{"id":18183,"date":"2022-02-12T12:20:27","date_gmt":"2022-02-12T12:20:27","guid":{"rendered":"https:\/\/zeepedia.com\/?p=18183"},"modified":"2023-01-22T09:13:23","modified_gmt":"2023-01-22T09:13:23","slug":"modigraph","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/modigraph\/","title":{"rendered":"Modigraph &#8211; Tacrolimus Uses, Dose And Side Effects"},"content":{"rendered":"\n<p><strong>0.2 mg and 1 mg&nbsp;granules&nbsp;tacrolimus for&nbsp;oral&nbsp;suspension<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Modigraf Is And What Modigraf Used For<\/h2>\n\n\n\n<p>Modigraf contains the active substance tacrolimus.\u00a0It is an immunosuppressive drug.\u00a0After an organ transplant (eg liver, kidney, heart), your body tries to repel the new organ<strong>.\u00a0Modigraf is used to control the immune system in your body, to accept the transplanted organ.<\/strong><\/p>\n\n\n\n<p>You can also be given Modigraf for an ongoing rejection reaction in your transplanted liver, kidney, heart, or another organ when another treatment you have received has not been able to control the immune system after your transplant. Modigraf is used for adults and children.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What You Need To Know Before Taking Modigraf<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do Not Take Modigraf<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>If you are allergic to tacrolimus or any of the other ingredients of this medicine (listed in section 6).<\/li><li>If you are allergic to sirolimus (another substance used to prevent the rejection of transplanted organs) or to any macrolide antibiotic (eg erythromycin, clarithromycin, josamycin).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings And Cautions<\/h2>\n\n\n\n<p>Talk to your doctor or pharmacist before taking Modigraf<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you have or have had liver problems<\/li><li>If you have diarrhea that lasts more than a day<\/li><li>If you get severe abdominal pain accompanied or not by other symptoms, such as chills, fever, nausea or vomiting<\/li><li>If you have a change in heart rhythm, so-called &#8220;QT prolongation&#8221;.<\/li><\/ul>\n\n\n\n<p>Avoid taking herbal medicines, e.g.&nbsp;St. John&#8217;s wort&nbsp;(&nbsp;<em>Hypericum perforatum<\/em>&nbsp;) or other herbal products as this may affect the effectiveness of Modigraf and the&nbsp;dose&nbsp;you need to take.&nbsp;If in doubt, consult your doctor before taking any herbal medicines or products.<\/p>\n\n\n\n<p>Your doctor may need to adjust the Modigraf dose. You should have regular contact with your doctor, who may occasionally need tests of blood, urine, heart function, and eyes, to determine the correct\u00a0dose\u00a0of Modigraf.<\/p>\n\n\n\n<p>Limit exposure to sunlight and UV light (ultraviolet light) while taking Modigraf.&nbsp;This is because immunosuppressive drugs such as Modigraf may increase the risk of developing skin cancer.&nbsp;In case of sun exposure, wear suitable protective clothing and sunscreen with a high sun protection factor.<\/p>\n\n\n\n<p><strong>Handling Precautions:<\/strong><\/p>\n\n\n\n<p>Direct contact with any part of the body, such as skin or eyes, or inhalation of&nbsp;solution for injection, powder, or&nbsp;granules&nbsp;with tacrolimus should be avoided.&nbsp;In such contact, skin and eyes should be rinsed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other Medicines And Modigraf<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<p>Concomitant treatment with Modigraf and ciclosporin (another medicine used to counteract the rejection of transplanted organs) is not recommended.<\/p>\n\n\n\n<p><strong>If you need to see a doctor other than your transplant specialist, tell your doctor that you are taking tacrolimus.