{"id":17975,"date":"2022-02-05T11:29:09","date_gmt":"2022-02-05T11:29:09","guid":{"rendered":"https:\/\/zeepedia.com\/?p=17975"},"modified":"2022-02-07T06:43:16","modified_gmt":"2022-02-07T06:43:16","slug":"mimpara","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/mimpara\/","title":{"rendered":"Mimpara &#8211; Cinacalcet uses, dose and side effects"},"content":{"rendered":"\n<p>30 mg, 60 mg, 90 mg&nbsp;film-coated tablets<br>cinacalcet<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Mimpara is and what it is used for<\/h2>\n\n\n\n<p>Mimpara is used to control the levels of\u00a0parathyroid hormone\u00a0(PTH),\u00a0calcium,\u00a0and phosphorus in the body.\u00a0It is used to treat problems in the organ called the parathyroid gland.\u00a0The parathyroid gland consists of four small\u00a0glands\u00a0in the throat near the thyroid gland and produces\u00a0a parathyroid\u00a0hormone (PTH).<\/p>\n\n\n\n<p>Mimpara is used in adults to:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>treat secondary&nbsp;hyperparathyroidism&nbsp;in adult patients with severe kidney disease who need&nbsp;dialysis&nbsp;to cleanse the blood of waste products.<\/li><li>reduce high levels of calcium in the blood (&nbsp;hypercalcaemia&nbsp;) in adult patients with thyroid cancer.<\/li><li>reduce high levels of calcium in the blood (&nbsp;hypercalcaemia&nbsp;) in adult patients with primary&nbsp;hyperparathyroidism&nbsp;when the gland cannot be removed.<\/li><\/ul>\n\n\n\n<p>Mimpara is used in children from 3 years up to 18 years to:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>treat secondary&nbsp;hyperparathyroidism&nbsp;in patients with severe kidney disease who need&nbsp;dialysis&nbsp;to cleanse the blood of waste products and whose disease can not be kept under control with other treatments.<\/li><\/ul>\n\n\n\n<p>In primary and secondary\u00a0hyperparathyroidism, too much PTH is produced by the parathyroid gland.\u00a0&#8220;Primary&#8221; means that\u00a0hyperparathyroidism\u00a0is not caused by another disease and &#8220;secondary&#8221; means that\u00a0hyperparathyroidism\u00a0is caused by another disease, e.g.\u00a0kidney disease.\u00a0Both primary and secondary\u00a0hyperparathyroidism\u00a0can cause a decrease in skeletal\u00a0calcium, which can lead to skeletal pain and\u00a0fractures, heart and blood vessel problems,\u00a0kidney stones, mental illness, and\u00a0coma.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before taking Mimpara<\/h2>\n\n\n\n<p><strong>Do not take Mimpara<\/strong>&nbsp;if you are allergic to cina calcium or any of the other ingredients of this medicine (listed in section 6).<\/p>\n\n\n\n<p><strong>Do not take Mimpara<\/strong>&nbsp;if you have low levels of calcium in your blood.&nbsp;Your doctor will check your blood calcium levels.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor, pharmacist, or nurse before taking Mimpara.<\/p>\n\n\n\n<p>Before you start taking Mimpara, tell your doctor if you have or have ever had:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li><strong>seizures<\/strong>&nbsp;(attacks or convulsions).&nbsp;The risk of seizures is greater if you have had them before<\/li><li><strong>liver problem<\/strong><\/li><li><strong>heart failure<\/strong><\/li><\/ul>\n\n\n\n<p>Mimpara lowers calcium levels in the blood.\u00a0Life-threatening events and death due to low calcium levels (hypocalcemia) have been reported in adults and children treated with Mimpara.<\/p>\n\n\n\n<p>Tell your doctor if you experience any of the following symptoms, which may be signs of low calcium levels:\u00a0spasms, twitches or cramps in the muscles, numbness or tingling in the fingers, toes, or around the mouth, or seizures, confusion or loss of consciousness while you treated with Mimpara.<\/p>\n\n\n\n<p>Low calcium levels can affect heart rate.