{"id":17903,"date":"2022-02-03T09:24:51","date_gmt":"2022-02-03T09:24:51","guid":{"rendered":"https:\/\/zeepedia.com\/?p=17903"},"modified":"2022-02-04T11:59:10","modified_gmt":"2022-02-04T11:59:10","slug":"mezavant","status":"publish","type":"post","link":"https:\/\/zeepedia.com\/medical\/medicines\/mezavant\/","title":{"rendered":"Mezavant &#8211; Mesalazine uses, dose and side effects"},"content":{"rendered":"\n<p>1200 mg&nbsp;enteral depot tablet<br>mesalazine<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Mezavant is and what it is used for<\/h2>\n\n\n\n<p>Mesalazine contained in Mezavant may also be approved for the treatment of other conditions not mentioned in this product information.\u00a0Ask your doctor, pharmacist, or another healthcare professional if you have any further questions, and always follow their instructions.<\/p>\n\n\n\n<p>Pharmacotherapeutic group: aminosalicylic acid and similar agents.<\/p>\n\n\n\n<p>Mezavant is an enteric-coated tablet containing the active substance mesalazine, which is an anti-inflammatory drug used to treat\u00a0ulcerative colitis.<\/p>\n\n\n\n<p>Ulcerative colitis&nbsp;is a disease of the&nbsp;colon&nbsp;(colon) and&nbsp;rectum&nbsp;(rectum), which makes the intestinal mucosa swollen and red (inflamed), leading to frequent and bloody stools along with stomach cramps.<\/p>\n\n\n\n<p>When Mezavant is given in an\u00a0acute\u00a0stage of\u00a0ulcerative colitis, it acts throughout the\u00a0colon\u00a0and\u00a0rectum\u00a0to treat\u00a0inflammation\u00a0and relieve symptoms.\u00a0The tablets can also be used to prevent the recurrence of\u00a0ulcerative colitis.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What you need to know before you take Mezavant<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Do not take Mezavant<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>if you are allergic (hypersensitive) to a group of medicines called salicylates (which include&nbsp;acetylsalicylic acid&nbsp;)<\/li><li>if you are allergic (hypersensitive) to mesalazine or any of the other ingredients of this medicine (listed in section 6 of this data)<\/li><li>if you have severe kidney or liver problems<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Warnings and cautions<\/h2>\n\n\n\n<p>Talk to your doctor before using Mezavant<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>if you have kidney or liver problems<\/li><li>if you have a history of heart inflammation (which may be caused by a heart infection)<\/li><li>if you have ever developed severe rash or dandruff, blistering and \/ or sores in your mouth after using Mezavant<\/li><li>if you have previously had an&nbsp;allergic reaction&nbsp;to sulfasalazine (another medicine used to treat&nbsp;ulcerative colitis&nbsp;)<\/li><li>if you have a narrowing or blockage in your stomach or intestines<\/li><li>if you have lung problems<\/li><\/ul>\n\n\n\n<p>Before and regularly during treatment, your doctor may take urine and blood samples to check that your kidneys are working well and that your blood is normal.<\/p>\n\n\n\n<p>Kidney stones&nbsp;can be formed when using Mezavant.&nbsp;Symptoms may include pain in the sides of the abdomen and blood in the urine.&nbsp;Be sure to drink enough fluids during treatment with Mezavant.<\/p>\n\n\n\n<p>Serious skin reactions, such as\u00a0Stevens-Johnson syndrome\u00a0and\u00a0toxic epidermal necrolysis, have been reported during treatment with Mezavant.\u00a0Stop using Mezavant and seek medical attention immediately if you experience any of the symptoms of these severe skin reactions described in section 4.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Children and young people<\/h2>\n\n\n\n<p>Mezavant is not recommended for use in children and adolescents weighing 50 kg or less and not for children under 10 years of age due to insufficient data on safety and efficacy (see section 3).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Other medicines and Mezavant<\/h2>\n\n\n\n<p>Studies have shown that Mezavant does not affect the following\u00a0antibiotics, which are used to treat infections: amoxicillin, metronidazole, or sulfamethoxazole.<\/p>\n\n\n\n<p>However, me Avant may affect some other medicines.\u00a0Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines.<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Mesalazine or sulfasalazine (taken to treat&nbsp;ulcerative colitis&nbsp;)<\/li><li>Non-steroidal anti-inflammatory drugs (for example, medicines containing&nbsp;acetylsalicylic acid&nbsp;,&nbsp;ibuprofen&nbsp;or&nbsp;diclofenac&nbsp;)<\/li><li>Azathioprine or 6-mercaptopurine or other drugs that are known to affect the function of&nbsp;bone marrow&nbsp;(so-called &#8220;immunosuppressive&#8221; drugs which reduce the activity of the body&#8217;s immune system).