&nbsp;Your doctor may need to consult your transplant specialist if you are taking another medicine that may increase or decrease the tacrolimus concentration in your blood.<\/strong><\/p>\n\n\n\n<p>The blood concentrations of Modigraf may be affected by other medicines you are taking and blood levels of other medicines may be affected by your taking Modigraf, which means that the Modigraf dose may need to be increased, decreased, or stopped.<\/p>\n\n\n\n<p>In some patients, tacrolimus concentrations in the blood have increased when they were taking other medicines at the same time.&nbsp;This can lead to serious&nbsp;side effects, such as problems with the kidneys and nervous system as well as disorders of the heart rhythm (see section 4).<\/p>\n\n\n\n<p>Effects on Modigraf concentrations in the blood can occur very quickly after starting another medicine.&nbsp;Therefore, continuous monitoring of the concentration of Modigraf in the blood may be needed during the first few days after you start taking another medicine and at frequent intervals for the duration of treatment with the other medicine.&nbsp;Some other medicines may reduce the concentration of tacrolimus in the blood, which may increase the risk of transplant rejection.&nbsp;You should especially tell your doctor if you are taking or have recently taken any medicines such as:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Medicines for fungal infections and\u00a0antibiotics\u00a0, especially so-called macrolide antibiotics used to treat\u00a0infections\u00a0, e.g.\u00a0ketoconazole\u00a0,\u00a0fluconazole\u00a0, itraconazole, posaconazole, voriconazole, clotrimazole, isavuconazole,\u00a0miconazole\u00a0, telithromycin, erythromycin, clarithromycin, josamycin, azithromycin, rifampicin, rifabutin and\u00a0isoniazid\u00a0.<\/li><li>Letermovir, which is used to prevent diseases caused by\u00a0CMV\u00a0(\u00a0cytomegalovirus\u00a0in humans)<\/li><li>HIV\u00a0protease\u00a0inhibitors\u00a0(eg ritonavir, nelfinavir, saquvinavir), the booster drug cobicistat and combination tablets, or non-nucleoside reverse transcriptase inhibitors against\u00a0HIV\u00a0(efavirenz, etravirine, nevirapine) used to\u00a0treat\u00a0HIV\u00a0infection<\/li><li>HCV\u00a0&#8211;\u00a0protease inhibitors\u00a0(eg telaprevir, boceprevir and the combination of ombitasvir \/ paritaprevir \/ ritonavir with or without dasabuvir, elbasvir \/ grazoprevir and glecaprevir \/ pibrentasvir), used to treat\u00a0hepatitis\u00a0C\u00a0infection<\/li><li>Nilotinib and imatinib, idelalisib, ceritinib, crizotinib, apalutamide, enzalutamide or mitotane (used to treat certain cancers)<\/li><li>Mycophenolic acid, which is used to suppress the immune system to prevent rejection of the transplanted organ<\/li><li>Medicines for\u00a0stomach ulcers\u00a0and acid reflux (eg omeprazole, lansoprazole or cimetidine)<\/li><li>Medicines for nausea and vomiting (eg metoclopramide)<\/li><li>Cisapride or\u00a0magnesium\u00a0-aluminum hydroxide, used to treat heartburn<\/li><li>Birth control pills\u00a0, hormone treatments containing ethinyl estradiol or hormone treatments with danazol<\/li><li>Medicines for high\u00a0blood pressure\u00a0or heart problems (eg nifedipine, nicardipine,\u00a0diltiazem\u00a0and verapamil)<\/li><li>Antiarrhythmics\u00a0(\u00a0amiodarone\u00a0) drugs used to treat\u00a0arrhythmias\u00a0(irregular heartbeat)<\/li><li>Drugs called &#8216;statins&#8217;, which are\u00a0used to treat high\u00a0cholesterol\u00a0and\u00a0triglycerides<\/li><li>Carbamazepine,\u00a0phenytoin\u00a0and phenobarbital used to treat\u00a0epilepsy<\/li><li>Metamizole, which is used to treat pain and fever<\/li><li>The corticosteroids\u00a0prednisolone and\u00a0methylprednisolone\u00a0, which are used to treat\u00a0inflammation\u00a0and suppress the immune system (eg when rejecting the transplanted organ)<\/li><li>Nefazodone used to treat depression<\/li><li>Herbal medicines containing\u00a0St. John&#8217;s wort\u00a0(\u00a0<em>Hypericum perforatum<\/em>\u00a0) or extracts of\u00a0<em>Schisandra sphenanthera<\/em><\/li><\/ul>\n\n\n\n<p>Tell your doctor if you are receiving treatment for&nbsp;hepatitis&nbsp;C. Drug treatment for&nbsp;hepatitis&nbsp;C can affect liver function and thus the tacrolimus concentration in the blood.