monoket OD with food, drink and alcohol<\/h2>\n\n\n\n<p>Taking alcohol with this medicine may increase the blood pressure-lowering effect.\u00a0Dizziness may occur when you take this medicine and the risk of getting dizzy increases if you drink alcohol at the same time.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n<p>Limited experience of use during pregnancy.&nbsp;Therefore, consult a physician before using this medicine during pregnancy.<\/p>\n\n\n\n<p>It is not known if this medicine passes into breast milk.\u00a0The risk of affecting the child can not be ruled out.\u00a0The need for this medicine and the benefits of breastfeeding must be weighed against the potential risks to the baby.\u00a0Therefore consult a doctor before use during breastfeeding.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Dizziness may occur when you take this medicine.&nbsp;You should keep this in mind when driving or using machines, for example.&nbsp;The risk of dizziness increases if you drink alcohol at the same time.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0Descriptions of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Monoket OD contains lactose and sucrose<\/h2>\n\n\n\n<p>This medicine contains&nbsp;lactose&nbsp;and sucrose.&nbsp;If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to use Monoket OD<\/h2>\n\n\n\n<p>Always use this medicine exactly as your doctor has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p>The recommended&nbsp;dose&nbsp;is 1 capsule of 50 mg daily in the morning.&nbsp;Dose&nbsp;one can be gradually increased to 75 mg and up to 100 mg once daily if necessary and in consultation with a physician.&nbsp;At the beginning of treatment, a&nbsp;dose&nbsp;of 25 mg is recommended for the first 2-4 days to avoid headaches.<\/p>\n\n\n\n<p>It is important to take the capsules at the same time each day.<\/p>\n\n\n\n<p>If you have the impression that this medicine is too strong or too weak, talk to your doctor or pharmacist.<\/p>\n\n\n\n<p>The capsules must not be chewed but swallowed whole with at least \u00bd glass of liquid.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you use more Monoket OD than you should\u00a0<\/h2>\n\n\n\n<p>Symptoms of overdose include headache, pale skin, sweating, weak\u00a0pulse, nausea, vomiting, diarrhea, dizziness, rapid heartbeat, dizziness on rising and lowering of\u00a0blood pressure.<\/p>\n\n\n\n<p>If you experience any of the above symptoms due to overdose, stop taking this medicine.&nbsp;Lie down with slightly raised legs as it can relieve symptoms.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist<strong>.<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><em>Angioedema<\/em>&nbsp;:<\/p>\n\n\n\n<p>Stop taking Monoket and contact a doctor immediately if you get any of the following symptoms (\u00a0angioedema\u00a0): swelling of the face, tongue, or throat;\u00a0difficulty swallowing;\u00a0hives,\u00a0and difficulty breathing.<\/p>\n\n\n\n<p><em>Very common (may affect more than 1 user in 10)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Headache that usually disappears with continued use.<\/li><\/ul>\n\n\n\n<p><em>Common (may affect up to 1 in 10 people)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Dizziness<\/li><li>Nausea<\/li><li>Feeling weak<\/li><li>Low&nbsp;blood pressure&nbsp;when standing<\/li><li>Increased heart rate.<\/li><\/ul>\n\n\n\n<p><em>Uncommon: (may affect up to 1 in 100 people)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Vomiting<\/li><li>Diarrhea<\/li><li>Exacerbated symptoms of angina.<\/li><\/ul>\n\n\n\n<p><em>Rare (may affect up to 1 in 1,000 people)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Allergic skin reactions (eg rash)<\/li><li>Redness&nbsp;.<\/li><\/ul>\n\n\n\n<p><em>Has been reported (occurs in an unknown number of users)<\/em><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Angioedema<\/li><li>Circulatory collapse (sometimes accompanied by slow irregular heartbeat and fainting)<\/li><li>Low&nbsp;blood pressure<\/li><li>Scaly skin<\/li><li>Somnolence<\/li><li>Heartburn<\/li><li>Hypoxemia&nbsp;(lack of oxygenation of the blood).<\/li><\/ul>\n\n\n\n<p>Severe symptoms due to low\u00a0blood pressure\u00a0have been reported during treatment with this type of medication and include nausea, vomiting, restlessness, paleness, and excessive sweating.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Monoket OD<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not store above 30 \u00b0 C.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the package and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<p>One capsule contains:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is&nbsp;isosorbide mononitrate&nbsp;25 mg, 50 mg and 100 mg respectively<\/li><li>The other ingredients are&nbsp;lactose monohydrate&nbsp;6.7 mg, 13.4 mg and 26.5 mg respectively, sucrose, maize starch, talc, ethylcellulose, macrogol, hydroxypropylcellulose, gelatin, titanium dioxide (dye E171), iron oxide (dye E172).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<p><strong><em>Monoket OD hard prolonged-release capsules 25 mg:<\/em><\/strong><\/p>\n\n\n\n<p>98 prolonged-release capsules (pressure pack)<\/p>\n\n\n\n<p>100 prolonged-release capsules (plastic jar, for dose dispensing only)<\/p>\n\n\n\n<p><strong><em>Monoket OD hard prolonged-release capsules 50 mg:<\/em><\/strong><\/p>\n\n\n\n<p>14 prolonged-release capsules (pressure pack)<\/p>\n\n\n\n<p>98 prolonged-release capsules (pressure pack)<\/p>\n\n\n\n<p>100 prolonged-release capsules (plastic jar, for dose dispensing only)<\/p>\n\n\n\n<p><strong><em>Monoket OD hard prolonged-release capsules 100 mg:<\/em><\/strong><\/p>\n\n\n\n<p>98 prolonged-release capsules (pressure pack)<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p>Merus Labs Luxco II S.\u00e0.RL<\/p>\n\n\n\n<p>26-28, rue Edward Steichen<\/p>\n\n\n\n<p>L-2540 Luxembourg<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Aesica Pharmaceuticals GmbH<\/p>\n\n\n\n<p>Alfred-Nobel-Strasse 10<\/p>\n\n\n\n<p>D-40789 Monheim<\/p>\n\n\n\n<p>Germany<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Monoket OD is used as a preventive treatment for angina in the heart ( angina pectoris ).<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,15580],"tags":[13095,17923,12209,12212,17919,17922,12210,17920,12211,17921],"class_list":["post-18256","post","type-post","status-publish","format-standard","hentry","category-medicines","category-m","tag-benefits-of-isosorbide-mononitrate","tag-benefits-of-monoket-od","tag-isosorbide-mononitrate","tag-isosorbide-mononitrate-side-effects","tag-monoket-od","tag-monoket-od-side-effects","tag-what-is-isosorbide-mononitrate","tag-what-is-monoket-od","tag-what-isosorbide-mononitrate-is-used-for","tag-what-monoket-od-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/18256","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=18256"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/18256\/revisions"}],"predecessor-version":[{"id":18314,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/18256\/revisions\/18314"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=18256"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=18256"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=18256"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}