&nbsp;Bone marrow&nbsp;is the&nbsp;tissue&nbsp;in the skeleton that produces&nbsp;blood cells&nbsp;.<\/li><li>Coumarin&nbsp;-type anticoagulants (drugs that prolong blood clotting time) e.g.&nbsp;warfarin<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Mezavant with food and drink<\/h2>\n\n\n\n<p>Mezavant should be taken with food and at the same time each day.&nbsp;The tablets should be swallowed whole and must not be crushed or chewed.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pregnancy and breastfeeding<\/h2>\n\n\n\n<p>As mesalazine passes into the fetus during pregnancy and is excreted in small amounts in breast milk, you should only use Mezavant during pregnancy and breastfeeding if your doctor tells you to.\u00a0Adverse outcomes (including low\u00a0blood cell counts\u00a0(\u00a0white blood cells,\u00a0red blood cells,\u00a0and\u00a0platelets\u00a0)) were reported in infants of mothers who took Mezavant during pregnancy.\u00a0Diarrhea has been reported in infants who were breastfed by mothers who used Mezavant.<\/p>\n\n\n\n<p>If you are pregnant or breastfeeding, think you may be pregnant, or are planning to have a baby, ask your doctor for advice before taking this medicine.<\/p>\n\n\n\n<p><strong>Impact on laboratory tests<\/strong><\/p>\n\n\n\n<p>If you are going to take urine samples, you must tell your doctor or nurse that you are taking or have recently taken this medicine, as it may affect some results.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Driving and using machines<\/h2>\n\n\n\n<p>Mezavant is unlikely to affect your ability to drive or use machines.<\/p>\n\n\n\n<p>You are responsible for assessing whether you are fit to drive a motor vehicle or perform work that requires sharpened attention.\u00a0One of the factors that can affect your ability in these respects is the use of drugs due to their effects and\/or\u00a0side effects.\u00a0The description of these effects and\u00a0side effects\u00a0can be found in other sections.\u00a0Read all the information in this leaflet for guidance.\u00a0If you are not sure, talk to your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Mezavant contains sodium<\/h2>\n\n\n\n<p>This medicine contains less than 1 mmol (23 mg)\u00a0sodium\u00a0per recommended maximum\u00a0dose\u00a0(4 tablets), ie is essential &#8216;sodium-free&#8217;.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to take Mezavant<\/h2>\n\n\n\n<p>Always take this medicine exactly as your doctor has told you.&nbsp;Ask your doctor or pharmacist if you are unsure.<\/p>\n\n\n\n<p>The recommended\u00a0dose\u00a0for adults is 2.4 g to 4.8 g (two to four tablets) taken once daily in an\u00a0acute\u00a0phase of\u00a0ulcerative colitis.\u00a0The maximum daily\u00a0dose\u00a0of 4.8 g should not be taken for more than 8 weeks.\u00a0Once your symptoms have subsided, and to prevent recurrent attacks, your doctor should instruct you to take 2.4 g (two tablets) daily.<\/p>\n\n\n\n<p>In the&nbsp;acute&nbsp;phase of&nbsp;ulcerative colitis&nbsp;(the first 8 weeks of treatment), the recommended&nbsp;dose&nbsp;for children and adolescents weighing more than 50 kg and aged 10 years or older is 2.4 g to 4.8 g (two to four tablets) once daily.<\/p>\n\n\n\n<p>To prevent recurrent episodes of&nbsp;ulcerative colitis&nbsp;in children and adolescents weighing more than 50 kg and aged 10 years or older, the recommended&nbsp;dose&nbsp;is 2.4 g (two tablets) once daily.<\/p>\n\n\n\n<p>Remember to take your tablets at the same time each day with food.&nbsp;The tablets should be swallowed whole and must not be crushed or chewed.<\/p>\n\n\n\n<p>When taking this medicine, be sure to drink fluids to maintain a good fluid balance, especially after severe or prolonged vomiting and\/or diarrhea, high fever, or heavy sweating.<\/p>\n\n\n\n<p>Mezavant is not recommended for use in children and adolescents weighing 50 kg or less, and not for children under 10 years of age due to insufficient data on safety and efficacy.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you take more Mezavant than you should<\/h2>\n\n\n\n<p>If you take more Mezavant than you should, you may experience one or more of the following symptoms:\u00a0tinnitus\u00a0(ringing in the ears), dizziness, headache, confusion, drowsiness, shortness of breath, increased fluid loss (associated with sweating, diarrhea, and vomiting), low blood sugar (which can cause dizziness), rapid breathing, altered blood levels, and increased body temperature.