&nbsp;Tacrolimus levels in the blood may decrease or increase depending on the medicines prescribed for&nbsp;hepatitis&nbsp;C. Your doctor may need to monitor your tacrolimus levels carefully and adjust your Modigraf&nbsp;dose&nbsp;after you start treatment for&nbsp;hepatitis&nbsp;C.<\/p>\n\n\n\n<p>Tell your doctor if you are taking or need to take&nbsp;ibuprofen&nbsp;(medicines for fever,&nbsp;inflammation,&nbsp;and pain),&nbsp;antibiotics&nbsp;(trimethoprim\/sulfamethoxazole, vancomycin or aminoglycoside antibiotics such as gentamicin), amphotericin B (medicines for fungal infections), or medicines for viral infections (eg .acyclovir, ganciclovir, cidofovir, foscarnet).&nbsp;These can aggravate kidney problems or problems in the nervous system when taken with Modigraf.<\/p>\n\n\n\n<p>Your doctor must also know if you are taking potassium supplements or certain&nbsp;diuretics, which are used for&nbsp;heart failure, high&nbsp;blood pressure,&nbsp;and kidney disease (eg amiloride, triamterene, or&nbsp;spironolactone&nbsp;), certain medicines used for fever,&nbsp;inflammation,&nbsp;and pain (so-called&nbsp;NSAIDs), such as&nbsp;ibuprofen&nbsp;), blood thinners or&nbsp;oral&nbsp;medication to treat&nbsp;diabetes&nbsp;while you are taking Modigraf.<\/p>\n\n\n\n<p>If you need to be vaccinated, tell your doctor in advance.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Modigraf With Food And Drink<\/h2>\n\n\n\n<p>You should generally take Modigraf on an empty stomach or at least 1 hour before or 2 to 3 hours after a meal.&nbsp;Grapefruit and grapefruit juice should be avoided while you are being treated with Modigraf, as it affects your blood levels.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy And Breastfeeding<\/h2>\n\n\n\n<p>If you take Modigraf during pregnancy, it can be transmitted to your baby through the placenta.&nbsp;It could affect your baby&#8217;s health or negatively affect your pregnancy.<\/p>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before using this medicine.<\/p>\n\n\n\n<p>Modigraf passes into breast milk.&nbsp;Therefore, you should not breastfeed while taking Modigraf.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving And Using Machines<\/h2>\n\n\n\n<p>Do not drive or use any tools or machines if you feel dizzy or sleepy, or have trouble seeing clearly after taking Modigraf.&nbsp;These effects are more common if you also drink alcohol.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Modigraf Contains Lactose And Sodium<\/h2>\n\n\n\n<p>Modigraf contains\u00a0lactose\u00a0(milk sugar).\u00a0If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine. This medicine contains less than 1 mmol\u00a0sodium\u00a0(23 mg) per\u00a0sachet, ie essentially &#8216;sodium-free&#8217;.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How To Take Modigraf<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Always take this medicine exactly as your doctor has told you.\u00a0Ask your doctor or pharmacist if you are unsure.\u00a0Modigraf should be prescribed by doctors who are trained in treating transplant patients and who have experience using drugs that control the body&#8217;s immune system (immunosuppressive drugs).<\/li><li>Make sure you get the same tacrolimus medicine every time you pick up your prescription unless your transplant doctor has decided to switch you to another tacrolimus medicine.<\/li><li>This medicine should be taken twice daily.