&nbsp;Tell your doctor if you have unusually fast or beating heartbeats, if you have heart rhythm problems, or if you are taking medicines that are known to cause heart rhythm problems while you are being treated with Mimpara.<\/p>\n\n\n\n<p>For more information, see section 4.<\/p>\n\n\n\n<p>When taking Mimpara, tell your doctor:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you start or stop smoking, as this may affect the way Mimpara works.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Children under 18 years of age with parathyroid cancer or primary&nbsp;hyperparathyroidism&nbsp;should not take Mimpara.<\/p>\n\n\n\n<p>If you are being treated for secondary\u00a0hyperparathyroidism, your doctor should check your calcium levels before starting treatment with Mimpara and regularly during treatment with Mimpara.\u00a0Tell your doctor if you experience any of the signs of low calcium levels described above.<\/p>\n\n\n\n<p>You must take Mimparados\u00a0one\u00a0by your doctor&#8217;s instructions.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Mimpara<\/h2>\n\n\n\n<p>Tell your doctor or pharmacist if you are taking or have recently taken or might take any other medicines, especially ethyl calcium or other medicines that lower your blood calcium levels.<\/p>\n\n\n\n<p>You should not use Mimpara with ethyl calcite.<\/p>\n\n\n\n<p>Tell your doctor if you are taking any of the following medicines.<\/p>\n\n\n\n<p>Drugs like these can affect how Mimpara works:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>medicines used to treat&nbsp;<strong>skin<\/strong>&nbsp;and&nbsp;<strong>fungal infections<\/strong>&nbsp;(&nbsp;ketoconazole&nbsp;, itraconazole and voriconazole)<\/li><li>drugs used to treat&nbsp;<strong>bacterial infections<\/strong>&nbsp;(telithromycin, rifampicin and&nbsp;ciprofloxacin&nbsp;)<\/li><li>a drug used to treat&nbsp;HIV&nbsp;<strong>infections<\/strong>&nbsp;and&nbsp;AIDS&nbsp;(&nbsp;ritonavir)<\/li><li>a drug used to treat&nbsp;<strong>depression<\/strong>&nbsp;(fluvoxamine).<\/li><\/ul>\n\n\n\n<p>Mimpara may affect the way medicines work as follows:<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>medicines used to treat&nbsp;<strong>depression<\/strong>&nbsp;(amitriptyline, desipramine, nortriptyline and clomipramine)<\/li><li>a drug used to relieve&nbsp;<strong>cough<\/strong>&nbsp;(dextromethorphan)<\/li><li>medicines used to treat&nbsp;<strong>changes in heart rate<\/strong>&nbsp;(&nbsp;flecainide&nbsp;and&nbsp;propafenone&nbsp;)<\/li><li>a medicine used to treat&nbsp;<strong>high&nbsp;blood pressure<\/strong>&nbsp;(&nbsp;metoprolol&nbsp;).<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Mimpara with food and drink<\/h2>\n\n\n\n<p>Mimpara should be taken with or after a meal.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy, breastfeeding and fertility<\/h2>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.<\/p>\n\n\n\n<p>Mimpara has not been tested in pregnant women.&nbsp;If you become pregnant, your doctor may choose to change your medication as Mimpara may harm the unborn baby.<\/p>\n\n\n\n<p>It is not known whether Mimpara is excreted in human milk.\u00a0Your doctor will discuss with you whether to discontinue either breastfeeding or treatment with Mimpara.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Dizziness and seizures have been reported in patients taking Mimpara.\u00a0If you experience these\u00a0side effects, do not drive or use machines.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Mimpara contains lactose<\/h2>\n\n\n\n<p>If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Mimpara<\/h2>\n\n\n\n<p>Always take this medicine exactly as your doctor or pharmacist has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.&nbsp;Your doctor will tell you how much Mimpara to take.