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">If you forget to take Mezavant<\/h2>\n\n\n\n<p>You must take your Mezavant tablets every day, even when you have no symptoms of\u00a0ulcerative colitis.\u00a0Always complete the entire prescribed treatment.<\/p>\n\n\n\n<p>If you forget to take your tablets, take them, as usual, the next day.\u00a0Do not take a double\u00a0dose\u00a0to make up for a forgotten tablet.<\/p>\n\n\n\n<p>If you have any further questions on the use of this product, ask your doctor or pharmacist.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Possible side effects<\/h2>\n\n\n\n<p><strong>Tell your doctor immediately<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>If you experience symptoms such as cramps, severe abdominal pain, bloody and increased bowel movements (diarrhea), fever, headache or rash.&nbsp;These symptoms may be signs of&nbsp;acute&nbsp;intolerance syndrome which may occur during an&nbsp;acute&nbsp;phase (&nbsp;relapse&nbsp;) of&nbsp;ulcerative colitis&nbsp;.&nbsp;This is a serious condition that rarely occurs, but requires your treatment to be stopped immediately.<\/li><li>If you develop unexplained bruising (without injury), rash,&nbsp;anemia&nbsp;(feeling tired, weak and pale, especially on the lips, nails and inside of the eyelids), fever (high body temperature), sore throat or unusual bleeding (eg nosebleeds) .<\/li><li>If you notice reddish, non-raised spots on the torso that resemble targets or are round, often with blisters in the middle, scaly skin, sores in the mouth, throat, nose, genitals and eyes.&nbsp;These severe skin rashes can be preceded by fever and&nbsp;flu-like symptoms&nbsp;.<\/li><li>If you develop an allergic swelling of the tongue, lips and around the eyes.<\/li><li>If you develop increased pressure in the brain that causes headaches that can begin behind the eyes and worsen with eye movements, with blurred or blurred vision, double vision, that you see flashes, difficulty looking to the side and short-term or permanent vision loss.&nbsp;These may be accompanied by dizziness, nausea, vomiting and ringing in the ears.<\/li><\/ul>\n\n\n\n<p>Like all medicines, this medicine can cause\u00a0side effects, although not everybody gets them.<\/p>\n\n\n\n<p><strong>Common\u00a0side effects<\/strong>,\u00a0occurring in less than 1 in 10 patients, are headache, changes in blood pressure,\u00a0flatulence\u00a0(flatulence), nausea, bloating or aching stomach,\u00a0inflammation-causing abdominal pain or diarrhea, diarrhea, indigestion, vomiting, abnormal liver function,\u00a0itching, joint pain, back pain, weakness, fatigue (extreme fatigue), fever.<\/p>\n\n\n\n<p><strong>Uncommon\u00a0side effects<\/strong>,\u00a0experienced by less than 1 in 100 patients, are decreased\u00a0platelet count, which increases the risk of bleeding and bruising, dizziness, drowsiness or tiredness, tremors or tremors, earache, rapid heartbeat, sore throat, inflamed\u00a0pancreas\u00a0( linked to pain in the upper abdomen and back and nausea), rectal\u00a0polyp\u00a0(a non-cancerous growth in the rectum which causes symptoms such as constipation and bleeding),\u00a0acne, hair loss, muscle pain,\u00a0hives, swollen face.<\/p>\n\n\n\n<p><strong>Rare\u00a0side effects<\/strong>,\u00a0experienced by less than 1 in 1,000 patients, are\u00a0kidney failure, the sharp decrease in the number of\u00a0white blood cells, which increases the risk of\u00a0infection, increased skin sensitivity to sunlight and ultraviolet light (\u00a0photosensitivity\u00a0).<\/p>\n\n\n\n<p><strong>The following&nbsp;side effects&nbsp;have been reported, but it is not known exactly how often they occur:<\/strong><\/p>\n\n\n\n<p>Severe decrease in the number of\u00a0blood cells, which may cause weakness or bruising, low number of\u00a0blood cells,\u00a0allergic reaction\u00a0(hypersensitivity), severe\u00a0allergic reaction\u00a0that causes difficulty breathing or dizziness, severe disease with blisters on the skin<\/p>\n\n\n\n<p>(which can cause the skin to be scary and painful, sore areas), or in<\/p>\n\n\n\n<p>mouth, eyes, and genitals,\u00a0allergic reaction\u00a0causing rash, fever, and\u00a0inflammation\u00a0of internal organs,\u00a0neuropathy\u00a0(abnormal or damaged nerves leading to numbness and tingling),\u00a0inflammation\u00a0of the heart and surrounding\u00a0tissue,\u00a0pneumonia, difficulty breathing or wheezing,\u00a0gallstones,\u00a0hepatitis\u00a0(\u00a0inflammation\u00a0of the liver which causes\u00a0flu-like symptoms and jaundice), liver toxicity (liver damage that may manifest as abnormal liver values), allergic swelling of the tongue, lips and around the eyes, reddening of the skin, especially rash on the face, skin more sensitive to sunlight along with joint pain,\u00a0arthritis, fatigue and general malaise, kidney problems (such as\u00a0inflammation\u00a0and scarring of the kidneys),\u00a0kidney stones\u00a0and kidney pain (see also section 2), decreased reversible sperm production\u00a0(which goes back).