\u00a0If your physical appearance has changed from the normal white\u00a0granules, or if the dose instructions have been changed, talk to your doctor or pharmacist as soon as possible to make sure you have received the correct medicine.<\/li><li>The starting dose to prevent rejection of your transplanted organ is determined by your doctor and is calculated according to your body weight.\u00a0The starting doses immediately after transplantation are normally in the range of 0.075\u20130.30 mg per kg body weight per day depending on the organ transplanted.\u00a0In the treatment of rejection, the same\u00a0dosage\u00a0can be used.<\/li><li>Dose\u00a0one depends on your general condition and on which another immunosuppressive drug (s) you are receiving.<\/li><li><strong>Children and young people<\/strong><ul><li>Children and adolescents should take\u00a0doses\u00a0of Modigraf calculated in the same way as adults.\u00a0In general, children need higher\u00a0doses\u00a0per kg of body weight to achieve the same effective blood concentrations as adults.<\/li><li>After you have started treatment with Modigraf, your doctor will take blood samples frequently to arrive at the correct\u00a0dose\u00a0and adjust the\u00a0dose\u00a0from time to time.\u00a0The dose of Modigraf\u00a0is usually reduced by your doctor once your condition has stabilized.\u00a0Your doctor will tell you exactly how many sachets to take.<\/li><li>You will need to take Modigraf every day for as long as you need immunosuppression to prevent rejection of your transplanted organ.\u00a0You should be in regular contact with your doctor.<\/li><li>Modigraf is taken orally twice daily, usually in the morning and in the evening.\u00a0Take Modigraf on an empty stomach or 2 to 3 hours after a meal.\u00a0Wait at least 1 hour for the next meal.<\/li><\/ul><\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">How To Mix Modigraf\u00a0Sachet\u00a0Before Taking It<\/h2>\n\n\n\n<p>Your doctor will tell you how many sachets you need to open and the amount of water needed to make a&nbsp;suspension.&nbsp;To measure the exact amount of water, you can use a&nbsp;syringe&nbsp;or a graduated cylinder gauge.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Pour the prescribed amount of water (room temperature) into a glass or cup, up to a maximum of 50 ml.\u00a0Place the cup with the water on a stable surface.\u00a0Do not use copper or spoons made of PVC (polyvinyl chloride) when taking Modigraf as the active substance in Modigraf may stick to PVC.\u00a0<\/li><li>Carefully open the number of prescribed sachets e.g.\u00a0using scissors where it is marked with an arrow.\u00a0<\/li><li>Hold the opened sachet between your thumb and forefinger over the cup with the open side of the sachet facing down.<\/li><li>\u00a0Gently tap the closed side of the sachet and pour the contents of each\u00a0sachet\u00a0into the glass or cup of water.<\/li><li>Do not use any utensils or liquid to empty the sachet.\u00a0If you follow these instructions, you will get the right amount of\u00a0granules from the sachet.\u00a0It is normal for some granules to remain,\u00a0the sachet\u00a0n is made that way.<\/li><li>Stir or swirl gently until the\u00a0granules\u00a0have completely dissolved.\u00a0Suspension\u00a0can be drawn up into a\u00a0syringe\u00a0or swallowed directly by the patient.\u00a0The liquid has a sweet taste.\u00a0<\/li><li>Rinse the glass or cup once with the same amount of water and drink it as well.\u00a0The liquid should be drunk immediately after\u00a0reconstitution.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Children And Young People<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">If You Take More Modigraf Than You Should<\/h2>\n\n\n\n<p>If you have accidentally taken too much Modigraf, contact your doctor or nearest hospital emergency department immediately.