<\/p>\n\n\n\n<p>Mimpara should be taken orally, with or after a meal.\u00a0The tablets should be swallowed whole and must not be chewed, crushed, or divided.<\/p>\n\n\n\n<p>Mimpara is also available as\u00a0granules\u00a0in capsules intended to be opened.\u00a0Children who require a\u00a0dose\u00a0lower than 30 mg or who are unable to swallow tablets should be treated with Mimpara\u00a0granules.<\/p>\n\n\n\n<p>Your doctor will take regular blood tests to check your disease progression and will adjust&nbsp;dose&nbsp;one if necessary.<\/p>\n\n\n\n<p><em>If you are being treated for secondary&nbsp;hyperparathyroidism<\/em><\/p>\n\n\n\n<p>The usual starting dose of Mimpara for adults is 30 mg (one tablet) once a day.<\/p>\n\n\n\n<p>The usual starting dose of Mimpara for children from 3 years up to 18 years is no more than 0.20 mg\/kg\/day.<\/p>\n\n\n\n<p><em>If you are being treated for thyroid cancer or primary hyperparathyroidism<\/em><\/p>\n\n\n\n<p>The usual starting dose of Mimpara for adults is 30 mg (one tablet) twice a day.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you take more Mimpara than you should<\/h2>\n\n\n\n<p>Contact your doctor immediately if you have taken too much Mimpara.\u00a0Possible signs of overdose are numbness and tingling around the mouth, muscle aches or cramps, and seizures.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Mimpara<\/h2>\n\n\n\n<p>Do not take a double\u00a0dose\u00a0to make up for a forgotten\u00a0dose.<\/p>\n\n\n\n<p>Even if you forget to take a&nbsp;dose&nbsp;of Mimpara, take the next&nbsp;dose&nbsp;as usual.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor, pharmacist, or nurse.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Contact a doctor immediately if you:<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>begins to feel numbness and tingling around the mouth, muscle aches or cramps and seizures.&nbsp;These may be signs that your calcium levels are too low (&nbsp;hypocalcaemia&nbsp;).<\/li><li>swelling of the face, lips, mouth, tongue or pharynx, which may cause difficulty swallowing and breathing (&nbsp;angioedema&nbsp;).<\/li><\/ul>\n\n\n\n<p><strong>Very common side effects: may affect more than 1 in 10 people<\/strong>&nbsp;<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>nausea and vomiting.&nbsp;These&nbsp;side effects&nbsp;are often relatively mild and do not last long.<\/li><\/ul>\n\n\n\n<p><strong>Common side effects: may affect up to 1 in 10 people<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>dizziness<\/li><li>numbness and tingling (&nbsp;paresthesia&nbsp;)<\/li><li>loss of (&nbsp;anorexia&nbsp;) or decreased appetite<\/li><li>muscle pain (&nbsp;myalgia&nbsp;)<\/li><li>weakness (&nbsp;asthenia&nbsp;)<\/li><li>rash<\/li><li>decreased <a href=\"https:\/\/zeepedia.com\/medical\/medicines\/tostrex\/\">testosterone<\/a> levels<\/li><li>high potassium levels in the blood (&nbsp;hyperkalemia&nbsp;)<\/li><li>allergic reactions (hypersensitivity)<\/li><li>headache<\/li><li>seizures<\/li><li>low&nbsp;blood pressure&nbsp;(&nbsp;hypotension&nbsp;)<\/li><li>upper respiratory tract infection<\/li><li>difficulty breathing (&nbsp;dyspnoea&nbsp;)<\/li><li>cough<\/li><li>indigestion (&nbsp;dyspepsia&nbsp;)<\/li><li>diarrhea<\/li><li>abdominal pain, abdominal pain &#8211; upper<\/li><li>constipation<\/li><li>muscle spasms<\/li><li>back pain<\/li><li>low calcium levels in the blood (&nbsp;hypocalcaemia&nbsp;).<\/li><\/ul>\n\n\n\n<p><strong>No known frequency: can not be calculated from the available data<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>hives&nbsp;(&nbsp;urticaria&nbsp;)<\/li><li>swelling of the face, lips, mouth, tongue or throat, which may cause difficulty in swallowing or breathing (&nbsp;angioedema&nbsp;)<\/li><li>unusually fast or beating heartbeat, which may be due to low calcium levels in the blood (&nbsp;QT&nbsp;\u2011extension and&nbsp;ventricular arrhythmia&nbsp;, secondary to hypocalcaemia)<\/li><\/ul>\n\n\n\n<p>After taking Mimpara, a very small number of patients with\u00a0heart failure\u00a0have experienced worsening of their condition and\/or low\u00a0blood pressure\u00a0(\u00a0hypotension\u00a0).