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How to store Mezavant<\/h2>\n\n\n\n<ul class=\"wp-block-list\"><li>Keep this medicine out of the sight and reach of children.<\/li><li>Do not store above 25 \u00b0 C.<\/li><li>Store in the original package.&nbsp;Moisture sensitive.<\/li><li>Do not use this medicine after the expiry date which is stated on the carton after \u201cEXP\u201d.&nbsp;The expiration date is the last day of the specified month.<\/li><li>Medicines should not be disposed of via wastewater or household waste.&nbsp;Ask your pharmacist how to dispose of medicines no longer required.&nbsp;These measures will help to protect the environment.<\/li><\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Contents of the pack and other information<\/h2>\n\n\n\n<h2 class=\"wp-block-heading\">Content declaration<\/h2>\n\n\n\n<p>The active substance is mesalazine 1200 mg.<\/p>\n\n\n\n<p>The other ingredients are carmellose sodium, carnauba wax, stearic acid,\u00a0colloidal\u00a0hydrated silica, sodium starch glycolate (type A), talc, magnesium stearate, Methacrylic acid &#8211; methyl methacrylate copolymer (1: 1),<\/p>\n\n\n\n<p>Methacrylic acid &#8211; methyl methacrylate copolymer (1: 2), triethyl citrate, titanium dioxide (E171), red iron oxide (E172), macrogol 6000.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What the medicine looks like and contents of the pack<\/h2>\n\n\n\n<p>Mezavant is supplied in blister packs of foil which are packed in a carton.&nbsp;The pack contains 60 or 120 tablets.<\/p>\n\n\n\n<p>Not all pack sizes may be marketed.<\/p>\n\n\n\n<p>The tablets are reddish-brown, oval (dimensions 20.5 \u00d7 9.5 \u00d7 7.5 mm), and embossed with S476.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Marketing Authorization Holder and Manufacturer<\/h2>\n\n\n\n<figure class=\"wp-block-table\"><table><tbody><tr><td><strong>Marketing Authorisation Holder<\/strong>Shire Pharmaceuticals Ireland LimitedBlock 2 &amp; 3 Miesian Plaza50 &#8211; 58 Baggot Street LowerDublin 2IrelandTel: +44 (0) 1256 894 959Email: medinfoEMEA@shire.com<\/td><td><strong>Manufacturer<\/strong>Cosmo SpAVia C. Colombo 120045 Lainate-MilanItaly<\/td><\/tr><tr><td><strong>Local representative<\/strong>Takeda Pharma ABBox 30143104 25 StockholmTel: 08-731 28 00Email: infosweden@takeda.com<\/td><td>&nbsp;<\/td><\/tr><\/tbody><\/table><\/figure>\n","protected":false},"excerpt":{"rendered":"<p>Mesalazine contained in Mezavant may also be approved for the treatment of other conditions not mentioned in this product information. Ask your doctor, pharmacist or other healthcare professional if you have any further questions and always follow their instructions.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"cybocfi_hide_featured_image":"","footnotes":""},"categories":[2200,15580],"tags":[17089,17522,9949,17088,9952,17517,17521,17520,9950,17518,9951,17519],"class_list":["post-17903","post","type-post","status-publish","format-standard","hentry","category-medicines","category-m","tag-benefits-of-mesalazine","tag-benefits-of-mezavant","tag-mesalazine","tag-mesalazine-side-effects","tag-mesalazine-tablet","tag-mezavant","tag-mezavant-side-effects","tag-mezavant-tablet","tag-what-is-mesalazine","tag-what-is-mezavant","tag-what-mesalazine-is-used-for","tag-what-mezavant-is-used-for"],"_links":{"self":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/17903","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/comments?post=17903"}],"version-history":[{"count":4,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/17903\/revisions"}],"predecessor-version":[{"id":17946,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/posts\/17903\/revisions\/17946"}],"wp:attachment":[{"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/media?parent=17903"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/categories?post=17903"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zeepedia.com\/medical\/wp-json\/wp\/v2\/tags?post=17903"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}