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If You Forget To Take Modigraf<\/h2>\n\n\n\n<p>Do not take a double&nbsp;dose&nbsp;to make up for a forgotten&nbsp;dose.&nbsp;If you forget to take your Modigraf&nbsp;dose, wait until it is time to take your next&nbsp;dose&nbsp;and then continue as before.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If You Stop Taking Modigraf<\/h2>\n\n\n\n<p>Ending treatment with Modigraf may increase the risk of rejection of your transplanted organ. Do not stop your treatment as long as your doctor does not tell you to. If you have any further questions on the use of this product, ask your doctor or pharmacist<strong>.<\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible Modigraf Side Effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them. Modigraf weakens the body&#8217;s defense mechanisms (immune system), which impairs the body&#8217;s ability to fight\u00a0infection.\u00a0When you take Modigraf you can therefore get more\u00a0infection\u00a0than usual.<\/p>\n\n\n\n<p>Serious\u00a0side effects\u00a0have been reported, including <\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Allergic and anaphylactic reactions (a very serious\u00a0allergic reaction\u00a0with loss of consciousness and difficulty breathing, requiring immediate medical attention).\u00a0<\/li><li>Benign and malignant\u00a0tumors\u00a0have been reported during treatment with Modigraf.<\/li><\/ul>\n\n\n\n<p><strong>Contact a doctor immediately if you have or suspect you have any of the following serious side effects:<\/strong><\/p>\n\n\n\n<p>Serious&nbsp;side effects&nbsp;(may affect up to 1 in 10 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Gastrointestinal\u00a0perforation: severe abdominal pain possibly accompanied by other symptoms, such as <ul><li>Chills<\/li><li>Fever<\/li><li>Nausea<\/li><li>Vomiting<\/li><\/ul><\/li><li>Insufficient function of the transplanted organ.<\/li><li>Dimsyn.<\/li><\/ul>\n\n\n\n<p>Serious uncommon&nbsp;side effects&nbsp;(may affect up to 1 in 100 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Hemolytic uremic syndrome, a condition with the following symptoms: <ul><li>Low or no urine production (\u00a0acute\u00a0renal failure\u00a0)<\/li><li>Extreme fatigue<\/li><li>Yellowing of the skin or eyes (jaundice) and abnormal bruising<\/li><li>Bleeding and signs of\u00a0infection\u00a0.<\/li><\/ul><\/li><\/ul>\n\n\n\n<p>Serious rare&nbsp;side effects&nbsp;(may affect up to 1 in 1,000 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Thrombotic thrombocytope purpura (or TTP): <ul><li>A condition characterized by fever and bruising under the skin that may appear as red pin-sized dots, with or without unexplained extreme fatigue, confusion, yellowing of the skin or eyes (jaundice), with symptoms of\u00a0acute\u00a0renal failure\u00a0(low or no urine production).<\/li><\/ul><\/li><li>Toxic\u00a0epidermal\u00a0necrolysis: damage and blisters on skin or mucous membranes, red swollen skin that can become detached from large parts of the body<\/li><li>Blindness<\/li><\/ul>\n\n\n\n<p>Serious very rare&nbsp;side effects&nbsp;(may affect up to 1 in 10,000 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Stevens-Johnson syndrome: unexplained widespread pain in the skin, swelling of the face, severe disease with blistering of the skin, mouth, eyes and genitals,\u00a0hives\u00a0, swollen tongue, red or purple skin rash spreading, flaky skin.<\/li><li><em>Torsades de Pointes<\/em>: <ul><li>Change in heart rate that may, but does not have to, be accompanied by symptoms such as <ul><li>Chest pain (angina)<\/li><li>Weakness<\/li><li>Dizziness or nausea<\/li><li>Palpitations and difficulty breathing<\/li><\/ul><\/li><\/ul><\/li><\/ul>\n\n\n\n<p>Serious&nbsp;side effects&nbsp;ar &#8211; no known frequency (frequency can not be calculated from the available data):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Opportunistic\u00a0infections\u00a0(caused by bacteria, fungi,\u00a0viruses\u00a0and\u00a0protozoa\u00a0): prolonged diarrhea, fever and <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/sore-throat\/\">sore throat<\/a>.