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Mimpara<\/h2>\n\n\n\n<p>Keep this medicine out of the sight and reach of children.<\/p>\n\n\n\n<p>Do not use this medicine after the expiry date which is stated on the carton and blister after EXP.&nbsp;The expiration date is the last day of the specified month.<\/p>\n\n\n\n<p>This medicine does not require any special storage.<\/p>\n\n\n\n<p>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the package and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>The active substance is cina calcium.&nbsp;Each film-coated tablet contains 30 mg, 60 mg and 90 mg of cina calcium (as hydrochloride), respectively.<\/li><li>Other ingredients are:<ul><li>Pregelatinized corn starch<\/li><li>Microcrystalline cellulose<\/li><li>Povidon<\/li><li>Krospovidon<\/li><li>Magnesium stearate<\/li><li>Colloidal&nbsp;anhydrous silica<\/li><\/ul><\/li><li>The tablets are coated with:<ul><li>Carnaubavax<\/li><li>Opadry green (contains&nbsp;lactose monohydrate&nbsp;, hypromellose, titanium dioxide (E171), glycerol triacetate, indigo carmine (E132), yellow iron oxide (E172))<\/li><li>Opadry colorless (contains hypromellose, macrogol)<\/li><\/ul><\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<p>Mimpara is a light green film-coated tablet.\u00a0The oval tablets have &#8220;30&#8221;, &#8220;60&#8221;, and &#8220;90&#8221; marked on one side and &#8220;AMG&#8221; on the other.<\/p>\n\n\n\n<p>30 mg tablets are approximately 9.7 mm long and 6.0 mm wide.<\/p>\n\n\n\n<p>60 mg tablets are approximately 12.2 mm long and 7.6 mm wide.<\/p>\n\n\n\n<p>90 mg tablets approximately 13.9 mm long and 8.7 mm wide.<\/p>\n\n\n\n<p>Mimpara is available in blister packs containing 30 mg, 60 mg, and 90 mg film-coated tablets.\u00a0Each blister pack contains 14, 28, or 84 tablets in an outer carton.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<p>Amgen Europe BV<\/p>\n\n\n\n<p>Minervum 7061<\/p>\n\n\n\n<p>4817 ZK Breda<\/p>\n\n\n\n<p>Netherlands<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Mimpara is used to control the levels of parathyroid hormone (PTH), calcium and phosphorus in the body. It is used to treat problems in the organ called the parathyroid gland. The parathyroid gland consists of four small glands in the throat near the thyroid gland and produces parathyroid hormone (PTH).<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,15580],"tags":[17524,17530,7232,7234,7241,17525,17529,17528,17523,7233,17526,17527],"class_list":["post-17975","post","type-post","status-publish","format-standard","hentry","category-medicines","category-m","tag-benefits-of-cinacalcet","tag-benefits-of-mimpara","tag-cinacalcet","tag-cinacalcet-side-effects","tag-cinacalcet-tablet","tag-mimpara","tag-mimpara-side-effects","tag-mimpara-tablet","tag-what-cinacalcet-is-used-for","tag-what-is-cinacalcet","tag-what-is-mimpara","tag-what-mimpara-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/17975","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=17975"}],"version-history":[{"count":3,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/17975\/revisions"}],"predecessor-version":[{"id":17978,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/17975\/revisions\/17978"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=17975"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=17975"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=17975"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}