<\/li><li>Benign and malignant\u00a0tumors\u00a0have been reported after treatment due to immunosuppression.<\/li><li>Cases of pure erythrocyteplasia (a very severe decrease in\u00a0red blood cell count\u00a0),\u00a0haemolytic anemia\u00a0(decreased\u00a0red blood cell count\u00a0due to increased degradation, along with fatigue) and febrile\u00a0neutropenia\u00a0(a decrease in\u00a0white blood cells\u00a0fighting\u00a0infection\u00a0, along with fever) has been reported.\u00a0It is not known exactly how often these\u00a0side effects\u00a0occur.\u00a0You may be asymptomatic or experience symptoms such as fatigue,\u00a0lethargy\u00a0, abnormal pallor, shortness of breath, dizziness, headache, chest pain and cold in the hands and feet, depending on the severity of the condition.<\/li><li>Cases of\u00a0agranulocytosis\u00a0(severe decrease in\u00a0white blood cell count\u00a0along with mouth ulcers, fever and\u00a0infection\u00a0(s)).\u00a0You may be asymptomatic or experience symptoms such as sudden fever, stiffness and sore throat.<\/li><li>Allergic and anaphylactic reactions with the following symptoms:<ul><li>Sudden itchy rash (\u00a0hives\u00a0)<\/li><li>Swelling of the hands, feet, ankles, face, lips, mouth or throat (which may cause difficulty swallowing or breathing) and you may feel that you are about to faint.<\/li><\/ul><\/li><li>Posterior reversible encephalopathy syndrome (PRES):<ul><li>Headache<\/li><li>Confusion<\/li><li>Mood swings, seizures and visual disturbances.\u00a0This may be a sign of a disease called posterior reversible encephalopathy syndrome, which has been reported in some patients treated with tacrolimus.<\/li><\/ul><\/li><li>Optic\u00a0neuropathy\u00a0(visual nerve damage):<ul><li>Problems with your vision such as blurred vision<\/li><li>Changes in color vision<\/li><li>Difficulty seeing details or that your field of\u00a0vision\u00a0is limited.<\/li><\/ul><\/li><\/ul>\n\n\n\n<p>The&nbsp;side effects&nbsp;listed below can also occur after you receive Modigraf and can be serious:<\/p>\n\n\n\n<p>Very common&nbsp;side effects&nbsp;(may affect more than 1 user in 10):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Increased <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/diabetes-type-1\/\">blood sugar<\/a><ul><li>Diabetes mellitus<\/li><li>Increased\u00a0potassium\u00a0in the blood<\/li><\/ul><\/li><li>Difficulty sleeping<\/li><li>Tremors, headaches<\/li><li>Increased\u00a0blood pressure<\/li><li>Abnormal liver function tests<\/li><li>Diarrhea<\/li><li>Nausea<\/li><li>Kidney problems<\/li><\/ul>\n\n\n\n<p>Common&nbsp;side effects&nbsp;(may affect up to 1 in 10 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Decreased number of\u00a0blood cells\u00a0(\u00a0platelets\u00a0, red or\u00a0white blood cells\u00a0)<\/li><li>Increased number of\u00a0white blood cells<\/li><li>Changes in the number of\u00a0red blood cells\u00a0(seen in blood samples)<\/li><li>Decreased\u00a0magnesium<ul><li>Phosphate<\/li><li>Potassium<\/li><li>Calcium\u00a0or\u00a0sodium\u00a0in the blood<\/li><li>Increased amount of fluid in the body<\/li><li>Increased amount of\u00a0uric acid\u00a0or fats in the blood<\/li><li>Decreased appetite<\/li><li>Increased acidity in the blood, other changes in blood salts (seen in blood samples)<\/li><\/ul><\/li><li>Anxiety<\/li><li>Confusion and difficulty orienting<\/li><li>Depression<\/li><li>Mood swings<\/li><li>Nightmares<\/li><li>Hallucinations<\/li><li>Mental illness<\/li><li>Seizures<\/li><li>Disturbances of consciousness<\/li><li>Ant crawling or numbness (sometimes painful) in the hands and feet<\/li><li>Dizziness<\/li><li>Reduced writing ability<\/li><li>Disorders of the nervous system<\/li><li>Increased photosensitivity<\/li><li>Eye diseases<\/li><li>Earrings<\/li><li>Decreased blood flow in the heart\u00a0vessels<\/li><li>Faster heartbeat<\/li><li>Bleeding<\/li><li>Partial or complete blockage of blood vessels<\/li><li>Decreased\u00a0blood pressure<\/li><li>Shortness of breath<\/li><li>Changes in the lungs<\/li><li>Fluid accumulation around the lungs<\/li><li>Inflammation\u00a0of the throat, <a href=\"https:\/\/zeepedia.com\/medical\/diseases\/cough-in-children\/\">cough<\/a>,\u00a0flu-like symptoms<\/li><li>Inflammation\u00a0or ulcers that cause abdominal pain or diarrhea, bleeding in the stomach<\/li><li>Inflammation\u00a0or ulcers in the mouth<\/li><li>Fluid accumulation in the abdomen<\/li><li>Vomiting<\/li><li>Abdominal pain<\/li><li>Digestive problems, constipation<\/li><li>Gas problems<\/li><li>Bloating<\/li><li>Loose stools<\/li><li>Stomach problems<\/li><li>Bile duct problems<\/li><li>Yellowing of the skin due to liver problems<\/li><li>Damage to liver tissue and liver inflammation<\/li><li>Itching\u00a0<\/li><li>Rash<\/li><li>Hair loss<\/li><li>Acne<\/li><li>Increased sweating<\/li><li>Pain in joints, limbs, back and feet<\/li><li>Muscle twitching<\/li><li>Insufficient renal function<\/li><li>Decreased urine output<\/li><li>Impaired or painful urination<\/li><li>General weakness<\/li><li>Fever<\/li><li>Accumulation of fluid in the body<\/li><li>Pain and discomfort<\/li><li>Increase in alkaline phosphatases in the blood<\/li><li>Weight gain<\/li><li>Feeling of disturbed temperature perception<\/li><\/ul>\n\n\n\n<p>Uncommon&nbsp;side effects&nbsp;(may affect up to 1 in 100 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Changes in blood clotting capacity, decrease in the number of all kinds of\u00a0blood cells\u00a0(seen in blood samples)<\/li><li>Dehydration<\/li><li>Decreased\u00a0protein\u00a0or sugar in the blood, increased\u00a0phosphate\u00a0in the blood<\/li><li>Coma\u00a0, cerebral haemorrhage,\u00a0stroke\u00a0, paralysis, brain disease, speech and language difficulties, memory problems<\/li><li>Clouding in the lens of the eye<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/impaired-hearing\/\">Impaired hearing<\/a><\/li><li>Irregular heartbeat, cardiac arrest, decreased heart rate, heart muscle disease, enlargement of the heart muscle, heavier heartbeat, abnormal\u00a0ECG\u00a0, abnormal heart rate and\u00a0heart rate<\/li><li>Blood clot in a friend in leg or arm<\/li><li>Shock<\/li><li>Breathing difficulties<ul><li>Respiratory disease<\/li><li>Asthma<\/li><\/ul><\/li><li>Obstacles in the intestinal passage<\/li><li>Increased blood level of\u00a0enzyme\u00a0et amylase<\/li><li>Regurgitation of contents from the stomach to the throat, slowed emptying of the stomach<\/li><li>Skin inflammation<ul><li>Burning sensation in the sun<\/li><\/ul><\/li><li>Joint diseases<\/li><li>Inability to urinate<\/li><li>Painful menstruation and abnormal menstrual bleeding<\/li><li>Decreased function of several organs<\/li><li>Flu-like symptoms<\/li><li>Increased sensitivity to heat and cold<\/li><li>Pressure over the chest<\/li><li>Nervousness or abnormal feeling<\/li><li>Increase of\u00a0enzyme\u00a0and\u00a0lactate dehydrogenase\u00a0in the blood<\/li><li>Weight loss<\/li><\/ul>\n\n\n\n<p>Rare&nbsp;side effects&nbsp;(may affect up to 1 in 1,000 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Small skin bleeds due to blood clots<\/li><li>Increased muscle stiffness<\/li><li><a href=\"https:\/\/zeepedia.com\/medical\/diseases\/sudden-hearing-loss-sudden-deafness\/\">Deafness<\/a><\/li><li>Accumulation of fluid around the heart<\/li><li>Acute breathing difficulties<\/li><li>Cyst formation in the pancreas<\/li><li>Problems with blood flow in the liver<\/li><li>Severe disease with blistering of the skin, mouth, eyes and genitals, increased hair growth<\/li><li>Thirst, falls, feeling of pressure over the chest, decreased mobility, sores<\/li><\/ul>\n\n\n\n<p>Very rare&nbsp;side effects&nbsp;(may affect up to 1 in 10,000 people):<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Muscle weakness<\/li><li>Abnormal echocardiogram (&nbsp;ECG&nbsp;)<\/li><li>Liver failure<\/li><li>Painful urination with blood in the urine<\/li><li>Increased amount of adipose tissue<\/li><\/ul>\n\n\n\n<p><strong><u>Children and young people<\/u><\/strong><\/p>\n\n\n\n<p>Children and adolescents may experience the same&nbsp;side effects&nbsp;as adults.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How To Store Modigraf<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Keep this medicine out of the sight and reach of children.<\/li><li>Do not use this medicine after the expiry date which is stated on the carton and sachet after \u201cEXP\u201d.\u00a0The expiration date is the last day of the specified month.<\/li><li>No special temperature instructions.<\/li><li>After\u00a0reconstitution, the oral\u00a0suspension\u00a0should be taken immediately.<\/li><\/ul>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents Of The Package And Other Information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content Declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is tacrolimus.<br>One&nbsp;Modigraf&nbsp;0.2 mg sachet contains 0.2 mg tacrolimus (as monohydrate).<br>One&nbsp;Modigraf&nbsp;1 mg sachet contains 1 mg tacrolimus (as monohydrate).<\/li><li>The other ingredients are:&nbsp;Lactose monohydrate&nbsp;, hypromellose (E464) and croscarmellose sodium (E468).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What The Medicine Looks Like And Contents Of The Pack<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Modigraf\u00a0granules\u00a0for\u00a0oral\u00a0suspension\u00a0contain white\u00a0granules\u00a0in sachets.<\/li><li>Packs of 50 sachets are provided.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder And Manufacturer<\/h2>\n\n\n\n<p><strong>Marketing Authorisation Holder<\/strong><\/p>\n\n\n\n<p>Astellas Pharma Europe BV<\/p>\n\n\n\n<p>Sylviusweg 62<\/p>\n\n\n\n<p>2333 BE Leiden<\/p>\n\n\n\n<p>Netherlands<\/p>\n\n\n\n<p><strong>Manufacturer<\/strong><\/p>\n\n\n\n<p>Astellas Ireland Co.&nbsp;Ltd.<\/p>\n\n\n\n<p>Killorglin, County Kerry, V93FC86<\/p>\n\n\n\n<p>Ireland<\/p>\n","protected":false},"excerpt":{"rendered":"<p>modigraph is used to prevent rejection in adults and children who have had a kidney, liver, or heart transplant (when the immune system attacks the transplanted organ).<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,15580],"tags":[17851,11513,17847,17850,4095,4097,17848,4096,17849,11512],"class_list":["post-18183","post","type-post","status-publish","format-standard","hentry","category-medicines","category-m","tag-benefits-of-modigraph","tag-benefits-of-tacrolimus","tag-modigraph","tag-modigraph-side-effects","tag-tacrolimus","tag-tacrolimus-side-effects","tag-what-is-modigraph","tag-what-is-tacrolimus","tag-what-modigraph-is-used-for","tag-what-tacrolimus-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/18183","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=18183"}],"version-history":[{"count":64,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/18183\/revisions"}],"predecessor-version":[{"id":46026,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/18183\/revisions\/46026"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=18183"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=18183"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=18183"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}